| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Nicolas, A Ju, Y Wu, H Eldirdiri, S Delcasso, Y Couderc, C Fornari, A Mitra, L Supiot, A Vérité, M Masson, S Rodriguez-Rozada, D Jacky, J S Wiegert, A Beyele. Linking emotional valence and anxiety in a mouse insula-amygdala circuit. Nature communications. vol 14. issue 1. 2023-08-21. PMID:37604802. |
responses of the insular cortex (ic) and amygdala to stimuli of positive and negative valence are altered in patients with anxiety disorders. |
2023-08-21 |
2023-09-07 |
mouse |
| Rodrigo Moraga-Amaro, Paula Muñoz, Tomás Villalobos, Sergio Linsambarth, Francisco Maldonado, Valeria Meirone, Bruno Femopase, Jimmy Stehber. Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder. Psychiatry research. vol 320. 2022-12-31. PMID:36586377. |
in this study, the combined stimulation of the insula and pfc using the dtms h4 (insula+lpfc) and h2 (pfc) coils were used to reduce anxiety in 13 subjects experiencing occupational stress, and 55 participants suffering from generalized anxiety disorder (gad). |
2022-12-31 |
2023-08-14 |
human |
| Ceylan Ergül, Çiğdem Ulaşoğlu Yildiz, Elif Kurt, Ani Kiçik, Raşit Tüke. Evaluation of Resting-State Functional Magnetic Resonance Imaging Findings of Patients with Social Anxiety Disorder. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 33. issue 2. 2022-06-22. PMID:35730507. |
the most prominent functional magnetic resonance imaging findings about social anxiety disorder are increased activity in emotional regulation areas (amygdala, insula, hippocampus, dorsal anterior cingulate cortex) and fear circuit, and altered activity in prefrontal cortex. |
2022-06-22 |
2023-08-14 |
Not clear |
| Nathaniel S Rieger, Juan A Varela, Alexandra J Ng, Lauren Granata, Anthony Djerdjaj, Heather C Brenhouse, John P Christianso. Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-02-27. PMID:35220413. |
the insular cortex is consistently implicated in stress-related social and anxiety disorders, which are associated with diminished ability to make and use inferences about the emotions of others to guide behavior. |
2022-02-27 |
2023-08-13 |
rat |
| Dinavahi V P S Murty, Songtao Song, Kelly Morrow, Jongwan Kim, Kesong Hu, Luiz Pesso. Distributed and Multifaceted Effects of Threat and Safety. Journal of cognitive neuroscience. 2021-12-23. PMID:34942650. |
a central goal of the study was to test the prediction that a subset of brain regions would exhibit sustained response profiles during threat periods, including the anterior insula, a region implicated in anxiety disorders. |
2021-12-23 |
2023-08-13 |
human |
| Murad Atmaca, Mustafa Koc, Osman Mermi, Sevda Korkmaz, Sabriye Aslan, Hanefi Yildiri. Insula volumes are altered in patients with social anxiety disorder. Behavioural brain research. vol 400. 2021-11-15. PMID:33181184. |
in the present study, we aimed at examining the volumes of the insula in more pure patients with a social anxiety disorder. |
2021-11-15 |
2023-08-13 |
Not clear |
| Murad Atmaca, Mustafa Koc, Osman Mermi, Sevda Korkmaz, Sabriye Aslan, Hanefi Yildiri. Insula volumes are altered in patients with social anxiety disorder. Behavioural brain research. vol 400. 2021-11-15. PMID:33181184. |
insula volumes are altered in patients with social anxiety disorder. |
2021-11-15 |
2023-08-13 |
Not clear |
| b' Bianca Besteher, Christian Gaser, Igor Nenadi\\xc4\\x8. Brain Structure and Subclinical Symptoms: A Dimensional Perspective of Psychopathology in the Depression and Anxiety Spectrum. Neuropsychobiology. vol 79. issue 4-5. 2021-04-06. PMID:31340207.' |
these studies show effects associated with subclinical symptoms in the hippocampus, anterior cingulate cortex, and anterior insula similar to major depression and changes in amygdala similar to anxiety disorders. |
2021-04-06 |
2023-08-13 |
human |
| Huiru Cui, Bin Zhang, Wei Li, Hui Li, Jiaoyan Pang, Qiang Hu, Lanlan Zhang, Yingying Tang, Zhi Yang, Jijun Wang, Chunbo Li, Georg Northof. Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder. Depression and anxiety. vol 37. issue 7. 2020-11-20. PMID:32196828. |
on the basis of the somatic symptoms in generalized anxiety disorder (gad), especially abnormal heartbeat perception, we hypothesized that abnormal activity in the insula was associated with interoceptive awareness in patients with gad. |
2020-11-20 |
2023-08-13 |
Not clear |
| Huiru Cui, Bin Zhang, Wei Li, Hui Li, Jiaoyan Pang, Qiang Hu, Lanlan Zhang, Yingying Tang, Zhi Yang, Jijun Wang, Chunbo Li, Georg Northof. Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder. Depression and anxiety. vol 37. issue 7. 2020-11-20. PMID:32196828. |
insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder. |
2020-11-20 |
2023-08-13 |
Not clear |
| Maxs Méndez-Ruette, Sergio Linsambarth, Rodrigo Moraga-Amaro, Daisy Quintana-Donoso, Luis Méndez, Giovanni Tamburini, Francisca Cornejo, Rodrigo F Torres, Jimmy Stehber. The Role of the Rodent Insula in Anxiety. Frontiers in physiology. vol 10. 2020-09-29. PMID:30984021. |
the human insula has been consistently reported to be overactivated in all anxiety disorders, activation which has been suggested to be proportional to the level of anxiety and shown to decrease with effective anxiolytic treatment. |
2020-09-29 |
2023-08-13 |
human |
| Elizabeth R Duval, Sonalee A Joshi, Stefanie Russman Block, James L Abelson, Israel Liberzo. Insula activation is modulated by attention shifting in social anxiety disorder. Journal of anxiety disorders. vol 56. 2019-06-05. PMID:29729828. |
insula activation is modulated by attention shifting in social anxiety disorder. |
2019-06-05 |
2023-08-13 |
human |
| Sabrina Suffren, Mélissa Chauret, Marouane Nassim, Franco Lepore, Françoise S Mahe. On a continuum to anxiety disorders: Adolescents at parental risk for anxiety show smaller rostral anterior cingulate cortex and insula thickness. Journal of affective disorders. vol 248. 2019-04-15. PMID:30711867. |
on a continuum to anxiety disorders: adolescents at parental risk for anxiety show smaller rostral anterior cingulate cortex and insula thickness. |
2019-04-15 |
2023-08-13 |
Not clear |
| Vasiliki Michopoulos, Abigail Powers, Charles F Gillespie, Kerry J Ressler, Tanja Jovanovi. Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 1. 2018-01-16. PMID:27510423. |
dysregulation of the stress axis in the face of increased sympathetic tone and decreased parasympathetic activity characteristic of anxiety disorders could further augment inflammation and contribute to increased symptoms by having direct effects on brain regions critical for the regulation of fear and anxiety (such as the prefrontal cortex, insula, amygdala, and hippocampus). |
2018-01-16 |
2023-08-13 |
Not clear |
| Xu Chen, Patrick D Hackett, Ashley C DeMarco, Chunliang Feng, Sabrina Stair, Ebrahim Haroon, Beate Ditzen, Giuseppe Pagnoni, James K Rillin. Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women. Brain imaging and behavior. vol 10. issue 2. 2017-09-14. PMID:26040978. |
anxiety disorders are characterized by hyperactivity in both the amygdala and the anterior insula. |
2017-09-14 |
2023-08-13 |
human |
| Raşit Tükel, Kubilay Aydın, Çağrı Yüksel, Erhan Ertekin, Ahmet Koyunc. Proton Magnetic Resonance Spectroscopy in Social Anxiety Disorder. The Journal of neuropsychiatry and clinical neurosciences. vol 28. issue 2. 2017-01-06. PMID:26569150. |
in the present study, 24 nonmedicated patients with social anxiety disorder (sad) were compared with 24 healthy control subjects to assess metabolite levels in the anterior cingulate, insula, caudate, and putamen using proton magnetic resonance spectroscopy. |
2017-01-06 |
2023-08-13 |
human |
| Desmond J Oathes, Lori M Hilt, Jack B Nitschk. Affective neural responses modulated by serotonin transporter genotype in clinical anxiety and depression. PloS one. vol 10. issue 2. 2015-11-20. PMID:25675343. |
utilizing a triallelic assay (5-httlpr and rs25531) to assess genetic variation linked with altered serotonin signaling, this fmri study investigated genetic influences on amygdala and anterior insula activity in 50 generalized anxiety disorder patients, 26 of whom also met dsm-iv criteria for social anxiety disorder and/or major depressive disorder, and 39 healthy comparison subjects. |
2015-11-20 |
2023-08-13 |
human |
| Heide Klumpp, Daniel A Fitzgerald, Edwin Cook, Stewart A Shankman, Mike Angstadt, K Luan Pha. Serotonin transporter gene alters insula activity to threat in social anxiety disorder. Neuroreport. vol 25. issue 12. 2015-02-24. PMID:25003950. |
serotonin transporter gene alters insula activity to threat in social anxiety disorder. |
2015-02-24 |
2023-08-13 |
Not clear |
| Heide Klumpp, Daniel A Fitzgerald, Edwin Cook, Stewart A Shankman, Mike Angstadt, K Luan Pha. Serotonin transporter gene alters insula activity to threat in social anxiety disorder. Neuroreport. vol 25. issue 12. 2015-02-24. PMID:25003950. |
amygdala and insula hyper-reactivity to threat is implicated in social anxiety disorder (sad) yet inconsistencies in activation have been reported. |
2015-02-24 |
2023-08-13 |
Not clear |
| Stephanie M Gorka, Brady D Nelson, K Luan Phan, Stewart A Shankma. Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression. Biology of mood & anxiety disorders. vol 4. 2014-10-22. PMID:25337388. |
prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. |
2014-10-22 |
2023-08-13 |
human |