| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
despite accruing evidence for relative preservation of episodic memory in the semantic variant of primary progressive aphasia (previously semantic dementia), the neural basis for this remains unclear, particularly in light of their well-established hippocampal involvement. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
the present study investigated the status of key components of papez circuit (hippocampus, mammillary bodies, anterior thalamus, cingulate cortex) and anterior temporal cortex using volumetric and quantitative cell counting methods in pathologically-confirmed cases with semantic variant of primary progressive aphasia (n = 8; 61-83 years; three males), behavioural variant frontotemporal dementia with tdp pathology (n = 9; 53-82 years; six males) and healthy controls (n = 8, 50-86 years; four males). |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
behavioural variant frontotemporal dementia cases with tdp pathology were selected because of the association between the semantic variant of primary progressive aphasia and tdp pathology. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
our findings revealed that the semantic variant of primary progressive aphasia and behavioural variant frontotemporal dementia show similar degrees of anterior thalamic atrophy. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
the mammillary bodies and hippocampal body and tail were preserved in the semantic variant of primary progressive aphasia but were significantly atrophic in behavioural variant frontotemporal dementia. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
importantly, atrophy in the anterior thalamus and mild progressive atrophy in the body of the hippocampus emerged as the main memory circuit regions correlated with increasing dementia severity in the semantic variant of primary progressive aphasia. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
we also show that by end-stage these neurons selectively degenerate in the semantic variant of primary progressive aphasia with preservation of neurons in the posterior cingulate cortex. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
overall, our findings demonstrate for the first time, severe atrophy, although not necessarily neuronal loss, across all relay nodes of papez circuit with the exception of the mammillary bodies and hippocampal body and tail in the semantic variant of primary progressive aphasia. |
2014-08-25 |
2023-08-13 |
Not clear |
| Rachel H Tan, Stephanie Wong, Jillian J Kril, Olivier Piguet, Michael Hornberger, John R Hodges, Glenda M Hallida. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24844729. |
despite the longer disease course in the semantic variant of primary progressive aphasia compared with behavioural variant frontotemporal dementia, we suggest here that the neural preservation of crucial memory relays (hippocampal→mammillary bodies and posterior cingulate→hippocampus) likely reflects the conservation of specific episodic memory components observed in most patients with semantic variant of primary progressive aphasia. |
2014-08-25 |
2023-08-13 |
Not clear |
| Brian B Avants, David J Libon, Katya Rascovsky, Ashley Boller, Corey T McMillan, Lauren Massimo, H Branch Coslett, Anjan Chatterjee, Rachel G Gross, Murray Grossma. Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population. NeuroImage. vol 84. 2014-08-11. PMID:24096125. |
the cohort includes164 patients with alzheimer's disease, behavioral-variant frontotemporal dementia, semantic variant primary progressive aphasia, non-fluent/agrammatic primary progressive aphasia, or corticobasal syndrome. |
2014-08-11 |
2023-08-12 |
Not clear |
| Federica Agosta, Sebastiano Galantucci, Elisa Canu, Stefano F Cappa, Giuseppe Magnani, Massimo Franceschi, Andrea Falini, Giancarlo Comi, Massimo Filipp. Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: a DT MRI study and a literature review. Brain and language. vol 127. issue 2. 2014-07-28. PMID:23890877. |
disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: a dt mri study and a literature review. |
2014-07-28 |
2023-08-12 |
Not clear |
| Federica Agosta, Sebastiano Galantucci, Elisa Canu, Stefano F Cappa, Giuseppe Magnani, Massimo Franceschi, Andrea Falini, Giancarlo Comi, Massimo Filipp. Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: a DT MRI study and a literature review. Brain and language. vol 127. issue 2. 2014-07-28. PMID:23890877. |
nonfluent (nfv) and semantic (sv) variants of primary progressive aphasia (ppa) are associated with distinct patterns of focal cortical atrophy and underlying pathology. |
2014-07-28 |
2023-08-12 |
Not clear |
| Robert Laforc. Behavioral and language variants of frontotemporal dementia: a review of key symptoms. Clinical neurology and neurosurgery. vol 115. issue 12. 2014-07-28. PMID:24446563. |
by contrast, the language variants or primary progressive aphasias (ppas) are marked by prominent language disturbances that can be subclassified into a non-fluent/agrammatic variant (nappa), a semantic variant (svppa), and a logopenic variant (lvppa). |
2014-07-28 |
2023-08-12 |
Not clear |
| Youngsin Jung, Joseph R Duffy, Keith A Joseph. Primary progressive aphasia and apraxia of speech. Seminars in neurology. vol 33. issue 4. 2014-07-14. PMID:24234355. |
the majority of primary progressive aphasia cases can be classified into three subtypes: nonfluent/agrammatic, semantic, and logopenic variants. |
2014-07-14 |
2023-08-12 |
Not clear |
| Jonathan Graff-Radford, David T Jones, Neill R Graff-Radfor. Pathophysiology of language, speech and emotions in neurodegenerative disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262187. |
the syndromes are progressive nonfluent aphasia, semantic dementia, logopenic aphasia, primary progressive apraxia of speech and dysprosody of speech. |
2014-07-11 |
2023-08-12 |
Not clear |
| Howard S Kirshne. Frontotemporal dementia and primary progressive aphasia, a review. Neuropsychiatric disease and treatment. vol 10. 2014-06-26. PMID:24966676. |
four clinical subtypes characterize the predominant presentations of this illness: behavioral or frontal variant ftd, progressive nonfluent aphasia, semantic dementia, and logopenic primary progressive aphasia. |
2014-06-26 |
2023-08-13 |
Not clear |
| M-Marsel Mesulam, Sandra Weintraub, Emily J Rogalski, Christina Wieneke, Changiz Geula, Eileen H Bigi. Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia. Brain : a journal of neurology. vol 137. issue Pt 4. 2014-05-21. PMID:24574501. |
the progressive supranuclear palsy subtype of ftld-tau consistently caused prominent speech abnormality together with agrammatism whereas ftld-tar dna binding protein 43 of type c consistently led to semantic primary progressive aphasia. |
2014-05-21 |
2023-08-12 |
Not clear |
| Chiara Cerami, Alessandra Marcone, Daniela Galimberti, Chiara Villa, Chiara Fenoglio, Elio Scarpini, Stefano F Capp. Novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia. Journal of Alzheimer's disease : JAD. vol 36. issue 3. 2014-02-17. PMID:23624518. |
novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia. |
2014-02-17 |
2023-08-12 |
human |
| Chiara Cerami, Alessandra Marcone, Daniela Galimberti, Chiara Villa, Chiara Fenoglio, Elio Scarpini, Stefano F Capp. Novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia. Journal of Alzheimer's disease : JAD. vol 36. issue 3. 2014-02-17. PMID:23624518. |
hereby, we describe a patient affected by semantic variant of primary progressive aphasia (svppa) with a highly positive family history of dementia, carrying a novel grn missense variation in exon 11 [g.2897 c > t (p.thr409met)], predicted in silico to be damaging to protein structure and function. |
2014-02-17 |
2023-08-12 |
human |
| M Küper, M Zöller, S Liebeskind, J Wiltfang, J Benninghof. PET imaging in a case of the semantic variant of primary progressive aphasia. Fortschritte der Neurologie-Psychiatrie. vol 81. issue 7. 2014-02-13. PMID:23856947. |
pet imaging in a case of the semantic variant of primary progressive aphasia. |
2014-02-13 |
2023-08-12 |
Not clear |