Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Tianhao Mei, Ying Chen, Yajuan Gao, Hang Zhao, Xingzhou Lyu, Jing Lin, Tianye Niu, Hongbin Han, Zhiqian Ton. Formaldehyde initiates memory and motor impairments under weightlessness condition. NPJ microgravity. vol 10. issue 1. 2024-10-29. PMID:39468074. |
especially, the accumulation of fa may inactivate the ataxia telangiectasia-mutated (atm) protein kinase by forming cross-linking, a process that is associated with ataxia. |
2024-10-29 |
2024-10-31 |
Not clear |
Jacopo Sartorelli, Lorena Travaglini, Vito Luigi Colona, Carlo Casali, Francesca Cumbo, Adele D'Amico, Daniela Longo, Antonio Novelli, Gessica Vasco, Enrico Bertini, Francesco Nicit. De Novo GRID2 Variant as a Cause of Ataxia with Oculomotor Apraxia and Alpha-Fetoprotein Elevation. Cerebellum (London, England). 2024-09-23. PMID:39312122. |
grid2 expression appears to be influenced by other genes related with ataxia and afp elevation, like atm and aptx, suggesting a possible shared mechanism. |
2024-09-23 |
2024-09-26 |
human |
Ofra Barnet-Griness, Stephen B Gruber, Steven M Lipkin, Katerina Shulman, Riad Haddad, Ronen Galili, Gad Renner. Ataxia telangiectasia-mutated rs56009889 and risk of common cancers. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2024-08-16. PMID:39150041. |
a polymorphic variant in the ataxia telangiectasia-mutated (atm) gene, rs56009889, was recently associated with an increased risk of lung cancer. |
2024-08-16 |
2024-08-18 |
human |
Young Don Kwak, Timothy I Shaw, Susanna M Downing, Ambika Tewari, Hongjian Jin, Yang Li, Lavinia C Dumitrache, Sachin Katyal, Kamran Khodakhah, Helen R Russell, Peter J McKinno. Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration. Science advances. vol 7. issue 51. 2024-08-15. PMID:34910524. |
here, we report new disease-relevant murine models of genome instability–driven neurodegeneration involving disabled atm and aptx that develop debilitating ataxia. |
2024-08-15 |
2024-08-17 |
Not clear |
Wei Li, Yongjian Ha. Polo-Like Kinase 1 and DNA Damage Response. DNA and cell biology. 2024-07-03. PMID:38959179. |
plk1 is not only an important target of the g2/m dna damage checkpoint but also negatively regulates the g2/m checkpoint commander ataxia telangiectasia-mutated (atm), promotes g2/m phase checkpoint recovery, and regulates homologous recombination repair by interacting with rad51 and brca1, the key factors of homologous recombination repair. |
2024-07-03 |
2024-07-10 |
Not clear |
Andrea J Hartlerode, Ahmed M Mostafa, Steven K Orban, Rachel Benedeck, Koral Campbell, Mark J Hoenerhoff, David O Ferguson, JoAnn M Sekiguch. Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder. Human molecular genetics. 2024-06-18. PMID:38888340. |
we demonstrate that, distinct from ataxia telangiectasia-like disorder caused by mre11 pathogenic missense or nonsense variants, mice and cultured cells expressing low mre11 levels do not display the anticipated defects in atm activation. |
2024-06-18 |
2024-06-21 |
mouse |
Asli Muvaffak, Kevin G Colema. PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation. Frontiers in oncology. vol 14. 2024-05-29. PMID:38807759. |
ataxia telangiectasia-mutated (atm) kinase is a central regulator of the dna damage response (ddr) signaling pathway, and its function is critical for the maintenance of genomic stability in cells that coordinate a network of cellular processes, including dna replication, dna repair, and cell cycle progression. |
2024-05-29 |
2024-06-03 |
human |
Nagesh Kishan Panchal, Poorva Samdani, Tiasa Sengupta, Sabina Evan Princ. Computational Analysis of Non-synonymous SNPs in ATM Kinase: Structural Insights, Functional Implications, and Inhibitor Discovery. Molecular biotechnology. 2024-03-15. PMID:38489015. |
ataxia telangiectasia-mutated (atm) protein kinase, a key player in cellular integrity regulation, is known for its role in dna damage response. |
2024-03-15 |
2024-03-18 |
Not clear |
Zhenbang Gu, Peng Huang, Jiali Zhao, Chen Luo, Lingmin Liao, Anwen Liu, Long Huan. Bilateral diffuse metastases in advanced lung adenocarcinoma harboring EGFR mutations was associated with a favorable prognosis to EGFR-TKIs. International journal of cancer. 2024-02-14. PMID:38353428. |
the co-mutation genes kirsten rat sarcoma viral oncogene homolog (kras) (9.4%), ataxia telangiectasia-mutated (atm) (7.4%) and mesenchymal-epithelial transition (met) (3.1%) only appeared in the control group after psm. |
2024-02-14 |
2024-02-16 |
rat |
Kevin Koschitzki, Irina Ivanova, Mark Bernebur. [Progeroid syndromes : Aging, skin aging, and mechanisms of progeroid syndromes]. Dermatologie (Heidelberg, Germany). 2023-08-31. PMID:37650893. |
while some of those genes encode proteins with a direct involvement in a dna repair machinery, such as nucleotide excision repair (ner), others destabilize the genome by compromising the stability of the nuclear envelope, when lamin a is dysfunctional in hutchinson-gilford progeria syndrome (hgps) or regulate the dna damage response (ddr) such as the ataxia telangiectasia-mutated (atm) gene. |
2023-08-31 |
2023-09-07 |
Not clear |
Yan Jin, Yiting Li, Shiyi He, Yijun Ge, Yun Zhao, Ke Zhu, Andong He, Siyu Li, Siyu Yan, Chao Ca. ATM participates in fine particulate matter-induced airway inflammation through regulating DNA damage and DNA damage response. Environmental toxicology. 2023-07-24. PMID:37483094. |
ataxia telangiectasia-mutated heterozygous (atm |
2023-07-24 |
2023-08-14 |
Not clear |
Elise Berthel, Laurent Pujo-Menjouet, Eymeric Le Reun, Laurène Sonzogni, Joëlle Al-Choboq, Abdennasser Chekroun, Adeline Granzotto, Clément Devic, Mélanie L Ferlazzo, Sandrine Pereira, Michel Bourguignon, Nicolas Fora. Toward an Early Diagnosis for Alzheimer's Disease Based on the Perinuclear Localization of the ATM Protein. Cells. vol 12. issue 13. 2023-07-14. PMID:37443782. |
in order to examine the molecular basis of this radiosensitivity, the atm-dependent dna double-strand breaks (dsb) signaling and repair were investigated by applying an approach based on the radiation-induced ataxia telangiectasia-mutated (atm) protein nucleoshuttling (rians) model. |
2023-07-14 |
2023-08-14 |
Not clear |
Timothy A Yap, Elisa Fontana, Elizabeth K Lee, David R Spigel, Martin Højgaard, Stephanie Lheureux, Niharika B Mettu, Benedito A Carneiro, Louise Carter, Ruth Plummer, Gregory M Cote, Funda Meric-Bernstam, Joseph O'Connell, Joseph D Schonhoft, Marisa Wainszelbaum, Adrian J Fretland, Peter Manley, Yi Xu, Danielle Ulanet, Victoria Rimkunas, Mike Zinda, Maria Koehler, Ian M Silverman, Jorge S Reis-Filho, Ezra Rose. Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nature medicine. 2023-06-05. PMID:37277454. |
ataxia telangiectasia and rad3-related kinase inhibitors (atri) have been shown to be synthetic lethal with loss of function (lof) of ataxia telangiectasia-mutated (atm) kinase, and preclinical studies have identified atri-sensitizing alterations in other dna damage response (ddr) genes. |
2023-06-05 |
2023-08-14 |
Not clear |
Watanya Trakarnphornsombat, Hiroshi Kimur. Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. Journal of cell science. 2023-03-31. PMID:36999484. |
on the induction of dsbs, histone h2ax becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), and dna-dependent protein kinase (dna-pk). |
2023-03-31 |
2023-08-14 |
Not clear |
Giovanna De Michele, Luigi Maione, Sirio Cocozza, Mario Tranfa, Chiara Pane, Daniele Galatolo, Anna De Rosa, Giuseppe De Michele, Francesco Saccà, Alessandro Fill. Ataxia and Hypogonadism: a Review of the Associated Genes and Syndromes. Cerebellum (London, England). 2023-03-30. PMID:36997834. |
in the second part, we mention clinical syndromes and genes (polr3a, clpp, eral1, hars, hsd17b4, lars2, twnk, polg, atm, wfs1, pmm2, fmr1) linked to complex phenotypes that include, among other features, ataxia and hypogonadism. |
2023-03-30 |
2023-08-14 |
Not clear |
Maria G Fencer, Kelly A Krupa, Gabrielle C Bleich, Sherry Grumet, Firas G Eladoumikdachi, Shicha Kumar, Maria J Kowzun, Lindsay B Potdevi. Diagnosis, Management, and Surveillance for Patients With PALB2, CHEK2, and ATM Gene Mutations. Clinical breast cancer. 2023-03-25. PMID:36966080. |
this study aims to capture clinical and surgical practice patterns of patients with deleterious mutations in partner and localizer of brca2 (palb2), checkpoint kinase 2 (chek2) and ataxia telangiesctasia mutated (atm) genes. |
2023-03-25 |
2023-08-14 |
Not clear |
Yuri Tozaki, Hiromasa Aoki, Rina Kato, Kohki Toriuchi, Saki Arame, Yasumichi Inoue, Hidetoshi Hayashi, Eiji Kubota, Hiromi Kataoka, Mineyoshi Aoyam. The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells. Cancers. vol 15. issue 3. 2023-02-11. PMID:36765693. |
in the present study, the combination of ataxia telangiectasia-mutated serine/threonine kinase (atm) and checkpoint kinase 1 (chk1) inhibition exhibited synergistic antitumor effects and induced synergistic lethality in colorectal cancer cells at a low dose. |
2023-02-11 |
2023-08-14 |
mouse |
Yelei Cen, Guohua Lou, Jinjin Qi, Minwei Li, Min Zheng, Yanning Li. Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury. Antioxidants (Basel, Switzerland). vol 12. issue 1. 2023-01-21. PMID:36671020. |
the downregulation of activated ataxia telangiectasia-mutated (atm) and dna damage response proteins in amsc-treated mouse liver indicated amscs blocked the jnk-atm pathway. |
2023-01-21 |
2023-08-14 |
mouse |
Jared R Erickson, Robert F Kalejta, Paul D Friese. Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection. Journal of virology. 2022-10-31. PMID:36314821. |
ddr signaling is initiated by the host insect's phosphatidylinositol-3 kinase-related kinases (pikks), including ataxia telangiectasia-mutated kinase (atm). |
2022-10-31 |
2023-08-14 |
Not clear |
Qian Zhou, Ting Che. BI6727, a polo-like kinase 1 inhibitor, synergizes with gefitinib to suppress hepatocellular carcinoma cells via a G2/M arrest mechanism. Die Pharmazie. vol 77. issue 7. 2022-10-06. PMID:36199185. |
furthermore, two critical checkpoints proteins ataxia telangiectasia-mutated (p-atm)/ atm and rad-3 related(p-atr) and another hallmark phosphorylated h2ax (γ-h2ax ) of dna damage were positively regulated in hcc cells exposed to gefitinib in combination with bi6727. |
2022-10-06 |
2023-08-14 |
Not clear |