| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeru Honda, Ken Matsumura, Yuji Hashimoto, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, Kinya Ishikaw. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023-04-28. PMID:37115382. |
temporal relationship between impairment of cerebellar motor learning and deterioration of ataxia in patients with cerebellar degeneration. |
2023-04-28 |
2023-08-14 |
Not clear |
| Takeru Honda, Ken Matsumura, Yuji Hashimoto, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, Kinya Ishikaw. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023-04-28. PMID:37115382. |
ataxia and impaired motor learning are both fundamental features in diseases affecting the cerebellum. |
2023-04-28 |
2023-08-14 |
Not clear |
| Kyriakos Vattis, Anna C Luddy, Jessey S Ouillon, Nicole M Eklund, Christopher D Stephen, Jeremy D Schmahmann, Adonay S Nunes, Anoopum S Gupt. Sensitive quantification of cerebellar speech abnormalities using deep learning models. medRxiv : the preprint server for health sciences. 2023-04-17. PMID:37066308. |
speech changes are one of the earliest and most evident manifestations of cerebellar ataxias. |
2023-04-17 |
2023-08-14 |
Not clear |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
proinflammatory activation of microglia in the cerebellum hyperexcites purkinje cells to trigger ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
however, direct evidence that cerebellar microglial activation in vivo is sufficient to induce ataxia is still lacking. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
here, by employing chemogenetic approaches to manipulate cerebellar microglia selectively and directly, we found that specific chemogenetic activation of microglia in the cerebellar vermis directly leads to ataxia symptoms in wild-type mice and aggravated ataxic motor deficits in 3-acetylpyridine (3-ap) mice, a classic mouse model of cerebellar ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
mechanistically, cerebellar microglial proinflammatory activation induced by either chemogenetic m3d(gq) stimulation or 3-ap modeling hyperexcites purkinje cells (pcs), which consequently triggers ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
our findings thus reveal a causal relationship between proinflammatory activation of cerebellar microglia and ataxic motor symptoms, which may offer novel evidence for therapeutic intervention for cerebellar ataxias by targeting microglia and microglia-derived inflammatory mediators. |
2023-04-17 |
2023-08-14 |
mouse |
| Carolina Santos, Sofia Malheiro, Manuel Correia, Joana Damási. Gene Suppression Therapies in Hereditary Cerebellar Ataxias: A Systematic Review of Animal Studies. Cells. vol 12. issue 7. 2023-04-13. PMID:37048110. |
gene suppression therapies in hereditary cerebellar ataxias: a systematic review of animal studies. |
2023-04-13 |
2023-08-14 |
Not clear |
| Carolina Santos, Sofia Malheiro, Manuel Correia, Joana Damási. Gene Suppression Therapies in Hereditary Cerebellar Ataxias: A Systematic Review of Animal Studies. Cells. vol 12. issue 7. 2023-04-13. PMID:37048110. |
hereditary cerebellar ataxias (hcas) are a heterogenous group of neurodegenerative disorders associated with severe disability. |
2023-04-13 |
2023-08-14 |
Not clear |
| Nicolaas J M Arts, Maud E G van Dorst, Sandra H Vos, Roy P C Kessel. Coordination and Cognition in Pure Nutritional Wernicke's Encephalopathy with Cerebellar Degeneration after COVID-19 Infection: A Unique Case Report. Journal of clinical medicine. vol 12. issue 7. 2023-04-13. PMID:37048595. |
alcoholic cerebellar degeneration is a restricted form of cerebellar degeneration, clinically leading to an ataxia of stance and gait and occurring in the context of alcohol misuse in combination with malnutrition and thiamine depletion. |
2023-04-13 |
2023-08-14 |
Not clear |
| Nicolaas J M Arts, Maud E G van Dorst, Sandra H Vos, Roy P C Kessel. Coordination and Cognition in Pure Nutritional Wernicke's Encephalopathy with Cerebellar Degeneration after COVID-19 Infection: A Unique Case Report. Journal of clinical medicine. vol 12. issue 7. 2023-04-13. PMID:37048595. |
however, a similar degeneration may also develop after non-alcoholic malnutrition, but evidence for a lasting ataxia of stance and gait and lasting abnormalities in the cerebellum is lacking in the few patients described with purely nutritional cerebellar degeneration (ncd). |
2023-04-13 |
2023-08-14 |
Not clear |
| Dmitry Yu Isaev, Roza M Vlasova, J Matias Di Martino, Christopher D Stephen, Jeremy D Schmahmann, Guillermo Sapiro, Anoopum S Gupt. Uncertainty of Vowel Predictions as a Digital Biomarker for Ataxic Dysarthria. Cerebellum (London, England). 2023-04-11. PMID:37039956. |
dysarthria is a common manifestation across cerebellar ataxias leading to impairments in communication, reduced social connections, and decreased quality of life. |
2023-04-11 |
2023-08-14 |
human |
| Andreas Traschütz, Astrid D Adarmes-Gomez, Mathieu Anheim, Jonathan Baets, Björn H Falkenburger, Janina Gburek-Augustat, Sarah Doss, Christoph Kamm, Peter Klivenyi, Marcus Grobe-Einsler, Thomas Klopstock, Martina Minnerop, Alexander Münchau, Chiara Pane, Mathilde Renaud, Filippo M Santorelli, Ludger Schöls, Dagmar Timmann, Stefan Vielhaber, Tobias B Haack, Bart P van de Warrenburg, Ginevra Zanni, Matthis Synofzi. Autosomal Recessive Cerebellar Ataxias in Europe: Frequency, Onset, and Severity in 677 Patients. Movement disorders : official journal of the Movement Disorder Society. 2023-04-07. PMID:37027459. |
autosomal recessive cerebellar ataxias in europe: frequency, onset, and severity in 677 patients. |
2023-04-07 |
2023-08-14 |
Not clear |
| Anhar Hassa. Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches. Tremor and other hyperkinetic movements (New York, N.Y.). vol 13. 2023-04-03. PMID:37008993. |
episodic ataxia (ea), characterized by recurrent attacks of cerebellar dysfunction, is the manifestation of a group of rare autosomal dominant inherited disorders. |
2023-04-03 |
2023-08-14 |
Not clear |
| Keisuke Ishii, Takao Kohno, Mitsuharu Hattor. Postnatal injection of Reelin protein into the cerebellum ameliorates the motor functions in reeler mouse. Neuroscience research. 2023-04-03. PMID:37011786. |
in both humans and mice, the lack of reelin gene causes cerebellar hypoplasia and ataxia. |
2023-04-03 |
2023-08-14 |
mouse |
| Mehri Salari, Masoud Etemadifar, Ronak Rashedi, Sayna Mardan. A Review of Ocular Movement Abnormalities in Hereditary Cerebellar Ataxias. Cerebellum (London, England). 2023-03-31. PMID:37000369. |
a review of ocular movement abnormalities in hereditary cerebellar ataxias. |
2023-03-31 |
2023-08-14 |
Not clear |
| Mehri Salari, Masoud Etemadifar, Ronak Rashedi, Sayna Mardan. A Review of Ocular Movement Abnormalities in Hereditary Cerebellar Ataxias. Cerebellum (London, England). 2023-03-31. PMID:37000369. |
cerebellar ataxias are a wide heterogeneous group of disorders that may present with fine motor deficits as well as gait and balance disturbances that have a significant influence on everyday activities. |
2023-03-31 |
2023-08-14 |
Not clear |
| Mehri Salari, Masoud Etemadifar, Ronak Rashedi, Sayna Mardan. A Review of Ocular Movement Abnormalities in Hereditary Cerebellar Ataxias. Cerebellum (London, England). 2023-03-31. PMID:37000369. |
to review the ocular movements in cerebellar ataxias in order to improve the clinical knowledge of cerebellar ataxias and related subtypes. |
2023-03-31 |
2023-08-14 |
Not clear |
| Nicole M Eklund, Jessey Ouillon, Vineet Pandey, Christopher D Stephen, Jeremy D Schmahmann, Jeremy Edgerton, Krzysztof Z Gajos, Anoopum S Gupt. Real-life ankle submovements and computer mouse use reflect patient-reported function in adult ataxias. Brain communications. vol 5. issue 2. 2023-03-30. PMID:36993945. |
thirty-four individuals with degenerative ataxias (spinocerebellar ataxia types 1, 2, 3 and 6 and multiple system atrophy of the cerebellar type) and eight age-matched controls completed the cross-sectional study. |
2023-03-30 |
2023-08-14 |
mouse |