| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel K Peterson, Philip Duvall, Deana Crocetti, Tara Palin, Joshua Robinson, Stewart H Mostofsky, Keri S Rosc. ADHD-related sex differences in frontal lobe white matter microstructure and associations with response control under conditions of varying cognitive load and motivational contingencies. Brain imaging and behavior. 2023-09-07. PMID:37676408. |
sex-based dissociation for the effect of diagnosis was observed in medial orbitofrontal cortex (mofc), with higher fa in girls with adhd and lower fa in boys with adhd. |
2023-09-07 |
2023-10-07 |
human |
| Yi-Chao Wang, Jun Liu, Yan-Chun Wu, Yan Wei, Hong-Jing Xie, Tao Zhang, Zhen Zhan. A randomized, sham-controlled trial of high-definition transcranial direct current stimulation on the right orbital frontal cortex in children and adolescents with attention-deficit hyperactivity disorder. Frontiers in psychiatry. vol 14. 2023-03-02. PMID:36860502. |
this study aimed to find out the clinical and cognitive effects of high-definition transcranial direct current stimulation (hd-tdcs) on the right orbital frontal cortex (ofc) in the treatment of attention deficit hyperactivity disorder (adhd). |
2023-03-02 |
2023-08-14 |
Not clear |
| Kwangmi Ahn, Luke J Norman, Cristina M Justice, Philip Sha. ADHD and its neurocognitive substrates: A two sample Mendelian randomization study. Translational psychiatry. vol 12. issue 1. 2022-09-09. PMID:36085199. |
we found that genetic risk for adhd was causally associated with a decreased area of lateral orbitofrontal cortex. |
2022-09-09 |
2023-08-14 |
Not clear |
| Katharine E Musella, Lisa L Weyand. Attention-deficit hyperactivity disorder and youth's emotion dysregulation: A systematic review of fMRI studies. Applied neuropsychology. Child. 2022-09-06. PMID:36065486. |
although studies varied in the structures investigated, the most notable differences appeared in the prefrontal cortex, orbitofrontal cortex, amygdala, and ventral striatum in adhd participants. |
2022-09-06 |
2023-08-14 |
human |
| Tammo Viering, Pieter J Hoekstra, Alexandra Philipsen, Jilly Naaijen, Andrea Dietrich, Catharina A Hartman, Barbara Franke, Jan K Buitelaar, Andrea Hildebrandt, Christiane M Thiel, Carsten Gießin. Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence. NeuroImage. vol 245. 2021-12-11. PMID:34813971. |
larger nodal efficiency of the right orbitofrontal cortex was related to a better course of adhd (99 participants, 42 females, age range: 10-29). |
2021-12-11 |
2023-08-13 |
human |
| Mrinaal Valmiki, Peter Fawzy, Surbhi Valmiki, Mohamed A Aid, Ali R Chaitou, Maria Zahid, Safeera Kha. Reinforcement and Compensatory Mechanisms in Attention-Deficit Hyperactivity Disorder: A Systematic Review of Case-Control Studies. Cureus. vol 13. issue 3. 2021-04-10. PMID:33833929. |
ventral striatal hypo-responsiveness, orbitofrontal cortex, and dopaminergic status in the brain are related to the pathogenesis of adhd. |
2021-04-10 |
2023-08-13 |
human |
| Kevin Tran, Joseph W. Case report: neuroimaging analysis of pediatric ADHD-related symptoms secondary to hypoxic brain injury. Brain injury. vol 33. issue 10. 2020-07-06. PMID:31307241. |
also, not normally observed in adhd patients were decreases in the metabolism of the orbitofrontal cortex, anterior cingulate, left anterior insular cortex, and left striatum. |
2020-07-06 |
2023-08-13 |
Not clear |
| Jana Tegelbeckers, Martin Kanowski, Kerstin Krauel, John-Dylan Haynes, Carolin Breitling, Hans-Henning Flechtner, Thorsten Kahn. Orbitofrontal Signaling of Future Reward is Associated with Hyperactivity in Attention-Deficit/Hyperactivity Disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 30. 2019-10-28. PMID:29954849. |
the orbitofrontal cortex (ofc) plays a key role in controlling goal-directed behavior, but the link between ofc dysfunction and behavioral deficits in adhd, particularly in adolescence, remains poorly understood. |
2019-10-28 |
2023-08-13 |
human |
| Francisco Zamorano, Pablo Billeke, Leonie Kausel, Josefina Larrain, Ximena Stecher, Jose M Hurtado, Vladimir López, Ximena Carrasco, Francisco Aboiti. Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28775285. |
finally, adhd subjects presented greater functional connectivity between rlpfc and bilateral orbitofrontal cortex than the td group. |
2019-06-04 |
2023-08-13 |
human |
| Rachel Yep, Stephen Soncin, Donald C Brien, Brian C Coe, Alina Marin, Douglas P Muno. Using an emotional saccade task to characterize executive functioning and emotion processing in attention-deficit hyperactivity disorder and bipolar disorder. Brain and cognition. vol 124. 2019-02-11. PMID:29698907. |
these findings support the role of fronto-striatal circuitry in mediating response inhibition deficits in both adhd and bd, and suggest that such deficits are exacerbated in bd during emotion processing, presumably via dysregulated limbic system circuitry involving the anterior cingulate and orbitofrontal cortex. |
2019-02-11 |
2023-08-13 |
human |
| Qi Liu, Lizhou Chen, Fei Li, Ying Chen, Lanting Guo, Qiyong Gong, Xiaoqi Huan. [Voxel-Based Morphometry in Medicated-naive Boys with Attention-deficit/hyperactivity Disorder(ADHD)]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 3. 2018-05-24. PMID:29709154. |
attention-deficit/hyperactivity disorder(adhd)is one of the most common neuro-developmental disorders occurring in childhood,characterized by symptoms of age-inappropriate inattention,hyperactivity/impulsivity,and the prevalence is higher in boys.although gray matter volume deficits have been frequently reported for adhd children via structural magnetic resonance imaging,few of them had specifically focused on male patients.the present study aimed to explore the alterations of gray matter volumes in medicated-naive boys with adhd via a relatively new voxel-based morphometry technique.according to the criteria of dsm-iv-tr,43medicated-naive adhd boys and 44age-matched healthy boys were recruited.the magnetic resonance image(mri)scan was performed via a 3t mri system with three-dimensional(3d)spoiled gradient recalled echo(spgr)sequence.voxel-based morphometry with diffeomorphic anatomical registration through exponentiated lie algebra in spm8 was used to preprocess the3dt1-weighted images.to identify gray matter volume differences between the adhd and the controls,voxelbased analysis of whole brain gray matter volumes between two groups were done via two sample t-test in spm8 with age as covariate,threshold at p<0.001.finally,compared to the controls,significantly reduced gray matter volumes were identified in the right orbitofrontal cortex(peak coordinates[-2,52,-25],t=4.01),and bilateral hippocampus(left:peak coordinates[14,0,-18],t=3.61;right:peak coordinates[-14,15,-28],t=3.64)of adhd boys.our results demonstrated obvious reduction of whole brain gray matter volumes in right orbitofrontal cortex and bilateral hippocampus in boys with adhd.this suggests that the abnormalities of prefrontal-hippocampus circuit may be the underlying cause of the cognitive dysfunction and abnormal behavioral inhibition in medicatednaive boys with adhd. |
2018-05-24 |
2023-08-13 |
Not clear |
| Marianne Oldehinkel, Christian F Beckmann, Barbara Franke, Catharina A Hartman, Pieter J Hoekstra, Jaap Oosterlaan, Dirk Heslenfeld, Jan K Buitelaar, Maarten Menne. Functional connectivity in cortico-subcortical brain networks underlying reward processing in attention-deficit/hyperactivity disorder. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27818941. |
task-based fmri studies have related atypical reward processing in adhd to altered bold activity in regions underlying reward processing such as ventral striatum and orbitofrontal cortex. |
2017-11-17 |
2023-08-13 |
Not clear |
| L J S Schweren, C A Hartman, M P Zwiers, D J Heslenfeld, B Franke, J Oosterlaan, J K Buitelaar, P J Hoekstr. Stimulant treatment history predicts frontal-striatal structural connectivity in adolescents with attention-deficit/hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 4. 2017-05-03. PMID:26899587. |
our findings are compatible with stimulant treatment enhancing orbitofrontal-striatal white matter connectivity, and emphasize the importance of the orbitofrontal cortex and its connections in adhd. |
2017-05-03 |
2023-08-13 |
human |
| New-Fei Ho, Joanna S X Chong, Hui Li Koh, Eleni Koukouna, Tih-Shih Lee, Daniel Fung, Choon Guan Lim, Juan Zho. Intrinsic Affective Network Is Impaired in Children with Attention-Deficit/Hyperactivity Disorder. PloS one. vol 10. issue 9. 2016-06-17. PMID:26406311. |
in this study, we use resting-state functional magnetic resonance imaging to test the hypothesis of diminished functional integration within the affective/limbic network (which includes the amygdala, hippocampus, subgenual cingulate cortex, orbitofrontal cortex and nucleus accumbens) of children with adhd, which is associated with their behavioral measures of emotional control deficits. |
2016-06-17 |
2023-08-13 |
human |
| Gopikrishna Deshpande, Peng Wang, D Rangaprakash, Bogdan Wilamowsk. Fully Connected Cascade Artificial Neural Network Architecture for Attention Deficit Hyperactivity Disorder Classification From Functional Magnetic Resonance Imaging Data. IEEE transactions on cybernetics. vol 45. issue 12. 2016-05-31. PMID:25576588. |
finally, the most discriminative connectivity features provided insights about the pathophysiology of adhd and showed reduced and altered connectivity involving the left orbitofrontal cortex and various cerebellar regions in adhd. |
2016-05-31 |
2023-08-13 |
human |
| Sucharita S Somkuwar, Kathleen M Kantak, Linda P Dwoski. Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder. Journal of neuroscience methods. vol 252. 2016-04-27. PMID:25680322. |
attention deficit hyperactivity disorder (adhd) is associated with hypofunctional medial prefrontal cortex (mpfc) and orbitofrontal cortex (ofc). |
2016-04-27 |
2023-08-13 |
rat |
| Rubi Hammer, Michael Tennekoon, Gillian E Cooke, Jessica Gayda, Mark A Stein, James R Boot. Feedback associated with expectation for larger-reward improves visuospatial working memory performances in children with ADHD. Developmental cognitive neuroscience. vol 14. 2016-03-07. PMID:26142072. |
when feedback was associated with small-reward, or when large-reward was expected but feedback was not available, boys with adhd exhibited altered neural activity in the medial orbitofrontal cortex and anterior insula. |
2016-03-07 |
2023-08-13 |
Not clear |
| Ning He, Fei Li, Yuanyuan Li, Lanting Guo, Lizhou Chen, Xiaoqi Huang, Su Lui, Qiyong Gon. Neuroanatomical deficits correlate with executive dysfunction in boys with attention deficit hyperactivity disorder. Neuroscience letters. vol 600. 2015-10-19. PMID:26049007. |
significantly reduced gray matter volumes were identified in the right orbitofrontal cortex, right primary motor/premotor cortex, left anterior cingulate cortex and left posterior midcingulate cortex of adhd patients compared with controls (p<0.05, corrected for family-wise errors). |
2015-10-19 |
2023-08-13 |
human |
| Jonathan Posner, Francesco Siciliano, Zhishun Wang, Jun Liu, Edmund Sonuga-Barke, Laurence Greenhil. A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression? Psychiatry research. vol 224. issue 2. 2014-12-18. PMID:25220159. |
compared with the hc participants, the participants with adhd had (i) reduced volumes of the left hippocampus and (ii) reduced functional connectivity between the left hippocampus and the left orbitofrontal cortex (ofc); these hippocampal effects were associated with more severe depressive symptoms, even after controlling for the severity of inattentive and hyperactive/impulsive symptoms. |
2014-12-18 |
2023-08-13 |
human |
| Alberto Fernández-Jaén, Sara López-Martín, Jacobo Albert, Daniel Martín Fernández-Mayoralas, Ana Laura Fernández-Perrone, Diana Quiñones Tapia, Beatriz Calleja-Pére. Cortical thinning of temporal pole and orbitofrontal cortex in medication-naïve children and adolescents with ADHD. Psychiatry research. vol 224. issue 1. 2014-12-05. PMID:25085707. |
cortical thinning of temporal pole and orbitofrontal cortex in medication-naïve children and adolescents with adhd. |
2014-12-05 |
2023-08-13 |
human |