| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Osama Al-Dalahmah, Matti Lam, Julie J McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A Jakubiak, Rebekka Kühn, Yoon A Kim, Maria Caterina De Rosa, Claudia A Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A DeTure, Jean Paul Vonsattel, Zbigniew K Wszolek, Dennis W Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R Schöler, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, James E Goldman, Vilas Menon, Peter Canoll, Gunnar Hargu. Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell stem cell. 2024-04-16. PMID:38626772. |
frontotemporal dementia (ftd) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. |
2024-04-16 |
2024-04-19 |
mouse |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
for the youngest individual with no documented dementia samples exhibited sparse tau deposits. |
2024-04-15 |
2024-04-17 |
Not clear |
| Irina Alafuzoff, Sylwia Libar. Ageing-Related Neurodegeneration and Cognitive Decline. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612875. |
age-related tau astrogliopathy (artag) was observed in 37% of the 1610 subjects and in 53% of those with dementia. |
2024-04-13 |
2024-04-15 |
human |
| Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiy. Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population. Psychiatry and clinical neurosciences. 2024-04-12. PMID:38606661. |
to assess the association between plasma amyloid β (aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (gfap), or neurofilament light chain (nfl) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population. |
2024-04-12 |
2024-04-14 |
Not clear |
| Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, Gábor Csukl. Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-12. PMID:38610055. |
risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis. |
2024-04-12 |
2024-04-15 |
human |
| Geert Mayer, Helmut Frohnhofen, Martha Jokisch, Dirk M Hermann, Janine Gronewol. Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review. Frontiers in neuroscience. vol 18. 2024-04-08. PMID:38586191. |
aging is accompanied by changes of sleep structure, deposition of beta-amyloid (aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (mci) as well as dementia. |
2024-04-08 |
2024-04-10 |
Not clear |
| Elijah Mak, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Matthew L Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R Jack, Hoon Ki Min, Manoj K Jain, Toji Miyagawa, Leah K Forsberg, Julie A Fields, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, Hugo Botha, Erik K St Louis, David S Knopman, Vijay K Ramanan, Dennis W Dickson, Neill R Graff-Radford, Tanis J Ferman, Ronald C Petersen, Val J Lowe, Bradley F Boeve, John T O'Brien, Kejal Kantarc. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-03. PMID:38570511. |
influences of amyloid-β and tau on white matter neurite alterations in dementia with lewy bodies. |
2024-04-03 |
2024-04-06 |
Not clear |
| Elijah Mak, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Matthew L Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R Jack, Hoon Ki Min, Manoj K Jain, Toji Miyagawa, Leah K Forsberg, Julie A Fields, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, Hugo Botha, Erik K St Louis, David S Knopman, Vijay K Ramanan, Dennis W Dickson, Neill R Graff-Radford, Tanis J Ferman, Ronald C Petersen, Val J Lowe, Bradley F Boeve, John T O'Brien, Kejal Kantarc. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-03. PMID:38570511. |
we evaluated the associations of tau and amyloid-β with dti and noddi parameters and examined the correlations of ad-related white matter injury with clinical dementia rating (cdr). |
2024-04-03 |
2024-04-06 |
Not clear |
| Dennis C Chan, ChaeMin Kim, Rachel Y Kang, Madison K Kuhn, Lynne M Beidler, Nanyin Zhang, Elizabeth A Procto. Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559177. |
alzheimer's disease is a neurodegenerative disorder characterized by progressive amyloid plaque accumulation, tau tangle formation, neuroimmune dysregulation, synapse an neuron loss, and changes in neural circuit activation that lead to cognitive decline and dementia. |
2024-04-01 |
2024-04-04 |
mouse |
| Po-Chung Yu, Ching-Min Kuo, I-Chun Che. Tau and delirium superimposed on dementia: A case report. SAGE open medical case reports. vol 12. 2024-04-01. PMID:38559407. |
tau and delirium superimposed on dementia: a case report. |
2024-04-01 |
2024-04-04 |
Not clear |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
the six brain-specific tau isoforms and their role in alzheimer's disease and related neurodegenerative dementia syndromes. |
2024-04-01 |
2024-04-03 |
human |
| Lisa Bransby, Nawaf Yassi, Emily Rosenich, Rachel Buckley, Qiao-Xin Li, Paul Maruff, Matthew Pase, Yen Ying Li. Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults. Neurobiology of aging. vol 138. 2024-03-27. PMID:38537555. |
this study aimed to determine associations between modifiable dementia risk factors (mdrf), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (aβ) and tau, and brain volume. |
2024-03-27 |
2024-03-30 |
Not clear |
| Martin Tolar, John A Hey, Aidan Power, Susan Abushakr. The Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473975. |
amyloid oligomers appear to be the primary factor causing the synaptic impairment, neuronal stress, spreading of tau pathology, and eventual cell death that lead to the clinical syndrome of ad dementia. |
2024-03-13 |
2024-03-15 |
Not clear |
| Daniel Pirici, Laurentiu Mogoanta, Daniela Adriana Ion, Samir Kumar-Sing. Fractal Analysis in Neurodegenerative Diseases. Advances in neurobiology. vol 36. 2024-03-12. PMID:38468042. |
the abnormal conformation and assembly of proteins is suggested to be the most probable cause for many of these neurodegenerative disorders, leading to the accumulation of abnormally aggregated proteins, for example, amyloid β (aβ) (alzheimer's disease and vascular dementia), tau protein (alzheimer's disease and frontotemporal lobar degeneration), α-synuclein (parkinson's disease and lewy body dementia), polyglutamine expansion diseases (huntington disease), or prion proteins (creutzfeldt-jakob disease). |
2024-03-12 |
2024-03-14 |
Not clear |
| María A Rodríguez-Santiago, Valerie Wojna, Eric Miranda-Valentín, Steven Arnold, Vanessa Sepúlveda-River. Diagnosing Alzheimer's disease: Which dementia screening test to use in elderly Puerto Ricans with mild cognitive impairment and early Alzheimer's disease? Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-03-08. PMID:38454965. |
our study aims to demonstrate a correlation between the screening tools, including the mini-mental state examination (mmse), montreal cognitive assessment (moca), and clinical dementia rating (cdr), and the biological biomarkers in the cerebrospinal fluid (csf) amyloid beta 1-42 (aβ42), phosphorylated tau (p-tau) proteins and total tau (t-tau)/aβ42 ratio in puerto ricans > 55 years old with mci and e-ad. |
2024-03-08 |
2024-03-10 |
human |
| Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. |
this view is based on the significant although modest efficacy of some antibodies targeting amyloid-β in alzheimer's disease and the fact that tau pathology correlates much better with the degree of dementia than amyloid-β lesions. |
2024-03-01 |
2024-03-04 |
Not clear |
| Lars Tatenhorst, Fabian Maass, Hannah Paul, Vivian Dambeck, Mathias Bähr, Rosanna Dono, Paul Lingo. Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-02-29. PMID:38424123. |
initially described as supporting functionality of synapses via glutamate receptors during cns development, glypican 4 (gpc-4) also plays a role in the context of dementia via tau hyperphosphorylation in alzheimer's disease, which is also a co-pathology in parkinson's disease dementia. |
2024-02-29 |
2024-03-03 |
human |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for faq (p = 0.042), meta-cognition index t score (p = 0.014) and age of parkinsonian motor symptom onset (p = 0.046). |
2024-02-26 |
2024-02-28 |
human |
| Vaishnavi S Jadhav, Jade G Stair, Randall J Eck, Samuel N Smukowski, Heather N Currey, Laura Garcia Toscano, Joshua C Hincks, Caitlin S Latimer, Paul N Valdmanis, Brian C Kraemer, Nicole F Liachk. Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets. Neurobiology of disease. 2024-02-20. PMID:38378122. |
alzheimer's disease (ad), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (aβ) and tau aggregates in the brain. |
2024-02-20 |
2024-02-23 |
caenorhabditis_elegans |
| A C Macedo, D F P A Durço, C Tissot, J Therriault, A O Vilela de Faria, É Aumont, S Servaes, N Rahmouni, J Fernandez-Arias, Y-T Wang, F Z Lussier, A Bieger, E R Zimmer, T A Pascoal, S Gauthier, P Rosa-Net. Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 2. 2024-02-20. PMID:38374747. |
in line with this, there is a trend for unimpaired cognition, mild cognitive impairment, and alzheimer's disease dementia to be compatible with early, intermediate, and late patterns of tau deposition based on pet-based braak stages. |
2024-02-20 |
2024-02-22 |
Not clear |