| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pranitha Y Premnath, Joseph J Locascio, Kayden J Mimmack, Christopher Gonzalez, Michael J Properzi, Onyinye Udeogu, Paul B Rosenberg, Gad A Marshall, Jennifer R Gatche. Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 1. 2024-02-15. PMID:38356477. |
longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: findings from the alzheimer's disease neuroimaging initiative. |
2024-02-15 |
2024-02-17 |
Not clear |
| Helena Dolphin, Adam H Dyer, Laura Morrison, Susan D Shenkin, Tomas Welsh, Sean P Kennell. New horizons in the diagnosis and management of Alzheimer's Disease in older adults. Age and ageing. vol 53. issue 2. 2024-02-11. PMID:38342754. |
importantly, some older adults with positive amyloid or tau pathological biomarkers may never experience cognitive impairment or dementia. |
2024-02-11 |
2024-02-14 |
Not clear |
| Issam Hmila, Jaunetta Hill, Karim E Shalaby, Khalid Ouararhni, Houari Abedsselem, Seyed Mohamad Sadegh Modaresi, Syed Waseem Bihaqi, Emily Marques, Anya Sondhi, Angela L Slitt, Nasser H Zawi. Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development. Ecotoxicology and environmental safety. vol 272. 2024-02-10. PMID:38340603. |
although hfd interfered with memory retrieval, biomarkers of dementia did not change except for total tau and phosphorylated tau. |
2024-02-10 |
2024-02-14 |
mouse |
| Jeffrey S Phillips, John L Robinson, Katheryn A Q Cousins, David A Wolk, Edward B Lee, Corey T McMillan, John Q Trojanowski, Murray Grossman, David J Irwi. Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 6. 2024-02-07. PMID:38050082. |
we leveraged a dataset comprising antemortem mri and postmortem histopathology to assess polypathologic associations with atrophy in a clinically heterogeneous sample of 125 human dementia patients (41 female, 84 male) with t1-weighted mri ≤ 5 years before death and postmortem ordinal ratings of amyloid-[formula: see text], tau, tdp-43, and [formula: see text]-synuclein. |
2024-02-07 |
2024-02-10 |
human |
| Liyuan Jiao, Ziye Jing, Wenjie Zhang, Xuesen Su, Hualei Yan, Shouyuan Tia. Codon Pattern and Context Analysis in Genes Triggering Alzheimer's Disease and Latent Tau Protein Aggregation Post-Anesthesia Exhibited Unique Molecular Patterns Associated with Functional Aspects. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306048. |
previous reports have demonstrated post-operative dementia and alzheimer's disease (ad), and increased amyloid-β levels and tau hyperphosphorylation have been observed in animal models post-anesthesia. |
2024-02-02 |
2024-02-04 |
Not clear |
| Kathrin Wenger, Arthur Viode, Mukesh Kumar, Hanno Steen, Judith A Stee. Quantitative profiling of posttranslational modifications of pathological tau via sarkosyl fractionation and mass spectrometry. Nature protocols. 2024-01-30. PMID:38291250. |
tau protein aggregation is associated with posttranslational modifications (ptms) in 75% of all dementia cases. |
2024-01-30 |
2024-02-02 |
human |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A Spindler, Thomas F Tropea, Daniel Weintraub, David A Wolk, Murray Grossman, Virginia Lee, Alice S Chen-Plotkin, Edward B Lee, David J Irwi. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of clinical and translational neurology. 2024-01-24. PMID:38263854. |
here, we examined tau epitopes marking various stages of tangle maturation to test the hypotheses that tau maturation is more strongly associated with beta-amyloid compared to alpha-synuclein, and within the context of mixed pathology, mature tau is linked to alzheimer's disease clinical phenotype and negatively associated with lewy body dementia. |
2024-01-24 |
2024-01-26 |
Not clear |
| Ling Wu, Stephanie Arvai, Shih-Hsiu J Wang, Andy J Liu, Bin X. Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF. Frontiers in molecular neuroscience. vol 16. 2024-01-23. PMID:38260807. |
we collected matching plasma and csf samples of a clinically diagnosed cohort of 35 cognitively normal, 34 amci, 17 namci, and 31 ad dementia cases (total 117 participants) with supplemental csf aβ42 and total tau ad biomarker levels and performed simoa p-tau181 assays. |
2024-01-23 |
2024-01-25 |
human |
| I V Litvinenko, K M Naumov, V Yu Lobzin, A Yu Emelin, P S Dynin, K A Kolmakova, V O Nikishi. [Traumatic brain injury as risk factor of Alzheimer's disease and possibilities of pathogenetic therapy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 1. 2024-01-23. PMID:38261283. |
tbi, provoking endothelial dysfunction, contributes to the development of metabolic disorders of β-amyloid and tau protein, which in turn leads to worsening vascular damage, resulting in a vicious circle that can ultimately lead to the development of ad and dementia. |
2024-01-23 |
2024-01-25 |
Not clear |
| Bram L van der Gaag, Natasja A C Deshayes, John J P Breve, John G J M Bol, Allert J Jonker, Jeroen J M Hoozemans, Jean-Philippe Courade, Wilma D J van de Ber. Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia. Acta neuropathologica. vol 147. issue 1. 2024-01-10. PMID:38198008. |
distinct tau and alpha-synuclein molecular signatures in alzheimer's disease with and without lewy bodies and parkinson's disease with dementia. |
2024-01-10 |
2024-01-13 |
human |
| Bram L van der Gaag, Natasja A C Deshayes, John J P Breve, John G J M Bol, Allert J Jonker, Jeroen J M Hoozemans, Jean-Philippe Courade, Wilma D J van de Ber. Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia. Acta neuropathologica. vol 147. issue 1. 2024-01-10. PMID:38198008. |
here, we aimed to determine whether tau and asyn profiles differ between ad cases with lewy bodies (ad-lb), pure ad and parkinson's disease with dementia (pdd) cases using epitope-, post-translational modification- (ptm) and isoform-specific tau and asyn antibody panels spanning from the n- to c-terminus. |
2024-01-10 |
2024-01-13 |
human |
| Muhammad Ayaz, Osama F Mosa, Asif Nawaz, Alashary Adam Eisa Hamdoon, Modawy Elnour Modawy Elkhalifa, Abdul Sadiq, Farhat Ullah, Alshebli Ahmed, Atul Kabra, Haroon Khan, H C Ananda Murth. Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 124. 2024-01-05. PMID:38181530. |
alzheimer's diseases (ad) and dementia are among the highly prevalent neurological disorders characterized by deposition of beta amyloid (aβ) plaques, dense deposits of highly phosphorylated tau proteins, insufficiency of acetylcholine (ach) and imbalance in glutamatergic system. |
2024-01-05 |
2024-01-08 |
Not clear |
| Pallabi Sil Paul, Tark Patel, Jae-Young Cho, Allan Yarahmady, Aria Khalili, Valentyna Semenchenko, Holger Wille, Marianna Kulka, Sue-Ann Mok, Satyabrata Ka. Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167993. |
evidence suggests that beta-amyloid (aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and development of alzheimer's disease (ad), the most common cause of dementia affecting the elderly population. |
2024-01-03 |
2024-01-06 |
Not clear |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
knowledge of the mechanisms for tau propagation in neurodegeneration is necessary for understanding the development of dementia. |
2023-12-21 |
2023-12-23 |
human |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
furthermore, elucidation of ev cargo components that mediate tau propagation will have potential as biomarkers and therapeutic strategies to ameliorate dementia of tauopathies. |
2023-12-21 |
2023-12-23 |
human |
| Khalid Iqba. Tau and Alzheimer's disease: Past, present and future. Cytoskeleton (Hoboken, N.J.). 2023-12-21. PMID:38126608. |
these discoveries of tau pathology in ad opened a new and a major area of research on tau and on the molecular pathology of this major cause of dementia in middle- and old-age individuals. |
2023-12-21 |
2023-12-23 |
human |
| Tabea M Soelter, Timothy C Howton, Amanda D Clark, Vishal H Oza, Brittany N Lasseign. Altered Glia-Neuron Communication in Alzheimer's Disease Affects WNT, p53, and NFkB Signaling Determined by snRNA-seq. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076822. |
alzheimer's disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. |
2023-12-11 |
2023-12-17 |
Not clear |
| Bide Zhang, Vanessa Lage-Rupprecht, Philipp Wegner, Astghik Sargsyan, Stephan Gebel, Marc Jacobs, Jürgen Klein, Martin Hofmann-Apitius, Alpha Tom Kodamulli. Design of the formalized and integrated Alzheimer's Disease Ontology and its application in retrieving textual data via text mining. Database : the journal of biological databases and curation. vol 2023. 2023-12-02. PMID:38041858. |
as one of the leading causes for dementia in the population, it is imperative that we discern exactly why alzheimer's disease (ad) has a strong molecular association with beta-amyloid and tau. |
2023-12-02 |
2023-12-10 |
Not clear |
| Melina J Lim, Suelen L Boschen, Aishe Kurti, Monica Castanedes Casey, Virginia R Phillips, John D Fryer, Dennis Dickson, Karen R Jansen-West, Leonard Petrucelli, Marion Delenclos, Pamela J McLea. Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893236. |
investigating the pathogenic interplay of alpha-synuclein, tau, and amyloid beta in lewy body dementia: insights from viral-mediated overexpression in transgenic mouse models. |
2023-10-30 |
2023-11-08 |
mouse |
| Tehniat Faraz Ahmed, Fauzia Imtiaz, Uzma Zaman, Affan Ahmed, Naila Shahba. Comparison Of Potential Plasma Biomarkers In Alzheimer's Disease And Neurodegenerative Dementias In Pakistani Population. JPMA. The Journal of the Pakistan Medical Association. vol 73. issue 10. 2023-10-26. PMID:37876071. |
this study aimed to compare the mean plasma levels of amyloid β42, phosphorylated tau and neurofilament light chain in patients diagnosed with alzheimer's clinical syndrome (acs), and other neurodegenerative dementias to find affordable and less-invasive means of diagnosing alzheimer's disease (ad) early in its course. |
2023-10-26 |
2023-11-08 |
human |