| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erin E Congdon, Changyi Ji, Amber M Tetlow, Yixiang Jiang, Einar M Sigurdsso. Tau-targeting therapies for Alzheimer disease: current status and future directions. Nature reviews. Neurology. 2023-10-24. PMID:37875627. |
ad is characterized pathologically by amyloid-β (aβ) plaques and tau neurofibrillary tangles in the brain, with associated loss of synapses and neurons, which eventually results in dementia. |
2023-10-24 |
2023-11-08 |
Not clear |
| Fernando Gonzalez-Ortiz, Thomas K Karikari, Giuseppe Mario Bentivenga, Simone Baiardi, Angela Mammana, Michael Turton, Przemysław R Kac, Andrea Mastrangelo, Peter Harrison, Sabina Capellari, Henrik Zetterberg, Kaj Blennow, Piero Parch. Levels of plasma brain-derived tau and p-tau181 in Alzheimer's disease and rapidly progressive dementias. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-20. PMID:37858957. |
levels of plasma brain-derived tau and p-tau181 in alzheimer's disease and rapidly progressive dementias. |
2023-10-20 |
2023-11-08 |
Not clear |
| Markku Kurkine. Donanemab: Not two without a third. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-10-13. PMID:37831471. |
(2023) reported in a phase iii clinical trial that donanemab treatment of early symptomatic ad patients with amyloid and tau pathology provided 35% and 36% slowing of clinical progression and cognitive decline, respectively, as measured using the integrated alzheimer's disease rating scale (iadrs) and clinical dementia rating-sum of boxes (cdr-sb) psychometric tests. |
2023-10-13 |
2023-10-15 |
Not clear |
| Eduardo Ramirez, Susantha K Ganegamage, Sehong Min, Henika Patel, Adedayo Ogunware, Germán Plascencia-Villa, Heba Alnakhala, Kazuma Shimanaka, Arati Tripathi, Kuang-Wei Wang, Xiongwei Zhu, Jean-Christophe Rochet, Min-Hao Kuo, Scott E Counts, George Perry, Ulf Dettmer, Cristian A Lasagna-Reeves, Jessica S Forti. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation. ACS chemical neuroscience. 2023-10-11. PMID:37818657. |
our drug discovery program focuses on the synthesis of multitarget-directed ligands to abrogate aberrant α-syn, tau (2n4r), and p-tau (1n4r) aggregation and to slow the progression of ad and related dementias. |
2023-10-11 |
2023-10-15 |
human |
| Antonina Kouli, Lennart R B Spindler, Tim D Fryer, Young T Hong, Maura Malpetti, Franklin I Aigbirhio, Simon R White, Marta Camacho, John T O'Brien, Caroline H Williams-Gra. Neuroinflammation is linked to dementia risk in Parkinson's disease. Brain : a journal of neurology. 2023-09-27. PMID:37757857. |
neuroinflammation and tau protein accumulation have been demonstrated in post-mortem pd brains, and in many other neurodegenerative disorders leading to dementia. |
2023-09-27 |
2023-10-07 |
human |
| Antonina Kouli, Lennart R B Spindler, Tim D Fryer, Young T Hong, Maura Malpetti, Franklin I Aigbirhio, Simon R White, Marta Camacho, John T O'Brien, Caroline H Williams-Gra. Neuroinflammation is linked to dementia risk in Parkinson's disease. Brain : a journal of neurology. 2023-09-27. PMID:37757857. |
to this end, we used pet neuroimaging with [11c]pk11195 to index neuroinflammation and [18f]av-1451 for misfolded tau in early pd patients, stratified according to dementia risk in our 'neuroinflammation and tau accumulation in parkinson's disease dementia' (net-pdd) study. |
2023-09-27 |
2023-10-07 |
human |
| Antonina Kouli, Lennart R B Spindler, Tim D Fryer, Young T Hong, Maura Malpetti, Franklin I Aigbirhio, Simon R White, Marta Camacho, John T O'Brien, Caroline H Williams-Gra. Neuroinflammation is linked to dementia risk in Parkinson's disease. Brain : a journal of neurology. 2023-09-27. PMID:37757857. |
we hypothesised that people with higher dementia risk have greater inflammation and/or tau accumulation in advance of significant cognitive decline. |
2023-09-27 |
2023-10-07 |
human |
| Antonina Kouli, Lennart R B Spindler, Tim D Fryer, Young T Hong, Maura Malpetti, Franklin I Aigbirhio, Simon R White, Marta Camacho, John T O'Brien, Caroline H Williams-Gra. Neuroinflammation is linked to dementia risk in Parkinson's disease. Brain : a journal of neurology. 2023-09-27. PMID:37757857. |
although there was minimal regional tau accumulation in pd, regional neuroinflammation and tau burden correlated in pd participants, with the strongest association in the high dementia risk group, suggesting possible co-localisation of these pathologies. |
2023-09-27 |
2023-10-07 |
human |
| Bhavarth P Dave, Yesha B Shah, Kunal G Maheshwari, Kaif A Mansuri, Bhadrawati S Prajapati, Humzah I Postwala, Mehul R Chorawal. Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development. Cellular and molecular neurobiology. 2023-09-19. PMID:37725199. |
alzheimer's disease (ad) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. |
2023-09-19 |
2023-10-07 |
Not clear |
| Christopher G Schwarz, Walter K Kremers, Stephen D Weigand, Carl M Prakaashana, Matthew L Senjem, Scott A Przybelski, Val J Lowe, Jeffrey L Gunter, Kejal Kantarci, Prashanthi Vemuri, Jonathan Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jac. Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research. NeuroImage. Clinical. vol 40. 2023-09-13. PMID:37703605. |
we created a retrospective sample of participants from three age- and sex-matched clinical groups (cognitively unimpaired, mild cognitive impairment, and ad dementia, and we performed region- and voxel-wise analyses of: hippocampal volume (n), white matter hyperintensity volume (v), amyloid pet (a), and tau pet (t) measures, each from multiple software pipelines, on their ability to separate cognitively defined groups and their degrees of correlation with age and clinical dementia rating (cdr)-sum of boxes (cdr-sb). |
2023-09-13 |
2023-10-07 |
human |
| Agnieszka Kulczyńska-Przybik, Maciej Dulewicz, Julia Doroszkiewicz, Renata Borawska, Agnieszka Słowik, Henrik Zetterberg, Jörg Hanrieder, Kaj Blennow, Barbara Mroczk. The Relationships between Cerebrospinal Fluid Glial (CXCL12, CX3CL, YKL-40) and Synaptic Biomarkers (Ng, NPTXR) in Early Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685973. |
in addition to amyloid and tau pathology in the central nervous system (cns), inflammatory processes and synaptic dysfunction are highly important mechanisms involved in the development and progression of dementia diseases. |
2023-09-09 |
2023-10-07 |
Not clear |
| John J Alam, Paul Maruff, Susan Doctrow, Hui-May Chu, Jennifer Conway, Stephen N Gomperts, Charlotte Teunisse. Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies. Neurology. 2023-09-01. PMID:37657939. |
association of plasma phosphorylated tau with the response to neflamapimod treatment in patients with dementia with lewy bodies. |
2023-09-01 |
2023-09-07 |
Not clear |
| Xiaoyu Tang, Zhipeng Kan, Na Li, Jinbao Huang, Jinsong Zhang, Henry J Thompson, Feng Gao, Yong Shen, Liang Zhang, Zhongwen Xie, Xiaochun Wan, Yijun Wan. Mechanisms underlying large-leaf yellow tea mediated inhibition of cognitive impairment in the 5xFAD model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 120. 2023-08-31. PMID:37651754. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by amyloid-β (aβ) peptides and hyperphosphorylated tau proteins. |
2023-08-31 |
2023-09-07 |
Not clear |
| Timothy J Baumgartner, Zahra Haghighijoo, Nana A Goode, Nolan M Dvorak, Parsa Arman, Fernanda Laezz. Voltage-Gated Na Life (Basel, Switzerland). vol 13. issue 8. 2023-08-26. PMID:37629512. |
voltage-gated na alzheimer's disease (ad) is the most common cause of dementia and is classically characterized by two major histopathological abnormalities: extracellular plaques composed of amyloid beta (aβ) and intracellular hyperphosphorylated tau. |
2023-08-26 |
2023-09-07 |
Not clear |
| Qi Zhang, Chunqiu Fan, Luyao Wang, Taoran Li, Min Wang, Ying Han, Jiehui Jian. Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of GeroScience. 2023-08-23. PMID:37610594. |
glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to alzheimer's disease: an exploratory study of amyloid-β (aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (cu) to dementia due to alzheimer's disease (ad), according to the diagnosis framework from the us national institute on aging and the alzheimer's association (nia-aa). |
2023-08-23 |
2023-09-07 |
human |
| Grace Minogue, Allegra Kawles, Antonia Zouridakis, Rachel Keszycki, Alyssa Macomber, Vivienne Lubbat, Nathan Gill, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of neurology. 2023-08-18. PMID:37592884. |
here, we investigated neuronal integrity and pathologic burden of tdp-43 and tau along the well-charted trisynaptic hippocampal circuit [dentate gyrus (dg), ca3, and ca1] in participants with amnestic dementia due to ad/tdp, amnestic dementia due to ad alone, or non-amnestic dementia due to tdp-43 proteinopathy associated with frontotemporal lobar degeneration (ftld-tdp). |
2023-08-18 |
2023-09-07 |
human |
| April C E van Gennip, Claudia L Satizabal, Russell P Tracy, Sigurdur Sigurdsson, Vilmundur Gudnason, Lenore J Launer, Thomas T van Slote. Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study. GeroScience. 2023-08-02. PMID:37530894. |
we investigated the associations of plasma neurofilament light (nfl), glial fibrillary acidic protein (gfap), and total tau (t-tau) with markers of cerebral small vessel disease (svd) and with incident dementia. |
2023-08-02 |
2023-08-14 |
Not clear |
| Keren Esther Kristina Mantik, Sujin Kim, Bonsang Gu, Sohee Moon, Hyo-Bum Kwak, Dong-Ho Park, Ju-Hee Kan. Repositioning of Anti-Diabetic Drugs against Dementia: Insight from Molecular Perspectives to Clinical Trials. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511207. |
brain insulin resistance in dementia is linked to disturbances in aβ production and clearance, tau hyperphosphorylation, microglial activation causing increased neuroinflammation, and the breakdown of tight junctions in the blood-brain barrier (bbb). |
2023-07-29 |
2023-08-14 |
Not clear |
| Aditi Halder, Eleanor Drummon. Strategies for translating proteomics discoveries into drug discovery for dementia. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488854. |
tauopathies, diseases characterized by neuropathological aggregates of tau including alzheimer's disease and subtypes of frontotemporal dementia, make up the vast majority of dementia cases. |
2023-07-25 |
2023-08-14 |
Not clear |
| S B Wharton, J E Simpson, P G Ince, C D Richardson, R Merrick, F E Matthews, C Brayn. Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies. Neuropathology and applied neurobiology. 2023-07-18. PMID:37462105. |
furthermore, additional pathologies such as limbic-predominant age related tdp-43 encephalopathy, ageing related tau astrogliopathy and primary age-related tauopathies contribute to late-life dementia. |
2023-07-18 |
2023-08-14 |
Not clear |