All Relations between Dementia and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Lin Sun, Jie Zhang, Wei Li, Jianhua Sheng, Shifu Xia. Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia. BMC medicine. vol 21. issue 1. 2023-06-06. PMID:37280592. neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia. 2023-06-06 2023-08-14 Not clear
Kai Sin Chin, Leonid Churilov, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Nawaf Yassi, Rosie Watso. Tau in dementia with Lewy bodies. The Australian and New Zealand journal of psychiatry. 2023-06-02. PMID:37264610. tau in dementia with lewy bodies. 2023-06-02 2023-08-14 Not clear
Kai Sin Chin, Leonid Churilov, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Nawaf Yassi, Rosie Watso. Tau in dementia with Lewy bodies. The Australian and New Zealand journal of psychiatry. 2023-06-02. PMID:37264610. this study aimed to investigate tau in people with dementia with lewy bodies using a second-generation tau positron emission tomography tracer as well as plasma p-tau181. 2023-06-02 2023-08-14 Not clear
Zhourui Wu, Ran Zhu, Yan Yu, Jianjie Wang, Xiao Hu, Wei Xu, Yilong Ren, Chen Li, Zhili Zeng, Bin Ma, Ning Xie, Gufa Lin, Bei Ma, Rongrong Zhu, Keqiang Ye, Liming Chen. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Progress in neurobiology. 2023-05-31. PMID:37257680. asparagine endopeptidase (aep) mediated dementia by enhancing amyloid plaque and tau hyperphosphorylation, indicating that it played an important role in neurodegeneration. 2023-05-31 2023-08-14 mouse
Brian Sheng Yep Yeo, Jin Hean Koh, Adele Chin Wei Ng, Shaun Loh, Anna See, Dennis Chuen Chai Seow, Song Tar To. The association of obstructive sleep apnea with blood and cerebrospinal fluid biomarkers of Alzheimer's dementia - A systematic review and meta-analysis. Sleep medicine reviews. vol 70. 2023-05-28. PMID:37245474. alzheimer's disease (ad) is the most common type of dementia and is characterized by the aggregation of extracellular amyloid-beta and intracellular hyperphosphorylation of tau proteins. 2023-05-28 2023-08-14 Not clear
Hidekazu Hiroak. Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges. Biophysics and physicobiology. vol 20. issue 1. 2023-05-26. PMID:37234855. there are two major hypotheses for the pathogenesis of alzheimer's dementia: the β-amyloid (aβ) hypothesis and the tau hypothesis. 2023-05-26 2023-08-14 Not clear
Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin d3 treatment in the mice model of vascular dementia. 2023-05-23 2023-08-14 mouse
Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. the aim of this study was to investigate the effect of vitamin d3 (vitd3) on inflammatory mechanisms, hyperphosphorylated tau (p-tau) in the hippocampus, and cognitive impairment of the mouse model of vascular dementia (vad). 2023-05-23 2023-08-14 mouse
Antonio Terracciano, Keenan Walker, Yang An, Martina Luchetti, Yannick Stephan, Abhay R Moghekar, Angelina R Sutin, Luigi Ferrucci, Susan M Resnic. The association between personality and plasma biomarkers of astrogliosis and neuronal injury. Neurobiology of aging. vol 128. 2023-05-21. PMID:37210782. personality traits have been associated with the risk of dementia and alzheimer's disease neuropathology, including amyloid and tau. 2023-05-21 2023-08-14 human
Luisa Diomede, Elisa R Zanier, Federico Moro, Gloria Vegliante, Laura Colombo, Luca Russo, Alfredo Cagnotto, Carmina Natale, Federica Marta Xodo, Ada De Luigi, Michele Mosconi, Marten Beeg, Marcella Catania, Giacomina Rossi, Fabrizio Tagliavini, Giuseppe Di Fede, Mario Salmon. Aβ1-6 Molecular psychiatry. 2023-05-17. PMID:37198260. aβ1-6 alzheimer's disease (ad), the leading cause of dementia in older adults, is a double proteinopathy characterized by amyloid-β (aβ) and tau pathology. 2023-05-17 2023-08-14 Not clear
Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blenno. Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies. Nature aging. 2023-05-17. PMID:37198279. in this study, we employed an immunoprecipitation mass spectrometry method to simultaneously quantify six phosphorylated (p-tau181, p-tau199, p-tau202, p-tau205, p-tau217 and p-tau231) and two non-phosphorylated plasma tau peptides in a total of 214 participants from the paris lariboisière and translational biomarkers of aging and dementia cohorts. 2023-05-17 2023-08-14 human
Ylenia Pastorello, Roxana O Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevi. Monomeric C-reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction. Brain pathology (Zurich, Switzerland). 2023-05-09. PMID:37158450. in vitro, in vivo, and human tissue co-localization analyses have linked mcrp to neurovascular dysfunction, vascular activation resulting in increased permeability, and leakage, compromise of blood brain barrier function, buildup of toxic proteins including tau and beta amyloid (aβ), association with and capacity to "manufacture" aβ-mcrp-hybrid plaques, and, greater susceptibility to neurodegeneration and dementia. 2023-05-09 2023-08-14 human
Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). 2023-05-09 2023-08-14 Not clear
Kumarappan Chidambara. Identification of BACE-1 Inhibitors against Alzheimer's Disease through E-Pharmacophore-Based Virtual Screening and Molecular Dynamics Simulation Studies: An Insilco Approach. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109481. alzheimer is a severe memory and cognitive impairment neurodegenerative disease that is the most common cause of dementia worldwide and characterized by the pathological accumulation of tau protein and amyloid-beta peptides. 2023-04-28 2023-08-14 Not clear
Nicolas R Barthélemy, Benjamin Saef, Yan Li, Brian A Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvadó, Shorena Janelidze, Chihiro Sato, Vitaliy Ovod, Rachel L Henson, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, John C Morris, Oskar Hansson, Randall J Bateman, Suzanne E Schindle. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease. Nature aging. vol 3. issue 4. 2023-04-28. PMID:37117788. in two independent cohorts of participants with symptoms of ad dementia (n = 55 and n = 90), csf pt217/t217 and pt205/t205 were better correlated with tau pet measures than csf p-tau181 concentration. 2023-04-28 2023-08-14 human
Nader Morshed, Meelim J Lee, Felicia H Rodriguez, Douglas A Lauffenburger, Diego Mastroeni, Forest M Whit. Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease. Nature aging. vol 1. issue 6. 2023-04-28. PMID:37117831. alzheimer's disease (ad) is a form of dementia characterized by amyloid-β plaques and tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. 2023-04-28 2023-08-14 Not clear
Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. then, we evaluated the associations between these measurements and ndis in 29 candidate wm tracts using pearson correlation and multiple regression models results: based on 223 participants who were amyloid positive (mean age of 78 y/o and 57.0% male, 119 cognitively unimpaired, 56 mci, 48 dementia), the results showed that wm tracts ndi decreased with increasing regional braak tau suvrs. 2023-04-17 2023-08-14 human
Monica van den Berg, Daniëlle Toen, Marleen Verhoye, Georgios A Keliri. Alterations in theta-gamma coupling and sharp wave-ripple, signs of prodromal hippocampal network impairment in the TgF344-AD rat model. Frontiers in aging neuroscience. vol 15. 2023-04-10. PMID:37032829. alzheimer's disease (ad) is a severe neurodegenerative disorder caused by the accumulation of toxic proteins, amyloid-beta (aβ) and tau, which eventually leads to dementia. 2023-04-10 2023-08-14 rat
Feng Han, Xufu Liu, Yifan Yang, Xiao Li. Sex-specific age-related changes in glymphatic function assessed by resting-state functional magnetic resonance imaging. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034667. the glymphatic system that clears out brain wastes, such as amyloid-β (aβ) and tau, through cerebrospinal fluid (csf) flow may play an important role in aging and dementias. 2023-04-10 2023-08-14 human
Shreya Gupta, Sanjay K A Jinka, Saugat Khanal, Neha Bhavnani, Fayez Almashhori, Jason Lallo, Amy Mathias, Yasmine Al-Rhayyel, Danielle Herman, John G Holden, Sheila M Fleming, Priya Rama. Cognitive dysfunction and increased phosphorylated tau are associated with reduced O-GlcNAc signaling in an aging mouse model of metabolic syndrome. Journal of neuroscience research. 2023-04-09. PMID:37031439. recent studies in patients and mouse models suggest a putative link between hyperphosphorylated tau, a component of alzheimer's disease-related dementia (adrd) pathology, and cerebral glucose hypometabolism. 2023-04-09 2023-08-14 mouse