| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, Mohammad Shariq, Saba Parveen, Shubhrat Maheshwar. Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment. Drug research. 2023-03-08. PMID:36889338. |
the pathophysiological processes of dementia and cognitive impairment are linked to advanced glycation end products (ages) and their receptor (rage).the neurofibrillary tangles (nfts) of abnormally hyperphosphorylated tau protein and senile plaques (sps), which are brought on by amyloid beta (aβ) deposition, are the hallmarks of alzheimer's disease (ad), a progressive neurodegenerative condition. |
2023-03-08 |
2023-08-14 |
Not clear |
| Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, Mohammad Shariq, Saba Parveen, Shubhrat Maheshwar. Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment. Drug research. 2023-03-08. PMID:36889338. |
in this review, we first discuss the early diagnosis of dementia and cognitive impairment, and then detail the interaction between rage and aβ and tau that is necessary to cause dementia and cognitive impairment pathology, and it is anticipated that the creation of rage probes will help in the diagnosis and treatment of dementia and cognitive impairment. |
2023-03-08 |
2023-08-14 |
Not clear |
| Tia Louise Cummins, Vincent Doré, Azadeh Feizpour, Natasha Krishnadas, Pierrick Bourgeat, Alby Elias, Fiona Lamb, Robert Williams, Malcolm John Hopwood, Susan Landau, Victor Villemagne, Michael Weiner, Christopher C Row. Tau, β-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study. Journal of neurotrauma. 2023-03-01. PMID:36855333. |
seventy male vietnam war veterans - 40 with tbi (aged 68.0±2.5 years) and 30 controls (aged 70.1±5.3 years) - with no prior diagnosis of dementia or mild cognitive impairment underwent β-amyloid (18f-florbetaben), tau (18f-flortaucipir) and 18f-fdg pet. |
2023-03-01 |
2023-08-14 |
human |
| Qi Qiu, Xia Lei, Yueying Wang, Hui Xiong, Yanming Xu, Huifeng Sun, Hongdan Xu, Ning Zhan. Naringin Protects against Tau Hyperphosphorylation in A Behavioural neurology. vol 2023. 2023-02-27. PMID:36844418. |
naringin protects against tau hyperphosphorylation in a alzheimer's disease (ad) is the most common form of dementia and a significant social and economic burden. |
2023-02-27 |
2023-08-14 |
Not clear |
| Vasilios C Constantinides, George P Paraskevas, Fotini Boufidou, Mara Bourbouli, Efstratios-Stylianos Pyrgelis, Leonidas Stefanis, Elisabeth Kapak. CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer's Disease and Frontotemporal Dementias. Diagnostics (Basel, Switzerland). vol 13. issue 4. 2023-02-25. PMID:36832271. |
alzheimer's disease dementia (add) may manifest with atypical phenotypes, resembling behavioral variant frontotemporal dementia (bvftd) and corticobasal syndrome (cbs), phenotypes which typically have an underlying frontotemporal lobar degeneration with tau proteinopathy (ftld-tau), such as pick's disease, corticobasal degeneration (cbd), progressive supranuclear palsy (psp), or ftld with tdp-43 proteinopathy (ftld-tdp). |
2023-02-25 |
2023-08-14 |
Not clear |
| Mónica Sánchez-Tapia, Alberto Mimenza-Alvarado, Lizbeth Granados-Domínguez, Adriana Flores-López, Adriana López-Barradas, Victor Ortiz, Claudia Pérez-Cruz, Hilda Sánchez-Vidal, Julieta Hernández-Acosta, José Alberto Ávila-Funes, Martha Guevara-Cruz, Armando R Tovar, Nimbe Torre. The Gut Microbiota-Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool. Nutrients. vol 15. issue 4. 2023-02-25. PMID:36839291. |
the gut microbiota-brain axis during aging, mild cognitive impairment and dementia: role of tau protein, β-amyloid and lps in serum and curli protein in stool. |
2023-02-25 |
2023-08-14 |
human |
| Dickson O Adedeji, Jasper Holleman, Robert-Paul Juster, Chinedu T Udeh-Momoh, Ingemar Kåreholt, Göran Hagman, Malin Aspö, Sofia Adagunodo, Krister Håkansson, Miia Kivipelto, Alina Solomon, Shireen Sind. Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients. Brain, behavior, & immunity - health. vol 28. 2023-02-23. PMID:36820052. |
several dementia and alzheimer's disease (ad) risk factors have been identified, yet little is known about the role of al and its associations with ad biomarkers (e.g., beta-amyloid (aβ) or tau) and cognitive function among memory clinic patients. |
2023-02-23 |
2023-08-14 |
Not clear |
| Stefano L Sensi, Mirella Russo, Pietro Tirabosch. Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer's disease and synucleinopathies. Handbook of clinical neurology. vol 192. 2023-02-16. PMID:36796942. |
the soluble to insoluble conversion also affects other normal brain proteins, such as tdp-43 and tau, accumulating in their insoluble states in both ad and dementia with lewy bodies (dlb). |
2023-02-16 |
2023-08-14 |
Not clear |
| Clifford R Jack, Heather J Wiste, Alicia Algeciras-Schimnich, Dan J Figdore, Christopher G Schwarz, Val J Lowe, Vijay K Ramanan, Prashanthi Vemuri, Michelle M Mielke, David S Knopman, Jonathan Graff-Radford, Bradley F Boeve, Kejal Kantarci, Petrice M Cogswell, Matthew L Senjem, Jeffrey L Gunter, Terry M Therneau, Ronald C Peterse. Predicting amyloid PET and tau PET stages with plasma biomarkers. Brain : a journal of neurology. 2023-02-15. PMID:36789483. |
participants (n = 1136) were enrolled in either the mayo clinic study of aging or the alzheimer's disease research center, had a concurrent amyloid pet, tau pet, and blood draw, and met clinical criteria for cognitively unimpaired (n = 864), mild cognitive impairment (n = 148), or alzheimer's clinical syndrome with dementia (n = 124). |
2023-02-15 |
2023-08-14 |
human |
| Afroza Rahman, Md Anwar Hossen, Mirza Farhana Iqbal Chowdhury, Sadia Bari, Nuzhat Tamanna, Syeda Salima Sultana, Sharar Naiarin Haque, Abdullah Al Masud, K M Saif-Ur-Rahma. Aducanumab for the treatment of Alzheimer's disease: a systematic review. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2023-02-12. PMID:36775284. |
studies reported that aducanumab reduced brain amyloid-beta plaques in a time- and dose-dependent manner (dose-response, p < 0.05) and a slowed decline in cognition (22% reduction) in the high-dose treated group, difference of -0.39 versus placebo in clinical dementia rating scale sum boxes (95% ci, -0.69 to -0.09; p = 0.012) along with a reduced amyloid positron emission tomography standard uptake value ratio score (p < 0.001) and plasma p181-tau (phosphorylated tau) level. |
2023-02-12 |
2023-08-14 |
human |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
cross-β helical filaments of tau and tmem106b in gray and white matter of multiple system tauopathy with presenile dementia. |
2023-01-30 |
2023-08-14 |
Not clear |
| Edoardo Nicolò Aiello, Federico Verde, Federica Solca, Ilaria Milone, Eleonora Giacopuzzi Grigoli, Antonella Dubini, Antonia Ratti, Roberta Ferrucci, Erminio Torresani, Alberto Priori, Nicola Ticozzi, Vincenzo Silani, Barbara Polett. Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-01-27. PMID:36705785. |
lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal csf p-tau the present study aimed to determine whether patients with mild cognitive impairment (mci) and dementia due to alzheimer's disease (ad), semantic verbal fluency (svf), and the semantic-phonemic discrepancy (spd) could predict abnormal cerebrospinal fluid (csf) phosphorylated tau (p-tau |
2023-01-27 |
2023-08-14 |
Not clear |
| Estibaliz Santiago-Mujika, Ruth Luthi-Carter, Flaviano Giorgini, Elizabeta B Mukaetova-Ladinsk. Tubulin Isotypes and Posttranslational Modifications in Vascular Dementia and Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 6. issue 1. 2023-01-06. PMID:36606207. |
although these two types of dementia have different etiologies, they share some similarities in their pathophysiology, such as neuronal loss and decreased levels of tau protein. |
2023-01-06 |
2023-08-14 |
Not clear |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
we conclude that the dg is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. |
2023-01-03 |
2023-08-14 |
human |
| Deepti Putcha, Yuta Katsumi, Michael Brickhouse, Ryn Flaherty, David H Salat, Alexandra Touroutoglou, Bradford C Dickerso. Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer's disease. NeuroImage. Clinical. vol 37. 2022-12-31. PMID:36586361. |
alzheimer's disease (ad) is characterized neuropathologically by β-amyloid (aβ) plaques, hyperphosphorylated tau neurofibrillary tangles, and neurodegeneration, which lead to a phenotypically heterogeneous cognitive-behavioral dementia syndrome. |
2022-12-31 |
2023-08-14 |
Not clear |
| Esen Saka Topçuoğlu, Ümit Özgür Akdemir, Lütfiye Özlem Ata. What is New in Nuclear Medicine Imaging for Dementia. Noro psikiyatri arsivi. vol 59. issue Suppl 1. 2022-12-29. PMID:36578980. |
amyloid positron emission tomography (pet) and tau pet, which are molecular imaging methods, [f18]fluorodeoxyglucose (fdg) pet showing the glucose metabolism pattern in the brain, dopamine transporter single photon emission computerized tomography (spect) that marks dopaminergic terminals are valuable tools for early recognition and differentiation of ad and its atypical variants, frontotemporal dementias and dementia with lewy bodies. |
2022-12-29 |
2023-08-14 |
Not clear |
| Anders Abildgaard, Tina Parkner, Cindy Soendersoe Knudsen, Hanne Gottrup, Henriette Kli. Diagnostic Cut-offs for CSF β-amyloid and Tau Proteins in a Danish Dementia Clinic. Clinica chimica acta; international journal of clinical chemistry. 2022-12-26. PMID:36572135. |
diagnostic cut-offs for csf β-amyloid and tau proteins in a danish dementia clinic. |
2022-12-26 |
2023-08-14 |
Not clear |
| Anders Abildgaard, Tina Parkner, Cindy Soendersoe Knudsen, Hanne Gottrup, Henriette Kli. Diagnostic Cut-offs for CSF β-amyloid and Tau Proteins in a Danish Dementia Clinic. Clinica chimica acta; international journal of clinical chemistry. 2022-12-26. PMID:36572135. |
analysis of beta-amyloid 1-42 (aβ42), total tau (t-tau) and phosphorylated-tau 181 (p-tau) in the cerebrospinal fluid (csf) is often performed as a part of the diagnostic work-up in case of suspected alzheimer's dementia (ad). |
2022-12-26 |
2023-08-14 |
Not clear |
| Dilek Mercan, Michael Thomas Henek. The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology. vol 11. issue 12. 2022-12-23. PMID:36552331. |
alzheimer's disease (ad), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia. |
2022-12-23 |
2023-08-14 |
Not clear |