All Relations between Dementia and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Morgan G Shelton, Kimberly A Kerns, Frank J Castora, Randolph A Colema. Incorporating Mitochondrial Gene Expression Changes Within a Testable Mathematical Model for Alzheimer's Disease: Stress Response Modulation Predicts Potential Therapeutic Targets. Journal of Alzheimer's disease : JAD. 2022-09-12. PMID:36093692. alzheimer's disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. 2022-09-12 2023-08-14 Not clear
Qingling Sun, Jingnian Ni, Mingqing Wei, Siwei Long, Ting Li, Dongsheng Fan, Tao Lu, Jing Shi, Jinzhou Tia. Plasma β-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable Alzheimer's disease dementia in Chinese individuals. Frontiers in aging neuroscience. vol 14. 2022-09-05. PMID:36062146. plasma β-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable alzheimer's disease dementia in chinese individuals. 2022-09-05 2023-08-14 Not clear
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. 2022-09-02 2023-08-14 mouse
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). 2022-09-02 2023-08-14 mouse
Garrett A Clemons, Alexandre Couto E Silva, Christina H Acosta, Mariana Sayuri Berto Udo, Vesna Tesic, Krista M Rodgers, Celeste Yin-Chieh Wu, Cristiane T Citadin, Reggie Hui-Chao Lee, Jake T Neumann, Shailaja Allani, Howard Prentice, Quanguang Zhang, Hung Wen Li. Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. Journal of cellular physiology. 2022-08-29. PMID:36036549. while ad-related dementia is associated with tau and amyloid beta accumulation, concurrent derangements in cerebral blood flow have been observed alongside these proteinopathies in humans and rodent models. 2022-08-29 2023-08-14 mouse
Adelaide R Tousley, Pamela W L Yeh, Hermes H Ye. Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol. Alcohol (Fayetteville, N.Y.). 2022-08-29. PMID:36038084. here we exposed a mouse model of alzheimer's disease (3xtg-ad), bearing 3 dementia associated transgenes: presenilin1 (ps1m146v), human amyloid precursor protein (appswe) and human tau (taup301s), to ethanol on gestational days 13.5-16.5 using an established binge-type maternal ethanol exposure paradigm. 2022-08-29 2023-08-14 mouse
Xavier Morató, Vanesa Pytel, Sara Jofresa, Agustín Ruiz, Mercè Boad. Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012569. pathologically, ad is characterized by the deposition of amyloid β-peptide (aβ) in the neuropil (neuritic plaques) and blood vessels (amyloid angiopathy), and by the accumulation of hyperphosphorylated tau in neurons (neurofibrillary tangles) in the brain, with associated loss of synapses and neurons, together with glial activation, and neuroinflammation, resulting in cognitive deficits and eventually dementia. 2022-08-26 2023-08-14 Not clear
Po-Sheng Chang, Hsi-Hsien Chou, Te-Jen Lai, Chi-Hua Yen, Ji-Cyun Pan, Ping-Ting Li. Investigation of coenzyme Q10 status, serum amyloid-β, and tau protein in patients with dementia. Frontiers in aging neuroscience. vol 14. 2022-08-12. PMID:35959290. investigation of coenzyme q10 status, serum amyloid-β, and tau protein in patients with dementia. 2022-08-12 2023-08-14 human
Po-Sheng Chang, Hsi-Hsien Chou, Te-Jen Lai, Chi-Hua Yen, Ji-Cyun Pan, Ping-Ting Li. Investigation of coenzyme Q10 status, serum amyloid-β, and tau protein in patients with dementia. Frontiers in aging neuroscience. vol 14. 2022-08-12. PMID:35959290. the purpose of this study was to investigate the relationships of coenzyme q10 status, biomarkers for dementia (amyloid β and tau protein), and antioxidant capacity in patients with dementia. 2022-08-12 2023-08-14 human
Oscar Ramos-Campoy, Albert Lladó, Beatriz Bosch, Mireia Ferrer, Agnès Pérez-Millan, Miguel Vergara, Laura Molina-Porcel, Laura Fort-Aznar, Ricardo Gonzalo, Fermín Moreno-Izco, Guadalupe Fernandez-Villullas, Mircea Balasa, Raquel Sánchez-Valle, Anna Antonel. Differential Gene Expression in Sporadic and Genetic Forms of Alzheimer's Disease and Frontotemporal Dementia in Brain Tissue and Lymphoblastoid Cell Lines. Molecular neurobiology. 2022-08-12. PMID:35962298. frontotemporal dementia (ftd) causes early-onset dementia associated to tau or tdp43 protein deposits. 2022-08-12 2023-08-14 human
Abdalla Z Mohamed, Paul Cumming, Fatima A Nasrallah, Alzheimer's Disease Neuroimaging Initiativ. Escalation of Tau Accumulation after a Traumatic Brain Injury: Findings from Positron Emission Tomography. Brain sciences. vol 12. issue 7. 2022-07-27. PMID:35884683. we hypothesized that a history of tbi would be associated with greater tau deposition in elders with high-risk for dementia. 2022-07-27 2023-08-14 human
Naresh Damuka, Miranda E Orr, Avinash H Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L Macauley, Christopher T Whitlow, Akiva Mintz, Suzanne Craft, Kiran Kumar Solingapuram Sa. Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI research. vol 12. issue 1. 2022-07-26. PMID:35881263. hyperphosphorylated tau, not bound to mts, forms intraneuronal pathology that correlates with dementia and can be tracked using positron emission tomography (pet) imaging. 2022-07-26 2023-08-14 mouse
John David Eun, Heidy Jimenez, Leslie Adrien, Adam Wolin, Philippe Marambaud, Peter Davies, Jeremy L Koppe. Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy. Molecular medicine (Cambridge, Mass.). vol 28. issue 1. 2022-07-20. PMID:35858831. we sought to investigate the impact of anesthesia on gene expression and on acute and long-term changes in tau biochemistry in transgenic models of tauopathy in order to better understand how anesthesia influences the pathophysiology of dementia. 2022-07-20 2023-08-14 mouse
John P Seiby. Alpha-synuclein PET and Parkinson's Disease Therapeutic Trials: Ever the Twain Shall Meet? Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022-07-19. PMID:35853738. unlike alzheimer's dementia where there are pet imaging biomarkers for the two rogue proteins, beta-amyloid and tau, there's no equivalent pet tracer to interrogate distribution of a-syn in brain. 2022-07-19 2023-08-14 Not clear
Siva Prasad Panda, Yogita Dhurandhar, Mehak Agrawa. The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. Mitochondrion. 2022-07-16. PMID:35842181. the epileptogenesis in patients with alzheimer's disease dementia (add) and parkinson's disease dementia (pdd) is due to involvement of amyloid plaques (aβ), phosphorylated tau (ptau), parkin, nf-kb and nlrp3 inflammasome.microglia, the prime protective and inflammatory cells in the brain exert crosstalk between mitophagy and inflammation. 2022-07-16 2023-08-14 Not clear
Diego Sepulveda-Falla, Justin S Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G Beach, Charles L White, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A Johnson, Reisa A Sperling, Eric M Reiman, Joseph F Arboleda-Velasquez, Kenneth S Kosik, Francisco Lopera, Yakeel T Quiro. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta neuropathologica. 2022-07-15. PMID:35838824. distinct tau neuropathology and cellular profiles of an apoe3 christchurch homozygote protected against autosomal dominant alzheimer's dementia. 2022-07-15 2023-08-14 Not clear
Alejandro Marmolejo-Garza, Tiago Medeiros-Furquim, Ramya Rao, Bart J L Eggen, Erik Boddeke, Amalia M Dolg. Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways. Biochimica et biophysica acta. Molecular cell research. 2022-07-15. PMID:35839870. alzheimer's disease (ad) is the main cause of dementia and it is defined by cognitive decline coupled to extracellular deposit of amyloid-beta protein and intracellular hyperphosphorylation of tau protein. 2022-07-15 2023-08-14 Not clear
Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid F Feiten, Seojin Lee, Ivan Martinez-Valbuena, Tim Karl, Gabor G Kovacs, Grant Morahan, Yazi D Ke, Lars M Ittne. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Acta neuropathologica. 2022-07-03. PMID:35780436. to this end, our work defines the first specific function of lamp5 interneurons in neuronal network hyperexcitation in ad and dementia with tau pathology. 2022-07-03 2023-08-14 mouse
Domenico Plantone, Matteo Pardini, Sara Locci, Flavio Nobili, Nicola De Stefan. B Lymphocytes in Alzheimer's Disease-A Comprehensive Review. Journal of Alzheimer's disease : JAD. 2022-06-27. PMID:35754274. alzheimer's disease (ad) represents the most common type of neurodegenerative dementia and is characterized by extracellular amyloid-β (aβ) deposition, pathologic intracellular tau protein tangles, and neuronal loss. 2022-06-27 2023-08-14 Not clear
Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Monica R Mariner, Lucia I Sue, Richard A Arce, Alireza Atri, Charles H Adler, Christine M Belden, Holly A Shill, Erika Driver-Dunckley, Shyamal H Mehta, Thomas G Beac. Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment. Journal of neuropathology and experimental neurology. 2022-06-25. PMID:35751438. to better understand when the ob is affected in relation to the hierarchical progression of aβ throughout the brain and whether ob pathology might be an indicator of ad severity, we assessed the presence of ob aβ and tau nf pathology in an autopsy cohort of 158 non demented control and 173 ad dementia cases. 2022-06-25 2023-08-14 Not clear