| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khalil S Rawji, Björn Neumann, Robin J M Frankli. Glial aging and its impact on central nervous system myelin regeneration. Annals of the New York Academy of Sciences. 2022-11-18. PMID:36398864. |
in addition to facilitating neurodegeneration, the aging glial cell population has negative implications for central nervous system remyelination, a regenerative process that is of particular importance to the chronic demyelinating disease multiple sclerosis. |
2022-11-18 |
2023-08-14 |
Not clear |
| Daniela M S Moura, Emma J Brennan, Robert Brock, Laura A Coca. Neuron to Oligodendrocyte Precursor Cell Synapses: Protagonists in Oligodendrocyte Development and Myelination, and Targets for Therapeutics. Frontiers in neuroscience. vol 15. 2022-02-04. PMID:35115904. |
this review summarizes the role of another glial cell type, oligodendrocytes, in shaping synapse formation, neuronal circuit development, and myelination in both normal development and in demyelinating disease. |
2022-02-04 |
2023-08-13 |
Not clear |
| Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Stacey Hose, Haitao Liu, Joseph Weiss, Christopher S Fitting, Imran A Bhutto, J Samuel Zigler, Jiang Qian, José-Alain Sahel, Debasish Sinha, Nadezda A Stepichev. Role of glia in optic nerve. Progress in retinal and eye research. vol 81. 2021-11-11. PMID:32771538. |
in many cases of multiple sclerosis (demyelinating disease of the cns) vision problems are the first manifestation of the disease, suggesting that rgcs and/or glia in the on are more sensitive to pathological conditions than cells in other parts of the cns. |
2021-11-11 |
2023-08-13 |
Not clear |
| Seung Ro Han, Yun Hee Kang, Seung-Min Yoo, Myung-Shin Lee, Seung-Hoon Le. Diverse Gene Expressions in the Prediction of Cuprizone-Induced Demyelination. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31916130. |
myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. |
2020-12-04 |
2023-08-13 |
mouse |
| Seung Ro Han, Yun Hee Kang, Hyungtaek Jeon, Suhyuk Lee, Sang-Jin Park, Dae-Yong Song, Sun Seek Min, Seung-Min Yoo, Myung-Shin Lee, Seung-Hoon Le. Differential Expression of miRNAs and Behavioral Change in the Cuprizone-Induced Demyelination Mouse Model. International journal of molecular sciences. vol 21. issue 2. 2020-10-08. PMID:31963761. |
the demyelinating diseases of the central nervous system involve myelin abnormalities, oligodendrocyte damage, and consequent glia activation. |
2020-10-08 |
2023-08-13 |
mouse |
| Laura Reiche, Patrick Küry, Peter Göttl. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Cells. vol 8. issue 12. 2020-08-31. PMID:31817891. |
finally, the rationale for a better understanding of pathways and modulators responsible for the glial cell imbalance as a possible source for future therapeutic interventions is given based on current experience on pro-oligodendroglial treatment approaches developed for demyelinating diseases, such as multiple sclerosis. |
2020-08-31 |
2023-08-13 |
mouse |
| Suyog Pol, Michele Sveinsson, Michelle Sudyn, Natan Babek, Danielle Siebert, Nicola Bertolino, Claire M Modica, Marilena Preda, Ferdinand Schweser, Robert Zivadino. Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 29. issue 1. 2020-03-04. PMID:30232810. |
teriflunomide's effect on glia in experimental demyelinating disease: a neuroimaging and histologic study. |
2020-03-04 |
2023-08-13 |
Not clear |
| Hao Yu, Mingfeng Wu, Geng Lu, Tingting Cao, Nan Chen, Yijia Zhang, Zhiguo Jiang, Hongbin Fan, Ruiqin Ya. Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination. Brain research. vol 1678. 2018-03-02. PMID:29038005. |
myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common in demyelinating diseases of the central nervous system (cns). |
2018-03-02 |
2023-08-13 |
mouse |
| Lukmanee Tradtrantip, Bjung-Ju Jin, Xiaoming Yao, Marc O Anderson, Alan S Verkma. Aquaporin-Targeted Therapeutics: State-of-the-Field. Advances in experimental medicine and biology. vol 969. 2017-09-07. PMID:28258578. |
the astrocyte water channel aquaporin-4 is a particularly compelling target because of its role of brain water movement, neuroexcitation and glia scarring, and because it is the target of pathogenic autoantibodies in the neuroinflammatory demyelinating disease neuromyelitis optica . |
2017-09-07 |
2023-08-13 |
Not clear |
| Fei Song, Manoj Bandara, Harvinder Deol, Jeffrey A Loeb, Joyce Benjamins, Robert P Lisa. Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors. Journal of neuroimmunology. vol 262. issue 1-2. 2013-11-18. PMID:23763772. |
soluble factors that promote survival and differentiation of glia and neurons during development are likely to play key roles in neurodegeneration and demyelinating diseases such as multiple sclerosis (ms) and have the potential to be important therapeutic targets. |
2013-11-18 |
2023-08-12 |
mouse |
| Tetsuya Mizun. [Disruption of interactions between immunocytes, glia and neurons in demyelinating diseases: a view from neuroscience]. Rinsho shinkeigaku = Clinical neurology. vol 51. issue 11. 2012-09-18. PMID:22277407. |
[disruption of interactions between immunocytes, glia and neurons in demyelinating diseases: a view from neuroscience]. |
2012-09-18 |
2023-08-12 |
Not clear |
| Richa B Tripathi, Leanne E Rivers, Kaylene M Young, Francoise Jamen, William D Richardso. NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 48. 2011-01-06. PMID:21123584. |
ng2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. |
2011-01-06 |
2023-08-12 |
mouse |
| Benjamin M Sega. The role of natural killer cells in curbing neuroinflammation. Journal of neuroimmunology. vol 191. issue 1-2. 2008-01-17. PMID:17904646. |
here we discuss the growing body of evidence that nk cells limit damage in autoimmune demyelinating disease by inhibiting autoreactive t cell responses without harming resident neurons or glia. |
2008-01-17 |
2023-08-12 |
Not clear |
| Alexandros Tzimourakas, Sevasti Giasemi, Maria Mouratidou, Domna Karagogeo. Structure-function analysis of protein complexes involved in the molecular architecture of juxtaparanodal regions of myelinated fibers. Biotechnology journal. vol 2. issue 5. 2007-09-04. PMID:17405182. |
one critical step towards the management and therapy of demyelinating diseases is to understand the basic functions of myelinating glia and their relationship with axons. |
2007-09-04 |
2023-08-12 |
Not clear |
| Dimitrios Papadopoulos, Lisa Ewans, Danielle Pham-Dinh, Johanna Knott, Richard Reynold. Upregulation of alpha-synuclein in neurons and glia in inflammatory demyelinating disease. Molecular and cellular neurosciences. vol 31. issue 4. 2006-11-22. PMID:16503161. |
upregulation of alpha-synuclein in neurons and glia in inflammatory demyelinating disease. |
2006-11-22 |
2023-08-12 |
rat |
| Maria Nikodemova, Ian D Duncan, Jyoti J Watter. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia. Journal of neurochemistry. vol 96. issue 2. 2006-02-17. PMID:16336636. |
cns inflammation mediated by microglial activation can result in neuronal and glial cell death in a variety of neurodegenerative and demyelinating diseases. |
2006-02-17 |
2023-08-12 |
Not clear |
| M Boja. [A neurologist's views on cellular and gene therapy in nervous system diseases]. Casopis lekaru ceskych. vol 142. issue 9. 2004-01-09. PMID:14608944. |
its application is expected in atrophic-degenerative and vascular diseases of cns, tumors, injuries, seizure, inflammatory and demyelinating diseases in which the replacement of neurons, glia and enhancement of their regeneration play the key role. |
2004-01-09 |
2023-08-12 |
Not clear |
| J G Boyd, V Skihar, M Kawaja, R Doucett. Olfactory ensheathing cells: historical perspective and therapeutic potential. Anatomical record. Part B, New anatomist. vol 271. issue 1. 2003-12-08. PMID:12619086. |
they are attracting increasing attention from neuroscientists as potential therapeutic agents for use in the repair of spinal cord injury and as a source of myelinating glia for use in remyelinating axons in demyelinating diseases such as multiple sclerosis. |
2003-12-08 |
2023-08-12 |
Not clear |
| Pratima Sur, Eric Anthony Sribnick, James Michael Wingrave, Mark Walter Nowak, Swapan Kumar Ray, Naren Lal Bani. Estrogen attenuates oxidative stress-induced apoptosis in C6 glial cells. Brain research. vol 971. issue 2. 2003-07-03. PMID:12706234. |
our results suggest that estrogen may have a protective role in minimizing glial cell apoptosis in neurological diseases such as demyelinating disease or central nervous system trauma. |
2003-07-03 |
2023-08-12 |
rat |
| P M Smith, R J Frankli. The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination. Journal of neuroimmunology. vol 119. issue 2. 2001-12-04. PMID:11585629. |
glial cell transplantation is a potential therapy for human demyelinating disease, though obtaining large numbers of human myelinating cells for transplantation remains a major stumbling block. |
2001-12-04 |
2023-08-12 |
human |