| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Blum Moyse, Hugues Berr. A coupled neural field model for the standard consolidation theory. Journal of theoretical biology. 2024-04-15. PMID:38621583. |
this suggests that neurogenesis in the hippocampus and distance-dependent synaptic plasticity coupled to synaptic depression and spike frequency adaptation, are indeed critical neurobiological processes in memory consolidation. |
2024-04-15 |
2024-04-18 |
Not clear |
| Yaxin Guo, Nuo Chen, Ming Zhao, Baihui Cao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Yan Li, Lining Zhan. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacological research. 2024-03-09. PMID:38460778. |
creb-regulated transcription coactivator 1 (crtc1), a pivotal synaptonuclear messenger, regulates synaptic plasticity and transmission to prevent depression. |
2024-03-09 |
2024-03-12 |
mouse |
| Fanhao Meng, Long Wan. Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 48. issue 10. 2024-03-03. PMID:38432881. |
bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity. |
2024-03-03 |
2024-03-06 |
Not clear |
| Fanhao Meng, Long Wan. Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 48. issue 10. 2024-03-03. PMID:38432881. |
hence, the introduction of synaptic plasticity research route and the construction of a comprehensive model of depression and insomnia comorbidity can provide new ideas for clinical depression insomnia comorbidity treatment plans. |
2024-03-03 |
2024-03-06 |
Not clear |
| Wenjing Wang, Ye Li, Liyan Wang, Xiao Chen, Tian Lan, Changmin Wang, Shihong Chen, Shuyan Y. FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins. Journal of affective disorders. 2024-01-11. PMID:38211741. |
synaptic plasticity changes in presynaptic terminals or postsynaptic membranes play a critical role in cognitive impairments and emotional disorders, but the underlying molecular mechanisms in depression remain largely unknown. |
2024-01-11 |
2024-01-14 |
Not clear |
| Kyle A Brown, Todd D Goul. Targeting metaplasticity mechanisms to promote sustained antidepressant actions. Molecular psychiatry. 2024-01-04. PMID:38177353. |
accordingly, the development of treatment modalities that specifically modulate the duration, direction, or magnitude of glutamatergic synaptic plasticity events such as long-term potentiation (ltp), defined here as metaplastogens, may be an effective approach to reverse the pathophysiology underlying depression and improve depression symptoms. |
2024-01-04 |
2024-01-07 |
Not clear |
| Yuhan Wu, Zhanpeng Zhu, Tian Lan, Shuhan Li, Ye Li, Changmin Wang, Yabo Feng, Xueqin Mao, Shuyan Y. Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Molecular neurobiology. 2023-12-06. PMID:38057644. |
recently, the involvement of synaptic plasticity in the pathogenesis of depression has shed light on the direction of developing novel antidepressants. |
2023-12-06 |
2023-12-10 |
rat |
| Yuhan Wu, Zhanpeng Zhu, Tian Lan, Shuhan Li, Ye Li, Changmin Wang, Yabo Feng, Xueqin Mao, Shuyan Y. Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Molecular neurobiology. 2023-12-06. PMID:38057644. |
in this study, we aimed to investigate the role of levomilnacipran in regulating synaptic plasticity and explore the possible molecular mechanisms of its antidepressant effects using a rat model of depression induced by lipopolysaccharide (lps). |
2023-12-06 |
2023-12-10 |
rat |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
perinatal depression and the role of synaptic plasticity in its pathogenesis and treatment. |
2023-11-25 |
2023-11-28 |
Not clear |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
emerging evidence indicates that synaptic plasticity is significantly involved in the pathophysiology and treatment of perinatal depression. |
2023-11-25 |
2023-11-28 |
Not clear |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
gabaergic theory of depression, stress, and the neuroplasticity model of depression indicate the role of synaptic plasticity in the pathogenesis of depression. |
2023-11-25 |
2023-11-28 |
Not clear |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
multiple factors related to perinatal depression like hormonal shifts, newer antidepressants, mood stabilizers, monoamine systems, biomarkers, neurotrophins, cytokines, psychotherapy and electroconvulsive therapy have demonstrated direct and indirect effects on synaptic plasticity. |
2023-11-25 |
2023-11-28 |
Not clear |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
in this review, we discuss and summarize the various patho-physiology-related effects of synaptic plasticity in depression. |
2023-11-25 |
2023-11-28 |
Not clear |
| Sonia Shenoy, Sufyan Ibrahi. Perinatal Depression and the Role of Synaptic Plasticity in Its Pathogenesis and Treatment. Behavioral sciences (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:37998688. |
we also discuss the association of treatment-related aspects related to psychotropics, electroconvulsive therapy, neuromodulation, psychotherapy, physical exercise and yoga with synaptic plasticity in perinatal depression. |
2023-11-25 |
2023-11-28 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a common thread linking different classes of antidepressants. Cell chemical biology. 2023-11-22. PMID:37992715. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis, and the monoamine hypothesis). |
2023-11-22 |
2023-11-29 |
mouse |
| Pu Yang, Haiyan Chen, Tian Wang, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain-related depression by upregulating BDNF/TrkB/CREB signaling pathway. Brain and behavior. 2023-11-10. PMID:37948105. |
electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain-related depression by upregulating bdnf/trkb/creb signaling pathway. |
2023-11-10 |
2023-11-20 |
rat |
| Pu Yang, Haiyan Chen, Tian Wang, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain-related depression by upregulating BDNF/TrkB/CREB signaling pathway. Brain and behavior. 2023-11-10. PMID:37948105. |
the onset and development of pain and depression are associated with altered neural synaptic plasticity. |
2023-11-10 |
2023-11-20 |
rat |
| Wing Sze Tse, Bartłomiej Pochwat, Bernadeta Szewczyk, Paulina Misztak, Bartosz Bobula, Krzysztof Tokarski, Remigiusz Worch, Marta Czarnota-Bojarska, Stuart A Lipton, Monika Zaręba-Kozioł, Monika Bijata, Jakub Wlodarczy. Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression. Neuropharmacology. 2023-10-05. PMID:37797736. |
restorative effect of nitrosynapsin on synaptic plasticity in an animal model of depression. |
2023-10-05 |
2023-10-07 |
mouse |
| Baile Ning, Zhifang Wang, Jiangshan He, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Fan Jiang, Wenbin F. The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex. Brain research. 2023-10-02. PMID:37783259. |
the rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting m1-ach receptors regulates synaptic plasticity in the prefrontal cortex. |
2023-10-02 |
2023-10-07 |
Not clear |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
moreover, tocilizumab could alleviate the "inflammatory storm" and impaired hippocampal synaptic plasticity in lps-challenged depression rats, inhibiting the hyperactivation of astrocyte and microglia, decreasing the peripheral and central abundance of il-6, crp, and tnf-α, and balancing the hippocampal expression levels of synaptic plasticity-associated proteins and key molecular in wnt/β-catenin signaling pathway. |
2023-09-17 |
2023-10-07 |
human |