All Relations between Depression and bmal1
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.) vol 165 issue 2023 36869551
||in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation.
| K H\\xc3\\xb8jgaard, S L Christiansen, E V Bouzinova, O Wibor. Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment. Psychopharmacology vol 235 issue 3 2019 29151193
||we applied in situ hybridization histochemistry to measure the expression levels of the core clock genes, period (per) 1 and 2 and bone and muscle arnt-like protein 1 (bmal1), in multiple brain regions believed to be implicated in depression.
| Julien Mendlewic. Disruption of the circadian timing systems: molecular mechanisms in mood disorders. CNS drugs vol 23 Suppl 2 issue 2009 19708722
||polymorphisms in the clock, bmal1, per3 and timeless genes have been associated with susceptibility to mood disorder, and single nucleotide polymorphisms and haplotypes in several circadian genes have been observed among those displaying certain circadian phenotypes, including worse mood in the evening, insomnia in mania and early, middle or late insomnia in depression.