| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian J Gerich, Sebastian Hepp, Irmelin Probst, Michael Mülle. Mitochondrial inhibition prior to oxygen-withdrawal facilitates the occurrence of hypoxia-induced spreading depression in rat hippocampal slices. Journal of neurophysiology. vol 96. issue 1. 2006-08-04. PMID:16611842. |
in rat hippocampal slices, this triggers a massive depolarization of ca1 neurons and a negative shift of the extracellular dc potential, the characteristic sign of hypoxia-induced spreading depression (hsd). |
2006-08-04 |
2023-08-12 |
rat |
| Shu Wang, Yan Gu, Hui-Li Wang, Xin-Mei Li, Ming Wang, Li-Guang Sun, Di-Yun Rua. Inhibitory effect of Cd2+ on glycine-induced chloride current in rat hippocampal neurons. Brain research bulletin. vol 69. issue 6. 2006-08-04. PMID:16716838. |
the results show that cd(2+) decreases i(gly) in acutely dissociated rat hippocampal neurons and the depression of i(gly) by cd(2+) may contribute to worsen the neurotoxicological impairment. |
2006-08-04 |
2023-08-12 |
rat |
| Raffaella Molteni, Francesca Calabrese, Francesco Bedogni, Enrico Tongiorgi, Fabio Fumagalli, Giorgio Racagni, Marco Andrea Riv. Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions. The international journal of neuropsychopharmacology. vol 9. issue 3. 2006-07-27. PMID:16035958. |
in fact, besides the well-established role of the hippocampus, increasing evidence indicates that other brain regions may be involved in the pathophysiology of depression and consequently be relevant for the therapeutic action of antidepressant drugs. |
2006-07-27 |
2023-08-12 |
human |
| Haiyun Xu, Zhong Chen, Jue He, Samson Haimanot, Xiaokun Li, Lillian Dyck, Xin-Min L. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus. vol 16. issue 6. 2006-07-27. PMID:16652337. |
animal studies demonstrate that some antipsychotics and antidepressants increase neurogenesis and bdnf expression in the hippocampus, which is reduced in volume in patients with depression or schizophrenia. |
2006-07-27 |
2023-08-12 |
rat |
| Haiyun Xu, Zhong Chen, Jue He, Samson Haimanot, Xiaokun Li, Lillian Dyck, Xin-Min L. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus. vol 16. issue 6. 2006-07-27. PMID:16652337. |
we hypothesized that the better therapeutic effects of combined treatment seen in schizophrenia and depression patients are related to the additive or synergistic effects of combined treatment on hippocampal neurogenesis and bdnf expression. |
2006-07-27 |
2023-08-12 |
rat |
| Flavia Magri, Luca Cravello, Luca Barili, Serena Sarra, Wilma Cinchetti, Fabrizio Salmoiraghi, Giuliana Micale, Ettore Ferrar. Stress and dementia: the role of the hypothalamicpituitary-adrenal axis. Aging clinical and experimental research. vol 18. issue 2. 2006-07-20. PMID:16702789. |
indeed, adrenal steroids modulate hippocampal plasticity, acting on excitability and long term potentiation or depression. |
2006-07-20 |
2023-08-12 |
human |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Stefan Bren\\xc3\\xa. The antidepressant effect of running is associated with increased hippocampal cell proliferation. The international journal of neuropsychopharmacology. vol 8. issue 3. 2006-07-19. PMID:15769301.' |
a common trait of antidepressant drugs, electroconvulsive treatment and physical exercise is that they relieve depression and up-regulate neurotrophic factors as well as cell proliferation and neurogenesis in the hippocampus. |
2006-07-19 |
2023-08-12 |
rat |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Stefan Bren\\xc3\\xa. The antidepressant effect of running is associated with increased hippocampal cell proliferation. The international journal of neuropsychopharmacology. vol 8. issue 3. 2006-07-19. PMID:15769301.' |
in order to identify possible biological underpinnings of depression and the antidepressant effect of running, we analysed cell proliferation, the level of the neurotrophic factor bdnf in hippocampus and dynorphin in striatum/accumbens in 'depressed' flinders sensitive line rats (fsl) and flinders resistant line (frl) rats with and without access to running-wheels. |
2006-07-19 |
2023-08-12 |
rat |
| Igor Branchi, Ivana D'Andrea, Jantine Sietzema, Marco Fiore, Veronica Di Fausto, Luigi Aloe, Enrico Allev. Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16477619. |
early social enrichment augments adult hippocampal bdnf levels and survival of brdu-positive cells while increasing anxiety- and "depression"-like behavior. |
2006-07-13 |
2023-08-12 |
mouse |
| Igor Branchi, Ivana D'Andrea, Jantine Sietzema, Marco Fiore, Veronica Di Fausto, Luigi Aloe, Enrico Allev. Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16477619. |
overall, these findings show that cn, an highly stimulating early social environment, increases adult neuronal plasticity, as suggested by high bdnf levels and augmented number of newly generated cells in the hippocampus, which is associated to an increased anxiety- and "depression"-like behavior. |
2006-07-13 |
2023-08-12 |
mouse |
| Reza Emdad, David Bonekamp, Hans Peter Sondergaard, Tomas Bjorklund, Ingrid Agartz, Martin Ingvar, Tores Theorel. Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls. Psychotherapy and psychosomatics. vol 75. issue 2. 2006-07-12. PMID:16508348. |
the aims of this study were to: (1) confirm previous hippocampus findings in ptsd patients compared to controls, using ethnically similar study groups where alcohol and drug abuse were non-existent; (2) test influence of disease duration as well as depression scores on possible morphological changes; (3) test whether the voxel-based morphometry (vbm) data confirm the group differences seen in the region of interest (roi) analysis, and (4) test the associations between the cognitive test scores and the morphological changes. |
2006-07-12 |
2023-08-12 |
human |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Stefan Bren\\xc3\\xa. Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 2. 2006-07-06. PMID:16034445.' |
our data support the hypothesis that npy neurotransmission in hippocampus is malfunctioning in depression and that antidepressive treatment, in this case wheel running, will normalize it. |
2006-07-06 |
2023-08-12 |
rat |
| Oliver von Bohlen und Halbach, Sonja Krause, Diego Medina, Carla Sciarretta, Liliana Minichiello, Klaus Unsicke. Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies. Biological psychiatry. vol 59. issue 9. 2006-06-28. PMID:16325153. |
changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (ltp), spatial learning, and depression. |
2006-06-28 |
2023-08-12 |
mouse |
| Anne Jouvenceau, Patrick Duta. A role for the protein phosphatase 2B in altered hippocampal synaptic plasticity in the aged rat. Journal of physiology, Paris. vol 99. issue 2-3. 2006-06-28. PMID:16442785. |
in hippocampal neurons from aged rats, a depression is always observed, suggesting a preferential activation of pp2b by nmda in these neurons. |
2006-06-28 |
2023-08-12 |
rat |
| Jing Qian, Jeffrey L Noebel. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 22. 2006-06-23. PMID:16738253. |
exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal ca3-ca1 synapse. |
2006-06-23 |
2023-08-12 |
Not clear |
| Katja Naie, Sabine Gundimi, Herbert Siegmund, Uwe Heinemann, Denise Manahan-Vaugha. Group III metabotropic glutamate receptor-mediated, chemically induced long-term depression differentially affects cell viability in the hippocampus. European journal of pharmacology. vol 535. issue 1-3. 2006-06-21. PMID:16545366. |
ap4 produced a slowly developing depression of evoked responses in both hippocampal regions which lasted for over 4 h. effects could be reversed by application of high frequency tetanus. |
2006-06-21 |
2023-08-12 |
rat |
| Nadia M Tsankova, Olivier Berton, William Renthal, Arvind Kumar, Rachel L Neve, Eric J Nestle. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature neuroscience. vol 9. issue 4. 2006-06-08. PMID:16501568. |
sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. |
2006-06-08 |
2023-08-12 |
mouse |
| Nadia M Tsankova, Olivier Berton, William Renthal, Arvind Kumar, Rachel L Neve, Eric J Nestle. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature neuroscience. vol 9. issue 4. 2006-06-08. PMID:16501568. |
to better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor (bdnf) splice variant mrnas (i-v) and their unique promoters in the hippocampus. |
2006-06-08 |
2023-08-12 |
mouse |
| Gigliola Grassi Zucconi, Sabrina Cipriani, Ioanna Balgkouranidou, Roberto Scatton. 'One night' sleep deprivation stimulates hippocampal neurogenesis. Brain research bulletin. vol 69. issue 4. 2006-06-08. PMID:16624668. |
among these, dysregulation of hippocampal neurogenesis has been recently implicated in the pathogenesis of depression. |
2006-06-08 |
2023-08-12 |
rat |
| Alexandre Serrano, Nasser Haddjeri, Jean-Claude Lacaille, Richard Robitaill. GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 20. 2006-06-08. PMID:16707789. |
gabaergic network activation of glial cells underlies hippocampal heterosynaptic depression. |
2006-06-08 |
2023-08-12 |
Not clear |