All Relations between Depression and hypothalamus

Publication Sentence Publish Date Extraction Date Species
Ying Wang, Xiaoli Chang, Haiyan Zhang, Yi Hou, Xinjie Zheng, Yujiao Zhang, Shaozong Che. Hypothalamic Gene Expression in a Rat Model of Chronic Unpredictable Mild Stress Treated with Electroacupuncture. Neurochemical research. 2024-03-24. PMID:38522048. as a crucial structure in the hypothalamus-pituitary-adrenal, the hypothalamus plays a key role in depression. 2024-03-24 2024-03-26 rat
Haimei Li, Xinlu Chen, Jingyi Dong, Ripeng Liu, Jinfeng Duan, Manli Huang, Shaohua Hu, Jing L. A direct estrogenic involvement in the expression of human hypocretin. Life sciences. 2024-03-21. PMID:38514004. hypocretin is synthesized exclusively in the hypothalamus and distributes inputs to several areas of the brain, which may play an important role in depression. 2024-03-21 2024-03-24 human
Haimei Li, Xinlu Chen, Jingyi Dong, Ripeng Liu, Jinfeng Duan, Manli Huang, Shaohua Hu, Jing L. A direct estrogenic involvement in the expression of human hypocretin. Life sciences. 2024-03-21. PMID:38514004. in conclusion, we found that estradiol may directly affect hypocretin neurons in the human hypothalamus via er binding to the hypocretin-ere, which may lead to the sex-specific pathogenesis of depression. 2024-03-21 2024-03-24 human
Musi Xie, Ying Huang, Wendan Cai, Bingqi Zhang, Haonan Huang, Qingwei Li, Pengmin Qin, Junrong Ha. Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review. Brain sciences. vol 14. issue 1. 2024-01-22. PMID:38248265. evidence suggests that a hyperarousal state in depression is characterized by abnormalities in sleep behavior, physiological (e.g., heart rate, skin conductance, pupil diameter) and electroencephalography (eeg) features, and altered activity in subcortical (e.g., hypothalamus and locus coeruleus) and cortical regions. 2024-01-22 2024-01-24 Not clear
Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao, Yu W. The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice. Journal of neuroinflammation. vol 20. issue 1. 2023-12-07. PMID:38062440. the hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. 2023-12-07 2023-12-17 mouse
Tian-Shun Shi, Wei-Yu Li, Yan-Mei Chen, Jie Huang, Wei Guan, Da-Wei Xu, Bo Jian. The antidepressant-like effects of escitalopram in mice require salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus of the hypothalamus. Journal of affective disorders. 2023-05-31. PMID:37257779. the salt-inducible kinase 1 (sik1)-creb-regulated transcription co-activator 1 (crtc1) system in the paraventricular nucleus (pvn) of the hypothalamus has been demonstrated to participate in not only depression neurobiology but also the antidepressant mechanisms of fluoxetine, paroxetine, venlafaxine, and duloxetine. 2023-05-31 2023-08-14 mouse
Zala Slabe, Rawien A Balesar, Ronald W H Verwer, Joop J Van Heerikhuize, Gwyneth A Pechler, Maja Zorović, Witte J G Hoogendijk, Dick F Swaa. Alterations in pituitary adenylate cyclase-activating polypeptide in major depressive disorder, bipolar disorder, and comorbid depression in Alzheimer's disease in the human hypothalamus and prefrontal cortex. Psychological medicine. 2023-05-25. PMID:37226771. alterations in pituitary adenylate cyclase-activating polypeptide in major depressive disorder, bipolar disorder, and comorbid depression in alzheimer's disease in the human hypothalamus and prefrontal cortex. 2023-05-25 2023-08-14 human
Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jian. Targeting PDK2 rescues stress-induced impaired brain energy metabolism. Molecular psychiatry. 2023-05-15. PMID:37188779. a dysregulated hypothalamus pituitary adrenal axis response with aberrant glucocorticoids (gcs) release is often observed in patients with depression. 2023-05-15 2023-08-14 mouse
Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.). vol 165. 2023-03-04. PMID:36869551. in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation. 2023-03-04 2023-08-14 mouse
Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pa. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. Journal of affective disorders. 2023-02-06. PMID:36746244. after depression behavior tests, seven segments (cortex, hippocampus, striatum, hypothalamus, serum, cecum, and colon) along the gut-brain axis were collected to characterize their kp metabolism. 2023-02-06 2023-08-14 rat
Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience. vol 15. 2022-12-05. PMID:36466807. function of brain-derived neurotrophic factor in the hypothalamus: implications for depression pathology. 2022-12-05 2023-08-14 Not clear
Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience. vol 15. 2022-12-05. PMID:36466807. however, much of the symptomatology for depression is consistent with disruptions in functions of the hypothalamus including changes in weight, activity levels, responses to stress, and sociability. 2022-12-05 2023-08-14 Not clear
Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience. vol 15. 2022-12-05. PMID:36466807. here, we review evidence for the role of bdnf and trkb signaling in the regions of the hypothalamus and their role in these autonomic and behavioral functions associated with depression. 2022-12-05 2023-08-14 Not clear
Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience. vol 15. 2022-12-05. PMID:36466807. understanding the role of bdnf signaling in the hypothalamus will lead to valuable insights for sex- and stress-dependent neurobiological underpinnings of depression pathology. 2022-12-05 2023-08-14 Not clear
Yuan Wang, Ling Liu, Jiang-Hong Gu, Cheng-Niu Wang, Wei Guan, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Yan-Mei Chen, Jie Huang, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Bo Jian. Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. Molecular psychiatry. 2022-11-26. PMID:36434056. salt-inducible kinase 1-creb-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. 2022-11-26 2023-08-14 mouse
Bob Daripa, Scott Lucches. Unusual Presentation of COVID-19 Headache and Its Possible Pathomechanism. Cureus. vol 14. issue 9. 2022-10-26. PMID:36284805. the possible covid-19 pain pathway pathomechanism engaging interleukin (il)-1, il-6, and tumor necrosis factor (tnf) alpha aided with a cortical spreading depression disturbing the hypothalamus is also described in this study. 2022-10-26 2023-08-14 human
Fu-Rong Yang, Xiao-Xu Zhu, Ming-Wang Kong, Xiao-Juan Zou, Qing-Yu Ma, Xiao-Juan Li, Jia-Xu Che. Xiaoyaosan Exerts Antidepressant-Like Effect by Regulating Autophagy Involves the Expression of GLUT4 in the Mice Hypothalamic Neurons. Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784760. many studies have proven that autophagy plays a pivotal role in the development of depression and it also affects the expression of glut4 in the hypothalamus. 2022-07-05 2023-08-14 mouse
Marie N N Hellem, Rachel Y Cheong, Simone Tonetto, Tua Vinther-Jensen, Rebecca K Hendel, Ida U Larsen, Troels T Nielsen, Lena E Hjermind, Asmus Vogel, Esben Budtz-Jørgensen, Åsa Petersén, Jørgen E Nielse. Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. Parkinsonism & related disorders. vol 99. 2022-05-17. PMID:35580426. non-motor symptoms like depression and altered social cognition are proposed to be caused by dysfunction of the hypothalamus. 2022-05-17 2023-08-13 Not clear
Hatice Solak, Z Isik Solak Gormus, Raviye Ozen Koca, Canan Eroglu Gunes, Selim Kutl. Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression? Neurochemical research. 2022-01-26. PMID:35080689. based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (cms) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. 2022-01-26 2023-08-13 rat
Daniela Baptista-de-Souza, Lígia Renata Rodrigues Tavares, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souz. Behavioral, hormonal, and neural alterations induced by social contagion for pain in mice. Neuropharmacology. vol 203. 2021-12-03. PMID:34774550. to amplify the knowledge about behavioral, hormonal, and neural alterations induced by cohabitation with a pair in neuropathic pain, we investigated the effects of this protocol on (i) pain (writhing, formalin, hot plate tests) and depression (sucrose splash test) responses, (ii) the serum levels of corticosterone, testosterone, and oxytocin, (iii) noradrenalin, dopamine and its metabolite (dopac and hva) levels in the amygdaloid complex and insular cortex, (iv) neuronal activation pattern (fosb labeling) in the ventral tegmental area (vta), paraventricular nucleus of the hypothalamus (pvn) and supraoptic nucleus (so). 2021-12-03 2023-08-13 mouse