| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hatice Solak, Z Isik Solak Gormus, Raviye Ozen Koca, Canan Eroglu Gunes, Selim Kutl. Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression? Neurochemical research. 2022-01-26. PMID:35080689. |
based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (cms) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. |
2022-01-26 |
2023-08-13 |
rat |
| Daniela Baptista-de-Souza, Lígia Renata Rodrigues Tavares, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souz. Behavioral, hormonal, and neural alterations induced by social contagion for pain in mice. Neuropharmacology. vol 203. 2021-12-03. PMID:34774550. |
to amplify the knowledge about behavioral, hormonal, and neural alterations induced by cohabitation with a pair in neuropathic pain, we investigated the effects of this protocol on (i) pain (writhing, formalin, hot plate tests) and depression (sucrose splash test) responses, (ii) the serum levels of corticosterone, testosterone, and oxytocin, (iii) noradrenalin, dopamine and its metabolite (dopac and hva) levels in the amygdaloid complex and insular cortex, (iv) neuronal activation pattern (fosb labeling) in the ventral tegmental area (vta), paraventricular nucleus of the hypothalamus (pvn) and supraoptic nucleus (so). |
2021-12-03 |
2023-08-13 |
mouse |
| Xiang Li, Si-Min Qi, Yu Wang, Hui-Wu Jiang, Ya-Huan Li, Bing-Cong Zhao, Tao Zhang, Yang Sun, Xing-Zhou Gao, Song-Xiao Quan, Peng-Fei Liu, Wen-Shan Li, Ji-Hong Wu, Tu-Ya Bao, Hui-Li Jian. Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 11. 2021-11-15. PMID:34431619. |
the expression levels of c-jun in the hypothalamus, c-fos in the pituitary gland, and c-fos and ap-1 in the serum of cums induced rat model of depression were detected by elisa. |
2021-11-15 |
2023-08-13 |
rat |
| Tanveer Singh, Rajesh Kumar Goe. Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities. Neurochemical research. vol 46. issue 6. 2021-10-12. PMID:33665775. |
we should also move beyond ads, and therefore, we reviewed common pathological mechanisms such as neuroinflammation, dysregulated hypothalamus pituitary adrenal (hpa) axis, altered neurogenesis, and altered tryptophan metabolism responsible for coexistent relationship of epilepsy and depression. |
2021-10-12 |
2023-08-13 |
Not clear |
| Rongrong Li, Chiyuan Ma, Yue Xiong, Huashan Zhao, Yali Yang, Li Xue, Baobei Wang, Tianxia Xiao, Jie Chen, Xiaohua Lei, Baohua Ma, Jian Zhan. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules. vol 11. issue 6. 2021-09-20. PMID:34207497. |
depression affects the reproductive axis at the hypothalamus and pituitary levels, which has a significant impact on female fertility. |
2021-09-20 |
2023-08-13 |
mouse |
| Weibo Gong, Wei Liao, Chui Fang, Yanchen Liu, Hong Xie, Faping Yi, Rongzhong Huang, Lixiang Wang, Jian Zho. Analysis of Chronic Mild Stress-Induced Hypothalamic Proteome: Identification of Protein Dysregulations Associated With Vulnerability and Resiliency to Depression or Anxiety. Frontiers in molecular neuroscience. vol 14. 2021-06-04. PMID:33737865. |
in summary, the current proteomic research on the hypothalamus provided insights into the specific and common molecular basis for the hpa dysfunction mechanisms that underlie resiliency and vulnerability to stress-induced depression or anxiety. |
2021-06-04 |
2023-08-13 |
rat |
| Wei Han, Qian Xue, Guohui Li, Jianmei Yin, Huiyong Zhang, Yunfen Zhu, Weijie Xing, Yuxia Cao, Yijun Su, Kehua Wang, Jianmin Zo. Genome-wide analysis of the role of DNA methylation in inbreeding depression of reproduction in Langshan chicken. Genomics. vol 112. issue 4. 2021-04-09. PMID:32057912. |
to investigate the potential dna methylation sites involved in the inbreeding depression of chicken reproduction, we carried out whole-genome bisulfite sequencing (wgbs) of hypothalamus and ovary tissues from the strongly and weakly inbred langshan chickens, respectively. |
2021-04-09 |
2023-08-13 |
chicken |
| Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirull. High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats. The European journal of neuroscience. 2021-03-26. PMID:33711185. |
changes in the expression levels of inflammatory (il-1β, tnf-α, il-6) and of stress response mediators (nr3c1, fkbp5) as well as of mood and metabolic regulators (bdnf, ghs-r) were investigated in the hippocampus, prefrontal cortex and hypothalamus, brain regions involved in the pathogenesis of depression and prone to inflammation in response to stress. |
2021-03-26 |
2023-08-13 |
rat |
| Yajing Hou, Yueyun Liu, Chenyue Liu, Zhiyi Yan, Qingyu Ma, Jianbei Chen, Man Zhang, Qiuying Yan, Xiaojuan Li, Jiaxu Che. Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus. Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 8. 2021-03-24. PMID:32175693. |
abnormal changes in the lateral region of the hypothalamus are associated with the comorbidity of depression and physical symptoms, and how the traditional chinese formula xiaoyaosan regulates these changes may reveal aspects of the pathogenesis of depression. |
2021-03-24 |
2023-08-13 |
rat |
| Yajing Hou, Yueyun Liu, Chenyue Liu, Zhiyi Yan, Qingyu Ma, Jianbei Chen, Man Zhang, Qiuying Yan, Xiaojuan Li, Jiaxu Che. Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus. Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 8. 2021-03-24. PMID:32175693. |
this study aimed to establish a rat model of depression in order to examine changes in orexin a/oxr1 expression in the lateral region of the hypothalamus and the effects of xiaoyaosan. |
2021-03-24 |
2023-08-13 |
rat |
| Yu Wu, Zhenhong Wei, Yonghong Li, Chaojun Wei, Yuanting Li, Pengfei Cheng, Hui Xu, Zhenhao Li, Rui Guo, Xiaoming Qi, Jing Jia, Yanjuan Jia, Wanxia Wang, Xiaoling Ga. Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31920518. |
perturbation of ephrin receptor signaling and glutamatergic transmission in the hypothalamus in depression using proteomics integrated with metabolomics. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu Wu, Zhenhong Wei, Yonghong Li, Chaojun Wei, Yuanting Li, Pengfei Cheng, Hui Xu, Zhenhao Li, Rui Guo, Xiaoming Qi, Jing Jia, Yanjuan Jia, Wanxia Wang, Xiaoling Ga. Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31920518. |
in the present study, isobaric tags for relative-absolute quantitation (itraq) combined with mass spectrometry and gas chromatography-mass spectrometry (gc-ms) were employed to detect the proteomes and metabolomes in the hypothalamus of the lipopolysaccharide (lps)-induced depression mouse, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiaozheng Liu, Wei Chen, Yunhai Tu, Hongtao Hou, Xiaoyan Huang, Xingli Chen, Zhongwei Guo, Guanghui Bai, Wei Che. The Abnormal Functional Connectivity between the Hypothalamus and the Temporal Gyrus Underlying Depression in Alzheimer's Disease Patients. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29487521. |
the abnormal functional connectivity between the hypothalamus and the temporal gyrus underlying depression in alzheimer's disease patients. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaozheng Liu, Wei Chen, Yunhai Tu, Hongtao Hou, Xiaoyan Huang, Xingli Chen, Zhongwei Guo, Guanghui Bai, Wei Che. The Abnormal Functional Connectivity between the Hypothalamus and the Temporal Gyrus Underlying Depression in Alzheimer's Disease Patients. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29487521. |
however, little is known of how the hypothalamus interacts with other brain regions in ad patients with depression (d-ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaozheng Liu, Wei Chen, Yunhai Tu, Hongtao Hou, Xiaoyan Huang, Xingli Chen, Zhongwei Guo, Guanghui Bai, Wei Che. The Abnormal Functional Connectivity between the Hypothalamus and the Temporal Gyrus Underlying Depression in Alzheimer's Disease Patients. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29487521. |
our results showed that d-ad patients had reduced fc among the hypothalamus, the right middle temporal gyrus (mtg) and the right superior temporal gyrus (stg) compared with the fc of nd-ad patients, suggesting that the abnormal fc between the hypothalamus and the temporal lobe may play a key role in the pathophysiology of depression in ad patients. |
2020-09-30 |
2023-08-13 |
Not clear |
| Priyanka Sharma, Simarpreet Virk Sandhu, Rajat Bhandari, Indu Verma, Ramanpreet Kaur Bhullar, Rajbir Kaur Khangur. Estimation of cortisol levels in patients with premalignant disorders and oral squamous cell carcinoma. Journal of oral and maxillofacial pathology : JOMFP. vol 22. issue 1. 2020-09-30. PMID:29731553. |
oral cancer has been a scourge on the human population that drastically affects the quality of life-causing chronic anxiety and depression leading to disturbance in hypothalamus pituitary axis reflected by cortisol hormone dysregulation. |
2020-09-30 |
2023-08-13 |
human |
| Jin Yang, Ling Zhang, Lu-Lu Cao, Jun Qi, Ping Li, Xi-Peng Wang, Xiu-Lan Su. MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model. Cells. vol 8. issue 9. 2020-05-11. PMID:31540304. |
compared to the sham group, the microrna-99a (mir-99a) level decreased significantly in the hypothalamus, and its target fk506-binding protein 51 (fkbp51) enormously increased; in contrast, the nuclear translocation of the progesterone receptor (pr) decreased in hypothalamic paraventricular nucleus (pvn) in the peri/postmenopausal depression mouse model. |
2020-05-11 |
2023-08-13 |
mouse |
| Eirini Vagena, Jae Kyu Ryu, Bernat Baeza-Raja, Nicola M Walsh, Catriona Syme, Jonathan P Day, Miles D Houslay, George S Bailli. A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling. Translational psychiatry. vol 9. issue 1. 2020-01-09. PMID:31076569. |
ffar1 inhibition and/or an increase of camp signaling in the hypothalamus could offer potential therapeutic targets to counteract the effects of dietary or genetically induced obesity on depression. |
2020-01-09 |
2023-08-13 |
mouse |
| Shilpi Modi, Divesh Thaploo, Pawan Kumar, Subash Khush. Individual differences in trait anxiety are associated with gray matter alterations in hypothalamus: Preliminary neuroanatomical evidence. Psychiatry research. Neuroimaging. vol 283. 2019-12-31. PMID:30530256. |
in a partial correlation analysis (with age, gender, and beck depression inventory (bdi) scores as covariates of no interest), trait anxiety was found to be negatively correlated with the gray matter volume of hypothalamus bilaterally and positively correlated with the gray matter volume of left thalamus. |
2019-12-31 |
2023-08-13 |
human |
| Xiong-Jun Mou, Hao Liu, Ning Lin, Xin Chen, Song-Lin Li. [Effects of Shugan Hewei Decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 15. 2019-10-21. PMID:31602893. |
[effects of shugan hewei decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats]. |
2019-10-21 |
2023-08-13 |
rat |