| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P E Paulson, D M Camp, T E Robinso. Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology. vol 103. issue 4. 1991-08-07. PMID:2062986. |
behavioral depression was associated with the transient decrease in the concentration of norepinephrine (ne) in the hypothalamus, and a transient decrease in the ability of an amph challenge to alter dopamine (da) concentrations in the caudate-putamen and nucleus accumbens. |
1991-08-07 |
2023-08-11 |
rat |
| M C Kos. Mechanism of ketanserin-induced sympatho-inhibition. European journal of pharmacology. vol 194. issue 2-3. 1991-08-02. PMID:1676374. |
caused a dose-related depression of sympathetic-cholinergic electrodermal responses evoked by electrical stimulation of the hypothalamus in pentobarbital anesthetized cats. |
1991-08-02 |
2023-08-11 |
Not clear |
| L S Brady, H J Whitfield, R J Fox, P W Gold, M Herkenha. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. The Journal of clinical investigation. vol 87. issue 3. 1991-04-10. PMID:1671867. |
in the light of data that major depression is associated with an activation of brain crh and lc-ne systems, the time-dependent effect of long-term imipramine administration on decreasing the gene expression of crh in the hypothalamus and th in the lc may be relevant to the therapeutic efficacy of this agent in depression. |
1991-04-10 |
2023-08-11 |
rat |
| L Vécsei, E Widerlöv, R Ekman, C Allin. Dose- and time-response effects of pantethine on open-field behavior, and on central neurotransmission in rats. Pharmacology, biochemistry, and behavior. vol 35. issue 1. 1990-04-26. PMID:1969162. |
injected in higher doses (1.95-3.90 mm/kg sc), the compound produced a marked depression of both open-field activity and noradrenaline levels, but increased the concentrations of dopamine and dopac in the hypothalamus. |
1990-04-26 |
2023-08-11 |
rat |
| M A Kling, H J Whitfield, H A Brandt, M A Demitrack, K Kalogeras, T D Geracioti, G I Perini, J R Calabrese, G P Chrousos, P W Gol. Effects of glucocorticoid antagonism with RU 486 on pituitary-adrenal function in patients with major depression: time-dependent enhancement of plasma ACTH secretion. Psychopharmacology bulletin. vol 25. issue 3. 1990-04-04. PMID:2560555. |
data from our group and others suggest that pituitary-adrenal activation in major depression reflects a defect at or above the hypothalamus which results in the hypersecretion of corticotropin-releasing hormone (crh); some have suggested, however, that elevated indices of cortisol secretion and lack of suppressibility to dexamethasone may be a manifestation of a primary defect in glucocorticoid receptor activation. |
1990-04-04 |
2023-08-11 |
human |
| D L Jone. Hypothalamic alpha-adrenergic blockade modifies drinking and blood pressure responses to central angiotensin II in conscious rats. Canadian journal of physiology and pharmacology. vol 66. issue 10. 1989-05-15. PMID:2907299. |
phentolamine mesylate in doses of 2.5-125 micrograms injected into the rostral hypothalamus produced a dose-dependent depression of both the drinking and pressor responses elicited by i.c.v. |
1989-05-15 |
2023-08-11 |
rat |
| J A Jesberger, J S Richardso. Brain output dysregulation induced by olfactory bulbectomy: an approximation in the rat of major depressive disorder in humans? The International journal of neuroscience. vol 38. issue 3-4. 1988-06-27. PMID:3286555. |
although the specific neurochemical abnormalities responsible have not been identified, the presenting symptoms of major depression are consistent with a disruption of normal neural communications between the limbic system and hypothalamus. |
1988-06-27 |
2023-08-11 |
rat |
| M A Karapetian, N S Akopian, O G Baklavadzhia. [Hypothalamic mechanisms regulating the activity of the respiratory neurons of the medulla oblongata in hypoxia]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 73. issue 7. 1987-12-08. PMID:3666206. |
at the maximal altitude (8000-9000 m), against the background of hypoxic depression of unit activity, the stimulation of hypothalamus exerted mainly a stimulating effect. |
1987-12-08 |
2023-08-11 |
Not clear |
| P W Gold, M A Kling, I Khan, J R Calabrese, K Kalogeras, R M Post, P C Avgerinos, D L Loriaux, G P Chrouso. Corticotropin releasing hormone: relevance to normal physiology and to the pathophysiology and differential diagnosis of hypercortisolism and adrenal insufficiency. Advances in biochemical psychopharmacology. vol 43. 1987-07-07. PMID:3035886. |
these data, along with the finding that a continuous infusion of crh to normal volunteers, reproduces the pattern and magnitude of hypercortisolism in depression and anorexia nervosa, suggest that the hypercortisolism in these disorders represents a defect at or above the hypothalamus resulting in the hypersecretion of crh. |
1987-07-07 |
2023-08-11 |
human |
| T P Bridge, J E Kleinman, B J Soldo, F Karou. Central catecholamines, cognitive impairment, and affective state in elderly schizophrenics and controls. Biological psychiatry. vol 22. issue 2. 1987-04-01. PMID:3814666. |
in the hypothalamus, there are significant direct relationships of homovanillic acid (hva) and 3-methoxy-4-hydroxyphenylglycol (mhpg) with depressed mood, as measured by an adaptation of the hamilton rating scale for depression. |
1987-04-01 |
2023-08-11 |
human |
| M J Twery, R L Mos. Sensitivity of rat forebrain neurons to growth hormone-releasing hormone. Peptides. vol 6. issue 4. 1985-12-30. PMID:3934650. |
although neurons excited by these peptides were encountered in thalamus and hypothalamus, depression of neuronal firing was the predominant response observed. |
1985-12-30 |
2023-08-11 |
human |
| M Ito, M Miyaoka, S Ishi. [Alterations in local cerebral glucose utilization during various anesthesia--the effect of urethane and a review]. No to shinkei = Brain and nerve. vol 36. issue 12. 1985-05-02. PMID:6529517. |
the neural structures in which no metabolic depression was observed were entorhinal cortex, many nuclei in hypothalamus, medial habenula-interpeduncular nucleus, nucleus tractus solitarius, and some white matters. |
1985-05-02 |
2023-08-12 |
rat |
| A Van Bogaer. [Hypothalamus, cardiovascular pression and depression center]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression. vol 23. issue 2. 1982-09-24. PMID:7102946. |
[hypothalamus, cardiovascular pression and depression center]. |
1982-09-24 |
2023-08-12 |
Not clear |
| M D Culler, N H McArthur, W L Dees, R E Owens, P G Harm. Inhibition of the postovariectomy depletion of hypothalamic luteinizing hormone releasing hormone (LHRH) by suckling. Biology of reproduction. vol 26. issue 4. 1982-08-07. PMID:7044434. |
these data from ovariectomized rats suggest that suckling inhibits lhrh release from the hypothalamus and hence provides an explanation for the depression of plasma lh observed in suckled ovariectomized and intact animals. |
1982-08-07 |
2023-08-12 |
rat |
| P R Lowenstein, M I Vacas, D P Cardinal. Effect of pentoxifylline on alpha- and beta-adrenoceptor sites in cerebral cortex medial basal hypothalamus and pineal gland of the rat. Neuropharmacology. vol 21. issue 3. 1982-06-14. PMID:6280095. |
the intraperitoneal injection of the methylxanthine derivative pentoxifylline (3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] brought about, 3 hr later, a significant depression of alpha- and beta-adrenoceptor sites in the cerebral cortex, and of beta-adrenoceptor sites in medial basal hypothalamus and pineal gland, (assessed from the specific binding of radioactive dihydroergocryptine and dihydroalprenolol respectively). |
1982-06-14 |
2023-08-12 |
rat |
| M J Millan, R Przewłocki, M Jerlicz, C Gramsch, V Höllt, A Her. Stress-induced release of brain and pituitary beta-endorphin: major role of endorphins in generation of hyperthermia, not analgesia. Brain research. vol 208. issue 2. 1981-06-13. PMID:6260287. |
a 5-min foot-shock instigated a significant depression in the levels of beta-endorphin immunoreactivity (beta-ei) in both the hypothalamus and periventricular beta-endorphinergic fibre-containing tissue. |
1981-06-13 |
2023-08-12 |
Not clear |
| B de Lignières, P Mauvais-Jarvi. [Hormones in depressive illness. The role of cortisol and sexual steroids (author's transl)]. Annales de biologie clinique. vol 37. issue 1. 1979-07-16. PMID:375781. |
it is actually highly probable than depression is linked to a decrease in noradrenergic activity in brain, at least in some areas including hypothalamus. |
1979-07-16 |
2023-08-11 |
Not clear |
| A N Iavorskiĭ, N N Samoilov, A V Rychk. [Effect of lithium chloride on the rat hypothalamus neurosecretory system]. Biulleten' eksperimental'noi biologii i meditsiny. vol 83. issue 1. 1977-06-11. PMID:856331. |
reaction of the hhns proved to depend directly on the amount of lithium administered and was characteriaed by the activation of the synthesis and elemination of the neurosecretion with a single administration on the preparation, or depression of the hormonopoiesis in the hypothalamus and exhaustion of the neurosecretion stores in the neurohypophysis in its course application. |
1977-06-11 |
2023-08-11 |
rat |
| H B Stoner, H W Marshal. Localization of the brain regions concerned in the inhibition of shivering by trauma. British journal of experimental pathology. vol 58. issue 1. 1977-04-28. PMID:836767. |
the injection of 6-ohda into the posterior part of the hypothalamus in the neighbourhood of the n. dorsomedialis or into the ventral ascending catecholaminergic bundle caudal to that nucleus prevented the depression of the ambient temperature threshold for the onset of shivering which usually occurs during hind-limb ischaemia and lowered the slope of the regression line relating the intensity of shivering to ambient temperature. |
1977-04-28 |
2023-08-11 |
rat |
| J A Colombo, D I Whitmoyer, F Ellendorff, C H Sawye. Effects of cortical spreading depression on multiunit activity in the preoptic area and hypothalamus of the female rat. Neuroendocrinology. vol 13. issue 3. 1974-04-17. PMID:4360499. |
effects of cortical spreading depression on multiunit activity in the preoptic area and hypothalamus of the female rat. |
1974-04-17 |
2023-08-11 |
rat |