| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cuijuan Yu, Shefali Rouen, Rick T Dobrowsk. Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination. Glia. vol 56. issue 8. 2008-07-10. PMID:18338795. |
as myelinated scs undergo substantial degeneration in diabetic neuropathy, we used myelinated sc/drg neuron co-cultures to determine if hyperglycemia and changes in cav-1 expression could enhance nrg-induced demyelination. |
2008-07-10 |
2023-08-12 |
Not clear |
| Michiru Fukunaga, Satoshi Miyata, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells. Annals of the New York Academy of Sciences. vol 1043. 2005-10-27. PMID:16037234. |
these results suggest a possible contribution of glucose-derived mg to the development of diabetic neuropathy by injuring the cellular constituent of the peripheral nerve system, such as scs, in the hyperglycemic milieu. |
2005-10-27 |
2023-08-12 |
rat |
| Michiru Fukunaga, Satoshi Miyata, Bing Fen Liu, Hiroyuki Miyazaki, Yushi Hirota, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochemical and biophysical research communications. vol 320. issue 3. 2004-08-26. PMID:15240103. |
we examined whether mg was capable of inducing apoptosis in schwann cells (scs), since recent studies have suggested a potential involvement of apoptotic cell death in the development of diabetic neuropathy. |
2004-08-26 |
2023-08-12 |
rat |
| C L Delaney, J W Russell, H L Cheng, E L Feldma. Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells. Journal of neuropathology and experimental neurology. vol 60. issue 2. 2001-03-29. PMID:11273003. |
in the current study, 2 model systems are used to study the mechanism of sc damage in diabetic neuropathy: the streptozotocin (stz)-treated diabetic rat and cultures of purified scs in vitro. |
2001-03-29 |
2023-08-12 |
rat |
| C L Delaney, J W Russell, H L Cheng, E L Feldma. Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells. Journal of neuropathology and experimental neurology. vol 60. issue 2. 2001-03-29. PMID:11273003. |
schwann cells (scs), the myelinating cells of the peripheral nervous system, are lost or damaged in patients suffering from diabetic neuropathy. |
2001-03-29 |
2023-08-12 |
rat |
| C L Delaney, J W Russell, H L Cheng, E L Feldma. Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells. Journal of neuropathology and experimental neurology. vol 60. issue 2. 2001-03-29. PMID:11273003. |
igf-i may be useful in preventing hyperglycemia-induced damage to scs in patients suffering from diabetic neuropathy. |
2001-03-29 |
2023-08-12 |
rat |