| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgenia Sitnikova, Dmitrii Perevozniuk, Elizaveta Rutskova, Shukhrat Uzakov, Viktor A Korshuno. Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy. Diagnostics (Basel, Switzerland). vol 12. issue 11. 2022-11-26. PMID:36428857. |
we aimed to uncover the role of the hippocampus in absence epilepsy using a genetic rat model of absence epilepsy (wag/rij rats), in which spike-wave discharges (swds) appear spontaneously in cortical eeg. |
2022-11-26 |
2023-08-14 |
rat |
| Evgenia Sitnikova, Dmitrii Perevozniuk, Elizaveta Rutskova, Shukhrat Uzakov, Viktor A Korshuno. Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy. Diagnostics (Basel, Switzerland). vol 12. issue 11. 2022-11-26. PMID:36428857. |
reduction of hippocampal high-frequency activity in wag/rij rats with a genetic predisposition to absence epilepsy. |
2022-11-26 |
2023-08-14 |
rat |
| Evgenia Sitnikova, Dmitrii Perevozniuk, Elizaveta Rutskova, Shukhrat Uzakov, Viktor A Korshuno. Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy. Diagnostics (Basel, Switzerland). vol 12. issue 11. 2022-11-26. PMID:36428857. |
further investigation of processes underlying swd-related reduction of hippocampal ripples and hfo oscillations may help to predict epileptic attacks and explain cognitive comorbidities in patients with absence epilepsy. |
2022-11-26 |
2023-08-14 |
rat |
| Evgenia Sitnikova, Dmitrii Perevozniuk, Elizaveta Rutskova, Shukhrat Uzakov, Viktor A Korshuno. Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy. Diagnostics (Basel, Switzerland). vol 12. issue 11. 2022-11-26. PMID:36428857. |
in contrast, absence epilepsy and other idiopathic epilepsies are known to result from thalamo-cortical abnormalities, with the hippocampus involvement considered to be only indirect. |
2022-11-26 |
2023-08-14 |
rat |
| Sathiya Sekar, Wendie N Marks, Venkat Gopalakrishnan, Quentin Greba, Terrance P Snutch, John G Howland, Changiz Taghibiglo. Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg. Clinical and experimental pharmacology & physiology. vol 47. issue 9. 2021-11-17. PMID:32304254. |
therefore, we examined the major components of pi3k/akt-mediated insulin signalling in cortical, thalamic, and hippocampal tissues collected from genetic absence epilepsy rats from strasbourg (gaers) and non-epileptic control (nec) rats. |
2021-11-17 |
2023-08-13 |
rat |
| Gabriele Di Cicco, Emanuela Marzano, Luisa Iacovelli, Roberta Celli, Gilles van Luijtelaar, Ferdinando Nicoletti, Richard T Ngomba, Mark J Wal. Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy. Neuropharmacology. vol 196. 2021-10-01. PMID:34197893. |
group i metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of wag/rij rats modelling absence epilepsy. |
2021-10-01 |
2023-08-13 |
rat |
| Gabriela G Regner, Patrícia Pereira, Douglas T Leffa, Carla de Oliveira, Rafael Vercelino, Felipe Fregni, Iraci L S Torre. Preclinical to Clinical Translation of Studies of Transcranial Direct-Current Stimulation in the Treatment of Epilepsy: A Systematic Review. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:29623027. |
we found that few preclinical findings have been translated into clinical research (number of sessions and effects on seizure frequency) and that most findings have not been tested clinically (effects of tdcs on status epilepticus and absence epilepsy, neuroprotective effects in the hippocampus, and combined use with specific medications). |
2020-09-29 |
2023-08-13 |
Not clear |
| Péter Papp, Zsolt Kovács, Péter Szocsics, Gábor Juhász, Zsófia Maglóczk. Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy. Epilepsy research. vol 145. 2019-04-05. PMID:29885592. |
here, we outline aspects of the electrophysiological and structural background of these dysfunctions by investigating changes in hippocampal and cortical gabaergic inhibitory interneurons in two genetically absence epileptic rat strains: the genetic absence epilepsy rats from strasbourg (gaers) and the wistar albino glaxo/rijswijk (wag/rij) rats. |
2019-04-05 |
2023-08-13 |
rat |
| Péter Papp, Zsolt Kovács, Péter Szocsics, Gábor Juhász, Zsófia Maglóczk. Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy. Epilepsy research. vol 145. 2019-04-05. PMID:29885592. |
our results suggest an enhanced synchronization and functional connections between the hippocampus and s1 cortex as well as thalamocortical activities during swds and a functional alteration of inhibitory mechanisms in the hippocampus and s1 cortex of two genetic models of absence epilepsy, presumably in relation with increased neuronal activity and seizure-induced neuronal injury. |
2019-04-05 |
2023-08-13 |
rat |
| Péter Papp, Zsolt Kovács, Péter Szocsics, Gábor Juhász, Zsófia Maglóczk. Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy. Epilepsy research. vol 145. 2019-04-05. PMID:29885592. |
alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy. |
2019-04-05 |
2023-08-13 |
rat |
| Slavianka Moyanova, Antonio De Fusco, Ines Santolini, Roberta Celli, Domenico Bucci, Federica Mastroiacovo, Giuseppe Battaglia, Ferdinando Nicoletti, Jane Tchekalarov. Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats? International journal of molecular sciences. vol 19. issue 7. 2018-11-15. PMID:29986414. |
abnormal hippocampal melatoninergic system: a potential link between absence epilepsy and depression-like behavior in wag/rij rats? |
2018-11-15 |
2023-08-13 |
rat |
| Slavianka Moyanova, Antonio De Fusco, Ines Santolini, Roberta Celli, Domenico Bucci, Federica Mastroiacovo, Giuseppe Battaglia, Ferdinando Nicoletti, Jane Tchekalarov. Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats? International journal of molecular sciences. vol 19. issue 7. 2018-11-15. PMID:29986414. |
these findings suggest that a defect of hippocampal melatoninergic system may be one of the mechanisms underlying the depression-like phenotype in wag/rij rats and that activation of melatonin receptors might represent a valuable strategy in the treatment of depression associated with absence epilepsy. |
2018-11-15 |
2023-08-13 |
rat |
| Sathiya Sekar, Entesar Omran, Venkat Gopalakrishnan, John G Howland, Terrance P Snutch, Changiz Taghibiglo. Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg. Epilepsy research. vol 136. 2018-05-07. PMID:28719803. |
elevated sterol regulatory elementary binding protein 1 and glua2 levels in the hippocampal nuclear fraction of genetic absence epilepsy rats from strasbourg. |
2018-05-07 |
2023-08-13 |
human |
| Sathiya Sekar, Entesar Omran, Venkat Gopalakrishnan, John G Howland, Terrance P Snutch, Changiz Taghibiglo. Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg. Epilepsy research. vol 136. 2018-05-07. PMID:28719803. |
to explore this issue, we examined the levels of mature srebp1, glua2, glyceraldehyde 3-phosphate dehydrogenase (gapdh), p53, and activated to total caspase 3 ratio in nuclear fractions (nf) of hippocampal homogenate from 8 to 10 week old male genetic absence epilepsy rats from strasbourg (gaers) and non-epileptic control (nec) strains. |
2018-05-07 |
2023-08-13 |
human |
| Nihan Çarçak, Ergin Dileköz, Rezzan Gülhan, Rüştü Onur, Filiz Yılmaz Onat, Yıldırım Sar. Increased inhibitory synaptic activity in the hippocampus (CA1) of genetic absence epilepsy rats: Relevance of kindling resistance. Epilepsy research. vol 126. 2017-12-19. PMID:27434859. |
increased inhibitory synaptic activity in the hippocampus (ca1) of genetic absence epilepsy rats: relevance of kindling resistance. |
2017-12-19 |
2023-08-13 |
rat |
| Isabelle Guillemain, Philippe Kahane, Antoine Depauli. Animal models to study aetiopathology of epilepsy: what are the features to model? Epileptic disorders : international epilepsy journal with videotape. vol 14. issue 3. 2016-04-23. PMID:22947423. |
the 36 experts were questioned, via the internet, on the most critical features of four prototypic forms of epilepsy (idiopathic generalised epilepsies with convulsive seizures, absence epilepsy, focal epilepsy associated with dysplasia, and focal epilepsy associated with hippocampal sclerosis) that should be taken into account with regards to the relevance of animal models of epilepsy. |
2016-04-23 |
2023-08-12 |
mouse |
| Akito Nakao, Takafumi Miki, Ken Shimono, Hiroaki Oka, Tomohiro Numata, Shigeki Kiyonaka, Kaori Matsushita, Hiroo Ogura, Tetsuhiro Niidome, Jeffrey L Noebels, Minoru Wakamori, Keiji Imoto, Yasuo Mor. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering. Pflugers Archiv : European journal of physiology. vol 467. issue 4. 2015-12-17. PMID:24947601. |
in absence epilepsy, although its association with cognitive impairments has been reported, the mechanisms underlying hippocampal synchrony remain poorly investigated. |
2015-12-17 |
2023-08-13 |
mouse |
| Akito Nakao, Takafumi Miki, Ken Shimono, Hiroaki Oka, Tomohiro Numata, Shigeki Kiyonaka, Kaori Matsushita, Hiroo Ogura, Tetsuhiro Niidome, Jeffrey L Noebels, Minoru Wakamori, Keiji Imoto, Yasuo Mor. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering. Pflugers Archiv : European journal of physiology. vol 467. issue 4. 2015-12-17. PMID:24947601. |
here we simultaneously recorded electrical activities from 64 sites in hippocampal slices of cav2.1 ca(2+) channel mutant tottering (tg) mice, a well-established mouse model of spontaneous absence epilepsy, to analyze the spatiotemporal pattern of cholinergically induced hippocampal network activity. |
2015-12-17 |
2023-08-13 |
mouse |
| Emilio Russo, Paolo Follesa, Rita Citraro, Caterina Camastra, Annalidia Donato, Daniela Isola, Andrew Constanti, Giovambattista De Sarro, Giuseppe Donat. The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 11. 2015-11-10. PMID:24889758. |
the mtor signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. |
2015-11-10 |
2023-08-13 |
rat |
| Jose F Tellez-Zenteno, Lizbeth Hernandez-Ronquillo, Farzad Moien-Afshar. Discontinuation of antiepileptic drugs after successful surgery: who and when? Epileptic disorders : international epilepsy journal with videotape. vol 14. issue 4. 2013-06-25. PMID:23238436. |
the most consistent risk factors for seizure relapse were: age older than 30 years at the time of surgery, persistent auras, early drug tapering, seizure recurrence before a reduction of drugs, normal mri, a longer period with epilepsy, absence of hippocampal sclerosis, and the presence of interictal discharges on eeg after surgery. |
2013-06-25 |
2023-08-12 |
Not clear |