| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander C Whitebirch, Bina Santoro, Anastasia Barnett, Christos Panagiotis Lisgaras, Helen E Scharfman, Steven A Siegelbau. Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-29. PMID:37643861. |
a significant proportion of temporal lobe epilepsy (tle) patients experience drug-resistant seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in the hippocampal ca1 and ca3 subfields, with a relative sparing of dentate gyrus granule cells and ca2 pyramidal neurons (pns). |
2023-08-29 |
2023-09-07 |
mouse |
| Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui She. Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488907. |
regulation of specific abnormal calcium signals in the hippocampal ca1 and primary cortex m1 alleviates the progression of temporal lobe epilepsy. |
2023-07-25 |
2023-08-14 |
mouse |
| Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui She. Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488907. |
however, the effect of fluctuating calcium activity in ca1 pyramidal neurons on temporal lobe epilepsy is unknown, and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal ca1 and primary motor cortex m1 of freely moving mice. |
2023-07-25 |
2023-08-14 |
mouse |
| Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui She. Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488907. |
in this study, we used a multi-channel fiber photometry system to continuously record calcium signals in ca1 and m1 during the temporal lobe epilepsy process. |
2023-07-25 |
2023-08-14 |
mouse |
| Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui She. Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488907. |
in particular, cortical spreading depression, which has recently been frequently used to represent the continuously and substantially increased calcium signals, was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from grade ii to grade v. however, vigorous calcium oscillations and highly synchronized calcium signals in ca1 and m1 were strongly related to convulsive motor seizures. |
2023-07-25 |
2023-08-14 |
mouse |
| N H Harbin, D J Lustberg, C Hurst, J Pare, K M Crotty, A L Waters, S M Yeligar, Y Smith, N T Seyfried, D Weinshenker, J R Heple. RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus. Neurobiology of disease. 2023-04-19. PMID:37075948. |
previous findings show that, unlike pcs of hippocampal areas ca1 and ca3, ca2 pcs are resistant to a number of neurological insults, including degeneration caused by temporal lobe epilepsy (tle). |
2023-04-19 |
2023-08-14 |
mouse |
| Nicholas H Harbin, Daniel J Lustberg, Cheyenne Hurst, Jean-Francois Pare, Kathryn M Crotty, Alaina L Waters, Samantha M Yeligar, Yoland Smith, Nicholas T Seyfried, David Weinshenker, John R Heple. RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus. bioRxiv : the preprint server for biology. 2023-02-13. PMID:36778349. |
previous findings show that, unlike pcs of hippocampal areas ca1 and ca3, ca2 pcs are resistant to a number of neurological insults, including degeneration caused by temporal lobe epilepsy (tle). |
2023-02-13 |
2023-08-14 |
mouse |
| Robyn M Busch, Lamis Yehia, Ingmar Blümcke, Bo Hu, Richard Prayson, Bruce P Hermann, Imad M Najm, Charis En. Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy. Brain communications. vol 4. issue 6. 2022-11-24. PMID:36419965. |
here, we use spatial quantitation to examine differential expression of targeted proteins and transcripts in four brain regions essential for episodic memory (dentate gyrus, ca3, ca1, neocortex) between temporal lobe epilepsy patients with and without episodic memory impairment. |
2022-11-24 |
2023-08-14 |
Not clear |
| Alexander C Whitebirch, John J LaFrancois, Swati Jain, Paige Leary, Bina Santoro, Steven A Siegelbaum, Helen E Scharfma. Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy. Neuron. 2022-08-20. PMID:35987207. |
the hippocampal ca2 region, an area important for social memory, has been suspected to play a role in temporal lobe epilepsy (tle) because of its resistance to degeneration observed in neighboring ca1 and ca3 regions in both humans and rodent models of tle. |
2022-08-20 |
2023-08-14 |
mouse |
| Barbara Puhahn-Schmeiser, Tobias Kleemann, Ramazan Jabbarli, Hans H Bock, Jürgen Beck, Thomas M Freima. Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution. Hippocampus. 2022-05-27. PMID:35621370. |
temporal lobe epilepsy is characterized by hippocampal neuronal death in ca1 and hilus. |
2022-05-27 |
2023-08-13 |
mouse |
| Akila Pai, Lara V Marcuse, Judy Alper, Bradley N Delman, John W Rutland, Rebecca E Feldman, Patrick R Hof, Madeline Fields, James Young, Priti Balchandan. Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs. Frontiers in neurology. vol 12. 2021-12-07. PMID:34867703. |
in this study, we present a novel application of the automated segmentation of hippocampal subfields (ashs) software to determine subfield volumes of the ca1, ca2/3, ca4/dg, and the subiculum using ultra high-field 7t mri scans, including t1-weighted mp2rage and t2-tse sequences, in 27 patients with either mesial temporal lobe epilepsy (mtle) or neocortical epilepsy (ne) compared to age and gender matched healthy controls. |
2021-12-07 |
2023-08-13 |
Not clear |
| Barbara Puhahn-Schmeiser, Kathrin Leicht, Florian Gessler, Thomas M Freima. Aberrant hippocampal mossy fibers in temporal lobe epilepsy target excitatory and inhibitory neurons. Epilepsia. vol 62. issue 10. 2021-10-01. PMID:34453315. |
the pathoanatomical correlate of temporal lobe epilepsy is hippocampal sclerosis, characterized by selective neuronal death of mossy cells in the hilus and of pyramidal cells in cornu ammonis 1. |
2021-10-01 |
2023-08-13 |
Not clear |
| Yi Shu, Can Zhu, Min Zeng, Qiong Zhan, Zhiping Hu, Xiaomei W. The protective effect of carbenoxolone on gap junction damage in the hippocampal CA1 area of a temporal lobe epilepsy rat model. Annals of translational medicine. vol 7. issue 22. 2020-10-01. PMID:31930025. |
the protective effect of carbenoxolone on gap junction damage in the hippocampal ca1 area of a temporal lobe epilepsy rat model. |
2020-10-01 |
2023-08-13 |
rat |
| Elizabeth C Arnold, Calli McMurray, Richard Gray, Daniel Johnsto. Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons. eNeuro. vol 6. issue 2. 2020-03-05. PMID:30957013. |
here, we show that the excitability of dorsal, but not ventral ca1 neurons, had an increased firing rate, reduced interspike interval (isi) and increased input resistance in a status epilepticus (se) model of temporal lobe epilepsy (tle). |
2020-03-05 |
2023-08-13 |
rat |
| Barbara Schmeiser, Josef Zentner, Marco Prinz, Armin Brandt, Thomas M Freima. Extent of mossy fiber sprouting in patients with mesiotemporal lobe epilepsy correlates with neuronal cell loss and granule cell dispersion. Epilepsy research. vol 129. 2018-01-03. PMID:27907826. |
the most frequent finding in temporal lobe epilepsy is hippocampal sclerosis, characterized by selective cell loss of hippocampal subregions ca1 and ca4 as well as mossy fiber sprouting (mfs) towards the supragranular region and granule cell dispersion. |
2018-01-03 |
2023-08-13 |
Not clear |
| Diego Lopez-Pigozzi, François Laurent, Jorge R Brotons-Mas, Mario Valderrama, Manuel Valero, Ivan Fernandez-Lamo, Elena Cid, Daniel Gomez-Dominguez, Beatriz Gal, Liset Menendez de la Prid. Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells during Theta-Gamma Rhythmopathies of Temporal Lobe Epilepsy. eNeuro. vol 3. issue 6. 2017-10-24. PMID:27896315. |
altered oscillatory dynamics of ca1 parvalbumin basket cells during theta-gamma rhythmopathies of temporal lobe epilepsy. |
2017-10-24 |
2023-08-13 |
human |
| Florian Weissinger, Matthias Wawra, Pawel Fidzinski, Mark Elsner, Hartmut Meierkord, Martin Holtkamp, Katharina Buchhei. Dentate gyrus autonomous ictal activity in the status epilepticus rat model of epilepsy. Brain research. vol 1658. 2017-08-08. PMID:28062187. |
in temporal lobe epilepsy, the dg becomes hyperexcitable and loses its gate function, enabling propagation of ictal activity into downstream structures such as ca3 and ca1 areas. |
2017-08-08 |
2023-08-13 |
rat |
| Sang Ryong Ki. Control of Granule Cell Dispersion by Natural Materials Such as Eugenol and Naringin: A Potential Therapeutic Strategy Against Temporal Lobe Epilepsy. Journal of medicinal food. vol 19. issue 8. 2017-04-24. PMID:27404051. |
the hippocampus is an important brain area where abnormal morphological characteristics are often observed in patients with temporal lobe epilepsy (tle), typically showing the loss of the principal neurons in the ca1 and ca3 areas of the hippocampus. |
2017-04-24 |
2023-08-13 |
mouse |
| Li Feng, Yi Shu, Qian Wu, Tiantian Liu, Hongyu Long, Huan Yang, Yi Li, Bo Xia. EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy. Molecular medicine reports. vol 15. issue 1. 2017-03-31. PMID:27959424. |
epha4 may contribute to microvessel remodeling in the hippocampal ca1 and ca3 areas in a mouse model of temporal lobe epilepsy. |
2017-03-31 |
2023-08-13 |
mouse |
| Laura Mumoli, Angelo Labate, Roberta Vasta, Antonio Gambardell. Letter: Beyond and within CA1 subfield in magnetic resonance imaging negative temporal lobe epilepsy. Epilepsia. vol 56. issue 9. 2015-11-17. PMID:26340699. |
letter: beyond and within ca1 subfield in magnetic resonance imaging negative temporal lobe epilepsy. |
2015-11-17 |
2023-08-13 |
Not clear |