| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Blümcke, A J Becker, C Klein, C Scheiwe, A A Lie, H Beck, A Waha, M G Friedl, R Kuhn, P Emson, C Elger, O D Wiestle. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744030. |
aberrant axonal reorganization and altered distribution of neurotransmitter receptor subtypes have been proposed as major pathogenic mechanisms for hippocampal hyperexcitability in chronic temporal lobe epilepsies (tle). |
2000-04-07 |
2023-08-12 |
human |
| E Pauli, K W Eberhardt, I Schäfer, B Tomandl, W J Huk, H Stefa. Chemical shift imaging spectroscopy and memory function in temporal lobe epilepsy. Epilepsia. vol 41. issue 3. 2000-03-22. PMID:10714399. |
hippocampal neuron loss and associated memory deficits are characteristic of intractable temporal lobe epilepsy (tle). |
2000-03-22 |
2023-08-12 |
Not clear |
| V Bouilleret, S Boyet, C Marescaux, A Nehli. Mapping of the progressive metabolic changes occurring during the development of hippocampal sclerosis in a model of mesial temporal lobe epilepsy. Brain research. vol 852. issue 2. 2000-03-09. PMID:10678750. |
mapping of the progressive metabolic changes occurring during the development of hippocampal sclerosis in a model of mesial temporal lobe epilepsy. |
2000-03-09 |
2023-08-12 |
mouse |
| U V Nägerl, I Mody, M Jeub, A A Lie, C E Elger, H Bec. Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684884. |
surviving granule cells of the sclerotic human hippocampus have reduced ca(2+) influx because of a loss of calbindin-d(28k) in temporal lobe epilepsy. |
2000-03-09 |
2023-08-12 |
human |
| B Stoffel-Wagner, S Beyenburg, M Watzka, I Blümcke, J Bauer, J Schramm, F Bidlingmaier, C E Elge. Expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia. vol 41. issue 2. 2000-03-02. PMID:10691110. |
expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. |
2000-03-02 |
2023-08-12 |
human |
| B Stoffel-Wagner, S Beyenburg, M Watzka, I Blümcke, J Bauer, J Schramm, F Bidlingmaier, C E Elge. Expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia. vol 41. issue 2. 2000-03-02. PMID:10691110. |
to investigate whether the human hippocampus is equipped with the enzymes 5alpha-reductase and 3alpha-hydroxysteroid oxidoreductase (3alpha-hsor), we studied the expression of 5alpha-reductase types 1 and 2 and 3alpha-hsor types 1 and 2 in the resected hippocampi of patients with medically intractable chronic temporal lobe epilepsy. |
2000-03-02 |
2023-08-12 |
human |
| F G Woermann, A E Everitt, S L Fre. Hemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis. Epilepsia. vol 41. issue 2. 2000-03-02. PMID:10691126. |
hemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis. |
2000-03-02 |
2023-08-12 |
Not clear |
| G Hageman. Hemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis. Epilepsia. vol 41. issue 2. 2000-03-02. PMID:10691127. |
hemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis. |
2000-03-02 |
2023-08-12 |
Not clear |
| A N van den Pol, D D Spence. Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658640. |
astrocytes were obtained from rat hippocampus or hypothalamus, chicken cortex, normal human cortex, human cortex lesion, and from the sclerotic human hippocampus after surgery for intractable temporal lobe epilepsy. |
2000-02-29 |
2023-08-12 |
human |
| L T van Elst, F G Woermann, L Lemieux, P J Thompson, M R Trimbl. Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain : a journal of neurology. vol 123 ( Pt 2). 2000-02-25. PMID:10648432. |
with hippocampal sclerosis, in the context of mesial temporal lobe sclerosis, being the most common cause of temporal lobe epilepsy, we hypothesized that the amygdala might be affected by the same pathogenic process in aggressive patients. |
2000-02-25 |
2023-08-12 |
Not clear |
| L T van Elst, F G Woermann, L Lemieux, P J Thompson, M R Trimbl. Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain : a journal of neurology. vol 123 ( Pt 2). 2000-02-25. PMID:10648432. |
hippocampal sclerosis was significantly less common in patients with temporal lobe epilepsy and ied. |
2000-02-25 |
2023-08-12 |
Not clear |
| L M Li, F Cendes, S B Antel, F Andermann, W Serles, F Dubeau, A Olivier, D L Arnol. Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. Annals of neurology. vol 47. issue 2. 2000-02-17. PMID:10665490. |
prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. |
2000-02-17 |
2023-08-12 |
Not clear |
| L M Li, F Cendes, S B Antel, F Andermann, W Serles, F Dubeau, A Olivier, D L Arnol. Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. Annals of neurology. vol 47. issue 2. 2000-02-17. PMID:10665490. |
the objective of this study was to assess which features of temporal lobe proton magnetic resonance spectroscopic imaging (1h-mrsi) are associated with satisfactory surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. |
2000-02-17 |
2023-08-12 |
Not clear |
| L M Li, F Cendes, S B Antel, F Andermann, W Serles, F Dubeau, A Olivier, D L Arnol. Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. Annals of neurology. vol 47. issue 2. 2000-02-17. PMID:10665490. |
we studied 21 patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy defined by magnetic resonance imaging volumetric measurements who underwent surgical treatment. |
2000-02-17 |
2023-08-12 |
Not clear |
| L M Li, F Cendes, S B Antel, F Andermann, W Serles, F Dubeau, A Olivier, D L Arnol. Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. Annals of neurology. vol 47. issue 2. 2000-02-17. PMID:10665490. |
we conclude that discriminant 1h-mrsi features associated with favorable surgical outcome in patients with temporal lobe epilepsy and bilateral hippocampal atrophy were (1) concordant 1h-mrsi lateralization, (2) a greater side-to-side asymmetry of naa/cr, and (3) an absence of contralateral posterior naa/cr reduction. |
2000-02-17 |
2023-08-12 |
Not clear |
| A A Lie, A Becker, K Behle, H Beck, B Malitschek, P J Conn, R Kuhn, R Nitsch, M Plaschke, J Schramm, C E Elger, O D Wiestler, I Blümck. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Annals of neurology. vol 47. issue 1. 2000-02-16. PMID:10632098. |
selective hippocampal cell loss and altered neurotransmitter receptor expression have been proposed as pathogenic mechanisms in the development of chronic mesial temporal lobe epilepsy (tle). |
2000-02-16 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
hippocampal sclerosis (hs) is a common derangement in many patients with temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
here, we determined neuronal density, and synaptophysin and glial fibrillary acidic protein (gfap) immunoreactivity in hippocampal specimens from patients with pharmaco-resistant temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
our results show the following: (i) in both groups of temporal lobe epilepsy patients, there was a significant loss in cell number in all major hippocampal sub-areas compared with autopsy control tissue; (ii) in hs patients, when compared with non-hs patients, there was a further decline in the number of principal cells in all hippocampal sub-areas analysed, which was associated with an increase in gfap immunoreactivity; (iii) the decline in cell density was accompanied by a reduced number of synaptic terminals; (iv) in the hs group, there were sprouted mossy fibres in the supragranular layer (sgl) of the dentate gyrus; (v) there was an increase in synaptophysin immunostaining in the sgl indicating that functionally active nerve terminals were formed; and (vi) b-50 immunoreactivity was also increased in the sgl in the hs group compared with the non-hs and control groups. |
2000-02-14 |
2023-08-12 |
Not clear |