| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Lerche, A Vezzani, H Beck, I Blümcke, Y Weber, C Elge. [New developments in epileptogenesis and therapeutic perspectives]. Der Nervenarzt. vol 82. issue 8. 2012-02-13. PMID:21789691. |
those are (1) inflammatory processes which play an increasingly important role for the generation of temporal lobe epilepsy with hippocampal sclerosis (tle with hs), (2) disturbances of intrinsic properties of neuronal compartments, in particular acquired defects of ion channels of which those in dendrites are described here for tle with hs, (3) epigenetic effects, which affect for example the methylation of promoters and secondarily can change the expression of specific genes in tle with hs, and finally (4) the epileptogenesis of idiopathic epilepsies which are caused by inborn genetic alterations affecting mainly ion channels. |
2012-02-13 |
2023-08-12 |
Not clear |
| Niels K Focke, Mahinda Yogarajah, Mark R Symms, Oliver Gruber, Walter Paulus, John S Dunca. Automated MR image classification in temporal lobe epilepsy. NeuroImage. vol 59. issue 1. 2012-02-13. PMID:21835245. |
we studied 38 patients with hippocampal sclerosis and unilateral (mesial) temporal lobe epilepsy (mtle) (20 left) undergoing presurgical evaluation and 22 neurologically normal control subjects. |
2012-02-13 |
2023-08-12 |
human |
| Kirsten Labudda, Markus Mertens, Jozsef Janszky, Christian G Bien, Friedrich G Woerman. Atypical language lateralisation associated with right fronto-temporal grey matter increases--a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients. NeuroImage. vol 59. issue 1. 2012-02-13. PMID:21839176. |
by combining language functional magnetic resonance imaging and voxel-based morphometry in patients with left-sided mesial temporal lobe epilepsy and hippocampal sclerosis, we studied whether atypical language dominance is associated with temporal and/or extratemporal cortical changes. |
2012-02-13 |
2023-08-12 |
Not clear |
| Kirsten Labudda, Markus Mertens, Jozsef Janszky, Christian G Bien, Friedrich G Woerman. Atypical language lateralisation associated with right fronto-temporal grey matter increases--a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients. NeuroImage. vol 59. issue 1. 2012-02-13. PMID:21839176. |
using verbal fluency functional magnetic resonance imaging for language lateralisation, we identified 20 patients with left-sided mesial temporal lobe epilepsy with hippocampal sclerosis and atypical language lateralisation. |
2012-02-13 |
2023-08-12 |
Not clear |
| Melanie Langer, Claudia Brandt, Wolfgang Lösche. Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats. [corrected]. Epilepsy research. vol 96. issue 3. 2012-02-07. PMID:21723093. |
outbred rat strains such as sprague-dawley (sd) or wistar are widely used in epilepsy models, including popular models of temporal lobe epilepsy in which spontaneous recurrent seizures (srs), hippocampal damage, and behavioral alterations develop after status epilepticus (se). |
2012-02-07 |
2023-08-12 |
rat |
| Fang Yi, Mutasem M Abuhamed, Li-li Long, Yi Li, Shu-yu Li, Zhi-guo Wu, Bo Xia. [Neuronal synaptic reconstruction in hippocampus in chronic phase of pilocarpine-treated rats]. Zhonghua yi xue za zhi. vol 91. issue 19. 2012-02-02. PMID:21756761. |
to explore the aberrant formation of excitatory and inhibitory circuit rearrangements of hippocampus in temporal lobe epilepsy. |
2012-02-02 |
2023-08-12 |
rat |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
selective upregulation of brain-derived neurotrophic factor (bdnf) transcripts and bdnf direct induction of activity independent n-methyl-d-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. |
2012-02-02 |
2023-08-12 |
human |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
brain-derived neurotrophic factor (bdnf) plays a critical role in many aspects of neuronal biology and hippocampal physiology and pathology, and has been implicated as a potential therapeutic target in temporal lobe epilepsy (tle). |
2012-02-02 |
2023-08-12 |
human |
| Y-X Ge, Y Liu, H-Y Tang, X-G Liu, X Wan. ClC-2 contributes to tonic inhibition mediated by α5 subunit-containing GABA(A) receptor in experimental temporal lobe epilepsy. Neuroscience. vol 186. 2012-01-30. PMID:21549811. |
temporal lobe epilepsy (tle), characterized by spontaneous recurrent seizures, learning and memory impairments is associated with neurodegeneration, abnormal reorganization of the circuitry and loss of functional inhibition in hippocampus. |
2012-01-30 |
2023-08-12 |
rat |
| Ji-Eun Kim, Seong-Il Yeo, Hea Jin Ryu, Chun Kee Chung, Min-Ju Kim, Tae-Cheon Kan. Changes in TWIK-related acid sensitive K+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21710317. |
changes in twik-related acid sensitive k+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model. |
2012-01-27 |
2023-08-12 |
human |
| Ji-Eun Kim, Seong-Il Yeo, Hea Jin Ryu, Chun Kee Chung, Min-Ju Kim, Tae-Cheon Kan. Changes in TWIK-related acid sensitive K+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21710317. |
in the present study, we analyzed expressions of tandem of p domains in a weak inwardly rectifying k+ channel (twik)-related acid-sensitive k+ (task) channel-1 and -3 in the hippocampus of patients with temporal lobe epilepsy (tle) and in rat model. |
2012-01-27 |
2023-08-12 |
human |
| Camara Aboubacar Damaye, Liwen Wu, Jing Peng, Fang He, Ciliu Zhang, Yang Lan, Shabbir Moizali Walijee, Fei Yi. An experimental study on dynamic morphological changes and expression pattern of GFAP and synapsin i in the hippocampus of MTLE models for immature rats. The International journal of neuroscience. vol 121. issue 10. 2012-01-25. PMID:21812737. |
to establish an animal model resembling human mesial temporal lobe epilepsy (mtle); observe the dynamic changes of mossy fiber sprouting (mfs) and neuron loss in the hippocampus; and investigate the expression changes of glial fibrillary acidic protein (gfap) and synapsin i in the hippocampus in immature rats. |
2012-01-25 |
2023-08-12 |
human |
| J J Ekstrand, W Pouliot, P Scheerlinck, F E Dude. Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus. Neuroscience. vol 192. 2012-01-18. PMID:21669257. |
the ventral hippocampus, however, represents the more homologous structure to the anterior hippocampus in humans, which is the area associated with the maximal damage in patients with temporal lobe epilepsy. |
2012-01-18 |
2023-08-12 |
rat |
| Sandhitsu R Das, Dawn Mechanic-Hamilton, John Pluta, Marc Korczykowski, John A Detre, Paul A Yushkevic. Heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy. NeuroImage. vol 58. issue 4. 2012-01-06. PMID:21763431. |
heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy. |
2012-01-06 |
2023-08-12 |
human |
| Ismini E Papageorgiou, Siegrun Gabriel, Andriani F Fetani, Oliver Kann, Uwe Heineman. Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats. Glia. vol 59. issue 11. 2012-01-06. PMID:21780187. |
reduction in both expression and activity of gs was reported in the hippocampus of patients with temporal lobe epilepsy (tle), and this reduction has been suggested to contribute to epileptogenesis. |
2012-01-06 |
2023-08-12 |
rat |
| Bharathi Hattiangady, Ashok K Shett. Neural stem cell grafting in an animal model of chronic temporal lobe epilepsy. Current protocols in stem cell biology. vol Chapter 2. 2012-01-03. PMID:21913169. |
neural stem cell (nsc) transplantation into the hippocampus could offer an alternative therapy to hippocampal resection in patients with drug-resistant chronic epilepsy, which afflicts ∼30% of mesial temporal lobe epilepsy (tle) cases. |
2012-01-03 |
2023-08-12 |
human |
| Julius A Steinbeck, Nadine Henke, Jessica Opatz, Joanna Gruszczynska-Biegala, Lars Schneider, Stephan Theiss, Nadine Hamacher, Barbara Steinfarz, Stefan Golz, Oliver Brüstle, Jacek Kuznicki, Axel Methne. Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21906591. |
both proteins were increased in brains of chronic epileptic rodents and strongly expressed in hippocampal specimens from medial temporal lobe epilepsy patients. |
2011-12-20 |
2023-08-12 |
Not clear |
| Melodie R Winawer, Sandra S Gildersleeve, Austin G Phillips, Daniel Rabinowitz, Abraham A Palme. Mapping a mouse limbic seizure susceptibility locus on chromosome 10. Epilepsia. vol 52. issue 11. 2011-12-19. PMID:21906048. |
using c57bl/6j × a/j chromosome substitution strains (css), we previously identified a locus on mouse chromosome 10 (ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic seizures and status epilepticus (status), followed by hippocampal cell loss and delayed-onset chronic spontaneous limbic seizures. |
2011-12-19 |
2023-08-12 |
mouse |
| Stéphanie Graebenitz, Olga Kedo, Erwin-Josef Speckmann, Ali Gorji, Heinz Panneck, Volkmar Hans, Nicola Palomero-Gallagher, Axel Schleicher, Karl Zilles, Hans-Christian Pap. Interictal-like network activity and receptor expression in the epileptic human lateral amygdala. Brain : a journal of neurology. vol 134. issue Pt 10. 2011-12-15. PMID:21893592. |
electrophysiological recordings, obtained intra-operatively in vivo in patients with medically intractable temporal lobe epilepsy, revealed the existence of interictal activity in amygdala and hippocampus. |
2011-12-15 |
2023-08-12 |
human |
| Daniel San-juan, Claudia Alfaro Tapia, Alfaro Tapia Claudia, Maricarmen Fernández González-Aragón, González-Aragón Fernández Maricarmen, Adriana Martínez Mayorga, Martínez Mayorga Adriana, Richard J Staba, J Staba Richard, Mario Alonso-Vanegas, Alonso-Vanegas Mari. The prognostic role of electrocorticography in tailored temporal lobe surgery. Seizure. vol 20. issue 7. 2011-12-12. PMID:21616682. |
intraoperative electrocorticography (ecog) has been in clinical use for many decades, yet the validity of this procedure in guiding resective surgery for temporal lobe epilepsy (tle) is still uncertain, especially in tailored temporal lobectomies in cases of tle with hippocampal sclerosis. |
2011-12-12 |
2023-08-12 |
Not clear |