| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanta Mondal, Shelby Prieto, Suresh B Rangasamy, Debashis Dutta, Kalipada Paha. Nebulization of low-dose aspirin ameliorates Huntington's pathology in N171-82Q transgenic mice. NeuroImmune pharmacology and therapeutics. vol 3. issue 1. 2024-03-27. PMID:38532785. |
huntington disease (hd), a devastating hereditary neurodegenerative disorder, is caused by expanded cag trinucleotide repeats in the huntingtin gene ( |
2024-03-27 |
2024-03-29 |
mouse |
| Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P Bates, G Bernhard Landwehrmeyer, Andreas Neuede. Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-03-08. PMID:38459427. |
the disease-causing mutation in huntington disease (hd) is a cag trinucleotide expansion in the huntingtin (htt) gene. |
2024-03-08 |
2024-03-11 |
mouse |
| Sunayana Dagar, Manish Sharma, George Tsaprailis, Catherina Scharager Tapia, Gogce Crynen, Preksha Sandipkumar Joshi, Neelam Shahani, Srinivasa Subramania. Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease. Molecular & cellular proteomics : MCP. 2024-03-06. PMID:38447791. |
huntington disease (hd) is caused by an expanded polyglutamine mutation in huntingtin (mhtt) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. |
2024-03-06 |
2024-03-09 |
Not clear |
| Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Staffler, Michael R Hayden, Amber L Southwel. Corrigendum to "Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease" [Neurobiology of Disease, 2024 Jan:190:106376]. Neurobiology of disease. 2024-02-24. PMID:38402018. |
corrigendum to "reducing huntingtin by immunotherapy delays disease progression in a mouse model of huntington disease" [neurobiology of disease, 2024 jan:190:106376]. |
2024-02-24 |
2024-02-27 |
mouse |
| Karin Dalene Skarping, Larissa Arning, Åsa Petersén, Huu Phuc Nguyen, Samuel Gebre-Medhi. Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome. Scientific reports. vol 14. issue 1. 2024-02-21. PMID:38383663. |
dna mismatch repair (mmr) is thought to contribute to the onset and progression of huntington disease (hd) by promoting somatic expansion of the pathogenic cag nucleotide repeat in the huntingtin gene (htt). |
2024-02-21 |
2024-02-24 |
Not clear |
| Nicholas S Caron, Amirah E-E Aly, Hailey Findlay Black, Dale D O Martin, Mandi E Schmidt, Seunghyun Ko, Christine Anderson, Emily M Harvey, Lorenzo L Casal, Lisa M Anderson, Seyed M R Rahavi, Gregor S D Reid, Michael N Oda, Danica Stanimirovic, Abedelnasser Abulrob, Jodi L McBride, Blair R Leavitt, Michael R Hayde. Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease. Journal of controlled release : official journal of the Controlled Release Society. 2024-01-12. PMID:38215984. |
systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein a-i nanodisks for huntington disease. |
2024-01-12 |
2024-01-15 |
mouse |
| Nicholas S Caron, Amirah E-E Aly, Hailey Findlay Black, Dale D O Martin, Mandi E Schmidt, Seunghyun Ko, Christine Anderson, Emily M Harvey, Lorenzo L Casal, Lisa M Anderson, Seyed M R Rahavi, Gregor S D Reid, Michael N Oda, Danica Stanimirovic, Abedelnasser Abulrob, Jodi L McBride, Blair R Leavitt, Michael R Hayde. Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease. Journal of controlled release : official journal of the Controlled Release Society. 2024-01-12. PMID:38215984. |
huntington disease (hd) is a dominantly inherited neurodegenerative disorder caused by a cag trinucleotide expansion mutation in the htt gene which codes for a toxic mutant huntingtin (mhtt) protein. |
2024-01-12 |
2024-01-15 |
mouse |
| Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R Hayden, Amber L Southwel. Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease. Neurobiology of disease. 2023-12-13. PMID:38092268. |
reducing huntingtin by immunotherapy delays disease progression in a mouse model of huntington disease. |
2023-12-13 |
2023-12-17 |
mouse |
| Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R Hayden, Amber L Southwel. Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease. Neurobiology of disease. 2023-12-13. PMID:38092268. |
in huntington disease (hd), the mutant huntingtin (mthtt) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. |
2023-12-13 |
2023-12-17 |
mouse |
| Elsa C Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cecile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A M Buijsen, Louise van der Weerd, Willeke van Roon-Mo. Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice. Neurobiology of disease. 2023-12-01. PMID:38040383. |
in huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (htt) protein. |
2023-12-01 |
2023-12-10 |
mouse |
| Douglas R Langbehn, Swati S Sathe, Clement Loy, Cristina Sampaio, Elizabeth A Mccuske. A Phenotypic Atlas for Huntington Disease Based on Data From the Enroll-HD Cohort Study. Neurology. Genetics. vol 9. issue 6. 2023-11-30. PMID:38035176. |
the variable cag repeat expansion in the huntingtin gene and its inverse relationship to motor dysfunction onset are fundamental features of huntington disease (hd). |
2023-11-30 |
2023-12-10 |
human |
| Hong Zhang, Si Wu, Laura S Itzhaki, Sarah Perret. Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins. Protein science : a publication of the Protein Society. 2023-10-19. PMID:37853955. |
huntington disease (hd) is associated with aggregation of huntingtin (htt) protein containing over 35 continuous q residues within the n-terminal exon 1 encoded region. |
2023-10-19 |
2023-11-08 |
Not clear |
| Daniele Bertoglio, Alison R Weiss, William Liguore, Lauren Drew Martin, Theodore Hobbs, John Templon, Sathya Srinivasan, Celia Dominguez, Ignacio Munoz-Sanjuan, Vinod Khetarpal, Jeroen Verhaeghe, Steven Staelens, Jeanne Link, Longbin Liu, Jonathan A Bard, Jodi L McBrid. In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023-08-17. PMID:37591545. |
in vivo cerebral imaging of mutant huntingtin aggregates using huntington disease (hd) is a neurodegenerative disorder caused by an expanded polyglutamine (cag) trinucleotide expansion in the huntingtin ( |
2023-08-17 |
2023-09-07 |
Not clear |
| Amirah E-E Aly, Nicholas S Caron, Hailey Findlay Black, Mandi E Schmidt, Christine Anderson, Seunghyun Ko, Helen J E Baddeley, Lisa Anderson, Lorenzo L Casal, Reza S M Rahavi, Dale O R Martin, Michael R Hayde. Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks. Journal of controlled release : official journal of the Controlled Release Society. 2023-07-19. PMID:37468110. |
lowering mutant huntingtin (mhtt) in the central nervous system (cns) using antisense oligonucleotides (asos) is a promising approach currently being evaluated in clinical trials for huntington disease (hd). |
2023-07-19 |
2023-08-14 |
Not clear |
| Jeremy M Van Raamsdonk, Hilal H Al-Shekaili, Laura Wagner, Tim W Bredy, Laura Chan, Jacqueline Pearson, Claudia Schwab, Zoe Murphy, Rebecca S Devon, Ge Lu, Michael S Kobor, Michael R Hayden, Blair R Leavit. Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice. Aging and disease. 2023-05-18. PMID:37199581. |
huntington disease (hd) is an adult-onset neurodegenerative disorder that is caused by a trinucleotide cag repeat expansion in the htt gene that codes for the protein huntingtin (htt in humans or htt in mice). |
2023-05-18 |
2023-08-14 |
mouse |
| Raffaella Bonavita, Gianluca Scerra, Rosaria Di Martino, Silvia Nuzzo, Elena Polishchuk, Mariagrazia Di Gennaro, Sarah V Williams, Maria Gabriella Caporaso, Carmen Caiazza, Roman Polishchuk, Massimo D'Agostino, Angeleen Fleming, Maurizio Renn. The HSPB1-p62/SQSTM1 functional complex regulates the unconventional secretion and transcellular spreading of the HD-associated mutant huntingtin protein. Human molecular genetics. 2023-03-27. PMID:36971475. |
huntington disease (hd) has autosomal dominant inheritance and is caused by mutations leading to an abnormal expansion in the polyglutamine (polyq) tract of the huntingtin (htt) protein, leading to the formation of htt inclusion bodies in neurons of affected patients. |
2023-03-27 |
2023-08-14 |
Not clear |
| Tariq O Faquih, N Ahmad Aziz, Sarah L Gardiner, Ruifang Li-Gao, Renée de Mutsert, Yuri Milaneschi, Stella Trompet, J Wouter Jukema, Frits R Rosendaal, Astrid Hylckama Vlieg, Ko Willems Dijk, Dennis O Mook-Kanamor. Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index. Human molecular genetics. 2023-01-30. PMID:36715614. |
tandem cag repeat sizes of 36 or more in the huntingtin gene (htt) cause huntington disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Andrea M Reyes-Ortiz, Edsel M Abud, Mara S Burns, Jie Wu, Sarah J Hernandez, Nicolette McClure, Keona Q Wang, Corey J Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W Poon, Ryan G Lim, Leslie M Thompso. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. iScience. vol 26. issue 1. 2023-01-02. PMID:36590162. |
huntington disease (hd) is a neurodegenerative disorder caused by expanded cag repeats in the huntingtin gene that alters cellular homeostasis, particularly in the striatum and cortex. |
2023-01-02 |
2023-08-14 |
mouse |
| Libo Yu-Taeger, Arianna Novati, Jonasz Jeremiasz Weber, Elisabeth Singer-Mikosch, Ann-Sophie Pabst, Fubo Cheng, Carsten Saft, Jennifer Koenig, Gisa Ellrichmann, Taneli Heikkinen, Mahmoud A Pouladi, Olaf Riess, Huu Phuc Nguye. Evidences for Mutant Huntingtin Inducing Musculoskeletal and Brain Growth Impairments via Disturbing Testosterone Biosynthesis in Male Huntington Disease Animals. Cells. vol 11. issue 23. 2022-12-11. PMID:36497038. |
evidences for mutant huntingtin inducing musculoskeletal and brain growth impairments via disturbing testosterone biosynthesis in male huntington disease animals. |
2022-12-11 |
2023-08-14 |
mouse |
| Irina Matlahov, Jennifer C Boatz, Patrick C A van der We. Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils. Journal of structural biology: X. vol 6. 2022-11-24. PMID:36419510. |
this challenge is exemplified by mutant huntingtin exon 1 (httex1), which self-assembles into pathogenic neuronal inclusions in huntington disease (hd). |
2022-11-24 |
2023-08-14 |
Not clear |