| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manzar Alam, Sarfraz Ahmed, Mohammad Abid, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. Therapeutic targeting of microtubule affinity-regulating kinase 4 in cancer and neurodegenerative diseases. Journal of cellular biochemistry. 2023-09-04. PMID:37661636. |
microtubule affinity-regulating kinase 4 (mark4) is a member of the ser/thr protein kinase family, phosphorylates the microtubule-connected proteins and plays a vital role in causing cancers and neurodegenerative diseases. |
2023-09-04 |
2023-09-07 |
Not clear |
| Manzar Alam, Sarfraz Ahmed, Mohammad Abid, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. Therapeutic targeting of microtubule affinity-regulating kinase 4 in cancer and neurodegenerative diseases. Journal of cellular biochemistry. 2023-09-04. PMID:37661636. |
in the current review, we aimed to provide detailed information on the structural features of mark4 targeted in drug development and its role in various signaling pathways related to cancer and neurodegenerative diseases. |
2023-09-04 |
2023-09-07 |
Not clear |
| Mohammed Alrouji, Debarati DasGupta, Ghulam Md Ashraf, Anwar L Bilgrami, Fahad A Alhumaydhi, Waleed Al Abdulmonem, Moyad Shahwan, Abdulrhman Alsayari, Akhtar Atiya, Anas Shams. Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches. International journal of biological macromolecules. 2023-03-04. PMID:36870649. |
mark4 is a druggable target for cancer, neurodegenerative diseases, and metabolic disorders. |
2023-03-04 |
2023-08-14 |
Not clear |
| Akhtar Atiya, Debarati Das Gupta, Abdulrhman Alsayari, Mohammed Alrouji, Abdulmajeed Alotaibi, Sharaf E Sharaf, Waleed Al Abdulmonem, Nasser M Alorfi, K M Abdullah, Anas Shams. Linagliptin and Empagliflozin Inhibit Microtubule Affinity Regulatory Kinase 4: Repurposing Anti-Diabetic Drugs in Neurodegenerative Disorders Using In Silico and In Vitro Approaches. ACS omega. vol 8. issue 7. 2023-02-27. PMID:36844587. |
in conclusion, linagliptin and empagliflozin may be promising mark4 inhibitors, which can further be exploited as potential lead molecules against mark4-directed neurodegenerative diseases. |
2023-02-27 |
2023-08-14 |
Not clear |
| Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md Imtaiyaz Hassa. Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease. International journal of biological macromolecules. 2022-10-18. PMID:36257368. |
microtubule-affinity regulating kinase 4 (mark4) is linked with the development of cancer, diabetes and neurodegenerative diseases. |
2022-10-18 |
2023-08-14 |
Not clear |
| Saleha Anwar, Moyad Shahwan, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy. Cellular signalling. 2022-08-12. PMID:35961526. |
finally, we summarize the latest findings regarding the role of mark4 in cancer, diabetes, and neurodegenerative disease path to provide a solid rationale for future investigation and therapeutic intervention. |
2022-08-12 |
2023-08-14 |
human |
| Anas Shamsi, Debarati DasGupta, Fahad A Alhumaydhi, Mohd Shahnawaz Khan, Suliman A Alsagaby, Waleed Al Abdulmonem, Md Imtaiyaz Hassan, Dharmendra Kumar Yada. Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation. RSC medicinal chemistry. vol 13. issue 6. 2022-07-11. PMID:35814926. |
since mark4 is a potential drug target and can be exploited for drug design and discovery for cancer and neurodegenerative disorders, the results presented here are of interest and may be further exploited for alzheimer's disease (ad) and other neurodegenerative diseases. |
2022-07-11 |
2023-08-14 |
Not clear |
| Nashrah Sharif Khan, Parvez Khan, Afreen Inam, Kamal Ahmad, Mohd Yousuf, Asimul Islam, Sher Ali, Amir Azam, Mohammad Husain, Md Imtaiyaz Hassa. Discovery of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as prospective microtubule affinity regulating kinase 4 inhibitors. RSC advances. vol 10. issue 34. 2022-05-06. PMID:35520423. |
microtubule affinity regulating kinase 4 (mark4) is a ser/thr kinase, considered as a potential drug target for cancer, diabetes and neurodegenerative diseases. |
2022-05-06 |
2023-08-13 |
human |
| Saleha Anwar, Shama Khan, Anas Shamsi, Farah Anjum, Alaa Shafie, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structure-based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases. Journal of cellular biochemistry. vol 122. issue 10. 2021-11-19. PMID:34121218. |
structure-based investigation of mark4 inhibitory potential of naringenin for therapeutic management of cancer and neurodegenerative diseases. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Omar Mohammed Ali Noman, Afzal Hussain, Asimul Islam, Faizan Ahmad, Mohammed F Alajmi, Md Imtaiyaz Hassa. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 38. issue 13. 2021-06-18. PMID:31512980. |
targeting the modulation of mark4 activity is an effective strategy for therapeutic intervention of alzheimer's and other mark4 associated neurodegenerative diseases. |
2021-06-18 |
2023-08-13 |
Not clear |
| Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Omar Mohammed Ali Noman, Afzal Hussain, Asimul Islam, Faizan Ahmad, Mohammed F Alajmi, Md Imtaiyaz Hassa. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 38. issue 13. 2021-06-18. PMID:31512980. |
having role of pyrazolopyrimidine derivatives in the therapeutic management of neurodegenerative diseases, we have tried to estimate their binding affinity with the mark4. |
2021-06-18 |
2023-08-13 |
Not clear |
| Saleha Anwar, Anas Shamsi, Rajiv K Kar, Aarfa Queen, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. International journal of biological macromolecules. vol 161. 2021-03-23. PMID:32535203. |
structural and biochemical investigation of mark4 inhibitory potential of cholic acid: towards therapeutic implications in neurodegenerative diseases. |
2021-03-23 |
2023-08-13 |
Not clear |
| Saleha Anwar, Anas Shamsi, Rajiv K Kar, Aarfa Queen, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. International journal of biological macromolecules. vol 161. 2021-03-23. PMID:32535203. |
microtubule affinity regulating kinase (mark4) is considered as a potential drug target for diabetes, cancer, and neurodegenerative diseases. |
2021-03-23 |
2023-08-13 |
Not clear |
| Farha Naz, Parvesh Singh, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Human microtubule affinity-regulating kinase 4 is stable at extremes of pH. Journal of biomolecular structure & dynamics. vol 34. issue 6. 2017-02-24. PMID:26208600. |
map/microtubule affinity-regulating kinase 4 (mark4) is a member of adenosine monophosphate-activated protein kinases, directly associated with cancer and neurodegenerative diseases. |
2017-02-24 |
2023-08-13 |
human |