| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Qiu, Zhixiong Li, David A Leigh, Bingbing Duan, Joseph E Stucky, Nami Kim, George Xie, Kun Ping Lu, Xiao Zhen Zho. The role of the Pin1- Frontiers in cell and developmental biology. vol 12. 2024-04-17. PMID:38628595. |
the role of the pin1- tauopathies are neurodegenerative diseases characterized by deposits of abnormal tau protein in the brain. |
2024-04-17 |
2024-04-19 |
Not clear |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
parkinson's disease (pd) is the second most frequently diagnosed neurodegenerative disease, and it is characterized by the intracellular and extracellular accumulation of α-synuclein (α-syn) and tau, which are major components of cytosolic protein inclusions called lewy bodies, in the brain. |
2024-04-13 |
2024-04-16 |
mouse |
| Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang W. Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578886. |
alzheimer's disease (ad) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (aβ) and tau associated molecular pathology and other pathogenic processes. |
2024-04-05 |
2024-04-10 |
Not clear |
| Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. |
antibodies against tau play an increasingly important role in studying these neurodegenerative diseases and the generation of tools to diagnose and treat them. |
2024-04-03 |
2024-04-05 |
mouse |
| Ashish Raj, Justin Toro. Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559176. |
the interaction of amyloid and tau in neurodegenerative diseases is a central feature and key to understanding ad pathophysiology. |
2024-04-01 |
2024-04-04 |
human |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
imbalances in the tau isoform ratio can lead to neurodegenerative diseases, underscoring the need for precise control over tau isoform balance. |
2024-04-01 |
2024-04-03 |
human |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
a neurodegenerative disease is considered a primary tauopathy when mapt mutations/haplotypes are its primary cause and/or tau is the main pathological feature. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
while it is known that different morphologies of tau filaments characterize different neurodegenerative diseases, there are few metrics of global and local structure complexity that enable to quantify their structural diversity rigorously. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
in this manuscript, we employ for the first time mathematical topology and geometry to classify neurodegenerative diseases by using cryo-electron microscopy structures of tau filaments that are available in the protein data bank. |
2024-03-30 |
2024-04-02 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanyan Zhao, Anna Mikes, Gergely Tóth, Franklin Aigbirhi. Detection of Small-Molecule Interactions with Fibrillar Tau Protein Aggregates Using Microscale Thermophoresis. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512669. |
aggregated fibrillar tau protein is a pathological hallmark of several neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. |
amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512672. |
under its aggregated form, tau is a hallmark of alzheimer's disease and other neurodegenerative diseases named tauopathies involving tau dysfunction and/or mutations. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Sarah Buchholz, Michael Bell-Simons, Cagla Cakmak, Jennifer Klimek, Li Gan, Hans Zempe. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512688. |
tau pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Felix Langerscheidt, Michael Bell-Simons, Hans Zempe. Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512687. |
pathological alterations of the neuronal tau protein are characteristic for many neurodegenerative diseases, called tauopathies. |
2024-03-21 |
2024-03-24 |
human |