| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhishek Dahal, Karthivashan Govindarajan, Satyabrata Ka. Administration of kainic acid differentially alters astrocyte markers and transiently enhanced phospho-tau level in adult rat hippocampus. Neuroscience. 2023-02-22. PMID:36805001. |
additionally, a role for microtubule associated tau protein, involved in various neurodegenerative diseases including alzheimer's disease, has also been suggested in the development of seizure and/or neurodegeneration in tle pathogenesis. |
2023-02-22 |
2023-08-14 |
human |
| Daniela Jimenez-Harrison, Carol J Huseby, Claire N Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, Jeff Kure. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Biochemistry. 2023-02-22. PMID:36813261. |
tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Kariem Ezzat, Andrea Sturchio, Alberto J Espa. The shift to a proteinopenia paradigm in neurodegeneration. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803814. |
we therefore advocate for a paradigm shift from proteinopathy (gof) to proteinopenia (lof) based on the universal depletion of soluble functional proteins in neurodegenerative diseases (low amyloid-β 42 in alzheimer's disease, low α-synuclein in parkinson's disease, and low tau in progressive supranuclear palsy) and supported by the confluence of biologic, thermodynamic, and evolutionary principles with proteins having evolved to perform a function, not to become toxic, and where protein depletion is consequential. |
2023-02-21 |
2023-08-14 |
Not clear |
| Eloise Masquelier, Esther Taxon, Sheng-Ping Liang, Yahya Al Sabeh, Lior Sepunaru, Michael J Gordon, Daniel E Mors. A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly. The Journal of biological chemistry. 2023-02-13. PMID:36781124. |
tau protein's reversible assembly and binding of microtubules in brain neurons are regulated by charge-neutralizing phosphorylation, while its hyperphosphorylation drives the irreversible formation of cytotoxic filaments associated with neurodegenerative diseases. |
2023-02-13 |
2023-08-14 |
Not clear |
| Tim Altendorf, Ian Gering, Beatrix Santiago-Schübel, Selma Aghabashlou Saisan, Gültekin Tamgüney, Markus Tusche, Dominik Honold, Sarah Schemmert, Wolfgang Hoyer, Jeannine Mohrlüder, Dieter Willbol. Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768484. |
the tau protein is involved in a multitude of different neurodegenerative diseases. |
2023-02-11 |
2023-08-14 |
Not clear |
| Anuradha Sharma, Poonam Piplan. Acridine: A Scaffold for the development of drugs for Alzheimer's disease. Current topics in medicinal chemistry. 2023-02-06. PMID:36740790. |
it is a most common age-related multifactorial neurodegenerative disease and characterized by two histopathological hallmarks; the formation of senile plaques composed of the amyloid-β (aβ) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2023-02-06 |
2023-08-14 |
Not clear |
| Kun Li, Ziqiang Wan. lncRNA NEAT1: key player in neurodegenerative diseases. Ageing research reviews. 2023-02-04. PMID:36738893. |
this review summarizes our current knowledge of the role of neat1 in neurodegenerative diseases and its association with the characteristic aggregation of misfolded proteins: amyloid-β and tau in ad, α-synuclein in pd, mutant huntingtin in hd, and tar dna-binding protein-43 fused in sarcoma/translocated in liposarcoma in als. |
2023-02-04 |
2023-08-14 |
Not clear |
| Anne-Marie Jacobsen, Nico C van de Merbel, Dorte K Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T Pedersen, Nina Rosenqvis. A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396. Journal of the American Society for Mass Spectrometry. 2023-01-31. PMID:36719168. |
hyperphosphorylated tau protein is well-known to be involved in the formation of neurofibrillary tangles and the progression of age-related neurodegenerative diseases (tauopathies), including alzheimer's disease (ad). |
2023-01-31 |
2023-08-14 |
mouse |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
the microtubule-associated protein tau (mapt) is one of the proteins that are central to neurodegenerative diseases. |
2023-01-30 |
2023-08-14 |
Not clear |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
cryogenic electron microscopy (cryo-em) studies have unveiled the structure of tau and tmem106b, from the cerebral cortex, in several neurodegenerative diseases; however, whether tau and tmem106b filaments from the gray and white matter share a common fold requires additional investigation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Bastien Herli. Hippocampal sclerosis linked to epilepsy: clinical consequences, histopathology and evolution with aging Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 20. issue 4. 2023-01-26. PMID:36700444. |
those deposits pattern is close to the one observed in patients with tau / amyloïd neurodegenerative diseases, which demonstrates a bilateral relationship between epilepsy, hippocampal sclerosis, and neurodegenerative diseases. |
2023-01-26 |
2023-08-14 |
human |
| Aleksandra Parka, Caroline Degel, Jakob Dreyer, Ulrike Richter, Benjamin Hall, Jesper F Bastlund, Bettina Laursen, Maiken Nedergaard, Florence Sotty, Paolo Bott. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model. Neurobiology of disease. vol 178. 2023-01-25. PMID:36696792. |
tau protein pathology is a hallmark of many neurodegenerative diseases, including alzheimer's disease or frontotemporal dementia. |
2023-01-25 |
2023-08-14 |
mouse |
| Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarma. Lissencephaly-1 mutations enhance traumatic brain injury outcomes in Drosophila. Genetics. 2023-01-23. PMID:36683334. |
these data suggest that lis-1 activity is required in the brain to ameliorate tbi outcomes through effects on axonal transport, microtubule stability, and other microtubule proteins such as tau, implicated in chronic traumatic encephalopathy, a tbi-associated neurodegenerative disease in humans. |
2023-01-23 |
2023-08-14 |
drosophila_melanogaster |
| Iftakher Hossain, Kaj Blennow, Jussi P Posti, Henrik Zetterber. Tau as a fluid biomarker of concussion and neurodegeneration. Concussion (London, England). vol 7. issue 2. 2023-01-23. PMID:36687115. |
here, we discuss the diagnostic dilemma and the relationship between concussion and neurodegenerative diseases and review the literature on tau as a promising biomarker for concussion. |
2023-01-23 |
2023-08-14 |
Not clear |
| Jingxin Chen, Wanyao Ma, Jiangchuan Yu, Xi Wang, Hongling Qian, Ping Li, Haiqiong Ye, Yue Han, Zhengding Su, Meng Gao, Yongqi Huan. (-)-Epigallocatechin-3-gallate, a Polyphenol from Green Tea, Regulates the Liquid-Liquid Phase Separation of Alzheimer's-Related Protein Tau. Journal of agricultural and food chemistry. 2023-01-23. PMID:36688583. |
complementary to the inhibitory activity of egcg in tau fibrillization, our findings provide novel insights into the biological activity of egcg and offer new clues for future studies on the molecular mechanism by which egcg alleviates neurodegenerative diseases. |
2023-01-23 |
2023-08-14 |
Not clear |
| Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Göt. Tyrosine phosphatase STEP Molecular brain. vol 16. issue 1. 2023-01-13. PMID:36639708. |
tyrosine phosphatase step synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia with tau pathology (ftd-tau), a group of primary tauopathies. |
2023-01-13 |
2023-08-14 |
Not clear |
| Jianing Jin, Dongning Su, Junjiao Zhang, Xiaohong Li, Tao Fen. Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis. Journal of neurology. 2023-01-12. PMID:36633672. |
to evaluate the difference of tau burden between patients with progressive supranuclear palsy (psp) and healthy controls (hcs) or other neurodegenerative diseases using tau-positron emission tomography (pet) imaging. |
2023-01-12 |
2023-08-14 |
Not clear |
| Evan Lester, Meaghan Van Alstyne, Kathleen L McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parke. Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 3. 2023-01-10. PMID:36626563. |
tau aggregates are a hallmark of multiple neurodegenerative diseases and can contain rnas and rna-binding proteins, including serine/arginine repetitive matrix protein 2 (srrm2) and pinin (pnn). |
2023-01-10 |
2023-08-14 |
Not clear |
| Evan Lester, Meaghan Van Alstyne, Kathleen L McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parke. Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 3. 2023-01-10. PMID:36626563. |
as css form in induced pluripotent stem cell (ipsc) derived neurons under inflammatory or hyperosmolar stress, they may affect tau aggregate propagation in neurodegenerative disease. |
2023-01-10 |
2023-08-14 |
Not clear |
| Xin Liu, Weiyi She, Herman H-Y Sung, Ian D Williams, Peiyuan Qia. Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage. International journal of biological macromolecules. 2023-01-09. PMID:36621732. |
alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by tau aggregating into neurofibrillary tangles. |
2023-01-09 |
2023-08-14 |
Not clear |