All Relations between Neurodegenerative Diseases and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ling Wu, Sidharth S Madhavan, Christopher Tan, Bin X. Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains. Pathogens (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36558893. tau aggregation associates with multiple neurodegenerative diseases including alzheimer's disease and rare tauopathies such as pick's disease, progressive supranuclear palsy, and corticobasal degeneration. 2022-12-23 2023-08-14 Not clear
Xibing He, Viet Hoang Man, Jie Gao, Junmei Wan. Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations. ACS chemical neuroscience. 2022-12-23. PMID:36563129. tau proteins not only have many important biological functions but also are associated with several neurodegenerative diseases, such as parkinson's disease and alzheimer's disease (ad). 2022-12-23 2023-08-14 Not clear
Goonho Park, Ke Xu, Leon Chea, Kyle Kim, Lance Safarta, Keon-Hyoung Song, Jian Wu, Soyoung Park, Hyejung Min, Nobuhiko Hiramatsu, Jaeseok Han, Jonathan H Li. Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation. The Journal of biological chemistry. 2022-12-23. PMID:36563857. tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. 2022-12-23 2023-08-14 Not clear
Bo Qi, Yu Song, Chen Chen, Lina Zhao, Wanjie Ma, Shuqi Meng, Xiaoli Zhuang, Huayi Lin, Jing Liang, Yan Cui, Keliang Xi. Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation. International immunopharmacology. vol 114. 2022-12-20. PMID:36538853. hyperphosphorylated tau is considered to play a significant role in the progression of neurodegenerative disease and also contributes to cognitive dysfunction in septic mice. 2022-12-20 2023-08-14 mouse
Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. 2022-12-19 2023-08-14 human
Júlia L B Simões, Leilane D Sobierai, Inayá F Leal, Miriam V R Dos Santos, João Victor Coiado, Margarete D Bagatin. Action of the purinergic and cholinergic anti-inflammatory pathways on oxidative stress in patients with Alzheimer's disease in the context of the COVID-19 pandemic. Neuroscience. 2022-12-16. PMID:36526078. this neurodegenerative disease is aggravated in cases involving sars-cov-2 and its inflammatory biomarkers, accelerating accumulation of β-amyloid peptide, hyperphosphorylation of tau protein, and production of reactive oxygen species, which lead to homeostasis imbalance. 2022-12-16 2023-08-14 Not clear
Allwin Ebenezer Sahayaraj, Renjith Viswanathan, Faina Pinhero, Arshad Abdul Vahid, Vinesh Vijaya. Sequence-Dependent Conformational Properties of PGGG Motif in Tau Repeats: Insights from Molecular Dynamics Simulations of Narrow Pick Filament. ACS chemical neuroscience. 2022-12-13. PMID:36512636. tauopathies are a class of neurodegenerative diseases correlated with the presence of pathological tau fibrils as a diagnostic marker. 2022-12-13 2023-08-14 Not clear
Tianqing Liu, Yuying Li, Yan Wang, Xiao-Xin Yan, Jiapei Dai, Mengchao Cu. Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease. European journal of medicinal chemistry. vol 246. 2022-12-09. PMID:36493618. for various neurodegenerative diseases, including alzheimer's disease (ad), the abnormal aggregation of tau is not only the predominant contributing factor but also a major biomarker for disease diagnosis. 2022-12-09 2023-08-14 Not clear
Anna Atlante, Giuseppina Amadoro, Valentina Latina, Daniela Valent. Therapeutic Potential of Targeting Mitochondria for Alzheimer's Disease Treatment. Journal of clinical medicine. vol 11. issue 22. 2022-11-26. PMID:36431219. alzheimer's disease (ad), a chronic and progressive neurodegenerative disease, is characterized by memory and cognitive impairment and by the accumulation in the brain of abnormal proteins, more precisely beta-amyloid (β-amyloid or aβ) and tau proteins. 2022-11-26 2023-08-14 Not clear
Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A Zughaibi, Mohammad Amjad Kamal, Shams Tabre. Nanomedicine-based immunotherapy for Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2022-11-26. PMID:36435391. alzheimer's disease (ad) is the most prevalent neurodegenerative disease caused by the deposition of amyloid β (aβ) fibrils forming extracellular plaques and the development of neurofibrillary tangles (nft) of intracellular hyperphosphorylated tau protein. 2022-11-26 2023-08-14 Not clear
Jonathan D Cherry, Zach H Baucom, Kaleb G Eppich, Daniel Kirsch, Erin R Dixon, Yorghos Tripodis, Kevin F Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F Crary, Dennis Dickson, Ann C McKe. Neuroimmune proteins can differentiate between tauopathies. Journal of neuroinflammation. vol 19. issue 1. 2022-11-19. PMID:36403052. tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). 2022-11-19 2023-08-14 Not clear
Stéphanie Levert, Julie Pilliod, Étienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frédéric Calon, Nicole Lecler. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Molecular neurobiology. 2022-11-18. PMID:36399251. the accumulation of hyperphosphorylated and aggregated tau is also seen in other neurodegenerative diseases such as frontotemporal lobar degeneration (ftld-tau). 2022-11-18 2023-08-14 Not clear
Hong Xu, Virginia M-Y Le. In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399276. in vitro amplification of pathogenic tau seeds from neurodegenerative disease patient brains. 2022-11-18 2023-08-14 human
Hong Xu, Virginia M-Y Le. In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399276. aggregated microtubule-associated protein tau (tau) is the hallmark lesion of a group of neurodegenerative diseases, termed tauopathies. 2022-11-18 2023-08-14 human
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairaja. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387285. many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17, are characterized by tau pathology. 2022-11-17 2023-08-14 mouse
Kurtis Mengham, Youssra Al-Hilaly, Sebastian Oakley, Kamillia Kasbi, Mahmoud B Maina, Louise C Serpel. Shapeshifting tau: from intrinsically disordered to paired-helical filaments. Essays in biochemistry. 2022-11-14. PMID:36373666. the ability of tau to adopt a wide variety of conformations appears fundamental both to its biological function and also its association with neurodegenerative diseases. 2022-11-14 2023-08-14 Not clear
Dahbia Yatoui, Philipp O Tsvetkov, Romain La Rocca, Viktoriia E Baksheeva, Diane Allegro, Gilles Breuzard, Géraldine Ferracci, Deborah Byrne, François Devre. Binding of two zinc ions promotes liquid-liquid phase separation of Tau. International journal of biological macromolecules. 2022-11-14. PMID:36375666. tau is a naturally disordered microtubule associated protein which forms intraneuronal aggregates in several neurodegenerative diseases including alzheimer's disease (ad). 2022-11-14 2023-08-14 Not clear
Dahbia Yatoui, Philipp O Tsvetkov, Romain La Rocca, Viktoriia E Baksheeva, Diane Allegro, Gilles Breuzard, Géraldine Ferracci, Deborah Byrne, François Devre. Binding of two zinc ions promotes liquid-liquid phase separation of Tau. International journal of biological macromolecules. 2022-11-14. PMID:36375666. with regard to the role of zinc ions in the aggregation of proteins in neurodegenerative diseases, these findings bring new insights to the understanding of the aggregation mechanism of tau protein induced by zinc. 2022-11-14 2023-08-14 Not clear
Ling Wu, Nailya Gilyazova, John F Ervin, Shih-Hsiu J Wang, Bin X. Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation. ACS chemical neuroscience. 2022-11-09. PMID:36350059. tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). 2022-11-09 2023-08-14 human
Xiaoying Chen, David M Holtzma. Emerging roles of innate and adaptive immunity in Alzheimer's disease. Immunity. 2022-11-09. PMID:36351425. alzheimer's disease (ad) is the most common neurodegenerative disease, with characteristic extracellular amyloid-β (aβ) deposition and intracellular accumulation of hyperphosphorylated, aggregated tau. 2022-11-09 2023-08-14 Not clear