| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan D Cherry, Zach H Baucom, Kaleb G Eppich, Daniel Kirsch, Erin R Dixon, Yorghos Tripodis, Kevin F Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F Crary, Dennis Dickson, Ann C McKe. Neuroimmune proteins can differentiate between tauopathies. Journal of neuroinflammation. vol 19. issue 1. 2022-11-19. PMID:36403052. |
tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). |
2022-11-19 |
2023-08-14 |
Not clear |
| Stéphanie Levert, Julie Pilliod, Étienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frédéric Calon, Nicole Lecler. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Molecular neurobiology. 2022-11-18. PMID:36399251. |
the accumulation of hyperphosphorylated and aggregated tau is also seen in other neurodegenerative diseases such as frontotemporal lobar degeneration (ftld-tau). |
2022-11-18 |
2023-08-14 |
Not clear |
| Hong Xu, Virginia M-Y Le. In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399276. |
in vitro amplification of pathogenic tau seeds from neurodegenerative disease patient brains. |
2022-11-18 |
2023-08-14 |
human |
| Hong Xu, Virginia M-Y Le. In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399276. |
aggregated microtubule-associated protein tau (tau) is the hallmark lesion of a group of neurodegenerative diseases, termed tauopathies. |
2022-11-18 |
2023-08-14 |
human |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairaja. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387285. |
many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17, are characterized by tau pathology. |
2022-11-17 |
2023-08-14 |
mouse |
| Kurtis Mengham, Youssra Al-Hilaly, Sebastian Oakley, Kamillia Kasbi, Mahmoud B Maina, Louise C Serpel. Shapeshifting tau: from intrinsically disordered to paired-helical filaments. Essays in biochemistry. 2022-11-14. PMID:36373666. |
the ability of tau to adopt a wide variety of conformations appears fundamental both to its biological function and also its association with neurodegenerative diseases. |
2022-11-14 |
2023-08-14 |
Not clear |
| Dahbia Yatoui, Philipp O Tsvetkov, Romain La Rocca, Viktoriia E Baksheeva, Diane Allegro, Gilles Breuzard, Géraldine Ferracci, Deborah Byrne, François Devre. Binding of two zinc ions promotes liquid-liquid phase separation of Tau. International journal of biological macromolecules. 2022-11-14. PMID:36375666. |
tau is a naturally disordered microtubule associated protein which forms intraneuronal aggregates in several neurodegenerative diseases including alzheimer's disease (ad). |
2022-11-14 |
2023-08-14 |
Not clear |
| Dahbia Yatoui, Philipp O Tsvetkov, Romain La Rocca, Viktoriia E Baksheeva, Diane Allegro, Gilles Breuzard, Géraldine Ferracci, Deborah Byrne, François Devre. Binding of two zinc ions promotes liquid-liquid phase separation of Tau. International journal of biological macromolecules. 2022-11-14. PMID:36375666. |
with regard to the role of zinc ions in the aggregation of proteins in neurodegenerative diseases, these findings bring new insights to the understanding of the aggregation mechanism of tau protein induced by zinc. |
2022-11-14 |
2023-08-14 |
Not clear |
| Ling Wu, Nailya Gilyazova, John F Ervin, Shih-Hsiu J Wang, Bin X. Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation. ACS chemical neuroscience. 2022-11-09. PMID:36350059. |
tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). |
2022-11-09 |
2023-08-14 |
human |
| Xiaoying Chen, David M Holtzma. Emerging roles of innate and adaptive immunity in Alzheimer's disease. Immunity. 2022-11-09. PMID:36351425. |
alzheimer's disease (ad) is the most common neurodegenerative disease, with characteristic extracellular amyloid-β (aβ) deposition and intracellular accumulation of hyperphosphorylated, aggregated tau. |
2022-11-09 |
2023-08-14 |
Not clear |
| Gabriele Saretzk. The telomerase connection of the brain and its implications for neurodegenerative diseases. Stem cells (Dayton, Ohio). 2022-11-04. PMID:36330760. |
protein degradation processes are prominently involved in degrading toxic proteins in the brain like amyloid-β, pathological tau and α-synuclein that are responsible for various neurodegenerative diseases. |
2022-11-04 |
2023-08-14 |
human |
| Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jian. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing research reviews. 2022-11-04. PMID:36332756. |
furthermore, ire1α is a significant factor in the regulation of neurodegenerative diseases that are caused by the phosphorylation of tau protein, the accumulation of α-synuclein (α-syn) and the toxic effects of mutant htt (mhtt). |
2022-11-04 |
2023-08-14 |
Not clear |
| Gabriel A Marx, Daniel G Koenigsberg, Andrew T McKenzie, Justin Kauffman, Russell W Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A Iida, Charles L White, Jamie M Walker, Timothy E Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F Crary, Kurt Farrel. Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-11-01. PMID:36316708. |
tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing neurofibrillary tangles (nfts). |
2022-11-01 |
2023-08-14 |
human |
| Long Feng, Shihui Fu, Yao Yao, Yulong Li, Longhe Xu, Yali Zhao, Leiming Lu. Roles for c-Abl in postoperative neurodegeneration. International journal of medical sciences. vol 19. issue 12. 2022-10-31. PMID:36313229. |
c-abl also plays a crucial role in neurodevelopment and neurodegenerative diseases, mainly through mechanisms such as neuroinflammation, oxidative stress (os), and tau protein phosphorylation. |
2022-10-31 |
2023-08-14 |
Not clear |
| Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E Ferrario, Germán Falasco, María Elena Aval. SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-24. PMID:36277399. |
abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2022-10-24 |
2023-08-14 |
human |
| E A Kovalenko, E V Makhnovich, N A Osinovskaya, A N Bogolepov. [Focused ultrasound as a non-invasive method with therapeutic potential in patients with Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 10. 2022-10-24. PMID:36279227. |
alzheimer's disease (ad) is a common, progressive neurodegenerative disease characterized by abnormal deposition of β-amyloid (aβ) and hyperphosphorylated tau protein. |
2022-10-24 |
2023-08-14 |
Not clear |
| Ashley C Knight, Christopher D Morrone, Cassis Varlow, Wai Haung Yu, Paul McQuade, Neil Vasde. Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain. Molecular imaging and biology. 2022-10-18. PMID:36258099. |
in vivo detection of transactivation response element dna binding protein-43 kda (tdp-43) aggregates through positron emission tomography (pet) would impact the ability to successfully develop therapeutic interventions for a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis (als). the purpose of the present study is to evaluate the ability of six tau pet radioligands to bind to tdp-43 aggregates in post-mortem brain tissues from als patients. |
2022-10-18 |
2023-08-14 |
Not clear |
| Pijush Chakraborty, Markus Zweckstette. Phase separation of the microtubule-associated protein tau. Essays in biochemistry. 2022-10-17. PMID:36251053. |
the aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of alzheimer's disease and several other neurodegenerative diseases. |
2022-10-17 |
2023-08-14 |
Not clear |
| Tomas Kavanagh, Aditi Halder, Eleanor Drummon. Tau interactome and RNA binding proteins in neurodegenerative diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-10-17. PMID:36253823. |
tau interactome and rna binding proteins in neurodegenerative diseases. |
2022-10-17 |
2023-08-14 |
human |
| Tomas Kavanagh, Aditi Halder, Eleanor Drummon. Tau interactome and RNA binding proteins in neurodegenerative diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-10-17. PMID:36253823. |
pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. |
2022-10-17 |
2023-08-14 |
human |