| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G Safa. Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias. Cells. vol 11. issue 19. 2022-10-14. PMID:36230957. |
recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to alzheimer's disease (ad) and monogenic frontotemporal lobar degeneration (ftld)-mapt p301l, and suggest that distinct strains of misfolded proteins drive the phenotypes and progression rates in many neurodegenerative diseases. |
2022-10-14 |
2023-08-14 |
human |
| Julia Sala-Jarque, Karolina Zimkowska, Jesús Ávila, Isidro Ferrer, José Antonio Del Rí. Towards a Mechanistic Model of Tau-Mediated Pathology in Tauopathies: What Can We Learn from Cell-Based In Vitro Assays? International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232835. |
tauopathies are a group of neurodegenerative diseases characterized by the hyperphosphorylation and deposition of tau proteins in the brain. |
2022-10-14 |
2023-08-14 |
Not clear |
| Cody McKee, Peter Shrager, Arindam Gosh Mazumder, Archan Ganguly, Abigail Mayer, Karl Foley, Nancy Ward, Margaret Youngman, Hailong Hou, Houhui Xi. Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development. Molecular neurobiology. 2022-10-05. PMID:36198882. |
our study suggests that nipp1 in neural precursor cells regulates phosphorylation of tau and cns myelination and may represent a novel therapeutic target for neurodegenerative diseases. |
2022-10-05 |
2023-08-14 |
mouse |
| Charline Fagnen, Johanna Giovannini, Marco Catto, Anne Sophie Voisin-Chiret, Jana Sopkova-de Oliveira Santo. On the Tracks of the Aggregation Mechanism of the PHF6 Peptide from Tau Protein: Molecular Dynamics, Energy, and Interaction Network Investigations. ACS chemical neuroscience. 2022-09-26. PMID:36153969. |
the formation of neurofibrillary tangles (nfts), composed of tau protein aggregates, is a hallmark of some neurodegenerative diseases called tauopathies. |
2022-09-26 |
2023-08-14 |
Not clear |
| Alisa Cario, Sanjula P Wickramasinghe, Elizabeth Rhoades, Christopher L Berge. The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches. The Journal of biological chemistry. 2022-09-26. PMID:36162501. |
tau misregulation is associated with a class of neurodegenerative diseases, known as tauopathies, including progressive supranuclear palsy (psp), pick's disease, and alzheimer's disease. |
2022-09-26 |
2023-08-14 |
Not clear |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. |
2022-09-24 |
2023-08-14 |
Not clear |
| Tingting Yao, Heng Xiao, Hong Wang, Xiaowei X. Recent Advances in PROTACs for Drug Targeted Protein Research. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142231. |
for example, protacs targeting ar, br, btk, tau, irak4, and other proteins have shown unprecedented clinical efficacy in cancers, neurodegenerative diseases, inflammations, and other fields. |
2022-09-23 |
2023-08-14 |
Not clear |
| Javad Sharifi-Rad, Simona Rapposelli, Simona Sestito, Jesús Herrera-Bravo, Alejandra Arancibia-Diaz, Luis A Salazar, Balakyz Yeskaliyeva, Ahmet Beyatli, Gerardo Leyva-Gómez, Carlos González-Contreras, Eda Sönmez Gürer, Miquel Martorell, Daniela Calin. Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation. Journal of personalized medicine. vol 12. issue 9. 2022-09-23. PMID:36143299. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and tau protein in brain neurons. |
2022-09-23 |
2023-08-14 |
Not clear |
| Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. |
significantly higher levels of aqp4 were found in ad and ftd patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between aqp4 and total tau levels was found. |
2022-09-17 |
2023-08-14 |
human |
| Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasan. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models. Neuropeptides. vol 96. 2022-09-10. PMID:36087426. |
traumatic brain injury (tbi), characterized by acute neurological impairment, is associated with a higher incidence of neurodegenerative diseases, particularly chronic traumatic encephalopathy (cte), alzheimer's disease (ad), and parkinson's disease (pd), whose hallmarks include hyperphosphorylated tau protein. |
2022-09-10 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
microglia and astrocytes have been described as playing important roles in synaptic spreading of toxic tau in several neurodegenerative diseases (nds). |
2022-09-02 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Kai Chen, Yuka A Martens, Axel Meneses, Daniel H Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M Holtzman, Todd E Golde, Guojun Bu, Na Zha. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular neurodegeneration. vol 17. issue 1. 2022-09-02. PMID:36056345. |
studies have shown that pathological species of α-syn and tau can spread in a prion-like manner between neurons, although these two proteins have distinct pathological roles and contribute to different neurodegenerative diseases. |
2022-09-02 |
2023-08-14 |
Not clear |
| Fatemehsadat Seyedaghamiri, Mojgan Rajabi, Gisou Mohadde. Targeting Novel microRNAs in Developing Novel Alzheimer's Disease Treatments. Neurochemical research. 2022-09-01. PMID:36048350. |
this neurodegenerative disease process is classically divided into two different pathologies cerebral accumulation of amyloid-β and hyperphosphorylated neurofibrillary tau tangles. |
2022-09-01 |
2023-08-14 |
Not clear |
| Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Maf. Circular RNAs in Alzheimer's Disease: A New Perspective of Diagnostic and Therapeutic Targets. CNS & neurological disorders drug targets. 2022-08-31. PMID:36043720. |
among various neurodegenerative diseases (nds), accumulating evidence has proposed key roles for circrnas in the pathogenesis of alzheimer's disease (ad); although the exact relationship between these rna molecules and ad progression is not clear, they have been believed to mostly act as mirna sponges or gene transcription modulators through correlating with multiple proteins, involved in the accumulation of amyloid β (aβ) peptides, as well as tau protein, as ad's pathological hallmark. |
2022-08-31 |
2023-08-14 |
Not clear |
| Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Ki. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of neurogenetics. 2022-08-24. PMID:36000467. |
tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as alzheimer's disease and other related tauopathies. |
2022-08-24 |
2023-08-14 |
Not clear |
| Kazuya Tsumagari, Yoshiaki Sato, Aki Shimozawa, Hirofumi Aoyagi, Hideyuki Okano, Junro Kuromits. Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies. iScience. vol 25. issue 8. 2022-08-22. PMID:35992067. |
abnormally accumulated tau protein aggregates are one of the hallmarks of neurodegenerative diseases, including alzheimer's disease (ad). |
2022-08-22 |
2023-08-14 |
mouse |
| Zhikai Zeng, Yann Fichou, Michael Vigers, Karen Tsay, Songi Ha. Illuminating the Structural Basis of Tau Aggregation by Intramolecular Distance Tracking: A Perspective on Methods. The journal of physical chemistry. B. 2022-08-22. PMID:35994024. |
the aggregation of the tau protein is central to several neurodegenerative diseases, collectively known as tauopathies. |
2022-08-22 |
2023-08-14 |
Not clear |
| Valerie Siahaan, Ruensern Tan, Tereza Humhalova, Lenka Libusova, Samuel E Lacey, Tracy Tan, Mariah Dacy, Kassandra M Ori-McKenney, Richard J McKenney, Marcus Braun, Zdenek Lansk. Microtubule lattice spacing governs cohesive envelope formation of tau family proteins. Nature chemical biology. 2022-08-22. PMID:35996000. |
tau is an intrinsically disordered microtubule-associated protein (map) implicated in neurodegenerative disease. |
2022-08-22 |
2023-08-14 |
Not clear |
| Keren Wood, Idit Maharshak, Yosef Koronyo, Maya Koronyo-Hamaou. [THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE]. Harefuah. vol 161. issue 8. 2022-08-18. PMID:35979573. |
alzheimer's disease is a neurodegenerative disease pathologically characterized by accumulation of abnormal amyloid-beta (aβ) and tau proteins. |
2022-08-18 |
2023-08-14 |
Not clear |