| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eva Baerends, Katia Soud, Jonas Folke, Anna-Kathrine Pedersen, Simon Henmar, Lisa Konrad, Matthew D Lycas, Yuki Mori, Bente Pakkenberg, David P D Woldbye, Oksana Dmytriyeva, Stanislava Pankratov. Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native Aβ oligomers to rats. Acta neuropathologica communications. vol 10. issue 1. 2022-08-16. PMID:35974377. |
alzheimer's disease (ad) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (aβ) and hyperphosphorylated tau along with a slow decline in cognitive functions. |
2022-08-16 |
2023-08-14 |
human |
| Faith L Anderson, Karl E Biggs, Brynn E Rankin, Matthew C Havrd. NLRP3 inflammasome in neurodegenerative disease. Translational research : the journal of laboratory and clinical medicine. 2022-08-11. PMID:35952982. |
in this review, we highlight evidence from model systems and patients indicating inflammasome activity in neurodegenerative disease associated with the nlrp3 inflammasome's ability to recognize pathologic forms of amyloid-β, tau, and α-synuclein. |
2022-08-11 |
2023-08-14 |
Not clear |
| Brittany N Dugger, Danielle Harvey, Thomas G Beach, Charles H Adle. Peripheral tau as a biomarker for neurodegenerative diseases: is life on Earth, life on Mars? Brain : a journal of neurology. 2022-08-10. PMID:35947169. |
peripheral tau as a biomarker for neurodegenerative diseases: is life on earth, life on mars? |
2022-08-10 |
2023-08-14 |
Not clear |
| Juan Li, Bin Zou, Xiao-Yu Cheng, Xin-He Yang, Jia Li, Chun-Hui Zhao, Rui-Xia Ma, Ji-Xiang Tian, Yao Ya. Therapeutic effects of total saikosaponins from Frontiers in pharmacology. vol 13. 2022-08-08. PMID:35935875. |
therapeutic effects of total saikosaponins from alzheimer's disease (ad) is a neurodegenerative disease characterized by memory loss and cognitive dysfunction in the elderly, with amyloid-beta (aβ) deposition and hyperphosphorylation of tau protein as the main pathological feature. |
2022-08-08 |
2023-08-14 |
Not clear |
| Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, Madeleine Marcus, Frances Henderson, W Keith Ray, Sandra Siedlak, Jianyong Li, Richard F Helm, Xiongwei Zhu, George S Bloom, Shih-Hsiu J Wang, Wen-Quan Zou, Bin X. Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936779. |
tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease, pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2022-08-08 |
2023-08-14 |
human |
| Helen C Murray, Chelsie Osterman, Paige Bell, Luca Vinnell, Maurice A Curti. Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature. Acta neuropathologica communications. vol 10. issue 1. 2022-08-06. PMID:35933388. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease associated with repetitive head trauma and is characterised by the perivascular accumulation of hyperphosphorylated tau (p-tau) in the depths of cortical sulci. |
2022-08-06 |
2023-08-14 |
human |
| Mennatallah O Zaki, S El-Desouky, Doaa A Elsherbiny, Mohamed Salama, Samar S Aza. Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling. Inflammopharmacology. 2022-08-03. PMID:35922737. |
tauopathy is a group of neurodegenerative diseases in which the pathogenesis processes are related to tau protein. |
2022-08-03 |
2023-08-14 |
mouse |
| Sophie A I Sanford, William A McEwa. Type-I Interferons in Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 16. 2022-08-01. PMID:35910253. |
signatures of type-i ifn-driven gene expression, and type-i ifns themselves, are observed in the central nervous system during neurodegenerative diseases including alzheimer's disease and other tauopathies, the umbrella term for diseases that feature aggregation of the cytosolic protein tau. |
2022-08-01 |
2023-08-14 |
Not clear |
| Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune, Mingyue Ji. Functional cooperation of α-synuclein and tau is essential for proper corticogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-29. PMID:35906071. |
alpha-synuclein (αsyn) and tau are abundant multifunctional neuronal proteins, and their intracellular deposits have been linked to many neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2022-07-29 |
2023-08-14 |
mouse |
| Xiaomin Yin, Yuanyuan Li, Xing Fan, Fang Huang, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Qun Gu, Liye Xia, Junze Bao, Xiaochuan Wang, Fei Liu, Wei Qia. SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy. Molecular psychiatry. 2022-07-25. PMID:35879403. |
hyperphosphorylation of the microtubule associated protein tau is associated with several neurodegenerative diseases including alzheimer's disease (ad), collectively referred to as tauopathies. |
2022-07-25 |
2023-08-14 |
mouse |
| Alexandria B Marciante, John Howard, Mia N Kelly, Juan Santiago Moreno, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Dose-dependent Phosphorylation of Endogenous Tau by Intermittent Hypoxia in Rat Brain. Journal of applied physiology (Bethesda, Md. : 1985). 2022-07-21. PMID:35861520. |
sleep apnea is comorbid in >50% of patients with alzheimer's disease-a progressive, neurodegenerative disease associated with brain amyloid and chronic tau dysregulation (pathology). |
2022-07-21 |
2023-08-14 |
human |
| Yasuhisa Ano, Yuta Takaichi, Rena Ohya, Kazuyuki Uchida, Hiroyuki Nakayama, Akihiko Takashim. Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice. Nutritional neuroscience. 2022-07-11. PMID:35816407. |
neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include alzheimer's disease and pick's disease. |
2022-07-11 |
2023-08-14 |
mouse |
| Sarah Holper, Rosie Watson, Nawaf Yass. Tau as a Biomarker of Neurodegeneration. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806324. |
less than 50 years since tau was first isolated from a porcine brain, its detection in femtolitre concentrations in biological fluids is revolutionizing the diagnosis of neurodegenerative diseases. |
2022-07-09 |
2023-08-14 |
Not clear |
| Cong Li. The Role of Mesenchymal Stem Cells in Regulating Astrocytes-Related Synapse Dysfunction in Early Alzheimer's Disease. Frontiers in neuroscience. vol 16. 2022-07-08. PMID:35801178. |
alzheimer's disease (ad), a neurodegenerative disease, is characterized by the presence of extracellular amyloid-β (aβ) aggregates and intracellular neurofibrillary tangles formed by hyperphosphorylated tau as pathological features and the cognitive decline as main clinical features. |
2022-07-08 |
2023-08-14 |
Not clear |
| Erpan Ahat, Sarah Bui, Jianchao Zhang, Felipe da Veiga Leprevost, Lisa Sharkey, Whitney Reid, Alexey I Nesvizhskii, Henry L Paulson, Yanzhuang Wan. GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. The Journal of biological chemistry. 2022-07-05. PMID:35780830. |
here, we surveyed several neurodegenerative disease related proteins, including mutant huntingtin (htt-q74), sod1, tau, and tdp43, for unconventional secretion; our results show that htt-q74 is most robustly secreted in a grasp55-dependent manner. |
2022-07-05 |
2023-08-14 |
Not clear |
| Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasso. Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta neuropathologica communications. vol 10. issue 1. 2022-06-28. PMID:35765058. |
tau has been extensively studied over several decades, especially in the context of neurodegenerative diseases where it can aberrantly aggregate to form a spectrum of pathological inclusions. |
2022-06-28 |
2023-08-14 |
human |
| Dina Medina-Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell-Valle, Alfonso Gutiérrez-Adán, Carlos Sanjuan, Antonio Jesús López-Gambero, Rubén Tovar, Juan Suárez, Francisco Javier Pavón, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonsec. D-Pinitol promotes Tau dephosphorylation through a Cyclin-dependent kinase 5 regulation mechanism: a new potential approach for Tauopathies? British journal of pharmacology. 2022-06-27. PMID:35760415. |
recent evidence links brain insulin resistance with neurodegenerative diseases where hyperphosphorylated tau protein contributes to neuronal cell death. |
2022-06-27 |
2023-08-14 |
Not clear |
| Antonia Moll, Lisa Marie Ramirez, Momchil Ninov, Juliane Schwarz, Henning Urlaub, Markus Zweckstette. Hsp multichaperone complex buffers pathologically modified Tau. Nature communications. vol 13. issue 1. 2022-06-27. PMID:35760815. |
because phosphorylated tau binds the hsp70/hsp90 machinery but is not recognized by hsp90 alone, the data establish the hsp70/hsp90 multichaperone complex as a critical regulator of tau in neurodegenerative diseases. |
2022-06-27 |
2023-08-14 |
human |
| Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Monica R Mariner, Lucia I Sue, Richard A Arce, Alireza Atri, Charles H Adler, Christine M Belden, Holly A Shill, Erika Driver-Dunckley, Shyamal H Mehta, Thomas G Beac. Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment. Journal of neuropathology and experimental neurology. 2022-06-25. PMID:35751438. |
the alzheimer disease (ad) neuropathological hallmarks amyloid β (aβ) and tau neurofibrillary (nf) pathology have been reported in the olfactory bulb (ob) in aging and in different neurodegenerative diseases, which coincides with frequently reported olfactory dysfunction in these conditions. |
2022-06-25 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
aggregation of misfolded microtubule associated protein tau into abnormal intracellular inclusions defines a class of neurodegenerative diseases known as tauopathies. |
2022-06-17 |
2023-08-14 |
Not clear |