All Relations between Neurodegenerative Diseases and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Neil Donison, Matthew Hintermayer, Maegha Subramaniam, Erin Santandrea, Kathryn Volkening, Michael J Stron. Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026695. upregulation of lrrk2 following traumatic brain injury does not directly phosphorylate thr phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. 2023-12-01 2023-12-10 Not clear
Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Par. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS chemical neuroscience. 2023-11-28. PMID:38014902. tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. 2023-11-28 2023-11-29 Not clear
Ryder Davidson, Reese I Krider, Philip Borsellino, Keith Noorda, George Alhwayek, Thomas A Vid. Untangling Tau: Molecular Insights into Neuroinflammation, Pathophysiology, and Emerging Immunotherapies. Current issues in molecular biology. vol 45. issue 11. 2023-11-25. PMID:37998730. future directions for tau immunotherapies may include combining treatments with aβ immunotherapy, which may result in more significant clinical outcomes for neurodegenerative diseases. 2023-11-25 2023-11-28 Not clear
Liangjuan Fang, Bin Jiao, Xixi Liu, Zhenghong Wang, Peng Yuan, Hui Zhou, Xuewen Xiao, Liqin Cao, Jifeng Guo, Beisha Tang, Lu She. Specific serum autoantibodies predict the development and progression of Alzheimer's disease with high accuracy. Brain, behavior, and immunity. 2023-11-21. PMID:37989443. importantly, these autoantibodies could distinguish ad from other neurodegenerative diseases and out-performed amyloid and tau protein concentrations in cerebrospinal fluid in predicting cognitive decline (p < 0.001). 2023-11-21 2023-11-29 human
Ahmet Sarper Bozkurt, Şenay Görücü Yílma. Ferroptotic Potency of ISM1 Expression in the Drug-Induced Alzheimer's Disease-Like Phenotype Under the Influence of Betulin. Journal of Alzheimer's disease : JAD. 2023-11-19. PMID:37980676. alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by two main pathological mechanisms, mostly hyperphosphorylated tau and amyloid-β toxicity. 2023-11-19 2023-11-29 Not clear
Yanli Jiang, Longfei Li, Ruozhen Wu, Liulin Wu, Bin Zhang, Jian-Zhi Wang, Rong Liu, Fei Liu, Jing Wang, Xiaochuan Wan. c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. The Journal of biological chemistry. 2023-11-17. PMID:37977223. the accumulation of abnormal tau protein is a common feature of various neurodegenerative diseases. 2023-11-17 2023-11-20 human
Maria Laura Passaro, Francesco Matarazzo, Gianmarco Abbadessa, Antonio Pezone, Antonio Porcellini, Fausto Tranfa, Michele Rinaldi, Ciro Costagliol. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle? Journal of clinical medicine. vol 12. issue 21. 2023-11-14. PMID:37959365. tauopathies represent a subclass of neurodegenerative diseases characterized by the abnormal deposition of tau protein within the brain and consequent microtubule destabilization. 2023-11-14 2023-11-20 Not clear
Susu Kong, Xi Wen, Yueju Wang, Rong Tan, Huiling Li, Yifeng T. Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution. ACS chemical neuroscience. 2023-11-08. PMID:37939215. to simply and rapidly detect the highly phosphorylated tau protein at threonine 217 (p-tau217) as a precautionary measure against alzheimer's disease and distinguish it from other neurodegenerative diseases, a novel immunosensor was prepared using luminol as the electrochemiluminescent (ecl) sensing probe reinforced by au-cu nanoparticles (au-cu nps). 2023-11-08 2023-11-20 human
Shengquan Zhang, Xiongxiong Wang, Zhihua Liu, Shan Jin, Chuan-Xi Ma. Using Drosophila Larval Neuromuscular Junction and Muscle Cells to Visualize Microtubule Network. Journal of visualized experiments : JoVE. issue 200. 2023-11-06. PMID:37929978. mutations in many microtubules regulatory proteins are associated with neurodevelopmental disorders and neurological diseases, such as microtubule-associated protein tau to neurodegenerative diseases, microtubule severing protein spastin and katanin 60 cause hereditary spastic paraplegia and neurodevelopmental abnormalities, respectively. 2023-11-06 2023-11-08 drosophila_melanogaster
Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzae. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905874. recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like glaucoma and age-related macular degeneration. 2023-10-31 2023-11-08 human
Mihika Gangolli, Sinisa Pajevic, Joong Hee Kim, Elizabeth B Hutchinson, Dan Benjamini, Peter J Basse. Correspondence of mean apparent propagator MRI metrics with phosphorylated tau and astrogliosis in chronic traumatic encephalopathy. Brain communications. vol 5. issue 5. 2023-10-30. PMID:37901038. chronic traumatic encephalopathy is a neurodegenerative disease that is diagnosed and staged based on the localization and extent of phosphorylated tau pathology. 2023-10-30 2023-11-08 Not clear
Terjahna Richards, Jeanette C Perron, Ketan Patel, John Wurpel, Sandra E Reznik, Francis Schann. Therapeutic Intervention of Neuroinflammatory Alzheimer Disease Model by Inhibition of Classical Complement Pathway with the Use of Anti-C1r Loaded Exosomes. Research square. 2023-10-27. PMID:37886595. alzheimer's disease (ad) is a complex neurodegenerative disease associated with memory decline, cognitive impairment, amyloid plaque formation and tau tangles. 2023-10-27 2023-11-08 Not clear
Dong-Hwi Kim, Da-Yoon Kim, Kyu-Sung Kim, Sang-Hoon Han, Hyeon-Jeong Go, Jae-Hyeong Kim, Kyu-Beom Lim, Dong-Hun Lee, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Yang-Kyu Choi, Yeun-Kyung Shin, Oh-Kyu Kwon, Do-Geun Kim, In-Soo Cho. Neurologic Effects of SARS-CoV-2 Transmitted among Dogs. Emerging infectious diseases. vol 29. issue 11. 2023-10-26. PMID:37877548. furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between sars-cov-2-associated small vessel disease and neurodegeneration. 2023-10-26 2023-11-08 dog
Abigail R Esquivel, Shannon E Hill, Laura J Blai. DnaJs are enriched in tau regulators. International journal of biological macromolecules. vol 253. issue Pt 7. 2023-10-26. PMID:37852393. the aberrant accumulation of tau protein is implicated as a pathogenic factor in many neurodegenerative diseases. 2023-10-26 2023-11-08 Not clear
Ester Piovesana, Claudia Magrin, Matteo Ciccaldo, Martina Sola, Manolo Bellotto, Maurizio Molinari, Stéphanie Papin, Paolo Paganett. Tau accumulation in degradative organelles is associated to lysosomal stress. Scientific reports. vol 13. issue 1. 2023-10-21. PMID:37865674. considering the presence of tau lesions in parkinson's disease as well as in multiple neurodegenerative disorders including alzheimer's disease, our data call for further studies on strategies to alleviate alp dysfunction as new therapeutic opportunity for neurodegenerative diseases and lsd. 2023-10-21 2023-11-08 human
Matthew J Benskey, Spencer Panoushek, Takashi Saito, Takaomi C Saido, Tessa Grabinski, Nicholas M Kanaa. Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse. Frontiers in aging neuroscience. vol 15. 2023-10-16. PMID:37842124. tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. 2023-10-16 2023-11-08 mouse
Mingyue Jin, Shengming Wang, Xiaodie Gao, Zhenyou Zou, Shinji Hirotsune, Liyuan Su. Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843221. in this review, we provide a summary of the recent findings on the functional roles of α-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases. 2023-10-16 2023-11-08 mouse
Mingyue Jin, Shengming Wang, Xiaodie Gao, Zhenyou Zou, Shinji Hirotsune, Liyuan Su. Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843221. a deep understanding of the interplay between α-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases. 2023-10-16 2023-11-08 mouse
Jiaxin Hu, Wenchi Sha, Shuangshuang Yuan, Jiarui Wu, Yunpeng Huan. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834471. tau protein aggregates can be found in a number of devastating neurodegenerative diseases known as "tauopathies", such as alzheimer's disease (ad), frontotemporal dementia (ftd), corticobasal degeneration (cbd), etc. 2023-10-14 2023-10-15 Not clear
Syed Jawad Ali Shah, Qianqian Zhang, Jingjing Guo, Hongli Liu, Huanxiang Liu, Jordi Villà-Freix. Identification of Aggregation Mechanism of Acetylated PHF6* and PHF6 Tau Peptides Based on Molecular Dynamics Simulations and Markov State Modeling. ACS chemical neuroscience. 2023-10-13. PMID:37830541. however, tau's dysfunction and accumulation in the human brain can lead to several neurodegenerative diseases, such as alzheimer's disease, down's syndrome, and frontotemporal dementia. 2023-10-13 2023-10-15 human