All Relations between Neurodegenerative Diseases and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Sydney M A Juan, Maria Daglas, Phan H Truong, Celeste Mawal, Paul A Adlar. Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury. Acta neuropathologica communications. vol 11. issue 1. 2023-07-18. PMID:37464280. repetitive mild traumatic brain injury (r-mtbi) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many of which are characterised by tau pathology, metal dyshomeostasis and behavioural impairments. 2023-07-18 2023-08-14 mouse
Marta Jorge-Oliva, Jan R T van Weering, Wiep Schepe. Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446051. tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. 2023-07-14 2023-08-14 Not clear
Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiméne. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer's disease? Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449594. although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, tau, or alpha-synuclein. 2023-07-14 2023-08-14 Not clear
Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). 2023-07-10 2023-08-14 Not clear
Elly E Liao, Mu Yang, Noah Nathan Kochen, Nagamani Vunnam, Anthony R Braun, David M Ferguson, Jonathan N Sach. Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology. Molecular neurobiology. 2023-07-10. PMID:37428404. proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and neurodegenerative diseases. 2023-07-10 2023-08-14 Not clear
Mingxi Dang, Feng Sang, Shijie Long, Yaojing Che. The Aging Patterns of Brain Structure, Function, and Energy Metabolism. Advances in experimental medicine and biology. vol 1419. 2023-07-07. PMID:37418208. finally, we discussed the relationship between amyloid-β deposition and tau accumulation in the brain, as pathological manifestations of neurodegenerative disease and aging. 2023-07-07 2023-08-14 Not clear
Leonora Szabo, Amandine Grimm, Juan Antonio García-León, Catherine M Verfaillie, Anne Ecker. Genetically Engineered Triple Cells. vol 12. issue 10. 2023-07-06. PMID:37408218. genetically engineered triple pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. 2023-07-06 2023-08-14 Not clear
Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Schöndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashue. Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature communications. vol 14. issue 1. 2023-07-04. PMID:37402718. tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as tauopathies. 2023-07-04 2023-08-14 Not clear
Bryan T Hurtle, Longxin Xie, Christopher J Donnell. Disrupting pathologic phase transitions in neurodegeneration. The Journal of clinical investigation. vol 133. issue 13. 2023-07-03. PMID:37395272. this review explores the known mechanisms contributing to aberrant protein phase transitions in neurodegenerative diseases, focusing on tau and tdp-43 proteinopathies and outlining potential therapeutic strategies to regulate these pathologic events. 2023-07-03 2023-08-14 human
Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. 2023-07-01 2023-08-14 Not clear
Nicole Tamvaka, Sireesha Manne, Naveen Kondru, Owen A Ros. Pick's Disease, Seeding an Answer to the Clinical Diagnosis Conundrum. Biomedicines. vol 11. issue 6. 2023-06-28. PMID:37371741. pick's disease (pid) is a devastating neurodegenerative disease that is characterized by dementia, frontotemporal lobar degeneration, and the aggregation of 3r tau in pathognomonic inclusions known as pick bodies. 2023-06-28 2023-08-14 Not clear
Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Daniel Abebe, Y Peng Lo. Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. Molecular psychiatry. 2023-06-27. PMID:37369719. alzheimer's disease (ad) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, aβ1-42 aggregation and cognitive dysfunction. 2023-06-27 2023-08-14 mouse
T M Axelsen, C Bager, A Bihlet, M A Karsdal, K Henriksen, M H E Tan. A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357295. recent studies have identified caspase-3-cleaved tau (tau-c), and adam-10 cleaved tau (tau-a) as possible markers of preclinical neurodegenerative disease. 2023-06-25 2023-08-14 human
Shelley L Forrest, Seojin Lee, Nasna Nassir, Ivan Martinez-Valbuena, Valerie Sackmann, Jun Li, Awab Ahmed, Maria Carmela Tartaglia, Lars M Ittner, Anthony E Lang, Mohammed Uddin, Gabor G Kovac. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy. Acta neuropathologica. 2023-06-24. PMID:37354322. microtubule-associated protein tau (mapt) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including progressive supranuclear palsy (psp). 2023-06-24 2023-08-14 human
Yi Yao, Yanmin Chang, Shaomin Li, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Lulu Li, Ruitian Liu, Rong Ma, Gang L. Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice. Brain research bulletin. 2023-06-17. PMID:37330021. human tauopathies, including alzheimer's disease (ad), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of tau protein. 2023-06-17 2023-08-14 mouse
Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxe. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. The Journal of clinical investigation. vol 133. issue 12. 2023-06-15. PMID:37317972. tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. 2023-06-15 2023-08-14 human
Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxe. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. The Journal of clinical investigation. vol 133. issue 12. 2023-06-15. PMID:37317972. despite limited clinical success to date, as we continue to refine our understanding of tau's pathogenic mechanism(s) in different neurodegenerative diseases, we remain optimistic that tau-targeting therapies will eventually play a central role in the treatment of tauopathies. 2023-06-15 2023-08-14 human
Jiaqian Wan, Yu Zou, Ruiqing Sun, Zhengdong Xu, Jiaxing Tang, Yehong Gong, Guanghong Wei, Qingwen Zhan. Destabilization mechanism of R3-R4 tau protofilament by purpurin: a molecular dynamics study. Physical chemistry chemical physics : PCCP. 2023-06-14. PMID:37314291. the accumulation of tau protein aggregates is a common feature observed in many neurodegenerative diseases. 2023-06-14 2023-08-14 Not clear
Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. 2023-06-12 2023-08-14 Not clear
Amelia D Hines, Stephanie McGrath, Amanda S Latham, Breonna Kusick, Lisa Mulligan, McKenzie L Richards, Julie A Moren. Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline. Frontiers in aging neuroscience. vol 15. 2023-06-12. PMID:37304080. it is well known that in neurodegenerative diseases, there is an increase in inflamed glial cells as well as an accumulation of hyperphosphorylation of tau (p-tau) and amyloid beta (aβ 2023-06-12 2023-08-14 human