| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole Tamvaka, Sireesha Manne, Naveen Kondru, Owen A Ros. Pick's Disease, Seeding an Answer to the Clinical Diagnosis Conundrum. Biomedicines. vol 11. issue 6. 2023-06-28. PMID:37371741. |
pick's disease (pid) is a devastating neurodegenerative disease that is characterized by dementia, frontotemporal lobar degeneration, and the aggregation of 3r tau in pathognomonic inclusions known as pick bodies. |
2023-06-28 |
2023-08-14 |
Not clear |
| Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Daniel Abebe, Y Peng Lo. Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. Molecular psychiatry. 2023-06-27. PMID:37369719. |
alzheimer's disease (ad) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, aβ1-42 aggregation and cognitive dysfunction. |
2023-06-27 |
2023-08-14 |
mouse |
| T M Axelsen, C Bager, A Bihlet, M A Karsdal, K Henriksen, M H E Tan. A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357295. |
recent studies have identified caspase-3-cleaved tau (tau-c), and adam-10 cleaved tau (tau-a) as possible markers of preclinical neurodegenerative disease. |
2023-06-25 |
2023-08-14 |
human |
| Shelley L Forrest, Seojin Lee, Nasna Nassir, Ivan Martinez-Valbuena, Valerie Sackmann, Jun Li, Awab Ahmed, Maria Carmela Tartaglia, Lars M Ittner, Anthony E Lang, Mohammed Uddin, Gabor G Kovac. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy. Acta neuropathologica. 2023-06-24. PMID:37354322. |
microtubule-associated protein tau (mapt) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including progressive supranuclear palsy (psp). |
2023-06-24 |
2023-08-14 |
human |
| Yi Yao, Yanmin Chang, Shaomin Li, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Lulu Li, Ruitian Liu, Rong Ma, Gang L. Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice. Brain research bulletin. 2023-06-17. PMID:37330021. |
human tauopathies, including alzheimer's disease (ad), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of tau protein. |
2023-06-17 |
2023-08-14 |
mouse |
| Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxe. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. The Journal of clinical investigation. vol 133. issue 12. 2023-06-15. PMID:37317972. |
tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. |
2023-06-15 |
2023-08-14 |
human |
| Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxe. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. The Journal of clinical investigation. vol 133. issue 12. 2023-06-15. PMID:37317972. |
despite limited clinical success to date, as we continue to refine our understanding of tau's pathogenic mechanism(s) in different neurodegenerative diseases, we remain optimistic that tau-targeting therapies will eventually play a central role in the treatment of tauopathies. |
2023-06-15 |
2023-08-14 |
human |
| Jiaqian Wan, Yu Zou, Ruiqing Sun, Zhengdong Xu, Jiaxing Tang, Yehong Gong, Guanghong Wei, Qingwen Zhan. Destabilization mechanism of R3-R4 tau protofilament by purpurin: a molecular dynamics study. Physical chemistry chemical physics : PCCP. 2023-06-14. PMID:37314291. |
the accumulation of tau protein aggregates is a common feature observed in many neurodegenerative diseases. |
2023-06-14 |
2023-08-14 |
Not clear |
| Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. |
tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. |
2023-06-12 |
2023-08-14 |
Not clear |
| Amelia D Hines, Stephanie McGrath, Amanda S Latham, Breonna Kusick, Lisa Mulligan, McKenzie L Richards, Julie A Moren. Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline. Frontiers in aging neuroscience. vol 15. 2023-06-12. PMID:37304080. |
it is well known that in neurodegenerative diseases, there is an increase in inflamed glial cells as well as an accumulation of hyperphosphorylation of tau (p-tau) and amyloid beta (aβ |
2023-06-12 |
2023-08-14 |
human |
| Marta Anglada-Huguet, Heike Endepols, Astrid Sydow, Ronja Hilgers, Bernd Neumaier, Alexander Drzezga, Senthilvelrajan Kaniyappan, Eckhard Mandelkow, Eva-Maria Mandelko. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298211. |
the accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. |
2023-06-11 |
2023-08-14 |
mouse |
| Monika Arbaciauskaite, Azady Pirhanov, Erik Ammermann, Yu Lei, Yong Ku Ch. Yeast biopanning against site-specific phosphorylations in tau. Protein engineering, design & selection : PEDS. 2023-06-09. PMID:37294629. |
the detection of site-specific phosphorylation in the microtubule-associated protein tau is emerging as a means to diagnose and monitor the progression of alzheimer's disease (ad) as well as other neurodegenerative diseases. |
2023-06-09 |
2023-08-14 |
Not clear |
| Houfang Long, Shuyi Zeng, Yunpeng Sun, Cong Li. Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics reports. vol 8. issue 1. 2023-06-08. PMID:37287686. |
several amyloid proteins including α-synuclein (α-syn), tau, amyloid β (aβ) protein, and tar dna-binding protein 43 kda (tdp-43) form pathological fibrils and deposit in patient brains of different neurodegenerative diseases (nds) such as parkinson's disease (pd), alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
2023-06-08 |
2023-08-14 |
human |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Arthur Ribeiro-Dos-Santos, Leonardo Miranda de Brito, Gilderlanio Santana de Araúj. The fusiform gyrus exhibits differential gene-gene co-expression in Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-05-31. PMID:37255536. |
alzheimer's disease (ad) is an irreversible neurodegenerative disease clinically characterized by the presence of β-amyloid plaques and tau deposits in various regions of the brain. |
2023-05-31 |
2023-08-14 |
Not clear |
| Lei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng, Erwei Ha. A new perspective on Alzheimer's disease: m6A modification. Frontiers in genetics. vol 14. 2023-05-31. PMID:37255714. |
as a neurodegenerative disease, alzheimer's disease (ad) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. |
2023-05-31 |
2023-08-14 |
Not clear |
| Jingshan Chen, Xue Zhao, Wenyan Zhang, Tianxiang Zhang, Siting Wu, Jinghao Shao, Fu-Dong Sh. Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-05-26. PMID:37237388. |
plasma amyloid-β (aβ) peptides and tau proteins are promising biomarkers of alzheimer's disease (ad), not only for predicting aβ and tau pathology but also for differentiating ad from other neurodegenerative diseases. |
2023-05-26 |
2023-08-14 |
Not clear |
| Siewert Hugelier, Hannah Kim, Melina Theoni Gyparaki, Charles Bond, Qing Tang, Adriana Naomi Santiago-Ruiz, Sílvia Porta, Melike Lakadamyal. ECLiPSE: A Versatile Classification Technique for Structural and Morphological Analysis of Super-Resolution Microscopy Data. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37215010. |
moreover, we demonstrate the versatility of our approach by applying it to two novel biological applications: quantifying the clearance of tau protein aggregates, a critical marker for neurodegenerative diseases, and differentiating between two distinct morphological features (morphotypes) of tar dna-binding protein 43 proteinopathy, potentially associated to different tdp-43 strains, each exhibiting unique seeding and spreading properties. |
2023-05-23 |
2023-08-14 |
Not clear |
| Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Jeffrey Dag. Blood biomarkers for Alzheimer's disease in clinical practice and trials. Nature aging. vol 3. issue 5. 2023-05-18. PMID:37202517. |
several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing ad from all other neurodegenerative diseases in patients with cognitive impairment. |
2023-05-18 |
2023-08-14 |
Not clear |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175990. |
alzheimer's disease (ad) and frontotemporal dementia (ftd) can be classified as tauopathies, which are a group of neurodegenerative diseases that develop toxic tau aggregates in specific brain regions. |
2023-05-14 |
2023-08-14 |
Not clear |