| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komak. Minocycline effects on memory and learning impairment in the beta-amyloid-induced Alzheimer's disease model in male rats using behavioral, biochemical, and histological methods. European journal of pharmacology. 2023-05-13. PMID:37179042. |
alzheimer's disease (ad), as an advanced neurodegenerative disease, is characterized by the everlasting impairment of memory, which is determined by hyperphosphorylation of intracellular tau protein and accumulation of beta-amyloid (aβ) in the extracellular space. |
2023-05-13 |
2023-08-14 |
rat |
| Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162924. |
the amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc) of the island of guam and the kii peninsula of japan is a fatal neurodegenerative disease of unknown cause that is characterised by the presence of abundant filamentous tau inclusions in brains and spinal cords. |
2023-05-10 |
2023-08-14 |
Not clear |
| S L Fowler, T S Behr, E Turkes, P Maglio Cauhy, M S Foiani, A Schaler, G Crowley, S Bez, E Ficulle, E Tsefou, D P O'Brien, R Fischer, B Geary, P Gaur, C Miller, P D'Acunzo, E Levy, K E Duff, B Ryskeldi-Falco. Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163117. |
the abnormal assembly of tau protein in neurons is the pathological hallmark of multiple neurodegenerative diseases, including alzheimer's disease (ad). |
2023-05-10 |
2023-08-14 |
Not clear |
| Naruhiko Sahara, Rin Yana. Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy. Frontiers in neuroscience. vol 17. 2023-05-08. PMID:37152607. |
neurofibrillary tangles (nfts) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy. |
2023-05-08 |
2023-08-14 |
mouse |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
tau seeds occur before earliest alzheimer's changes and are prevalent across neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
furthermore, ad tau co-pathology is thought to influence features and progression of other neurodegenerative diseases including lewy body disease; yet measurements of different types of tau seeds in the setting of such diseases is an unmet need. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
seed quantitation across a spectrum of neurodegenerative disease cases and controls indicated tau seeding activity can be detected well before accompanying histopathological indication of tau deposits, and even prior to the earliest evidence of alzheimer's-related tau accumulation anywhere in the brain. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
this study suggests 3r/4r tau seeds are widespread even prior to the earliest stages of alzheimer's disease changes, including in normal, and even young individuals, with prevalence across multiple neurodegenerative diseases to further define disease subtypes. |
2023-05-08 |
2023-08-14 |
Not clear |
| Joseph B Rayma. Focusing on oligomeric tau as a therapeutic target in Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. 2023-05-04. PMID:37140480. |
tau has commanded much attention as a potential therapeutic target in neurodegenerative diseases. |
2023-05-04 |
2023-08-14 |
Not clear |
| Kumarappan Chidambara. Identification of BACE-1 Inhibitors against Alzheimer's Disease through E-Pharmacophore-Based Virtual Screening and Molecular Dynamics Simulation Studies: An Insilco Approach. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109481. |
alzheimer is a severe memory and cognitive impairment neurodegenerative disease that is the most common cause of dementia worldwide and characterized by the pathological accumulation of tau protein and amyloid-beta peptides. |
2023-04-28 |
2023-08-14 |
Not clear |
| Nadia El Mammeri, Olivia Gampp, Pu Duan, Mei Hon. Membrane-induced tau amyloid fibrils. Communications biology. vol 6. issue 1. 2023-04-28. PMID:37117483. |
the intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in human brains afflicted with alzheimer's disease and other neurodegenerative diseases. |
2023-04-28 |
2023-08-14 |
human |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090552. |
tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the |
2023-04-24 |
2023-08-14 |
Not clear |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
intraneuronal aggregates of the microtubule binding protein tau are a hallmark of different neurodegenerative diseases including alzheimer's disease (ad). |
2023-04-22 |
2023-08-14 |
mouse |
| Christopher Daniel Morrone, Radha Raghuraman, S Abid Hussaini, Wai Haung Y. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-04-21. PMID:37085942. |
this phenomenon extends beyond β-amyloid and tau, with interactions of sleep impairment with the homeostasis of tdp-43, α-synuclein, fus, and huntingtin proteins, implicating sleep loss as an important consideration in an array of neurodegenerative diseases and in cases of mixed neuropathology. |
2023-04-21 |
2023-08-14 |
Not clear |
| Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T Myöhäne. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine. vol 15. issue 691. 2023-04-12. PMID:37043557. |
tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. |
2023-04-12 |
2023-08-14 |
mouse |
| Haiyang Zhong, Hongli Liu, Huanxiang Li. Molecular Mechanism of Tau Misfolding and Aggregation: Insights from Molecular Dynamics Simulation. Current medicinal chemistry. 2023-04-09. PMID:37031392. |
tau dysfunction has a close association with many neurodegenerative diseases, which are collectively referred to as tauopathies. |
2023-04-09 |
2023-08-14 |
Not clear |
| Rebecca L Kow, Aristide H Black, Brandon P Henderson, Brian C Kraeme. Sut-6/NIPP1 modulates tau toxicity. Human molecular genetics. 2023-03-31. PMID:37000013. |
neurodegenerative diseases exhibiting the pathological accumulation of tau such as alzheimer's disease and related disorders still have no disease-modifying treatments and the molecular mechanisms of neurodegeneration remain unclear. |
2023-03-31 |
2023-08-14 |
human |
| Bote Qi, Jingwang Tan, Yunxiang Sun, Meng Cao, Jinghan Lin, Qingwen Zhang, Yu Zo. Mechanistic Insights into the Binding of Different Positron Emission Tomography Tracers to Chronic Traumatic Encephalopathy Tau Protofibrils. ACS chemical neuroscience. 2023-03-31. PMID:37000128. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease associated with exposure to repetitive head impacts, and it is neuropathologically defined as the accumulation of abnormally hyperphosphorylated tau (p-tau). |
2023-03-31 |
2023-08-14 |
Not clear |
| Bote Qi, Jingwang Tan, Yunxiang Sun, Meng Cao, Jinghan Lin, Qingwen Zhang, Yu Zo. Mechanistic Insights into the Binding of Different Positron Emission Tomography Tracers to Chronic Traumatic Encephalopathy Tau Protofibrils. ACS chemical neuroscience. 2023-03-31. PMID:37000128. |
previous experimental studies reported that positron emission tomography (pet) technique using several tau tracers are available for imaging certain neurodegenerative diseases. |
2023-03-31 |
2023-08-14 |
Not clear |
| Letizia Clementi, Samantha Sabetta, Veronica Zelli, Chiara Compagnoni, Alessandra Tessitore, Vincenzo Mattei, Adriano Angelucc. Mitotic phosphorylation of Tau/MAPT modulates cell cycle progression in prostate cancer cells. Journal of cancer research and clinical oncology. 2023-03-31. PMID:37000265. |
tau/mapt (microtubule associated protein tau) protein is actively studied for the pathologic consequences of its aberrant proteostasis in central nervous system leading to neurodegenerative diseases. |
2023-03-31 |
2023-08-14 |
Not clear |