| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
in summary, our findings offer a deeper understanding of the relationship between trem2 variants and ship1 in microglial functions, and emphasize the therapeutic potential of targeting the trem2 and ship1 pathways in microglia for neurodegenerative diseases. |
2024-04-13 |
2024-04-16 |
mouse |
| Yuxi Liu, Witty Kwok, Hyojung Yoon, Jae Cheon Ryu, Patrick Stevens, Tara R Hawkinson, Cameron J Shedlock, Roberto A Ribas, Terrymar Medina, Shannon B Keohane, Douglas Scharre, Lei Bruschweiler-Li, Rafael Bruschweiler, Alban Gaultier, Karl Obrietan, Ramon C Sun, Sung Ok Yoo. Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-04-02. PMID:38565291. |
microglia undergo two-stage activation in neurodegenerative diseases, known as disease-associated microglia (dam). |
2024-04-02 |
2024-04-05 |
human |
| Emma Davis, Amy F Lloy. The proteomic landscape of microglia in health and disease. Frontiers in cellular neuroscience. vol 18. 2024-04-01. PMID:38560294. |
their presence in neurodegenerative diseases is known, with neurodegeneration-associated risk genes heavily expressed in microglia, highlighting their importance in contributing to disease pathogenesis. |
2024-04-01 |
2024-04-04 |
Not clear |
| Natascha Vidovic, Björn Spitta. Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542077. |
the transcriptomic profiling of these populations has led to the subclassification of specific disease-associated microglia and microglia clusters in neurodegenerative diseases. |
2024-03-28 |
2024-03-30 |
human |
| L Iovino, J Vander Zwaag, G Kaur, M Khakpour, V Giusti, M Donadon, A Chiavegato, L Tenorio-Lopes, E Greggio, M E Tremblay, L Civier. Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease. Neurobiology of disease. 2024-03-25. PMID:38527708. |
microglia are heterogenous, with a variety of states recently identified in aging and neurodegenerative disease models. |
2024-03-25 |
2024-03-28 |
mouse |
| Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J Keagle, Justin A McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A Nickerson, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, Daryl A Bosc. Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. Nature communications. vol 15. issue 1. 2024-03-21. PMID:38509062. |
microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. |
2024-03-21 |
2024-03-23 |
human |
| Cory A Diemler, Michael MacLean, Sarah E Heuer, Amanda A Hewes, Olivia J Marola, Richard T Libby, Gareth R Howel. Microglia Depletion leads to Increased Susceptibility to Ocular Hypertension-Dependent Glaucoma. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496398. |
in recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. |
2024-03-18 |
2024-03-20 |
mouse |
| Paige E Anton, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464118. |
studies utilizing rodent models of neurodegenerative disease reveal heightened activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and nod like receptor 3 (nlrp3) mediate microglia activation and associated neuronal injury. |
2024-03-11 |
2024-03-14 |
Not clear |
| Fatma Gonca Kocanci, Azize Yasemin Goks. Anti-inflammatory and antioxidative actions of tacrolimus (FK506) on human microglial HMC3 cell line. Scandinavian journal of immunology. vol 99. issue 2. 2024-03-05. PMID:38441214. |
shifting the focus from neurons to microglia in drug discovery for neurodegenerative diseases has become an important therapeutic target. |
2024-03-05 |
2024-03-07 |
human |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
roles of microglia in neurodegenerative diseases. |
2024-02-21 |
2024-02-23 |
Not clear |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
in recent years, microglia have attracted attention owing to their roles in various neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2024-02-21 |
2024-02-23 |
Not clear |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
understanding this detailed classification is necessary to elucidate the association between microglia and neurodegenerative diseases. |
2024-02-21 |
2024-02-23 |
Not clear |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
in this review, we discuss the diverse roles of microglia in neurodegenerative diseases and highlight their potential as therapeutic targets. |
2024-02-21 |
2024-02-23 |
Not clear |
| Ming-Lei Guo, Yan Cheng, Damian Martinez Pineda, Rachael E Dempsey, Lifang Yan. Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals. Aging and disease. 2024-02-20. PMID:38377024. |
lipid droplets accumulating microglia (ldam), identified as a novel inflammatory phenotype, elevate neuroinflammation and exaggerate neuronal injuries in aging and multiple neurodegenerative diseases. |
2024-02-20 |
2024-02-23 |
human |
| Chan Rim, Min-Jung You, Minyeop Nahm, Min-Soo Kwo. Emerging role of senescent microglia in brain aging-related neurodegenerative diseases. Translational neurodegeneration. vol 13. issue 1. 2024-02-20. PMID:38378788. |
emerging role of senescent microglia in brain aging-related neurodegenerative diseases. |
2024-02-20 |
2024-02-23 |
Not clear |
| Chan Rim, Min-Jung You, Minyeop Nahm, Min-Soo Kwo. Emerging role of senescent microglia in brain aging-related neurodegenerative diseases. Translational neurodegeneration. vol 13. issue 1. 2024-02-20. PMID:38378788. |
given the role of microglia in eliminating senescent cells, the accumulation of senescent microglia may lead to the acceleration of brain aging, contributing to inflammaging and increased vulnerability to neurodegenerative diseases. |
2024-02-20 |
2024-02-23 |
Not clear |
| Chan Rim, Min-Jung You, Minyeop Nahm, Min-Soo Kwo. Emerging role of senescent microglia in brain aging-related neurodegenerative diseases. Translational neurodegeneration. vol 13. issue 1. 2024-02-20. PMID:38378788. |
in this review, we propose the idea that the senescence of microglia, which is notably vulnerable to aging, could potentially serve as a central catalyst in the progression of neurodegenerative diseases. |
2024-02-20 |
2024-02-23 |
Not clear |
| Chan Rim, Min-Jung You, Minyeop Nahm, Min-Soo Kwo. Emerging role of senescent microglia in brain aging-related neurodegenerative diseases. Translational neurodegeneration. vol 13. issue 1. 2024-02-20. PMID:38378788. |
the senescent microglia are emerging as a promising target for mitigating neurodegenerative diseases. |
2024-02-20 |
2024-02-23 |
Not clear |
| Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M Kanninen, Pasi I Jalava, Tarja Malm, Paula Korhone. Particulate matter from car exhaust alters function of human iPSC-derived microglia. Particle and fibre toxicology. vol 21. issue 1. 2024-02-15. PMID:38360668. |
microglia are the immune cells of the brain implicated in the progression of neurodegenerative diseases. |
2024-02-15 |
2024-02-18 |
human |
| Jian Sheng Loh, Wen Qi Mak, Li Kar Stella Tan, Chu Xin Ng, Hong Hao Chan, Shiau Hueh Yeow, Jhi Biau Foo, Yong Sze Ong, Chee Wun How, Kooi Yeong Kha. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal transduction and targeted therapy. vol 9. issue 1. 2024-02-15. PMID:38360862. |
as the gut microbiome provides essential cues to microglia, astrocytes, and oligodendrocytes, we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative diseases. |
2024-02-15 |
2024-02-18 |
human |