| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Wang, Limei Cui, He Zhao, Huhuifen He, Liang Chen, Xicheng Song, Dawei Liu, Jingjing Qiu, Yan Su. Exploring the Connectivity of Neurodegenerative Diseases: Microglia as the Center. Journal of inflammation research. vol 16. 2023-12-19. PMID:38107384. |
although it is difficult to describe the complex morphological structure of microglia in a unified manner, this does not prevent them from being a target for future treatment of neurodegenerative diseases. |
2023-12-19 |
2023-12-21 |
Not clear |
| Jack Humphrey, Erica Brophy, Roman Kosoy, Biao Zeng, Elena Coccia, Daniele Mattei, Ashvin Ravi, Anastasia G Efthymiou, Elisa Navarro, Benjamin Z Muller, Gijsje Jlj Snijders, Amanda Allan, Alexandra Münch, Reta Birhanu Kitata, Steven P Kleopoulos, Stathis Argyriou, Zhiping Shao, Nancy Francoeur, Chia-Feng Tsai, Marina A Gritsenko, Matthew E Monroe, Vanessa L Paurus, Karl K Weitz, Tujin Shi, Robert Sebra, Tao Liu, Lot D de Witte, Alison M Goate, David A Bennett, Vahram Haroutunian, Gabriel E Hoffman, John F Fullard, Panos Roussos, Towfique Ra. Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing. medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38076956. |
microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. |
2023-12-11 |
2023-12-17 |
human |
| Maria Cristina Barbalace, Michela Freschi, Irene Rinaldi, Eugenia Mazzara, Tullia Maraldi, Marco Malaguti, Cecilia Prata, Filippo Maggi, Riccardo Petrelli, Silvana Hrelia, Cristina Angelon. Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068924. |
identification of anti-neuroinflammatory bioactive compounds in essential oils and aqueous distillation residues obtained from commercial varieties of neuroinflammation, which is mainly triggered by microglia, is a key contributor to multiple neurodegenerative diseases. |
2023-12-09 |
2023-12-17 |
Not clear |
| Rebecca Ferrisi, Francesca Gado, Caterina Ricardi, Beatrice Polini, Clementina Manera, Grazia Chiellin. The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer's Disease. Journal of clinical medicine. vol 12. issue 23. 2023-12-09. PMID:38068253. |
here, we review the current knowledge regarding the involvement of cbrs in the modulation of microglia activation phenotypes, highlighting the role of neuroinflammation in the pathogenesis of neurodegenerative diseases, like ad. |
2023-12-09 |
2023-12-17 |
Not clear |
| Andrea Amerio, Luca Magnani, Gabriele Arduino, Fabio Fesce, Renato de Filippis, Alberto Parise, Alessandra Costanza, Khoa D Nguyen, Daniele Saverino, Domenico De Berardis, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Pasquale De Fazio, Mario Amor. Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia. Current neuropharmacology. 2023-12-04. PMID:38031778. |
several studies are concurrently highlighting the importance of microglia, the resident immune cells of the central nervous system, in a huge number of neurodegenerative diseases, including multiple sclerosis, alzheimer's and parkinson's diseases, as well as ssds. |
2023-12-04 |
2023-12-10 |
Not clear |
| Gizem Terzioglu, Tracy L Young-Pears. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-11-30. PMID:38017562. |
through rigorous examination of the intricate connections between microglial signaling pathways across several experimental systems and postmortem analyses, the field will be better equipped to tailor newly emerging therapeutic strategies targeting microglia in neurodegenerative diseases. |
2023-11-30 |
2023-12-07 |
human |
| Gizem Terzioglu, Tracy L Young-Pears. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-11-30. PMID:38017562. |
through rigorous examination of the intricate connections between microglial signaling pathways across several experimental systems and postmortem analyses, the field will be better equipped to tailor newly emerging therapeutic strategies targeting microglia in neurodegenerative diseases. |
2023-11-29 |
2023-12-07 |
human |
| Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Par. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS chemical neuroscience. 2023-11-28. PMID:38014902. |
tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. |
2023-11-28 |
2023-11-29 |
Not clear |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
recent research suggests that baicalein has potential to reduce neuroinflammation and prevent neurodegenerative diseases by affecting microglia, while the specific molecular mechanism of baicalein in regulating microglia in the treatment of ad is still unclear. |
2023-11-25 |
2023-11-28 |
mouse |
| Ilaria Piano, Arianna Votta, Patrizia Colucci, Francesca Corsi, Sara Vitolo, Chiara Cerri, Dario Puppi, Michele Lai, José Fernando Maya-Vetencourt, Massimiliano Leigheb, Chiara Gabellini, Elisabetta Ferrar. Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine. Scientific reports. vol 13. issue 1. 2023-11-18. PMID:37978212. |
microglia chronic activation is a hallmark of several neurodegenerative diseases, including the retinal ones, possibly contributing to their etiopathogenesis. |
2023-11-18 |
2023-11-20 |
Not clear |
| E Richard Stanley, Fabrizio Biundo, Şölen Gökhan, Violeta Chit. Differential regulation of microglial states by colony stimulating factors. Frontiers in cellular neuroscience. vol 17. 2023-11-15. PMID:37964794. |
recent studies have emphasized the role of microglia in the progression of many neurodegenerative diseases. |
2023-11-15 |
2023-11-20 |
mouse |
| Maria A Boylan, Andrew Pincetic, Gary Romano, Nadine Tatton, Sara Kenkare-Mitra, Arnon Rosentha. Targeting Progranulin as an Immuno-Neurology Therapeutic Approach. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958929. |
loss-of-function (lof) mutations causing decreased levels of progranulin (pgrn), an immune regulatory protein, lead to dysfunctional microglia and are associated with multiple neurodegenerative diseases, including frontotemporal dementia caused by the progranulin gene ( |
2023-11-14 |
2023-11-20 |
Not clear |
| Edward S Wickstead, Bradley T Elliott, Sarah Pokorny, Christopher Biggs, Stephen J Getting, Simon McArthu. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958978. |
neuroinflammation driven primarily by microglia directly contributes to neuronal death in many neurodegenerative diseases. |
2023-11-14 |
2023-11-20 |
Not clear |
| Shilauni Dadwal, Michael T Henek. Microglia heterogeneity in health and disease. FEBS open bio. 2023-11-09. PMID:37945346. |
in this review, we discuss the latest advances in the field of microglia research, focusing specifically on the origin and subpopulations of microglia, the populations of microglia types in the brains of patients with neurodegenerative diseases, and how microglia are regulated in the healthy cns. |
2023-11-09 |
2023-11-20 |
human |
| Julie J Ahn, Robert H Miller, Yusra Isla. Isolation of Pure Astrocytes and Microglia from the Adult Mouse Spinal Cord For In Vitro Assays and Transcriptomic Studies. Journal of visualized experiments : JoVE. issue 200. 2023-11-06. PMID:37930016. |
astrocytes and microglia play pivotal roles in central nervous system development, injury responses, and neurodegenerative diseases. |
2023-11-06 |
2023-11-08 |
mouse |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases. |
2023-10-31 |
2023-11-08 |
Not clear |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
this review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including alzheimer's disease, huntington's chorea, and parkinson's disease. |
2023-10-31 |
2023-11-08 |
Not clear |
| Yonghae Son, In-Jun Yeo, Jin-Tae Hong, Seong-Kug Eo, Dongjun Lee, Koanhoi Ki. Side-Chain Immune Oxysterols Induce Neuroinflammation by Activating Microglia. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894967. |
the activation of microglia and subsequent neuroinflammation elicited by the immune oxysterols can contribute to the development of neurodegenerative diseases. |
2023-10-30 |
2023-11-08 |
mouse |
| Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodi. Cell-Type-Specific Mitochondrial Quality Control in the Brain: A Plausible Mechanism of Neurodegeneration. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833867. |
during aging, activated microglia undergo phenotypic alterations that can lead to neuroinflammation, which is a well-accepted event in the pathogenesis of neurodegenerative diseases. |
2023-10-14 |
2023-10-15 |
Not clear |
| Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodi. Cell-Type-Specific Mitochondrial Quality Control in the Brain: A Plausible Mechanism of Neurodegeneration. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833867. |
several common mechanisms are shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. |
2023-10-14 |
2023-10-15 |
Not clear |