All Relations between Neurodegenerative Diseases and microglial cell

Publication Sentence Publish Date Extraction Date Species
Samar F Darwish, Abdullah M M Elbadry, Amir S Elbokhomy, Ghidaa A Salama, Rania M Salam. The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. Frontiers in aging. vol 4. 2023-09-25. PMID:37744008. the dual face of microglia (m1/m2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. 2023-09-25 2023-10-07 Not clear
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. 2023-09-22 2023-10-07 Not clear
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. microglia activation is observed in various neurodegenerative diseases. 2023-09-22 2023-10-07 Not clear
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including alzheimer's disease, parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with lewy bodies and huntington's disease. 2023-09-22 2023-10-07 Not clear
Björn F Vahsen, Sumedha Nalluru, Georgia R Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M L Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R Turner, Sally A Cowley, Kevin Talbo. C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37736756. amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. 2023-09-22 2023-10-07 human
Katsura Takano-Kawabe, Kazuyuki Matoba, Yoichi Nakamura, Mitsuaki Moriyam. Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia. Neurochemical research. 2023-09-13. PMID:37702891. activation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including alzheimer's disease (ad). 2023-09-13 2023-10-07 mouse
Kaushiki Biswa. Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation. Journal of neuroimmunology. vol 383. 2023-09-06. PMID:37672840. microglia mediated neuroinflammation in neurodegenerative diseases: a review on the cell signaling pathways involved in microglial activation. 2023-09-06 2023-10-07 Not clear
Kaushiki Biswa. Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation. Journal of neuroimmunology. vol 383. 2023-09-06. PMID:37672840. microglia, the immune sentinels of the central nervous system (cns), have emerged to be the central players in many neurological and neurodegenerative diseases. 2023-09-06 2023-10-07 Not clear
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C Marzin, Robert C J Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C Trolese, Takashi Saito, Takaomi C Saido, Katharine H Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A Galloway, Rochelle Y Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I Radulescu, Jia Hui Wong, Anna M Barron, Amy M Smith, Samuel J Barnes, David W Hampton, Paul van der Valk, Steven Jacobson, Owain W Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B Tournier, Philippe Millet, Paul M Matthews, Craig S Moore, Sandra Amor, David R Owe. Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases. Nature communications. vol 14. issue 1. 2023-08-28. PMID:37640701. translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases. 2023-08-28 2023-09-07 mouse
Qi Huang, Yanfu Wang, Shanshan Chen, Fengxia Lian. Glycometabolic Reprogramming of Microglia in Neurodegenerative Diseases: Insights from Neuroinflammation. Aging and disease. 2023-08-23. PMID:37611905. glycometabolic reprogramming of microglia in neurodegenerative diseases: insights from neuroinflammation. 2023-08-23 2023-09-07 Not clear
Heike Mrowetz, Mohamed H Kotob, Jennifer Forster, Iren Aydin, Michael Stefan Unger, Jana Lubec, Ahmed M Hussein, Jovana Malikovic, Daniel Daba Feyissa, Volker Korz, Harald Höger, Gert Lubec, Ludwig Aigne. Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600518. one putative mechanism underlying cognitive heterogeneity might be neuroinflammation, exerted through microglia, the brain's innate immune cells, as neuroinflammation is central to brain aging and neurodegenerative diseases. 2023-08-21 2023-09-07 Not clear
Pei Y Ng, Cheng Zhang, Hu Li, Darren J Bake. Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice. Journal of Alzheimer's disease : JAD. 2023-08-07. PMID:37545233. the existence and contribution of microglia with senescent-like alterations in the pathogenesis of age-related neurodegenerative diseases like alzheimer's disease (ad) have been suggested in recent years. 2023-08-07 2023-08-14 mouse
Wenze Deng, Pengcheng Yi, Yanhong Xiong, Jun Ying, Yue Lin, Yao Dong, Gen Wei, Xifeng Wang, Fuzhou Hu. Gut Metabolites Acting on the Gut-Brain Axis: Regulating the Functional State of Microglia. Aging and disease. 2023-08-07. PMID:37548933. at the same time, we highlight the roles of gut metabolites affecting microglia in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders. 2023-08-07 2023-08-14 Not clear
Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan L. Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation. Aging and disease. 2023-08-07. PMID:37548945. neuroinflammation, characterized by the secretion of abundant inflammatory mediators, proinflammatory polarization of microglia, and the recruitment of infiltrating myeloid cells to foci of inflammation, drives or exacerbates the pathological processes of central nervous system disorders, especially in neurodegenerative diseases. 2023-08-07 2023-08-14 Not clear
Miao Wei, Guowei Zhang, Zeyu Huang, Xuemeng Ding, Qing Sun, Yujian Zhang, Rongrong Zhu, Huaijin Guan, Min J. ATP-P2X Journal of neuroinflammation. vol 20. issue 1. 2023-07-31. PMID:37525172. atp-p2x dysfunction of microglia during aging affects normal neuronal function and results in the occurrence of neurodegenerative diseases. 2023-07-31 2023-08-14 Not clear
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Steven. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology. 2023-07-27. PMID:37500887. microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as alzheimer's disease. 2023-07-27 2023-08-14 human
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Steven. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology. 2023-07-27. PMID:37500887. we found that exposure of human stem-cell-differentiated microglia to synaptosomes, myelin debris, apoptotic neurons or synthetic amyloid-beta fibrils generated transcriptional diversity that mapped to gene signatures identified in human brain microglia, including disease-associated microglia, a state enriched in neurodegenerative diseases. 2023-07-27 2023-08-14 human
Antonisamy William James, Ghaith A Bahader, Mohammad Albassan, Zahoor A Sha. The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. Neurochemistry international. 2023-07-16. PMID:37454816. a better understanding of bip's molecular mechanism and role in microglial function may contribute to developing novel therapies for microglia dysfunction-associated neurodegenerative diseases. 2023-07-16 2023-08-14 mouse
Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiméne. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer's disease? Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449594. although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, tau, or alpha-synuclein. 2023-07-14 2023-08-14 Not clear
Sarah A Kent, Veronique E Miro. Microglia regulation of central nervous system myelin health and regeneration. Nature reviews. Immunology. 2023-07-14. PMID:37452201. in this review, we discuss recent work that reveals the changes in white matter with ageing and neurodegenerative disease, how this relates to microglia dynamics during myelin damage and regeneration, and factors that influence the regenerative functions of microglia. 2023-07-14 2023-08-14 Not clear