| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Steven. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology. 2023-07-27. PMID:37500887. |
we found that exposure of human stem-cell-differentiated microglia to synaptosomes, myelin debris, apoptotic neurons or synthetic amyloid-beta fibrils generated transcriptional diversity that mapped to gene signatures identified in human brain microglia, including disease-associated microglia, a state enriched in neurodegenerative diseases. |
2023-07-27 |
2023-08-14 |
human |
| Antonisamy William James, Ghaith A Bahader, Mohammad Albassan, Zahoor A Sha. The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. Neurochemistry international. 2023-07-16. PMID:37454816. |
a better understanding of bip's molecular mechanism and role in microglial function may contribute to developing novel therapies for microglia dysfunction-associated neurodegenerative diseases. |
2023-07-16 |
2023-08-14 |
mouse |
| Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiméne. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer's disease? Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449594. |
although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, tau, or alpha-synuclein. |
2023-07-14 |
2023-08-14 |
Not clear |
| Sarah A Kent, Veronique E Miro. Microglia regulation of central nervous system myelin health and regeneration. Nature reviews. Immunology. 2023-07-14. PMID:37452201. |
in this review, we discuss recent work that reveals the changes in white matter with ageing and neurodegenerative disease, how this relates to microglia dynamics during myelin damage and regeneration, and factors that influence the regenerative functions of microglia. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yiyi Yang, Marta García-Cruzado, Hairuo Zeng, Lluís Camprubí-Ferrer, Bazhena Bahatyrevich-Kharitonik, Sara Bachiller, Tomas Deierbor. LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease. Brain, behavior, and immunity. 2023-07-12. PMID:37437821. |
microglia have an innate immunity memory (iim) with divergent functions in different animal models of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-07-12 |
2023-08-14 |
mouse |
| Lionel A Rodriguez, Matthew Nguyen Tran, Renee Garcia-Flores, Elizabeth A Pattie, Heena R Divecha, Sun Hong Kim, Joo Heon Shin, Yong Kyu Lee, Carly Montoya, Andrew E Jaffe, Leonardo Collado-Torres, Stephanie C Page, Keri Martinowic. TrkB-dependent regulation of molecular signaling across septal cell types. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425939. |
upregulated genes are enriched in ls microglia, associated with immune response and inflammation, and linked to both neurodegenerative disease and neuropsychiatric disorders. |
2023-07-10 |
2023-08-14 |
Not clear |
| Evangelia Xingi, Paraskevi N Koutsoudaki, Irini Thanou, Minh-Son Phan, Maria Margariti, Anja Scheller, Jean-Yves Tinevez, Frank Kirchhoff, Dimitra Thomaido. LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex. Cells. vol 12. issue 10. 2023-07-06. PMID:37408252. |
the neurovascular unit (nvu), composed of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring the physiological functioning of the central nervous system (cns), which gets affected and contributes to the pathology of several neurodegenerative diseases. |
2023-07-06 |
2023-08-14 |
mouse |
| Evangelia Xingi, Paraskevi N Koutsoudaki, Irini Thanou, Minh-Son Phan, Maria Margariti, Anja Scheller, Jean-Yves Tinevez, Frank Kirchhoff, Dimitra Thomaido. LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex. Cells. vol 12. issue 10. 2023-07-06. PMID:37408252. |
neuroinflammation is a common feature of neurodegenerative diseases and is primarily related to the activation state of perivascular microglia and astrocytes, which constitute two of its major cellular components. |
2023-07-06 |
2023-08-14 |
mouse |
| Jingyi Luo, Qing Lian, Deliang Zhu, Minglei Zhao, Tingfang Mei, Bizhi Shang, Zeqiu Yang, Chujun Liu, Wenchang Xu, Lan Zhou, Keling Wu, Xinqi Liu, Yuhua Lai, Fuxiang Mao, Weihua Li, Chengguo Zuo, Kang Zhang, Mingkai Lin, Yehong Zhuo, Yizhi Liu, Lin Lu, Ling Zha. PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis. Genes & diseases. vol 10. issue 4. 2023-07-03. PMID:37397520. |
taken together, our study provides important insights linking activated microglia to rgcs death in the glaucoma pathogenesis and other rgc-related neurodegenerative diseases. |
2023-07-03 |
2023-08-14 |
mouse |
| Salome Funes, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Jonathan Jung, Shankaracharya, Matthew Unger, Debra Cameron, Pepper Dawes, Pamela J Keagle, Justin A McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, Daryl A Bosc. Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398081. |
microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be fully elucidated. |
2023-07-03 |
2023-08-14 |
human |
| Salome Funes, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Jonathan Jung, Shankaracharya, Matthew Unger, Debra Cameron, Pepper Dawes, Pamela J Keagle, Justin A McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, Daryl A Bosc. Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398081. |
these outcomes demonstrate the utility of imgs for neurodegenerative disease research and highlight microglia vesicular degradation pathways as potential therapeutic targets for these disorders. |
2023-07-03 |
2023-08-14 |
human |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
| Wael Mohamed, Jaya Kumar, Badrah S Alghamdi, Al-Hassan Soliman, Yamashita Toshihid. Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388502. |
alzheimer's, als, parkinson's, frontotemporal dementia (ftd), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular. |
2023-06-30 |
2023-08-14 |
Not clear |
| Luise Schlotterose, Mariya S Pravdivtseva, Frowin Ellermann, Olav Jansen, Jan-Bernd Hövener, Frank D Sönnichsen, François Cossais, Ralph Lucius, Kirsten Hatterman. Resveratrol Mitigates Metabolism in Human Microglia Cells. Antioxidants (Basel, Switzerland). vol 12. issue 6. 2023-06-28. PMID:37371977. |
the recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. |
2023-06-28 |
2023-08-14 |
human |
| Juciano Gasparotto, Nauana Somensi, Carolina Saibro Girardi, Reykla Ramon Bittencourt, Laura Martinewski de Oliveira, Laura Piloneto Hoefel, Ingrid Matsubara Scheibel, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Tiago Fleming Outeiro, Daniel Pens Gelai. Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease. Journal of neurochemistry. 2023-06-28. PMID:37381043. |
as chronic inflammation is consistently present in neurodegenerative diseases, it was largely assumed that rage could act as a critical modulator of neuroinflammation in parkinson's disease (pd), similar to what was reported for alzheimer's disease (ad), where rage is postulated to mediate pro-inflammatory signaling in microglia by binding to amyloid-β peptide. |
2023-06-28 |
2023-08-14 |
Not clear |
| Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, David C Rubinsztei. Microglial cytokines poison neuronal autophagy via CCR5, a druggable target. Autophagy. 2023-06-26. PMID:37358357. |
in the prodromal phase of neurodegenerative diseases, microglia switch to an activated state resulting in increased secretion of pro-inflammatory factors. |
2023-06-26 |
2023-08-14 |
mouse |
| Tatsuyuki Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto, Ken Uemura, Tamae Kondo, Koki Sakurai, Takaaki Ozawa, Takatoshi Hikida, Okiru Komine, Koji Yamanaka, Yuki Fujita, Toshihide Yamashita, Tomonori Matsumoto, Eiji Har. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Communications biology. vol 6. issue 1. 2023-06-23. PMID:37353538. |
microglial senescence is predominantly detected in disease-associated microglia, which appear in ageing and neurodegenerative diseases. |
2023-06-23 |
2023-08-14 |
mouse |
| Yaodan Zhang, Yuyang Miao, Xiangyang Xiong, Jin Tan, Zhaoli Han, Fanglian Chen, Ping Lei, Qiang Zhan. Microglial exosomes alleviate intermittent hypoxia-induced cognitive deficits by suppressing NLRP3 inflammasome. Biology direct. vol 18. issue 1. 2023-06-13. PMID:37312196. |
as critical inflammatory cells, exosomes secreted by microglia have been found to affect the spread of pathologic proteins and neuropathology in neurodegenerative diseases. |
2023-06-13 |
2023-08-14 |
mouse |
| Giorgia Serena Gullotta, Giuseppe Costantino, Maria Angela Sortino, Simona Federica Spampinat. Microglia and the Blood-Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298096. |
here, we report the specific crosstalk of microglia with all the bbb cell types focusing in particular on the involvement of microglia in the modulation of bbb function in neuroinflammatory conditions that occur in conjunction with an acute event, such as a stroke, or in a slow neurodegenerative disease, such as alzheimer's disease. |
2023-06-11 |
2023-08-14 |
Not clear |
| Ester Pérez-Martín, Laura Pérez-Revuelta, Cristina Barahona-López, David Pérez-Boyero, José R Alonso, David Díaz, Eduardo Weruag. Oleoylethanolamide Treatment Modulates Both Neuroinflammation and Microgliosis, and Prevents Massive Leukocyte Infiltration to the Cerebellum in a Mouse Model of Neuronal Degeneration. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298639. |
neurodegenerative diseases involve an exacerbated neuroinflammatory response led by microglia that triggers cytokine storm and leukocyte infiltration into the brain. |
2023-06-11 |
2023-08-14 |
mouse |