| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca De Chirico, Eleonora Poeta, Giorgia Babini, Iliana Piccolino, Barbara Monti, Francesca Massenzi. New models of Parkinson's like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors. Frontiers in cellular neuroscience. vol 16. 2022-12-16. PMID:36523814. |
microglia activation and neuroinflammation have been extensively studied in murine models of neurodegenerative diseases; however, to overcome the genetic differences between species, a human cell model of microglia able to recapitulate the activation profiles described in patients is needed. |
2022-12-16 |
2023-08-14 |
human |
| Ye Man Tang, Nisha S Pulimood, Stefano Stifan. Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases. ASN neuro. vol 14. 2022-12-16. PMID:36524236. |
comparing the characteristics of microglia preparations generated using different human ipsc-based differentiation methods to model neurodegenerative diseases. |
2022-12-16 |
2023-08-14 |
human |
| Ye Man Tang, Nisha S Pulimood, Stefano Stifan. Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases. ASN neuro. vol 14. 2022-12-16. PMID:36524236. |
dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases such as amyotrophic lateral sclerosis (als) and alzheimer's disease. |
2022-12-16 |
2023-08-14 |
human |
| Wendiao Zhang, Jiamei Jiang, Zhenhong Xu, Hongye Yan, Beisha Tang, Chunyu Liu, Chao Chen, Qingtuan Men. Microglia-containing human brain organoids for the study of brain development and pathology. Molecular psychiatry. 2022-12-10. PMID:36474001. |
increasing evidence has implicated microglia dysfunction in the pathogenesis of various brain disorders ranging from psychiatric disorders to neurodegenerative diseases. |
2022-12-10 |
2023-08-14 |
human |
| Huiling Hu, Xiaoxia Lu, Lisi Huang, Yuqing He, Xiuli Liu, Ying Wang, Chaohui Dua. Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway. Metabolic brain disease. 2022-12-01. PMID:36454504. |
microglia are resident immune cells in the brain and are closely associated with central nervous system inflammation and neurodegenerative diseases. |
2022-12-01 |
2023-08-14 |
Not clear |
| Kazuya Takahash. Microglial heterogeneity in amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology. 2022-11-28. PMID:36440536. |
in recent years, there have been a series of reports on the existence of disease-associated microglia (dam) in the lesions of various neurodegenerative diseases. |
2022-11-28 |
2023-08-14 |
mouse |
| Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C Ikezu, Francis Shue, Sydney V Doss, Alla Alnobani, Yuka A Martens, Melissa Wren, Yan W Asmann, Bin Zhang, Guojun Bu, Chia-Chen Li. Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination. Molecular neurodegeneration. vol 17. issue 1. 2022-11-24. PMID:36419137. |
abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. |
2022-11-24 |
2023-08-14 |
Not clear |
| Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A Garcia, Christopher D Link, Charles Hoeffer, Anushree Chatterjee, Prashant Nagpa. Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine. ACS chemical neuroscience. 2022-11-21. PMID:36410860. |
however, chronic neuroinflammation leading to the activation of immune cells like microglia and astrocytes causes damage to the nervous tissue, and it is causally linked to a range of neurodegenerative diseases such as alzheimer's diseases (ad), multiple sclerosis (ms), parkinson's disease (pd), and many others. |
2022-11-21 |
2023-08-14 |
mouse |
| Nima Javanmehr, Kiarash Saleki, Parsa Alijanizadeh, Nima Rezae. Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases. Journal of neuroinflammation. vol 19. issue 1. 2022-11-18. PMID:36397116. |
also, we address the feasibility of targeting microglia as a therapeutic strategy in neurodegenerative diseases. |
2022-11-18 |
2023-08-14 |
Not clear |
| Sam J Washer, Marta Perez-Alcantara, Yixi Chen, Juliette Steer, William S James, Gosia Trynka, Andrew R Bassett, Sally A Cowle. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Scientific reports. vol 12. issue 1. 2022-11-14. PMID:36376339. |
there is increasing genetic evidence for the role of microglia in neurodegenerative diseases, including alzheimer's, parkinson's, and motor neuron disease. |
2022-11-14 |
2023-08-14 |
human |
| Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hira. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications biology. vol 5. issue 1. 2022-11-12. PMID:36369525. |
our vectors transduced ramified microglia in healthy tissues and reactive microglia in lipopolysaccharide-treated mice and a mouse model of neurodegenerative disease. |
2022-11-12 |
2023-08-14 |
mouse |
| Cristina Russo, Maria Stella Valle, Antonella Russo, Lucia Malaguarner. The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362220. |
the interplay between ghrelin and microglia in neuroinflammation: implications for obesity and neurodegenerative diseases. |
2022-11-11 |
2023-08-14 |
Not clear |
| Cristina Russo, Maria Stella Valle, Antonella Russo, Lucia Malaguarner. The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362220. |
recent research has attempted to clarify the role of ghre signaling in microglia on the regulation of energy balance, obesity, neuroinflammation and the occurrence of neurodegenerative diseases. |
2022-11-11 |
2023-08-14 |
Not clear |
| Cristina Russo, Maria Stella Valle, Antonella Russo, Lucia Malaguarner. The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362220. |
these studies strongly suggest that ghre modulates microglia activity and thus affects the pathophysiology of neurodegenerative diseases. |
2022-11-11 |
2023-08-14 |
Not clear |
| Jiaotai Shi, Chengbo Wang, Chunyan Sang, Stanislas Nsanzamahoro, Tian Chai, Jun Wang, Aimei Yang, Junli Yan. Tabersonine Inhibits the Lipopolysaccharide-Induced Neuroinflammatory Response in BV2 Microglia Cells via the NF- Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364344. |
tabersonine inhibits the lipopolysaccharide-induced neuroinflammatory response in bv2 microglia cells via the nf- the occurrence and development of neurodegenerative diseases is related to a variety of physiological and pathological changes. |
2022-11-11 |
2023-08-14 |
Not clear |
| Kristen M Pitts, Cameron E Neeson, Nathan E Hall, Jonathan B Lin, Henisk K Falah, Silas L Wang, Kristine T Lo, Christian E Song, Milica A Margeta, David A Solá-Del Vall. Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma. Translational vision science & technology. vol 11. issue 11. 2022-11-01. PMID:36318198. |
galectin-3 (gal-3) and apolipoprotein e (apoe) are markers of activated microglia in neurodegenerative diseases of the central nervous system, whose targeting is protective in mouse models of glaucoma. |
2022-11-01 |
2023-08-14 |
mouse |
| Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tan. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. 2022-11-01. PMID:36318443. |
numerous studies have proven that microglia can participate in the occurrence and progression of neurodegenerative diseases (ndds), such as alzheimer's disease (ad), by regulating synaptic plasticity. |
2022-11-01 |
2023-08-14 |
Not clear |
| Wen-Yuan Ju, Qing Wang, Li-Juan Song, Zhi-Bin Ding, Xiao-Hui Li, Gajendra Kumar, Yuqing Yan, Cun-Gen M. Drug-induced microglial phagocytosis in multiple sclerosis and experimental autoimmune encephalomyelitis and the underlying mechanisms. Molecular biology reports. 2022-10-30. PMID:36309614. |
it indicates that the phagocytosis of microglia has many beneficial and harmful effects in central neurodegenerative diseases. |
2022-10-30 |
2023-08-14 |
Not clear |
| Dorothy P Schafer, Jacob M Stillma. Microglia are SYK of Aβ and cell debris. Cell. vol 185. issue 22. 2022-10-28. PMID:36306731. |
during neurodegenerative disease, resident cns macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. |
2022-10-28 |
2023-08-14 |
Not clear |
| Jae Kwang Kim, Hye Jin Yang, Younghoon G. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290574. |
therefore, the management of microglial cell activation and their inflammatory response is an important therapeutic approach for preventing neurodegenerative diseases. |
2022-10-27 |
2023-08-14 |
Not clear |