| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. |
amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. |
2024-03-19 |
2024-03-21 |
human |
| Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. |
2024-03-13 |
2024-03-16 |
mouse |
| Firas Abu Hanna, Yoav Zehavi, Eran Cohen-Barak, Morad Khayat, Nasim Warwar, Roni Shreter, Richard J Rodenburg, Ronen Spiege. Lack of mitochondrial complex I assembly factor NDUFAF2 results in a distinctive infantile-onset brainstem neurodegenerative disease with early lethality. Orphanet journal of rare diseases. vol 19. issue 1. 2024-02-28. PMID:38419071. |
lack of mitochondrial complex i assembly factor ndufaf2 results in a distinctive infantile-onset brainstem neurodegenerative disease with early lethality. |
2024-02-28 |
2024-03-02 |
Not clear |
| Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi X. Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis. Reviews in the neurosciences. 2024-02-21. PMID:38381656. |
amyotrophic lateral sclerosis (als) is a rare neurodegenerative disease which damages upper and lower motor neurons (umn and lmn) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related umn and lmn, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D'Alessandr. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Frontiers in molecular neuroscience. vol 16. 2024-01-31. PMID:38292023. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. |
2024-01-31 |
2024-02-02 |
mouse |
| Jian Lu, An-Xu He, Zhuo-Ying Jin, Meng Zhang, Zhong-Xin Li, Fan Zhou, Lin Ma, Hong-Ming Jin, Jia-Ying Wang, Xu She. Desloratadine alleviates ALS-like pathology in hSOD1 Acta pharmacologica Sinica. 2024-01-29. PMID:38286832. |
desloratadine alleviates als-like pathology in hsod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. |
2024-01-29 |
2024-02-01 |
Not clear |
| Mario Díaz, Noemí Fabelo, M Virginia Martín, Guido Santos, Isidre Ferre. Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-29. PMID:38285093. |
amyotrophic lateral sclerosis (als) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal cord and brainstem whose etiopathogenesis remains unclear. |
2024-01-29 |
2024-01-31 |
human |
| Susanne G Muelle. Mapping internal brainstem structures using T1 and T2 weighted 3T images. Frontiers in neuroimaging. vol 2. 2024-01-01. PMID:38161488. |
many neurodegenerative diseases affect the brainstem and often do so in an early stage. |
2024-01-01 |
2024-01-05 |
Not clear |
| Rachel Waller, Joanna J Bury, Charlie Appleby-Mallinder, Matthew Wyles, George Loxley, Aditi Babel, Saleh Shekari, Mbombe Kazoka, Helen Wollff, Ammar Al-Chalabi, Paul R Heath, Pamela J Shaw, Janine Kirb. Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162899. |
amyotrophic lateral sclerosis is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the motor cortex, brainstem and spinal cord. |
2024-01-01 |
2024-01-05 |
Not clear |
| Minqi Hu, Feifei Xu, Shizhou Liu, Yuan Yao, Qing Xia, Caiting Zhu, Xinwen Zhang, Haiyan Tang, Zubair Qaiser, Shuwei Liu, Yuchun Tan. Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis. Brain imaging and behavior. 2023-12-28. PMID:38155336. |
while previous research has indicated that changes in brainstem anatomy can serve as a biomarker for aging and neurodegenerative diseases, the structural changes that occur in the brainstem during normal aging remain unclear. |
2023-12-28 |
2023-12-31 |
Not clear |
| Minqi Hu, Feifei Xu, Shizhou Liu, Yuan Yao, Qing Xia, Caiting Zhu, Xinwen Zhang, Haiyan Tang, Zubair Qaiser, Shuwei Liu, Yuchun Tan. Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis. Brain imaging and behavior. 2023-12-28. PMID:38155336. |
these findings provide a systematic description of age associations with brainstem structures in healthy adults and may provide a reference for future research on brain aging and neurodegenerative diseases. |
2023-12-28 |
2023-12-31 |
Not clear |
| Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Li. RABGGTB plays a critical role in ALS pathogenesis. Brain research bulletin. 2023-12-02. PMID:38042502. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease. |
2023-12-02 |
2023-12-10 |
Not clear |
| Lijun Zhou, Wenzhi Chen, Shishi Jiang, Renshi X. In Vitro Models of Amyotrophic Lateral Sclerosis. Cellular and molecular neurobiology. 2023-10-23. PMID:37870685. |
amyotrophic lateral sclerosis (als) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. |
2023-10-23 |
2023-11-08 |
Not clear |
| Serenella Anzilotti, Valeria Valente, Paola Brancaccio, Cristina Franco, Antonella Casamassa, Giovanna Lombardi, Alessandra Palazzi, Andrea Conte, Simona Paladino, Lorella Maria Teresa Canzoniero, Lucio Annunziato, Giovanna Maria Pierantoni, Giuseppe Pignatar. Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-20. PMID:37729728. |
amyotrophic lateral sclerosis (als) is a progressive and often fatal neurodegenerative disease characterized by the loss of motor neurons (mns) in spinal cord, motor cortex and brainstem. |
2023-09-20 |
2023-10-07 |
mouse |
| Sang-Won Yoo, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Ki. Exploring the link between essential tremor and Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-09-15. PMID:37714868. |
recent studies have suggested et as a possible neurodegenerative disease whose subgroup contained lewy bodies in the brainstem, as in pd. |
2023-09-15 |
2023-10-07 |
Not clear |
| Wan Zhou, Renshi X. Current insights in the molecular genetic pathogenesis of amyotrophic lateral sclerosis. Frontiers in neuroscience. vol 17. 2023-08-28. PMID:37638324. |
amyotrophic lateral sclerosis (als) is a progressive and fatal neurodegenerative disease that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. |
2023-08-28 |
2023-09-07 |
Not clear |
| M A B S Akhonda, Mary E Faulkner, Zhaoyuan Gong, John P Laporte, Sarah Church, Jarod D'Agostino, Jan Bergeron, Christopher M Bergeron, Luigi Ferrucci, Mustapha Bouhrar. The effect of the human brainstem myelination on gait speed in normative aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-08-09. PMID:37555749. |
understanding the potential relationship between brainstem demyelination and motor function may be useful for the early diagnosis of neurodegenerative diseases and to understand age-related gait impairments that have no apparent cause. |
2023-08-09 |
2023-08-16 |
human |
| M A B S Akhonda, Mary E Faulkner, Zhaoyuan Gong, John P Laporte, Sarah Church, Jarod D'Agostino, Jan Bergeron, Christopher M Bergeron, Luigi Ferrucci, Mustapha Bouhrar. The effect of the human brainstem myelination on gait speed in normative aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-08-09. PMID:37555749. |
these original findings provide evidence that the level of brainstem myelination may affect gait performance among cognitively unimpaired adults who are free from any clinically detectable neurodegenerative diseases. |
2023-08-09 |
2023-08-16 |
human |
| M A B S Akhonda, Mary E Faulkner, Zhaoyuan Gong, John P Laporte, Sarah Church, Jarod D'Agostino, Jan Bergeron, Christopher M Bergeron, Luigi Ferrucci, Mustapha Bouhrar. The effect of the human brainstem myelination on gait speed in normative aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-08-09. PMID:37555749. |
further studies are needed to understand the longitudinal changes in brainstem myelination with aging and neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2023-08-09 |
2023-08-16 |
human |
| Rachel A Matt, Renee S Martin, Andrew K Evans, Joel R Gever, Gabriel A Vargas, Mehrdad Shamloo, Anthony P For. Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease. Handbook of experimental pharmacology. 2023-07-26. PMID:37495851. |
adrenoceptors (ars) throughout the brain are stimulated by noradrenaline originating mostly from neurons of the locus coeruleus, a brainstem nucleus that is ostensibly the earliest to show detectable pathology in neurodegenerative diseases such as alzheimer's and parkinson's diseases. |
2023-07-26 |
2023-08-14 |
Not clear |