| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akansh Goal, Khadga Raj, Shamsher Singh, Rimpi Aror. Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice. Current research in neurobiology. vol 6. 2024-04-15. PMID:38616958. |
alzheimer's disease (ad) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. |
2024-04-15 |
2024-04-17 |
mouse |
| Huiru Zhao, Guiyu Lou, Yupu Shao, Tao Wang, Hongdan Wang, Qiannan Guo, Wenke Yang, Hongyan Liu, Shixiu Lia. Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome. Journal of molecular neuroscience : MN. vol 74. issue 2. 2024-03-27. PMID:38536538. |
this study aimed to identify hub genes and synergistic crosstalk among cernas in the ds fetal hippocampus as potential targets for the treatment of ds-related neurodegenerative diseases. |
2024-03-27 |
2024-03-30 |
Not clear |
| Terry L Davidson, Richard J Stevenso. Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396670. |
one purpose of this review is to assess the vulnerability of the hippocampus to the most prevalent types of insults in multiple biomedical domains (i.e., neuroactive pathogens, neurotoxins, neurological conditions, trauma, aging, neurodegenerative disease, acquired brain injury, mental health conditions, endocrine disorders, developmental disabilities, nutrition) and to evaluate whether these insults affect the hippocampus first and more prominently compared to other brain loci. |
2024-02-24 |
2024-02-26 |
Not clear |
| Yeon Kyeong Ko, Eunbi Kim, Eun-Jae Lee, Soo Jeong Nam, Yeshin Kim, Seongheon Kim, Se-Young Choi, Hyun Young Kim, Youngnim Cho. Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer's disease patients. PloS one. vol 19. issue 2. 2024-02-10. PMID:38335187. |
alzheimer's disease (ad) is a neurodegenerative disease accompanied by neuroimmune inflammation in the frontal cortex and hippocampus. |
2024-02-10 |
2024-02-12 |
human |
| Masatake Fujimura, Takamitsu Unok. BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance. Environmental toxicology. 2024-02-07. PMID:38323385. |
methylmercury (mehg) causes selective neuronal damage to cerebrocortical neurons (ccns) in the central nervous system, but not to hippocampal neurons (hins), which are highly vulnerable to neurodegenerative diseases. |
2024-02-07 |
2024-02-09 |
rat |
| Ji-Yun Kang, Ji-Yeon Gu, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Le. A Food & function. 2024-02-02. PMID:38305768. |
a the hippocampal memory deficit stands out as a primary symptom in neurodegenerative diseases, including alzheimer's disease. |
2024-02-02 |
2024-02-04 |
Not clear |
| Lucas Gephine, Candice M Roux, Thomas Freret, Michel Boulouard, Marianne Lege. Vulnerability of Spatial Pattern Separation in 5xFAD Alzheimer's Disease Mouse Model. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306047. |
this age-related neurodegenerative disease is characterized by an early decline in episodic and spatial memory associated with progressive disruption of the hippocampal functioning. |
2024-02-02 |
2024-02-04 |
mouse |
| Micaela Gliozzi, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Stefano Ruga, Federica Scarano, Francesca Bosco, Lorenza Guarnieri, Roberta Macrì, Rocco Mollace, Catherine Belzung, Vincenzo Mollac. The dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: role of kynurenine catabolism. Pharmacological research. 2024-02-01. PMID:38301816. |
the comprehension of these mechanisms can open novel perspectives in the management of diabetic/depressed patients, but also in the understanding the pathogenesis of other neurodegenerative disease characterized by the compromission of hippocampal function. |
2024-02-01 |
2024-02-04 |
mouse |
| Kaden L Nystuen, Shannon M McNamee, Monica Akula, Kristina M Holton, Margaret M DeAngelis, Neena B Haide. Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments. Bioengineering (Basel, Switzerland). vol 11. issue 1. 2024-01-22. PMID:38247923. |
alzheimer's disease (ad) is a complex neurodegenerative disease resulting in progressive loss of memory, language and motor abilities caused by cortical and hippocampal degeneration. |
2024-01-22 |
2024-01-24 |
Not clear |
| Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qi. Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration. Neuropharmacology. 2024-01-05. PMID:38181970. |
aside from abnormal accumulation of l-isoasp, pimt knockout (ko) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (nds), including alzheimer's disease (ad) and related dementias, and parkinson's disease (pd). |
2024-01-05 |
2024-01-08 |
mouse |
| Wenxue Liu, Min Jia, Keyin Zhang, Jiang Chen, Xiyu Zhu, Ruisha Li, Zhenjun Xu, Yanyu Zang, Yapeng Wang, Jun Pan, Daqing Ma, Jianjun Yang, Dongjin Wan. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. Aging cell. 2023-12-29. PMID:38155547. |
although increased a1 astrocytes and abnormal hippocampal networks are involved in neurodegenerative diseases, whether a1 astrocytes and hippocampal network changes are involved in the delirium-like behavior of aged mice remains unknown. |
2023-12-29 |
2023-12-31 |
mouse |
| Zhi Chen, Chunyan Ao, Yan Liu, Yue Yang, Ying Liu, Qian Ming, Changzhe Li, Hua Zhao, Jiaqi Ban, Jun L. Manganese induces oxidative damage in the hippocampus by regulating the expression of oxidative stress-related genes via modulation of H3K18 acetylation. Environmental toxicology. 2023-12-22. PMID:38129942. |
prolonged exposure to manganese (mn) contributes to hippocampal mn accumulation, which leads to neurodegenerative diseases called manganese poisoning. |
2023-12-22 |
2023-12-24 |
rat |
| Lubna H Tahtamouni, Sydney A Alderfer, Thomas B Kuhn, Laurie S Minamide, Soham Chanda, Michael R Ruff, James R Bambur. Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001943. |
cofilactin rod pathology, which can initiate synapse loss, has been extensively studied in rodent neurons, hippocampal slices, and in vivo mouse models of human neurodegenerative diseases such as alzheimer's disease (ad). |
2023-11-25 |
2023-11-28 |
mouse |
| Yiqin Ji, Wanbo Huang, Yijun Chen, Xincai Zhang, Fan Wu, Wan Tang, Zihui Lu, Changshun Huan. Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice. Brain research bulletin. 2023-11-08. PMID:37939860. |
the inhibition of matrix metalloproteinases (mmps) has shown potential potential in the treatment of various neurodegenerative diseases, and perioperative neurocognitive disorders (pnd) is accompanied by the increased expression of mmp-2 and mmp-9 in the hippocampus. |
2023-11-08 |
2023-11-20 |
mouse |
| R M Aljarar. Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat. Brazilian journal of biology = Revista brasleira de biologia. vol 83. 2023-10-20. PMID:37851769. |
alzheimer's disease (ad) is the most common neurodegenerative disease characterized by hippocampal, and cortical neuron deterioration, oxidative stress, and severe cognitive dysfunction. |
2023-10-20 |
2023-11-08 |
rat |
| Yi-Ju Lee, Sin-Rong Chen, Ping-En Ko, Mon-Yuan Yang, Meng-Hsuin Yu, Chau-Jong Wang, Huei-Jane Le. Quercetin-3-O-β-d-glucuronide in the Nuciferine Leaf Polyphenol Extract Promotes Neurogenesis Involving the Upregulation of the Tropomyosin Receptor Kinase (Trk) Receptor and AKT/Phosphoinositide 3-Kinase Signaling Pathway. Journal of agricultural and food chemistry. 2023-10-11. PMID:37819167. |
the impairment of hippocampal neurogenesis in adults may lead to neurodegenerative disease, such as alzheimer's disease. |
2023-10-11 |
2023-10-15 |
human |
| Daniele Lana, Giada Magni, Elisa Landucci, Gary L Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannin. Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761971. |
phenomic microglia diversity as a druggable target in the hippocampus in neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
rat |
| Yang Liu, Wen Guo, Si-Lu Hon. Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D-galactose-induced aging mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 10. 2023-09-28. PMID:37768886. |
in the present study, we investigated the impact of aerobic exercise on hippocampal neuronal apoptosis in aging mice and the potential involvement of dapk1 and its downstream pathways based on recent data that dapk1 may be associated with neuronal death in neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
mouse |
| Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T Sutherland, Mark Larance, Anthony S Do. The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus. Molecular neurodegeneration. vol 18. issue 1. 2023-09-19. PMID:37726834. |
the hippocampus was chosen as it is highly susceptible to atrophy with ageing and in several neurodegenerative diseases. |
2023-09-19 |
2023-10-07 |
human |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |