| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ram Kumar Manthari, Prathyusha Koyya, Santhi Latha Pandrang. Brain-Derived Neurotrophic Factor - The Protective Agent Against Neurological Disorders. CNS & neurological disorders drug targets. 2023-06-08. PMID:37287291. |
a growing body of literature reveals that most neurodegenerative diseases could be due to the gradual failure of neurons in the brain's neocortex, hippocampus, and various subcortical areas. |
2023-06-08 |
2023-08-14 |
Not clear |
| Robyn M Busch, Lamis Yehia, Ingmar Blümcke, Bo Hu, Richard Prayson, Bruce P Hermann, Imad M Najm, Charis En. Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy. Brain communications. vol 4. issue 6. 2022-11-24. PMID:36419965. |
several proteins associated with neurodegenerative disease were overexpressed in the neocortex of patients with impaired memory, corroborating our prior findings using bulk transcriptomics. |
2022-11-24 |
2023-08-14 |
Not clear |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. |
2022-09-24 |
2023-08-14 |
Not clear |
| Md Nabiul Islam, Yukio Takeshita, Akie Yanai, Amami Imagawa, Mir Rubayet Jahan, Greggory Wroblewski, Joe Nemoto, Ryutaro Fujinaga, Koh Shinod. Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor. Neuroscience. vol 340. 2017-11-06. PMID:27984179. |
in normal brains, it is abundantly expressed particularly in the limbic-hypothalamic regions that tend to be spared from neurodegeneration, whereas the areas with little hap1 expression, including the striatum, thalamus, cerebral neocortex and cerebellum, are targets in several neurodegenerative diseases. |
2017-11-06 |
2023-08-13 |
rat |
| Xianlong Wang, Chunwei Cao, Jiaojiao Huang, Jing Yao, Tang Hai, Qiantao Zheng, Xiao Wang, Hongyong Zhang, Guosong Qin, Jinbo Cheng, Yanfang Wang, Zengqiang Yuan, Qi Zhou, Hongmei Wang, Jianguo Zha. One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system. Scientific reports. vol 6. 2016-12-27. PMID:26857844. |
pig shows multiple superior characteristics in anatomy, physiology, and genome that have made this species to be more suitable models for human diseases, especially for neurodegenerative diseases, because they have similar cerebral convolutions compared with human neocortex. |
2016-12-27 |
2023-08-13 |
human |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
alzheimer's disease (ad) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. |
2014-06-24 |
2023-08-12 |
Not clear |
| J J Rodríguez, H N Noristani, T Hilditch, M Olabarria, C Y Yeh, J Witton, A Verkhratsk. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. Neuroscience letters. vol 552. 2014-05-15. PMID:23827221. |
alzheimer's disease (ad) is an irreversible neurodegenerative disease that is characterised by the presence of β-amyloid (aβ) plaques, neurofibrillary tangles (nfts) and synaptic loss specifically in brain regions involved in learning and memory such as the neocortex and the hippocampus. |
2014-05-15 |
2023-08-12 |
mouse |
| José Julio Rodríguez, Harun N Noristani, Alexei Verkhratsk. The serotonergic system in ageing and Alzheimer's disease. Progress in neurobiology. vol 99. issue 1. 2013-07-10. PMID:22766041. |
alzheimer's disease (ad) is one of the major neurodegenerative diseases that deteriorates cognitive functions and primarily affects associated brain regions involved in learning and memory, such as the neocortex and the hippocampus. |
2013-07-10 |
2023-08-12 |
Not clear |
| Anhar Hassan, Jennifer L Whitwell, Bradley F Boeve, Clifford R Jack, Joseph E Parisi, Dennis W Dickson, Keith A Joseph. Symmetric corticobasal degeneration (S-CBD). Parkinsonism & related disorders. vol 16. issue 3. 2010-05-24. PMID:20018548. |
corticobasal degeneration (cbd) is a neurodegenerative disease characterized pathologically by neuronal loss, gliosis and tau deposition in neocortex, basal ganglia and brainstem. |
2010-05-24 |
2023-08-12 |
Not clear |
| Sanjeev Chawla, Sumei Wang, Peachie Moore, John H Woo, Lauren Elman, Leo F McCluskey, Elias R Melhem, Murray Grossman, Harish Poptan. Quantitative proton magnetic resonance spectroscopy detects abnormalities in dorsolateral prefrontal cortex and motor cortex of patients with frontotemporal lobar degeneration. Journal of neurology. vol 257. issue 1. 2010-03-09. PMID:19688233. |
frontotemporal lobar degeneration (ftld) is a neurodegenerative disease of the frontal and temporal neocortex. |
2010-03-09 |
2023-08-12 |
Not clear |
| Melissa Ray, Iwo Bohr, J Michael McIntosh, Clive Ballard, Ian McKeith, Sylvie Chalon, Denis Guilloteau, Robert Perry, Elaine Perry, J A Court, Margaret Piggot. Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum. Neuroscience letters. vol 372. issue 3. 2005-01-05. PMID:15542244. |
dementia with lewy bodies (dlb) is a neurodegenerative disease associated with a range of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine receptors (nachrs) in neocortex, hippocampus, thalamus and basal ganglia. |
2005-01-05 |
2023-08-12 |
Not clear |
| Lisa A Catapano, Paola Arlotta, Tene A Cage, Jeffrey D Mackli. Stage-specific and opposing roles of BDNF, NT-3 and bFGF in differentiation of purified callosal projection neurons toward cellular repair of complex circuitry. The European journal of neuroscience. vol 19. issue 9. 2004-06-14. PMID:15128396. |
cellular repair of neuronal circuitry affected by neurodegenerative disease or injury may be approached in the adult neocortex via transplantation of neural precursors ("neural stem cells") or via molecular manipulation and recruitment of new neurons from endogenous precursors in situ. |
2004-06-14 |
2023-08-12 |
mouse |
| Pascale Piolino, Béatrice Desgranges, Serge Belliard, Vanessa Matuszewski, Catherine Lalevée, Vincent De la Sayette, Francis Eustach. Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases. Brain : a journal of neurology. vol 126. issue Pt 10. 2003-11-06. PMID:12821510. |
in order to test these models, we studied three groups of patients with a neurodegenerative disease predominantly affecting different cerebral structures namely the mtl (13 patients in the early stages of alzheimer's disease) and the neocortex involving either the anterior temporal lobe (10 patients with semantic dementia) or the frontal lobe (15 patients with the frontal variant of frontotemporal dementia, fv-ftd). |
2003-11-06 |
2023-08-12 |
human |
| E Y Snyder, C Yoon, J D Flax, J D Mackli. Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 21. 1997-11-24. PMID:9326667. |
because photolytic degeneration simulates some mechanisms underlying apoptotic neurodegenerative diseases, these results also suggest the possibility of neural precursor transplantation as a potential cell replacement or molecular support therapy for some diseases of neocortex, even in the adult. |
1997-11-24 |
2023-08-12 |
mouse |
| L F Agnati, P Cortelli, R Pettersson, K Fux. The concept of trophic units in the central nervous system. Progress in neurobiology. vol 46. issue 6. 1996-02-13. PMID:8545544. |
the concept of trophic unit may help to understand some features of neurodegenerative diseases, for example, the clustering of tangles in the neocortex and in the entorhinal cortex of alzheimer's patients [corrected]. |
1996-02-13 |
2023-08-12 |
Not clear |
| D M Armstrong, S LeRoy, D Shields, R D Terr. Somatostatin-like immunoreactivity within neuritic plaques. Brain research. vol 338. issue 1. 1985-10-03. PMID:2862952. |
alzheimer's disease or senile dementia of the alzheimer type (sdat) is a progressive neurodegenerative disease that is characterized pathologically by two types of microscopic lesions in the neocortex: the neurofibrillary tangle and neuritic plaque. |
1985-10-03 |
2023-08-11 |
Not clear |