| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-quan Lü, Yi-cheng L. [Myelin associated inhibitors and regeneration of optic nerve]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 42. issue 9. 2007-03-20. PMID:17173755. |
blocking the inhibitors and their receptors or changing the intrinsic state of the neuron to overcome the inhibition may promote retinal ganglion cell axonal regeneration after optic nerve injury, which bring a hope to solve the problem of repair of injured optic nerve. |
2007-03-20 |
2023-08-12 |
Not clear |
| Hou-bin Huang, Zhi-zhong Ma, Mao-nian Zhan. [Regeneration of optic nerve fibers following graded injuries in rats]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 42. issue 3. 2007-03-06. PMID:16643759. |
to investigate the changes of retinal ganglion cell (rgc) and their axons, and nerve regeneration ability following graded optic nerve injury (oni) in rats. |
2007-03-06 |
2023-08-12 |
rat |
| Simone G Leaver, Qi Cui, Ora Bernard, Alan R Harve. Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice. The European journal of neuroscience. vol 24. issue 12. 2007-03-06. PMID:17229081. |
we used a gene therapy approach in transgenic mice to assess the cooperative effects of combining anti-apoptotic and growth-promoting stimuli on adult retinal ganglion cell (rgc) survival and axonal regeneration following intraorbital optic nerve injury. |
2007-03-06 |
2023-08-12 |
mouse |
| Zahidul Karim, Akira Sawada, Hideaki Kawakami, Tetsuya Yamamoto, Takazumi Taniguch. A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat. Current eye research. vol 31. issue 3. 2006-05-04. PMID:16531285. |
a new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat. |
2006-05-04 |
2023-08-12 |
rat |
| Xiao Liu, Elizabeth Hawkes, Tatsuto Ishimaru, Tony Tran, David W Sretava. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554460. |
here, we investigated axonal plasticity after optic nerve injury and found that macrophages recruited into the injury site and adult retinal ganglion cell (rgc) axons, which undergo injury-induced sprouting and terminal remodeling, were linked by their respective expression of a ligand and receptor pair active in axon guidance. |
2006-04-14 |
2023-08-12 |
Not clear |
| Cheng-Wu Zhang, Qiang Lu, Si-Wei You, Ye Zhi, Henry K Yip, Wutian Wu, Kwok-Fai So, Qi Cu. CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury. Investigative ophthalmology & visual science. vol 46. issue 4. 2005-05-12. PMID:15790921. |
cntf and bdnf have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury. |
2005-05-12 |
2023-08-12 |
Not clear |
| Katarzyna Kotulska, Joanna Lewin-Kowalik, Barski Jaroslaw-Jerzy, Magdalena Larysz-Brysz, Wiesław Marcol, Zbigniew Fu. Bcl-2 deficiency deprives peripheral nerves of neurotrophic activity against injured optic nerve. Journal of neuroscience research. vol 73. issue 6. 2003-10-14. PMID:12949911. |
optic nerve injury leads to retinal ganglion cell apoptosis, thus preventing fiber regeneration. |
2003-10-14 |
2023-08-12 |
mouse |
| Hana Levkovitch-Verbin, Harry A Quigley, Keith R G Martin, Donald J Zack, Mary Ellen Pease, Danielle F Valent. A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Investigative ophthalmology & visual science. vol 44. issue 8. 2003-08-11. PMID:12882786. |
to use a rat model of optic nerve injury to differentiate primary and secondary retinal ganglion cell (rgc) injury. |
2003-08-11 |
2023-08-12 |
rat |
| Jonathan Kipnis, Tal Mizrahi, Ehud Hauben, Iftach Shaked, Ethan Shevach, Michal Schwart. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 24. 2003-01-14. PMID:12429857. |
here we show that this ability, assessed by retinal ganglion cell survival after optic nerve injury or locomotor activity after spinal cord contusion, is decreased if the animals were immunized as neonates with myelin proteins (resulting in their nonresponsiveness as adults to myelin proteins) or injected with naturally occurring regulatory cd4(+)cd25(+) t cells immediately after the injury, and is improved by elimination of these regulatory t cells. |
2003-01-14 |
2023-08-12 |
mouse |
| An-Guor Wang, Chia-Ming Lee, Yu-Chuan Wang, Chi-Hung Lin, Ming-Ji Fan. Up-regulation of cytochrome oxidase in the retina following optic nerve injury. Experimental eye research. vol 74. issue 5. 2002-08-20. PMID:12076086. |
in conclusion, both the expression of cox1 mrna in retina and the activity of cox in inner plexiform layer and retinal ganglion cell layer were elevated following optic nerve injury without affecting total retinal mitochondrial mass. |
2002-08-20 |
2023-08-12 |
mouse |
| Hao Chen, Arthur J Webe. Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor. Glia. vol 38. issue 2. 2002-05-30. PMID:11948805. |
müller glia play an important role in maintaining retinal homeostasis, and brain-derived neurotrophic factor (bdnf) has proven to be an effective retinal ganglion cell (rgc) neuroprotectant following optic nerve injury. |
2002-05-30 |
2023-08-12 |
rat |
| J Kipnis, E Yoles, H Schori, E Hauben, I Shaked, M Schwart. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 13. 2001-07-26. PMID:11425884. |
moreover, the rate of retinal ganglion cell survival was higher when the optic nerve injury was preceded by an unrelated cns (spinal cord) injury in the resistant strains but not in the susceptible strains. |
2001-07-26 |
2023-08-12 |
mouse |
| E Yoles, E Hauben, O Palgi, E Agranov, A Gothilf, A Cohen, V Kuchroo, I R Cohen, H Weiner, M Schwart. Protective autoimmunity is a physiological response to CNS trauma. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 11. 2001-06-21. PMID:11356861. |
(4) retinal ganglion cell survival after optic nerve injury was higher (119 +/- 3.7%) in transgenic mice overexpressing a t cell receptor (tcr) for mbp and lower (85 +/- 1.3%) in mice overexpressing a t cell receptor for the non-self antigen ovalbumin than in matched wild types. |
2001-06-21 |
2023-08-12 |
mouse |
| M R Kreutz, A Bien, C K Vorwerk, T M Böckers, C I Seidenbecher, W Tischmeyer, B A Sabe. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Brain research. Molecular brain research. vol 69. issue 2. 1999-08-03. PMID:10366744. |
optic nerve injury led exclusively to the upregulation of c-jun, with cellular label indicative for c-jun mrna in the retinal ganglion cell layer after two days, three days and one week post-injury. |
1999-08-03 |
2023-08-12 |
rat |
| A Bien, C I Seidenbecher, T M Böckers, B A Sabel, M R Kreut. Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. Journal of neurotrauma. vol 16. issue 2. 1999-06-22. PMID:10098960. |
apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. |
1999-06-22 |
2023-08-12 |
Not clear |
| A Bien, C I Seidenbecher, T M Böckers, B A Sabel, M R Kreut. Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. Journal of neurotrauma. vol 16. issue 2. 1999-06-22. PMID:10098960. |
we have investigated time course and characteristics of retinal ganglion cell (rgc) death after partial optic nerve injury. |
1999-06-22 |
2023-08-12 |
Not clear |
| L A Wheeler, R Lai, E Woldemussi. From the lab to the clinic: activation of an alpha-2 agonist pathway is neuroprotective in models of retinal and optic nerve injury. European journal of ophthalmology. vol 9 Suppl 1. 1999-06-07. PMID:10230601. |
the selective alpha-2 agonist brimonidine was used as a pharmacological probe to activate alpha 2 receptor-mediated neuroprotective signaling pathways and quantitate the enhancement of retinal ganglion cell survival and function in animals with ischemic retinal and optic nerve injury. |
1999-06-07 |
2023-08-12 |
Not clear |
| D M Lang, M Monzón-Mayor, C E Bandtlow, C A Stuerme. Retinal axon regeneration in the lizard Gallotia galloti in the presence of CNS myelin and oligodendrocytes. Glia. vol 23. issue 1. 1998-06-08. PMID:9562185. |
retinal ganglion cell (rgc) axons in lizards (reptiles) were found to regenerate after optic nerve injury. |
1998-06-08 |
2023-08-12 |
rat |
| H Gao, X Qiao, F Hefti, J G Hollyfield, B Knuse. Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. Investigative ophthalmology & visual science. vol 38. issue 9. 1997-09-15. PMID:9286274. |
elevated mrna expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. |
1997-09-15 |
2023-08-12 |
Not clear |
| U Schmitt, B A Sabe. MK-801 reduces retinal ganglion cell survival but improves visual performance after controlled optic nerve crush. Journal of neurotrauma. vol 13. issue 12. 1997-04-03. PMID:9002064. |
we therefore evaluated the role of excitotoxicity mediated by the nmda glutamate receptor subtype on retinal ganglion cell (rgc) survival and visual performance after optic nerve injury in adult rats. |
1997-04-03 |
2023-08-12 |
rat |