All Relations between Pantothenate Kinase-Associated Neurodegeneration and Cortical amygdalar area

Reference Sentence Publish Date Extraction Date Species
Luca Mignani, Daniela Zizioli, Deepak Khatri, Nicola Facchinello, Marco Schiavone, Giuseppe De Palma, Dario Finazz. Bi-Allelic Mutations in Zebrafish International journal of molecular sciences vol 23 issue 21 2022 36361705 sequence variations in pantothenate kinase 2 (pank2), the first enzyme of coa biosynthesis, are found in patients affected by pantothenate kinase associated neurodegeneration (pkan), one of the most common forms of neurodegeneration, with brain iron accumulation. 2022-11-11 2022-11-15 Not clear
Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizb\\xc3\\xa9 Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Straus. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS chemical biology vol 16 issue 11 2021 34582681 the pantothenate analogue hopantenate (hopan) is widely used as a modulator of coenzyme a (coa) levels in cell biology and disease models\xe2\x94\x80especially for pantothenate kinase associated neurodegeneration (pkan), a genetic disease rooted in impaired coa metabolism. 2022-01-31 2022-01-13 Not clear
Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizb\\xc3\\xa9 Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Straus. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS chemical biology vol 16 issue 11 2021 34582681 the pantothenate analogue hopantenate (hopan) is widely used as a modulator of coenzyme a (coa) levels in cell biology and disease models\xe2\x94\x80especially for pantothenate kinase associated neurodegeneration (pkan), a genetic disease rooted in impaired coa metabolism. 2021-11-23 2022-01-13 Not clear
Chitra Subramanian, Jiangwei Yao, Matthew W Frank, Charles O Rock, Suzanne Jackowsk. A pantothenate kinase-deficient mouse model reveals a gene expression program associated with brain coenzyme a reduction. Biochimica et biophysica acta. Molecular basis of disease vol 1866 issue 5 2020 31918006 the differential expression of the four-active mammalian pank isoforms regulates coa levels in different tissues and pank2 mutations lead to pantothenate kinase associated neurodegeneration (pkan). 2020-10-27 2022-01-13 Not clear
Daniela Zizioli, Natascia Tiso, Adele Guglielmi, Claudia Saraceno, Giorgia Busolin, Roberta Giuliani, Deepak Khatri, Eugenio Monti, Giuseppe Borsani, Francesco Argenton, Dario Finazz. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Neurobiology of disease vol 85 issue 2016 26476142 pantothenate kinase associated neurodegeneration (pkan) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (pank2), encoding an essential enzyme for coenzyme a (coa) biosynthesis. 2016-09-21 2022-01-12 Not clear
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