| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Merve Direktor, Peter Gass, Dragos Int. Understanding the therapeutic action of antipsychotics: from molecular to cellular targets with focus on the islands of Calleja. The international journal of neuropsychopharmacology. 2024-04-17. PMID:38629703. |
here we discuss results suggesting a main role of the islands of calleja, still poorly studied gabaergic granule cell clusters in the ventral striatum, as cellular targets of several innovative atypical antipsychotics (clozapine, cariprazine and xanomeline/emraclidine) effective in treating also negative symptoms of schizophrenia. |
2024-04-17 |
2024-04-19 |
Not clear |
| Agata Zięba, Damian Bartuzi, Piotr Stępnicki, Dariusz Matosiuk, Tomasz M Wróbel, Tuomo Laitinen, Marián Castro, Agnieszka Anna Kaczo. Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening. ChemMedChem. 2024-04-15. PMID:38619283. |
ligands of this protein, particularly atypical antipsychotics, are useful in the treatment of numerous mental disorders, including schizophrenia and major depressive disorder. |
2024-04-15 |
2024-04-17 |
Not clear |
| Justina A Warnick, Rachel I Gifeisman, Khevna P Joshi, Sophie A Roe, Rick A Hiciano, Christopher P Conroy, Sohrab Zahed. Dual Atypical Antipsychotics in Treatment-Resistant Schizophrenia: A Correctional Case Report and Review of Literature. Journal of correctional health care : the official journal of the National Commission on Correctional Health Care. 2024-04-02. PMID:38563618. |
dual atypical antipsychotics in treatment-resistant schizophrenia: a correctional case report and review of literature. |
2024-04-02 |
2024-04-04 |
Not clear |
| Yong Zhao, Yifan Li, Jing Du, Chuanlong Fang, Wansheng Li, Mengyu Lv, Yue Wu, Kai Wang, Tingting Wu, Yanghua Tian, Juanjuan Zhan. Modulation of hemispheric asymmetry in executive control of attention in schizophrenia with atypical antipsychotic treatment: Potential benefits of olanzapine. Schizophrenia research. Cognition. vol 36. 2024-03-12. PMID:38469136. |
deficits in executive control of attention have been reported in schizophrenia patients, but can be ameliorated by treatment of atypical antipsychotics along with the symptoms. |
2024-03-12 |
2024-03-14 |
Not clear |
| Diana Siriwardena, Chahaya M Gauci, Ali Mohtashami, Sarit Badiani, Shahrir Kabi. Clozapine-Induced Refractory Colonic Pseudo-Obstruction. Cureus. vol 16. issue 2. 2024-03-04. PMID:38435172. |
the management of treatment-resistant schizophrenia (trs) is challenging as the medications involved, often atypical antipsychotics, have a host of associated adverse effects. |
2024-03-04 |
2024-03-06 |
Not clear |
| Sylvie Perreault, Laurie-Anne Boivin Proulx, Judith Brouillette, Stéphanie Jarry, Marc Dorai. Antipsychotics and Risks of Cardiovascular and Cerebrovascular Diseases and Mortality in Dwelling Community Older Adults. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399393. |
antipsychotics were not linked with cvd/cev risk, except for atypical antipsychotics in patients with schizophrenia and typical antipsychotics in patients with dementia. |
2024-02-24 |
2024-02-26 |
Not clear |
| b' Kristin Richards, Michael Johnsrud, Christopher Zacker, Rahul Sasan\\xc3\\xa. Association Between Persistence with Oral Atypical Antipsychotic Medications and Hospital and Emergency Department Utilization in Medicaid Patients with Schizophrenia. Patient preference and adherence. vol 18. 2024-01-23. PMID:38259956.' |
to examine 1-year persistence with oral atypical antipsychotics (oaaps) for medicaid patients with schizophrenia and assess the association between oaap persistence and hospital and emergency department (ed) resource utilization. |
2024-01-23 |
2024-01-25 |
Not clear |
| Yaoyao Zhang, Wei Tang, Bei Tang, Kaili Fan, Ke Zhao, Xinyu Fang, Hui Li. Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function. Frontiers in immunology. vol 14. 2024-01-18. PMID:38235140. |
altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function. |
2024-01-18 |
2024-01-20 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759688. |
considering the expressions of gaba-b and iii-mglu receptors (localised in the presynaptic regions), the activation of gaba-b and iii-mglu receptors can explain the distinct therapeutic advantages of clozapine in schizophrenia or trs associated with n-methyl-d-aspartate (nmda) receptor disturbance compared with other atypical antipsychotics via the inhibition of the persistent tonic hyperactivation of thalamocortical glutamatergic transmission in the prefrontal cortex. |
2023-09-28 |
2023-10-07 |
Not clear |
| Xinyu Fang, Chunying Gao, Weifeng Wu, Xiuxiu Hu, Miaomiao Shao, Chou Zhou, Renliang Cai, Jin Fang, Yi Li, Yue Xu, Xiangrong Zhan. The role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: Evidence based on altered composition and function in a cross-sectional study. Psychiatry research. vol 328. 2023-09-17. PMID:37717547. |
the role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: evidence based on altered composition and function in a cross-sectional study. |
2023-09-17 |
2023-10-07 |
Not clear |
| Soumitra Das, Annie Itrat, Mary Elizabeth Trejo Hernandez, Rasish Subedi, Thusanth Jogarajah, Sreshatha Vashist, Nikitha Daggal. Clozapine-induced eosinophilia: A case report. SAGE open medical case reports. vol 11. 2023-09-05. PMID:37667744. |
clozapine is one of the best atypical antipsychotics and is highly effective in treating treatment-resistant schizophrenia. |
2023-09-05 |
2023-09-07 |
Not clear |
| Hidekazu Sotoyam. Putative neural mechanisms underlying release-mode-specific abnormalities in dopamine neural activity in a schizophrenia-like model: The distinct roles of glutamate and serotonin in the impaired regulation of dopamine neurons. The European journal of neuroscience. 2023-08-23. PMID:37611917. |
these results provide an idea about the mechanism of dopamine disturbance in schizophrenia and may be informative in explaining the effects of atypical antipsychotics as distinct from those of typical drugs. |
2023-08-23 |
2023-09-07 |
Not clear |
| Yanlin Wang, Xiaofeng Wang, Frank Larsen, Dana Cahill, Argie Zoubroulis, Caroline Ward, Eva Kohegyi, Arash Raoufini. Population Pharmacokinetic Analysis of Brexpiprazole to Support its Indication and Dose Selection in Adolescents With Schizophrenia. Journal of clinical pharmacology. 2023-07-18. PMID:37461192. |
in order to accelerate pediatric drug development, the united states food and drug administration (fda) released a general advice letter to sponsors permitting the effectiveness of atypical antipsychotics for the treatment of schizophrenia in adults to be extrapolated to adolescents based on a pharmacokinetic (pk) analysis to support dose selection, plus a safety study. |
2023-07-18 |
2023-08-14 |
Not clear |
| Michal R Tomaszewski, Jun Meng, Hyking D Haley, Charles M Harrell, Terrence P Mcdonald, Corin O Miller, Sean M Smit. Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment. Journal of lipid research. 2023-07-02. PMID:37393952. |
weight gain is a common harmful side effect of atypical antipsychotics used for schizophrenia treatment. |
2023-07-02 |
2023-08-14 |
mouse |
| Avijeet S Chopra, Dusica Hadzi Boskovic, Amit Kulkarni, Jeffrey M Cochra. Cost-Effectiveness of Aripiprazole Tablets with Sensor versus Oral Atypical Antipsychotics for the Treatment of Schizophrenia Using a Patient-Level Microsimulation Modeling Approach. ClinicoEconomics and outcomes research : CEOR. vol 15. 2023-05-30. PMID:37252199. |
cost-effectiveness of aripiprazole tablets with sensor versus oral atypical antipsychotics for the treatment of schizophrenia using a patient-level microsimulation modeling approach. |
2023-05-30 |
2023-08-14 |
Not clear |
| Daria A Kamaeva, Daria V Kazantseva, Anastasiia S Boiko, Irina A Mednova, Liudmila P Smirnova, Elena G Kornetova, Svetlana A Ivanov. The Influence of Antipsychotic Treatment on the Activity of Abzymes Targeting Myelin and Levels of Inflammation Markers in Patients with Schizophrenia. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189796. |
the study included 40 patients with schizophrenia: 15 treated with first-generation antipsychotics and 25 treated with atypical antipsychotics for 6 weeks. |
2023-05-16 |
2023-08-14 |
Not clear |
| Gia Han Le, Emily S Gillissie, Taeho Greg Rhee, Bing Cao, Yazen Alnefeesi, Ziji Guo, Joshua D Di Vincenzo, Muhammad Youshay Jawad, Andrew M March, Ranuk Ramachandra, Leanna M W Lui, Roger S McIntyr. Efficacy, safety, and tolerability of ulotaront (SEP-363856, a trace amine-associated receptor 1 agonist) for the treatment of schizophrenia and other mental disorders with similar pathophysiology: a systematic review of preclinical and clinical trials. Expert opinion on investigational drugs. 2023-04-25. PMID:37096491. |
the classical approach to treat schizophrenia uses typical and atypical antipsychotics; however, limitations include low efficacy in mitigating negative symptoms and cognitive dysfunctions, and a range of adverse effects. |
2023-04-25 |
2023-08-14 |
Not clear |
| V V Tiguntsev, V I Gerasimova, E G Kornetova, O Yu Fedorenko, A N Kornetov, A A Goncharova, E G Poltavskaya, A S Boyk. [Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics]. Molekuliarnaia biologiia. vol 57. issue 1. 2023-03-28. PMID:36976738. |
[association of the level of serum prolactin with polymorphic variants of the grin2a, gpm3, and gpm7 genes in patients with schizophrenia taking conventional and atypical antipsychotics]. |
2023-03-28 |
2023-08-14 |
Not clear |
| V V Tiguntsev, V I Gerasimova, E G Kornetova, O Yu Fedorenko, A N Kornetov, A A Goncharova, E G Poltavskaya, A S Boyk. [Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics]. Molekuliarnaia biologiia. vol 57. issue 1. 2023-03-28. PMID:36976738. |
we formulated a hypothesis that polymorphic variants of the grin2a, grm3, and grm7 genes may be associated with the development of hyperprolactinemia in patients with schizophrenia taking conventional and atypical antipsychotics as basic treatment. |
2023-03-28 |
2023-08-14 |
Not clear |
| V V Tiguntsev, V I Gerasimova, E G Kornetova, O Yu Fedorenko, A N Kornetov, A A Goncharova, E G Poltavskaya, A S Boyk. [Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics]. Molekuliarnaia biologiia. vol 57. issue 1. 2023-03-28. PMID:36976738. |
an association of polymorphic variants of the grin2a, grm3, and grm7 genes with the development of hyperprolactinemia in patients with schizophrenia taking conventional and atypical antipsychotics has been established for the first time. |
2023-03-28 |
2023-08-14 |
Not clear |