| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
why do so many genetic insults lead to purkinje cell degeneration and spinocerebellar ataxia? |
2019-02-18 |
2023-08-13 |
Not clear |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
the genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive purkinje cell degeneration. |
2019-02-18 |
2023-08-13 |
Not clear |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
the main question that remains yet unsolved is why do some many genetic insults lead to purkinje cell degeneration and spinocerebellar ataxia? |
2019-02-18 |
2023-08-13 |
Not clear |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
in this review, we discuss the current consensus on shared mechanisms underlying the pervasive purkinje cell loss in spinocerebellar ataxia. |
2019-02-18 |
2023-08-13 |
Not clear |
| Etsuko Shimobayashi, Josef P Kapfhamme. Calcium Signaling, PKC Gamma, IP3R1 and CAR8 Link Spinocerebellar Ataxias and Purkinje Cell Dendritic Development. Current neuropharmacology. vol 16. issue 2. 2018-10-01. PMID:28554312. |
calcium signaling, pkc gamma, ip3r1 and car8 link spinocerebellar ataxias and purkinje cell dendritic development. |
2018-10-01 |
2023-08-13 |
Not clear |
| Rogier van der Stijl, Sebo Withoff, Dineke S Verbee. Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration. Neurobiology of disease. vol 108. 2018-07-23. PMID:28823930. |
spinocerebellar ataxia: mirnas expose biological pathways underlying pervasive purkinje cell degeneration. |
2018-07-23 |
2023-08-13 |
mouse |
| James M Dell'Orco, Stefan M Pulst, Vikram G Shakkotta. Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2. Human molecular genetics. vol 26. issue 20. 2018-03-05. PMID:29016852. |
potassium channel dysfunction underlies purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2. |
2018-03-05 |
2023-08-13 |
mouse |
| James M Dell'Orco, Stefan M Pulst, Vikram G Shakkotta. Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2. Human molecular genetics. vol 26. issue 20. 2018-03-05. PMID:29016852. |
in a mouse model of spinocerebellar ataxia type 2 (sca2), a progressive reduction in purkinje neuron firing frequency accompanies cell atrophy. |
2018-03-05 |
2023-08-13 |
mouse |
| Yu Miyazaki, Xiaofei Du, Shin-Ichi Muramatsu, Christopher M Gome. An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Science translational medicine. vol 8. issue 347. 2017-12-07. PMID:27412786. |
spinocerebellar ataxia type 6 (sca6) is a dominantly inherited neurodegenerative disease characterized by slowly progressive ataxia and purkinje cell degeneration. |
2017-12-07 |
2023-08-13 |
mouse |
| Jan Cendeli. Transplantation and Stem Cell Therapy for Cerebellar Degenerations. Cerebellum (London, England). vol 15. issue 1. 2016-10-21. PMID:26155762. |
in purkinje cell degeneration mice, lurcher mutant mice and mouse models of spinocerebellar ataxia type 1 and type 2 and niemann-pick disease type c. despite the lack of direct comparative studies, it appears that there might be differences in graft development and functioning between various types of cerebellar degeneration. |
2016-10-21 |
2023-08-13 |
mouse |
| Kenji Sakai, Chiho Ishida, Akiyoshi Morinaga, Kazuya Takahashi, Masahito Yamad. Case Study: Somatic Sprouts and Halo-Like Amorphous Materials of the Purkinje Cells in Huntington's Disease. Cerebellum (London, England). vol 14. issue 6. 2016-08-15. PMID:25962893. |
although this finding usually appeared in developmental brains, several neurodegenerative disorders, including menkes kinky hair disease, familial spinocerebellar ataxia, acute encephalopathy linked to familial hemiplegic migraine, and several other conditions, have been reported showing sprouting from the soma of purkinje cell. |
2016-08-15 |
2023-08-13 |
Not clear |
| Tomonori Aikawa, Kaoru Mogushi, Kumiko Iijima-Tsutsui, Kinya Ishikawa, Miyano Sakurai, Hiroshi Tanaka, Hidehiro Mizusawa, Kei Watas. Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. Human molecular genetics. vol 24. issue 17. 2016-05-11. PMID:26034136. |
loss of myd88 alters neuroinflammatory response and attenuates early purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. |
2016-05-11 |
2023-08-13 |
mouse |
| Gülin Öz, Emily Kittelson, Döne Demirgöz, Orion Rainwater, Lynn E Eberly, Harry T Orr, H Brent Clar. Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology. Neurobiology of disease. vol 74. 2016-01-06. PMID:25446943. |
suppression of transgene expression in a conditional transgenic mouse model of spinocerebellar ataxia 1 (sca1) reverses the purkinje cell pathology and motor dysfunction that are hallmarks of sca1. |
2016-01-06 |
2023-08-13 |
mouse |
| Cleo J L M Smeets, Justyna Jezierska, Hiroyuki Watanabe, Anna Duarri, Michiel R Fokkens, Michel Meijer, Qin Zhou, Tania Yakovleva, Erik Boddeke, Wilfred den Dunnen, Jan van Deursen, Georgy Bakalkin, Harm H Kampinga, Bart van de Sluis, Dineke S Verbee. Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26169942. |
elevated mutant dynorphin a causes purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. |
2015-11-16 |
2023-08-13 |
mouse |
| James M Dell'Orco, Aaron H Wasserman, Ravi Chopra, Melissa A C Ingram, Yuan-Shih Hu, Vikrant Singh, Heike Wulff, Puneet Opal, Harry T Orr, Vikram G Shakkotta. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269637. |
in a mouse model of the polyglutamine disorder spinocerebellar ataxia type 1 (sca1), we tested the hypothesis that cerebellar purkinje neuron atrophy serves an adaptive role rather than being simply a nonspecific response to injury. |
2015-11-05 |
2023-08-13 |
mouse |
| Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. |
recently, we identified loss-of-function mutations in the kcnd3 gene as the cause of spinocerebellar ataxia type 19/22 (sca19/22), revealing a previously unknown role for the voltage-gated potassium channel, kv4.3, in purkinje cell survival. |
2015-10-29 |
2023-08-13 |
Not clear |
| Katherine E Hekman, Christopher M Gome. The autosomal dominant spinocerebellar ataxias: emerging mechanistic themes suggest pervasive Purkinje cell vulnerability. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 5. 2015-06-22. PMID:25136055. |
the autosomal dominant spinocerebellar ataxias: emerging mechanistic themes suggest pervasive purkinje cell vulnerability. |
2015-06-22 |
2023-08-13 |
Not clear |
| Katherine E Hekman, Christopher M Gome. The autosomal dominant spinocerebellar ataxias: emerging mechanistic themes suggest pervasive Purkinje cell vulnerability. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 5. 2015-06-22. PMID:25136055. |
the spinocerebellar ataxias are a genetically heterogeneous group of disorders with clinically overlapping phenotypes arising from purkinje cell degeneration, cerebellar atrophy and varying degrees of degeneration of other grey matter regions. |
2015-06-22 |
2023-08-13 |
Not clear |
| Filippo Tempia, Eriola Hoxha, Giulia Negro, Musaad A Alshammari, Tahani K Alshammari, Neli Panova-Elektronova, Fernanda Laezz. Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27. Frontiers in cellular neuroscience. vol 9. 2015-06-19. PMID:26089778. |
parallel fiber to purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27. |
2015-06-19 |
2023-08-13 |
mouse |
| Jingmin Ji, Melanie L Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P Kapfhamme. Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. Neurobiology of disease. vol 70. 2015-04-21. PMID:24937631. |
increased protein kinase c gamma activity induces purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. |
2015-04-21 |
2023-08-13 |
mouse |