| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Bernard, I A Kerman, R C Thompson, E G Jones, W E Bunney, J D Barchas, A F Schatzberg, R M Myers, H Akil, S J Watso. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Molecular psychiatry. vol 16. issue 6. 2011-09-19. PMID:20386568. |
the locus coeruleus (lc) is the primary source of extensive noradrenergic innervation of the forebrain and as such exerts a powerful regulatory role over cognitive and affective functions, which are dysregulated in mdd. |
2011-09-19 |
2023-08-12 |
human |
| Matthew W Hale, Kathleen F Dady, Andrew K Evans, Christopher A Lowr. Evidence for in vivo thermosensitivity of serotonergic neurons in the rat dorsal raphe nucleus and raphe pallidus nucleus implicated in thermoregulatory cooling. Experimental neurology. vol 227. issue 2. 2011-02-14. PMID:21111735. |
together, these results provide evidence for multiple but anatomically discrete thermosensitive serotonergic systems that may have implications for the regulation of body temperature, as well as, via projections to forebrain targets, cognitive and affective functions. |
2011-02-14 |
2023-08-12 |
rat |
| J M Sprague, W W Chambers, E Stella. Attentive, Affective, and Adaptive Behavior in the Cat: Sensory deprivation of the forebrain by lesions in the brain stem results in striking behavioral abnormalities. Science (New York, N.Y.). vol 133. issue 3447. 2010-07-02. PMID:17819594. |
attentive, affective, and adaptive behavior in the cat: sensory deprivation of the forebrain by lesions in the brain stem results in striking behavioral abnormalities. |
2010-07-02 |
2023-08-12 |
mouse |
| B Meyers, A D'Agostino, J Walker, M F Kritze. Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19909795. |
sex differences and gonadal hormone influences are well known for diverse aspects of forebrain amine and indolamine neurotransmitter systems, the cognitive and affective functions they govern and their malfunction in mental illness. |
2010-03-08 |
2023-08-12 |
mouse |
| Jason J Radley, Kristin L Gosselink, Paul E Sawchenk. A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 22. 2009-06-22. PMID:19494154. |
complementing its roles in cognitive and affective information processing, the medial prefrontal cortex (mpfc) is a nodal point of a limbic forebrain circuit that modulates stress-related homeostatic mechanisms, including the hypothalamic-pituitary-adrenal (hpa) axis. |
2009-06-22 |
2023-08-12 |
Not clear |
| Saturnino Spiga, Alessandra Lintas, Marco Dian. Addiction and cognitive functions. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991875. |
the major elements of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie enduring changes in a number of forebrain circuits (involving the ventral striatum and prefrontal cortex) that receive input from midbrain dopamine neurons and are involved in affective and cognitive mechanisms, respectively. |
2008-12-09 |
2023-08-12 |
human |
| Rajesh Kumar, Paul M Macey, Mary A Woo, Jeffry R Alger, Ronald M Harpe. Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatric research. vol 64. issue 3. 2008-11-12. PMID:18458651. |
congenital central hypoventilation syndrome (cchs) patients show reduced breathing drive during sleep, decreased hypoxic and hypercapnic ventilatory responses, and autonomic and affective deficits, suggesting both brainstem and forebrain injuries. |
2008-11-12 |
2023-08-12 |
Not clear |
| Suriyaphun S Mungarndee, Robert F Lundy, Ralph Norgre. Expression of Fos during sham sucrose intake in rats with central gustatory lesions. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 3. 2008-10-17. PMID:18635449. |
thus ventral forebrain areas associated with affective responses appear to be activated directly by pbn gustatory neurons rather than via the thalamocortical taste system. |
2008-10-17 |
2023-08-12 |
rat |
| Aaron M Rozeboom, Huda Akil, Audrey F Seasholt. Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 11. 2007-05-14. PMID:17360585. |
these data suggest that the functions of forebrain mr may overlap with gr in hypothalamic-pituitary-adrenal axis regulation, but they dissociate significantly from gr in the modulation of affective responses, with gr overexpression increasing anxiety-like behavior and mr overexpression dampening it. |
2007-05-14 |
2023-08-12 |
mouse |
| Elisabeth Petrasch-Parwez, Huu-Phuc Nguyen, Marlen Löbbecke-Schumacher, Hans-Werner Habbes, Stefan Wieczorek, Olaf Riess, Karl-Hermann Andres, Rolf Dermietzel, Stephan Von Hörste. Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease. The Journal of comparative neurology. vol 501. issue 5. 2007-04-27. PMID:17299753. |
in conclusion, the tghd rat model reflects to a remarkable extent the cellular and subcellular neuropathological key features as observed in human hd and hd mouse brains and hints of changes in limbic forebrain systems, which may elucidate the emotional dysfunction in the tghd rat and affective disturbances in hd patients. |
2007-04-27 |
2023-08-12 |
mouse |
| Juan A Mico, Esther Berrocoso, Antonio Ortega-Alvaro, Juan Gibert-Rahola, M Olga Rojas-Corrale. The role of 5-HT1A receptors in research strategy for extensive pain treatment. Current topics in medicinal chemistry. vol 6. issue 18. 2006-11-30. PMID:17017970. |
in particular, the raphe nuclei may play a crucial role in integrating the nociceptive and affective information through descending projections to the spinal cord and ascending projections to the forebrain. |
2006-11-30 |
2023-08-12 |
Not clear |
| A D Bud Crai. Forebrain emotional asymmetry: a neuroanatomical basis? Trends in cognitive sciences. vol 9. issue 12. 2006-02-09. PMID:16275155. |
there is considerable psychophysiological evidence to indicate that the left and right halves of the human forebrain differentially associate with particular emotions and affective traits. |
2006-02-09 |
2023-08-12 |
human |
| B He, S E Counts, S E Perez, J G Hohmann, J B Koprich, J W Lipton, R A Steiner, J N Crawley, E J Mufso. Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice. Neuroscience. vol 133. issue 2. 2005-08-30. PMID:15885921. |
moreover, there was evidence for ectopic neuronal gal expression in forebrain limbic regions that mediate cognitive and affective behaviors, including the piriform and entorhinal cortex and amygdala. |
2005-08-30 |
2023-08-12 |
mouse |
| Eleni T Tzavara, Frank P Bymaster, Richard J Davis, Mark R Wade, Kenneth W Perry, Jurgen Wess, David L McKinzie, Chris Felder, George G Nomiko. M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 12. 2005-04-05. PMID:15231726. |
dopaminergic neurons projecting from the midbrain to forebrain regions, such as the nucleus accumbens and the prefrontal cortex, regulate motor and cognitive functions and coordinate the patterned response of the organism to sensory, affective, and rewarding stimuli. |
2005-04-05 |
2023-08-12 |
mouse |
| J V BRADY, W J NAUT. Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat. Journal of comparative and physiological psychology. vol 46. issue 5. 2003-05-01. PMID:13109048. |
subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat. |
2003-05-01 |
2023-08-12 |
rat |
| L Carlstrom, Z J Ke, J R Unnerstall, R S Cohen, S C Pande. Estrogen modulation of the cyclic AMP response element-binding protein pathway. Effects of long-term and acute treatments. Neuroendocrinology. vol 74. issue 4. 2001-12-19. PMID:11598379. |
also, the influence of estrogen in the brain appears to extend well beyond areas associated with reproduction and may include forebrain areas linked to affective and cognitive behaviors. |
2001-12-19 |
2023-08-12 |
rat |
| A FERNANDEZ DE MOLINA, R W HUNSPERGE. Central representation of affective reactions in forebrain and brain stem: electrical stimulation of amygdala, stria terminalis, and adjacent structures. The Journal of physiology. vol 145. issue 2. 2000-07-01. PMID:13642299. |
central representation of affective reactions in forebrain and brain stem: electrical stimulation of amygdala, stria terminalis, and adjacent structures. |
2000-07-01 |
2023-08-12 |
Not clear |
| I M Rachman, J R Unnerstall, D W Pfaff, R S Cohe. Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 23. 1998-12-16. PMID:9811905. |
our results suggest that estrogen-induced neurochemical changes in forebrain neurons may translate into an altered behavioral output in the affective domain. |
1998-12-16 |
2023-08-12 |
rat |
| R W HUNSPERGE. [Affective behavior patterns elicited by electrical stimulation of the brain stem and forebrain]. Journal de physiologie. vol 55. 1998-11-01. PMID:13955736. |
[affective behavior patterns elicited by electrical stimulation of the brain stem and forebrain]. |
1998-11-01 |
2023-08-12 |
Not clear |
| K C Berridge, S Peciñ. Benzodiazepines, appetite, and taste palatability. Neuroscience and biobehavioral reviews. vol 19. issue 1. 1995-07-06. PMID:7770192. |
in studies of the effect of benzodiazepines on affective reactions that are naturally elicited from rats by tastes, we have shown that (a) benzodiazepines enhance hedonic taste palatability in a receptor-specific fashion; (b) the relevant receptors and the minimal neural circuitry required to mediate benzodiazepine-induced palatability enhancement both exist complete in the decerebrate brain stem; and (c) even in normal brains, receptors in the brain stem, not forebrain, are the primary substrate for the benzodiazepine-induced enhancement of taste palatability. |
1995-07-06 |
2023-08-12 |
human |