| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Hui Tang, Tingting You, Hui Ge, Jingxi Gao, Yingyi Wang, Chunmei Bai, Zhao Sun, Qin Han, Robert Chunhua Zha. Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma. International immunopharmacology. vol 133. 2024-04-14. PMID:38615380. |
anlotinib may enhance the efficacy of anti-pd1 therapy by inhibiting the akt pathway and promoting the apoptosis of cafs in lung adenocarcinoma. |
2024-04-14 |
2024-04-17 |
Not clear |
| Hui Tang, Tingting You, Hui Ge, Jingxi Gao, Yingyi Wang, Chunmei Bai, Zhao Sun, Qin Han, Robert Chunhua Zha. Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma. International immunopharmacology. vol 133. 2024-04-14. PMID:38615380. |
mechanistically, anlotinib affects caf apoptosis and cell viability at least in part by inhibiting the akt pathway. |
2024-04-14 |
2024-04-17 |
Not clear |
| Hui Tang, Tingting You, Hui Ge, Jingxi Gao, Yingyi Wang, Chunmei Bai, Zhao Sun, Qin Han, Robert Chunhua Zha. Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma. International immunopharmacology. vol 133. 2024-04-14. PMID:38615380. |
in conclusion, our study suggested that anlotinib could regulate the tme, inhibit the akt pathway and promote caf apoptosis, providing new insights into the antitumor effect of anlotinib and improving the efficacy of immunotherapy. |
2024-04-14 |
2024-04-17 |
Not clear |
| LaKendria K Brown, Thanigaivelan Kanagasabai, Guoliang Li, Sherly I Celada, Jelonia T Rumph, Samuel E Adunyah, LaMonica V Stewart, Zhenbang Che. Co-targeting SKP2 and KDM5B inhibits prostate cancer progression by abrogating AKT signaling with induction of senescence and apoptosis. The Prostate. 2024-04-12. PMID:38605532. |
co-targeting skp2 and kdm5b inhibits prostate cancer progression by abrogating akt signaling with induction of senescence and apoptosis. |
2024-04-12 |
2024-04-14 |
Not clear |
| Jingjing Li, Shaik A Hussain, Jayasimha R Daddam, Mengjie Su. Bergapten attenuates human papillary thyroid cancer cell proliferation by triggering apoptosis and the GSK-3β, P13K and AKT pathways. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2024-04-09. PMID:38591347. |
bergapten attenuates human papillary thyroid cancer cell proliferation by triggering apoptosis and the gsk-3β, p13k and akt pathways. |
2024-04-09 |
2024-04-11 |
human |
| Rong Wu, Zhibin Zhang, Qingxia Xu, Fang Liu, Yu Zhan, Qiuxiao Wang, Lijuan Du, Xuegui Tan. Integration of network pharmacology and experimental verifications reveals the Bian-Se-Tong mixture can alleviate constipation in STC rats by reducing apoptosis of Cajal cells via activating PI3K-Akt signaling pathway. Heliyon. vol 10. issue 7. 2024-04-08. PMID:38586320. |
in-depth mechanistic studies have shown that bstm can significantly reduce the apoptosis of intestinal cajal cells, downregulate the expression of bax and c-caspase 3, upregulate the expression of bcl-2 and c-kit, and promote the phosphorylation of akt. |
2024-04-08 |
2024-04-10 |
rat |
| Kening Sun, Ping Chen, Liang Zhang, Zhidong Lu, Qunhua Ji. Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway. Acta pharmaceutica (Zagreb, Croatia). vol 74. issue 1. 2024-03-30. PMID:38554386. |
deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and g2/m cell cycle arrest: involvement of akt and p38 mapk signalling pathway. |
2024-03-30 |
2024-04-02 |
human |
| Jialiang Lin, Longjie Wang, Yuhao Wu, Qian Xiang, Yongzhao Zhao, Xuanqi Zheng, Shuai Jiang, Zhuoran Sun, Dongwei Fan, Weishi L. Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy. Experimental & molecular medicine. 2024-03-27. PMID:38531963. |
mechanistically, mitochondrial translocation of dj-1 promoted the recruitment of hexokinase 2 (hk2) to damaged mitochondria by activating akt and subsequently parkin-dependent mitophagy to inhibit oxidative stress-induced apoptosis in npcs. |
2024-03-27 |
2024-03-29 |
rat |
| Linyuan Yu, Chenyu Ling, Yizhu Li, Huiduo Guo, Anying Xu, Heying Qian, Gang L. The Bombyx mori G protein β subunit 1 (BmGNβ1) gene inhibits BmNPV infection. Journal of invertebrate pathology. 2024-03-27. PMID:38537687. |
overexpression of bmgnβ1 in bmn cells was also correlated with apoptosis and a modification in transcript levels ofgenes involved in host response to bmnpv infection (pi3k, akt, bmp53, bmfoxo, caspase-1, bmp21, bmpkn and bmcreb), suggesting that bmgnβ1 may influence the apoptotic host response of infected b. mori through the pi3k-akt pathway. |
2024-03-27 |
2024-03-30 |
Not clear |
| Chen-Lin Yu, Yu-Wei Lai, Jih-Jung Chen, Jie-Jen Lee, Tsung-Hsien Chou, Chen-Chen Huang, Shih-Chia Liu, Guang-Wei Chen, Chung-Hsin Tsai, Shih-Wei Wan. Cryptocaryone induces apoptosis in human hepatocellular carcinoma cells by inhibiting aerobic glycolysis through Akt and c-Src signaling pathways. Journal of food and drug analysis. vol 31. issue 4. 2024-03-25. PMID:38526828. |
cryptocaryone induces apoptosis in human hepatocellular carcinoma cells by inhibiting aerobic glycolysis through akt and c-src signaling pathways. |
2024-03-25 |
2024-03-28 |
human |
| Chen-Lin Yu, Yu-Wei Lai, Jih-Jung Chen, Jie-Jen Lee, Tsung-Hsien Chou, Chen-Chen Huang, Shih-Chia Liu, Guang-Wei Chen, Chung-Hsin Tsai, Shih-Wei Wan. Cryptocaryone induces apoptosis in human hepatocellular carcinoma cells by inhibiting aerobic glycolysis through Akt and c-Src signaling pathways. Journal of food and drug analysis. vol 31. issue 4. 2024-03-25. PMID:38526828. |
these results suggest that cryptocaryone may promote cell apoptosis by inhibiting foxo1-mediated aerobic glycolysis through akt and c-src signaling cascades in human hcc cells. |
2024-03-25 |
2024-03-28 |
human |
| Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Apirath Wangteeraprasert, Worasak Kaewkong, Julintorn Somran, Naphat Kaewpaeng, Supawadee Parhira, Piyarat Srisawan. Combination of ethyl acetate fraction from Calotropis gigantea stem bark and sorafenib induces apoptosis in HepG2 cells. PloS one. vol 19. issue 3. 2024-03-25. PMID:38527038. |
reactive oxygen species (ros) levels were assessed in combination with the expression of the phosphatidylinositol-3-kinase (pi3k)/ protein kinase b (akt)/ mammalian target of rapamycin (mtor) pathway, which was suggested for association with ros-induced apoptosis. |
2024-03-25 |
2024-03-28 |
Not clear |
| Guo Chen, Xinyuan Li, Xiang Zhou, Yang Li, Haitao Yu, Xiang Peng, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Yuhua Mei, Li Li, Yu Liu, Xin Gou, Yuanbin Jian. Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis. Scientific reports. vol 14. issue 1. 2024-03-21. PMID:38509215. |
in this study, we found that mir-100-5p was enriched in hucmsc-sevs, and mir-100-5p targeted fkbp5 and inhibited hk-2 cell apoptosis by activating the akt pathway. |
2024-03-21 |
2024-03-23 |
mouse |
| Guo Chen, Xinyuan Li, Xiang Zhou, Yang Li, Haitao Yu, Xiang Peng, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Yuhua Mei, Li Li, Yu Liu, Xin Gou, Yuanbin Jian. Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis. Scientific reports. vol 14. issue 1. 2024-03-21. PMID:38509215. |
overall, this study revealed an effect of hucmsc-sevs on inhibiting apoptosis; hucmsc-sevs reduced renal ir injury by delivering mir-100-5p to hk-2 cells, targeting fkbp5 and thereby promoting akt-473 phosphorylation to activate the akt pathway. |
2024-03-21 |
2024-03-23 |
mouse |
| Qian Deng, Jia-Qi Liang, Chen-Hui Gao, Xia Ge, Jin-Jin Zheng, Qing-Ping Zhan. Effects of electroacupuncture on the PI3K/Akt/CREB signaling pathway and hippocampal neuronal apoptosis in diabetic cognitive impairment rats. Zhen ci yan jiu = Acupuncture research. vol 49. issue 3. 2024-03-19. PMID:38500323. |
to observe the effects of electroacupuncture (ea) on the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/camp response element binding protein (creb) signaling pathway-related proteins and hippocampal neuron apoptosis in diabetic cognitive impairment (dci) rats, and to explore the mechanisms of ea in treating dci. |
2024-03-19 |
2024-03-21 |
rat |
| Liqiao Chen, Liangliang Wang, Zongqi Han, Peng Qin, Guangxu Niu, Jingxia D. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. The Tohoku journal of experimental medicine. vol 262. issue 3. 2024-03-18. PMID:38123304. |
then, sphk1/2 activity, cell viability, proliferation, apoptosis, invasion, and protein expressions of phosphorylated-protein kinase b (p-akt), akt, phosphorylated-mammalian target of rapamycin (p-mtor) and mtor were detected. |
2024-03-18 |
2024-03-20 |
Not clear |
| Sara M Elgendy, Dana M Zaher, Nadin H Sarg, Nour N Abu Jayab, Dima W Alhamad, Taleb H Al-Tel, Hany A Oma. Autophagy inhibition potentiates energy restriction-induced cell death in hepatocellular carcinoma cells. IUBMB life. 2024-03-18. PMID:38497226. |
the treatment combination promoted hcc death through apoptosis, cell cycle arrest, and inhibition of akt and erk activation, which are known to play a key role in cellular proliferation. |
2024-03-18 |
2024-03-20 |
human |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
cdc-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through akt signaling pathway. |
2024-03-04 |
2024-03-07 |
mouse |
| Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhe. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. In vitro cellular & developmental biology. Animal. 2024-03-04. PMID:38438604. |
mechanistically, clk3 regulated the phosphorylation status of akt, a key player in the regulation of apoptosis. |
2024-03-04 |
2024-03-07 |
mouse |