| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prakash Nayana, Pavan Gollapalli, Hanumanthappa Manjunath. Investigating the structural basis of piperine targeting AKT1 against prostate cancer through Journal of biomolecular structure & dynamics. 2024-03-26. PMID:38529821. |
investigating the structural basis of piperine targeting akt1 against prostate cancer through akt1, significantly impacts many tumours cell functions, like transcription, apoptosis, glucose metabolism, cell proliferation, and cell migration. |
2024-03-26 |
2024-03-28 |
human |
| Silvia Codenotti, Leonardo Sandrini, Delia Mandracchia, Luisa Lorenzi, Giovanni Corsetti, Maura Poli, Michela Asperti, Valentina Salvi, Daniela Bosisio, Eugenio Monti, Stefania Mitola, Luca Triggiani, Michele Guescini, Enrico Pozzo, Maurilio Sampaolesi, Stefano Gastaldello, Matteo Cassandri, Francesco Marampon, Alessandro Fanzan. Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma. Cancers. vol 16. issue 5. 2024-03-13. PMID:38473215. |
we found that treatment with cholesterol-lowering drugs such as lovastatin and simvastatin promoted cell apoptosis in all rms lines by reducing akt1 and cav1 levels and increasing intracellular ros levels. |
2024-03-13 |
2024-03-15 |
human |
| Wen Zhang, Mei-Ling Hu, Xiu-Yun Shi, Xiang-Long Chen, Xue Su, Hua-Zhao Qi, Li Yuan, Hui Zhan. Discovery of novel Akt1 inhibitors by an ensemble-based virtual screening method, molecular dynamics simulation, and in vitro biological activity testing. Molecular diversity. 2024-01-19. PMID:38240951. |
inhibition of akt1 activity can promote cancer cell apoptosis and inhibit tumor growth. |
2024-01-19 |
2024-01-21 |
Not clear |
| Qiuyu Li, Xiaolong Lin, Xiaowen Bo, Siyuan Chen, Donghui Zhao, Qin Ma, Yuhao Zhao, Hong Yang, Jinghua Liu, Qian Fa. Identification of Reduced mTOR T1262 Phosphorylation as a Novel Mechanism and Therapeutic Target of Apoptosis in Senescent Cardiomyocytes. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-01-08. PMID:38190427. |
in hypoxia/reoxygenation cardiomyocytes, mtort1262 phosphorylation deficiency (mtort1262a, lentivirus-mediated transfection) inhibited akt1, suppressed nf-κb, activated foxo1/3a signaling, and ultimately exacerbated apoptosis. |
2024-01-08 |
2024-01-10 |
mouse |
| Lei He, Zifan Lu, Yuanyuan Zhang, Linhong Yan, Lihua Ma, Xiaoling Dong, Zijie Wu, Zhenqing Dai, Baoyi Tan, Ruikun Sun, Shengli Sun, Chengyong L. The effect of polystyrene nanoplastics on arsenic-induced apoptosis in HepG2 cells. Ecotoxicology and environmental safety. vol 269. 2023-12-15. PMID:38100851. |
in addition, transcriptome analysis revealed that tp53, akt1, casp3, actb, bcl2l1, casp8, xiap, mcl1, nfkbia, and casp7 were the top 10 hub genes for ps that enhanced the role of as in hepg2 cell apoptosis. |
2023-12-15 |
2023-12-18 |
Not clear |
| De-Pei Yin, Huanle Zhang, Hua Teng, Dan Zhang, Peipei Chen, Lixiao Xie, Ji-Sheng Li. Overexpressed Gαi1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma. Cell death & disease. vol 14. issue 12. 2023-12-04. PMID:38049415. |
in gαi1-silenced primary npc cells, a s473d constitutively-active mutant akt1 (caakt1) restored akt-s6k phosphorylation and ameliorated gαi1 shrna-induced proliferation inhibition, migration reduction and apoptosis. |
2023-12-04 |
2023-12-10 |
mouse |
| Yin Li, Lei Feng, Lin Bai, Hao Jian. Study of Therapeutic Mechanisms of Puerarin against Sepsis-Induced Myocardial Injury by Integrating Network Pharmacology, Bioinformatics Analysis, and Experimental Validation. Critical reviews in immunology. vol 43. issue 3. 2023-10-12. PMID:37824375. |
in vivo experiments indicated that pue promoted cell proliferation, downregulated akt1, casp3, tp53, and mapk3, and inhibited inflammation, myocardial injury, os, and apoptosis in the cell model. |
2023-10-12 |
2023-10-15 |
Not clear |
| Yin Li, Lei Feng, Lin Bai, Hao Jian. Study of Therapeutic Mechanisms of Puerarin against Sepsis-Induced Myocardial Injury by Integrating Network Pharmacology, Bioinformatics Analysis, and Experimental Validation. Critical reviews in immunology. vol 43. issue 3. 2023-10-12. PMID:37824375. |
pue might inhibit inflammation, myocardial injury, os, and apoptosis to treat simi by reducing akt1, casp3, tp53, and mapk3. |
2023-10-12 |
2023-10-15 |
Not clear |
| Xinqian He, Yongzhi Sun, Xiaomeng Lu, Fan Yang, Ting Li, Changsheng Deng, Jianping Song, Xin'an Huan. Assessment of the anti-inflammatory mechanism of quercetin 3,7-dirhamnoside using an integrated pharmacology strategy. Chemical biology & drug design. 2023-10-08. PMID:37806949. |
this indicates that the anti-inflammatory mechanisms of qdr involve regulation of akt1 and mtor to prevent apoptosis and of nos3 which leads to the release of endothelial no. |
2023-10-08 |
2023-10-15 |
Not clear |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
in contrast, the addition of pp242, an inhibitor of the mtor signaling pathway also inhibited mrna and protein expression levels of mtor, akt1, foxo1, and eif4ebp1 and promoted mitophagy and apoptosis, which were consistent with the effect of nab treatment. |
2023-09-09 |
2023-10-07 |
cattle |
| Wenwei Sun, Meimei Wang, Jun Zhao, Shuang Zhao, Wenchao Zhu, Xiaoting Wu, Feifei Li, Wei Liu, Zhuo Wang, Meng Gao, Yiyue Zhang, Jin Xu, Meijia Zhang, Qiang Wang, Zilong Wen, Juan Shen, Wenqing Zhang, Zhibin Huan. Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. Nature communications. vol 14. issue 1. 2023-09-02. PMID:37660128. |
we also found that akt1 is selectively expressed in gabaergic neurons and that sc97 (an akt1 activator) and exogenous akt1 mrna can reverse the apoptosis caused by sulindac. |
2023-09-02 |
2023-09-07 |
mouse |
| Morteza Golbashirzadeh, Hamid Reza Heidari, Ali Asghar Aghamolayi, Yasin Fattahi, Mehdi Talebi, Ahmad Yari Khosroushah. In vitro siRNA-mediated GPX4 and AKT1 silencing in oxaliplatin resistance cancer cells induces ferroptosis and apoptosis. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-08-26. PMID:37632628. |
in vitro sirna-mediated gpx4 and akt1 silencing in oxaliplatin resistance cancer cells induces ferroptosis and apoptosis. |
2023-08-26 |
2023-09-07 |
Not clear |
| Morteza Golbashirzadeh, Hamid Reza Heidari, Ali Asghar Aghamolayi, Yasin Fattahi, Mehdi Talebi, Ahmad Yari Khosroushah. In vitro siRNA-mediated GPX4 and AKT1 silencing in oxaliplatin resistance cancer cells induces ferroptosis and apoptosis. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-08-26. PMID:37632628. |
akt1 and gpx4 are essential regulator genes of apoptosis and ferroptosis pathways. |
2023-08-26 |
2023-09-07 |
Not clear |
| Ruojun Zhang, Nahid Akhtar, Atif Khurshid Wani, Khalid Raza, Vikas Kaushi. Discovering Deleterious Single Nucleotide Polymorphisms of Human AKT1 Oncogene: An In Silico Study. Life (Basel, Switzerland). vol 13. issue 7. 2023-07-29. PMID:37511907. |
akt1 is a serine/threonine kinase necessary for the mediation of apoptosis, angiogenesis, metabolism, and cell proliferation in both normal and cancerous cells. |
2023-07-29 |
2023-08-14 |
human |
| Zhongbo Xu, Manyang Shen, Lin L. Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking. Medicine. vol 102. issue 29. 2023-07-21. PMID:37478218. |
the central core targets were il6, mapk14, signal transducer and activator of transcription 3, rela, vegfa, ccnd1, casp3, ar, fos, jun, egfr, mapk1, akt1, myc, and esr1; gene ontology functional enrichment analysis yielded 911 gene ontology items (p < .01), while kyoto encyclopedia of genes and genomes pathway enrichment yielded 138 signal pathways (p < .01), primarily including oxidative reactions, vascular regulation, apoptosis, and pi3k-akt signaling pathway. |
2023-07-21 |
2023-08-14 |
Not clear |
| Yangyang Zhang, Rui Kong, Wenbo Yang, Keyi Hu, Zhongjie Zhao, Le Li, Xinglong Geng, Liwei Liu, Hongze Chen, Peng Xiao, Danxi Liu, Yan Luo, Hua Chen, Jisheng Hu, Bei Su. DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer. Cancer letters. 2023-06-30. PMID:37390887. |
dusp2 significantly promoted apoptosis in pdac both in vitro and in vivo, mainly through akt1 rather than erk1/2. |
2023-06-30 |
2023-08-14 |
Not clear |
| Yangyang Zhang, Rui Kong, Wenbo Yang, Keyi Hu, Zhongjie Zhao, Le Li, Xinglong Geng, Liwei Liu, Hongze Chen, Peng Xiao, Danxi Liu, Yan Luo, Hua Chen, Jisheng Hu, Bei Su. DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer. Cancer letters. 2023-06-30. PMID:37390887. |
mechanistically, dusp2 competed with akt1 to bind to casein kinase 2 alpha 1 (csnk2a1) and inhibited the phosphorylation of akt1, which plays a crucial role in apoptosis resistance. |
2023-06-30 |
2023-08-14 |
Not clear |
| Yu-Guo Wang, Yong-Qi Dou, Zi-Qiao Yan, Yue Ga. [Molecular mechanism of ginsenoside Rg_1 against radiation enteritis: based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 10. 2023-06-07. PMID:37282941. |
cellular experiment indicated that rg_1 can effectively improve cell viability and survival, decrease apoptosis after irradiation, promote the expression of akt1 and b-cell lymphoma-extra large(bcl-xl), and inhibit the expression of the pro-apoptotic protein bcl-2-associated x protein(bax). |
2023-06-07 |
2023-08-14 |
Not clear |
| Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I Katz, Gwen A Lomberk, Raul A Urrutia, Jonathan P Kat. KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. Cell death & disease. vol 14. issue 5. 2023-05-02. PMID:37130837. |
by contrast, severe stress results in klf5 loss, such that akt1 and akt3 are not induced, and cells preferentially undergo apoptosis. |
2023-05-02 |
2023-08-14 |
human |
| Juliane Stehle, Jörn Weisner, Leanne Eichhorn, Daniel Rauh, Malte Dresche. Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-02-16. PMID:36795969. |
the serine/threonine kinase akt1 is part of the pi3k/akt pathway and plays a key role in the regulation of various cellular processes such as cell growth, proliferation, and apoptosis. |
2023-02-16 |
2023-08-14 |
Not clear |